Vitamin
Inhibitory Selectivity
Vitamin Products
Catalog No. | Information | Product Use Citations | Product Validations |
---|---|---|---|
S1469 |
CalcifediolCalcifediol (Calcidiol, 25-dihydroxyvitamin D3, 1,25-dihydroxyvitamin D3) is a major circulating metabolite of vitamin D3 and acts as a competitive inhibitor with an apparent Ki of 3.9 μM. It also suppresses PTH secretion and mRNA (ED50=2 nM). |
![]() ![]() (E) Qualitative representations of zebrafish larvae, showing ISV to be unchanged or slightly reduced in response to 20 μM seocalcitol, maxacalcitol, calcitriol, calcifediol and tacalcitol treatment between 6 hpf and 2 dpf. Scale bar represents 200 μm. (F) Qualitative representation of intact ISV after 10 μM seocalcitol, maxacalcitol, calcitriol, calcifediol and tacalcitol treatment from 2-5 dpf. Scale bar represents 200 μm.
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S1468 |
AlfacalcidolAlfacalcidol is a non-selective VDR activator medication. |
![]() ![]() Vitamin D analogs induce adenylate kinase release from S. mutans planktonic cells. S. mutans UA159 cultures were grown in TY medium + 1% (w/v) glucose to exponential phase and used to inoculate fresh medium containing ciprofloxacin (positive control), DMSO (negative control), alfacalcidol, calcitriol, or doxercalciferol at 16, 32, and 64 μg/mL for 4h. Cell lysis was detected using the AK assay as described in Materials and Methods. Data is represented as relative luminescence units (RLU) normalized to background (DMSO) and is representative of three replicate cultures performed in triplicate. (* p<0.05; Student’s t-Test; two-tailed).
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S1921 |
PhenindionePhenindione (Rectadione, phenylindandione) is an anticoagulant which functions as a Vitamin K antagonist. |
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S5668 |
ChlorindioneChlorindione is an antagonist of vitamin K. |
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S4144 |
Amprolium HClAmprolium chloride is a thiamin antagonist, which prevents carbohydrate synthesis by blocking thiamine uptake. |
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S6681New |
ParicalcitolParicalcitol (Paracalcin, Zemplar, 19-Nor-1-25-OH2D2, 19-Nor-colecalciferol) is a selective vitamin D receptor agonist. Paricalcitol suppresses parathyroid hormone mRNA expression and inhibits parathyroid cell proliferation. Pariccitol is used to treat secondary hyperparathyroidism in chronic kidney disease. |
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S1466 |
CalcitriolCalcitriol (RO215535, Topitriol) is a nonselective vitamin D receptor activator/agonist(VDRA), exhibiting a 10-fold higher vitamin D receptor (VDR) binding affinity(IC50=0.4 nM) than the selective VDRA paricalcitol. |
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S3114 |
Vitamin CVitamin C (Ascorbic acid) is a water-soluble vitamin indicated for the prevention and treatment of scurvy. |
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S1467 |
DoxercalciferolDoxercalciferol (1α-hydroxyvitamin D2) is a synthetic vitamin D2 analog, suppressing parathyroid synthesis and secretion, used to treat secondary hyperparathyroidism and metabolic bone disease. |
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S3130 |
Biotin (Vitamin B7)Biotin is a water-soluble B-vitamin and is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids. |
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S1902 |
Vitamin B12Vitamin B12 (Cobalamin, Cyanocobalamin) is a water soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood. |
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S1744 |
Nicotinic AcidNicotinic Acid is a water-soluble vitamin belonging to the vitamin B family. |
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S4063 |
cholecalciferol (Vitamin D3)Cholecalciferol (Vitamin D3) is a form of vitamin D, binds and activates a H305F/H397Y mutant vitamin D receptor (VDR) with EC50 of 300 nM. |
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S1767 |
Beta CaroteneBeta Carotene is an organic compound and classified as a terpenoid. It is a precursor (inactive form) of vitamin A. |
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S2540 |
RiboflavinRiboflavin (Vitamin B2) is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals. |
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S3211 |
Thiamine HCl (Vitamin B1)Thiamine or vitamin B1 is a water-soluble vitamin of the B complex, its phosphate derivatives are involved in many cellular processes. |
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S5082 |
Vitamin K2Vitamin K2 (Menaquinone) is an important fat-soluble vitamin that plays critical roles in protecting heart and brain, and building strong bones. It also plays an important role in cancer protection. |
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S5592 |
Vitamin AVitamin A (Retinol) is a naturally occuring fat-soluble vitamin that is important for normal vision, the immune system, and reproduction. It also plays roles in normal functioning of heart, lungs, kidneys, and other organs. |
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S4503 |
Calcium D-PanthotenateCalcium D-Panthotenate (D-Pantothenic Acid Calcium), also called vitamin B5 Calcium, is a water-soluble vitamin and an essential nutrient for many animals. |
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S5568 |
TocofersolanTocofersolan (Tocophersolan) is a synthetic water-soluble version of vitamin E that is used in treatment of vitamin E deficiency. |
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S5386 |
7-Dehydrocholesterol7-Dehydrocholesterol (7-DHC, Provitamin D3) is the direct precursor of free cholesterol in the cholesterol biosynthetic pathway in mammalian tissues and also a biosynthetic precursor to vitamin D3. |
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S4126 |
Retinyl (Vitamin A) PalmitateRetinyl (Vitamin A) Palmitate is a more stable, synthetic version of the essential nutrient vitamin A joined to palmitic acid. |
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S5474 |
Dibenzoyl ThiamineDibenzoyl Thiamine (Bentiamine, O,S-Dibenzoylthiamine), a lipophilic derivative of vitamin B (thiamine), is a kind of food additive that can be rapidly absorbed into the body and converted to thiamine. |
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S6104 |
(±)-α-Tocopherol(±)-α-Tocopherol is a biologically active form of vitamin E, which is a lipid-soluble antioxidant that protects cellular membranes from oxidative damage. |
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S5203 |
SulbutiamineSulbutiamine is a synthetic derivative of thiamine (vitamin B1), belonging to a class of supplements shown to help improve memory, learning capacity, decision-making, concentration, and focus. |
||
S4605 |
Folic acidFolic acid (Folacin, Vitamin B9, Vitamin M, Pteroylglutamic acid, Folate), a B vitamin, plays an important role in cell division and in the synthesis of amino acids and nucleic acids like DNA. |
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S6102 |
Thiamine pyrophosphate hydrochlorideThiamine pyrophosphate hydrochloride (cocarboxylase) is a thiamine (vitamin B1) derivative which is produced by the enzyme thiamine diphosphokinase. It is a coenzyme of many enzymes, most of which occur in prokaryotes and is involved in the regulation of basic metabolism. |
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S2297 |
ErgosterolErgosterol is a sterol and a biological precursor (a provitamin) to vitamin D2. |
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S4871 |
Pyridoxal 5-phosphate monohydratePyridoxal 5-phosphate monohydrate is an active vitamin B6 metabolite, which is a cofactor in many reactions of amino acid metabolism. |
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S6614 |
FursultiamineFursultiamine (Thiamine tetrahydrofurfuryl disulfide) is a nutritional supplement and vitamin B1 derivative, with potential antineoplastic activity. |
||
S4695 |
D panthenolD panthenol (Dexpanthenol, D-Panthenol, Pantothenol, Ilopan, D-Pantothenyl alcohol) is an alcoholic analogue of D-pantothenic acid and cholinergic agent. |
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S4083 |
Vitamin A AcetateVitamin A Acetate (Retinyl, Retinol) is a group of unsaturated nutritional hydrocarbons, that includes retinol, retinal, retinoic acid, and several provitamin A carotenoids, among which beta-carotene is the most important. |
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S3681 |
Vitamin E AcetateVitamin E Acetate (Tocopherol) is the stable form of Vitamin E most often used in cosmetic formulations for its skin care benefits. It protects the cells against free radicals and prevents the peroxidation of body fats as an in-vivo antioxidant. |
||
S3665 |
TroloxTrolox is a cell-permeable, water-soluble derivative of vitamin E with potent antioxidant properties. |
||
S4698 |
Vitamin K1Vitamin K1 (Phyllohydroquinone, Phylloquinone, Phytomenadione, Phytonadione), made by plants, is a major type of dietary vitamin K, which is well-known for its role in blood clotting. Vitamin K1 is directly involved in photosynthesis. |
||
S3739 |
CalcipotrieneCalcipotriene (Calcipotriol, MC903) is a synthetic derivative of calcitriol, a form of vitamin D. It can induce differentiation and suppresses proliferation of keratinocytes, reversing abnormal keratinocyte changes in psoriasis, and lead to normalization of epidermal growth. Calcipotriol is a synthetic VitD3 analogue with a high affinity for the vitamin D receptor. |
||
S4779 |
Menadiol DiacetateMenadiol Diacetate (Vitamin K4, Acetomenaphthone, Kapilin) is a synthetic hydrophilic menadione compound, which is clinically used as hemostasis medicine. It induces caspase-3-related apoptosis pathway via mitochondrial dysfunction and DNA fragmentation. |
||
S3113 |
Pyridoxine HClPyridoxine HCl (Vitamin B6) is a form of vitamin B6. |
||
S4994 |
MethylcobalaminMethylcobalamin (Mecobalamin, Vancomin, Methycobal, Cobametin) is one active form of vitamin B12 which can directly participate in homocysteine metabolism. It is used to treat some nutritional diseases and other diseases in clinic, such as Alzheimer's disease and rheumatoid arthritis. |
||
S5846 |
ApocarotenalApocarotenal is a carotenoid found in spinach and citrus fruits and plays a role as a precursor of vitamin A. |
||
S4245 |
Sodium ascorbateSodium Ascorbate is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement. |
||
S4987 |
Inositol niacinateInositol Niacinate (Inositol hexanicotinate, Myo-Inositol hexanicotinate) is a formulation of niacin, which is also called vitamin B3, an essential human nutrient. |
||
S3980 |
PyridoxinePyridoxine (Pyridoxol, Vitamin B6, Gravidox), also known as vitamin B6, is a form of vitamin B6 found commonly in food and used as dietary supplement. It is a cofactor for both glutamic acid decarboxylase and GABA transaminase. |
||
S5220 |
D-PantethinePantethine (Bis-pantethine, Pantetina, Pantomin, Pantosin) is a naturally occurring compound synthesized in the body from pantothenic acid (vitamin B5) via addition of cysteamine and used as a dietary supplement for lowering blood cholesterol and triglycerides. |
||
S5558 |
D-Pantothenate SodiumD-Pantothenate Sodium, the sodium salt of D-pantothenate, is a derivative of vitamin B5 which is an an essential nutrient and plays important roles in the oxidation of fats and carbohydrates and certain amino acids. |
||
S4811 |
VitaMin UVitamin U (Methylmethioninesulfonium Chloride, Cabagin-U, Smethylmethionine) is a vitamin found in green vegetables. It is used in the treatment of peptic ulcers, colitis, and gastritis and has an effect on secretory, acid-forming, and enzymatic functions of the intestinal tract. |
||
S5311 |
Pyridoxal phosphatePyridoxal phosphate (Pyridoxal 5'-phosphate, PAL-P, PLP, Vitamin B6), the active form of vitamin B6, acts as a coenzyme in all transamination reactions, and in certain decarboxylation, deamination, and racemization reactions of amino acids. |
Catalog No. | Information | Product Use Citations | Product Validations |
---|---|---|---|
S1469 |
CalcifediolCalcifediol (Calcidiol, 25-dihydroxyvitamin D3, 1,25-dihydroxyvitamin D3) is a major circulating metabolite of vitamin D3 and acts as a competitive inhibitor with an apparent Ki of 3.9 μM. It also suppresses PTH secretion and mRNA (ED50=2 nM). |
![]() ![]() (E) Qualitative representations of zebrafish larvae, showing ISV to be unchanged or slightly reduced in response to 20 μM seocalcitol, maxacalcitol, calcitriol, calcifediol and tacalcitol treatment between 6 hpf and 2 dpf. Scale bar represents 200 μm. (F) Qualitative representation of intact ISV after 10 μM seocalcitol, maxacalcitol, calcitriol, calcifediol and tacalcitol treatment from 2-5 dpf. Scale bar represents 200 μm.
|
Catalog No. | Information | Product Use Citations | Product Validations |
---|---|---|---|
S1468 |
AlfacalcidolAlfacalcidol is a non-selective VDR activator medication. |
![]() ![]() Vitamin D analogs induce adenylate kinase release from S. mutans planktonic cells. S. mutans UA159 cultures were grown in TY medium + 1% (w/v) glucose to exponential phase and used to inoculate fresh medium containing ciprofloxacin (positive control), DMSO (negative control), alfacalcidol, calcitriol, or doxercalciferol at 16, 32, and 64 μg/mL for 4h. Cell lysis was detected using the AK assay as described in Materials and Methods. Data is represented as relative luminescence units (RLU) normalized to background (DMSO) and is representative of three replicate cultures performed in triplicate. (* p<0.05; Student’s t-Test; two-tailed).
|
Catalog No. | Information | Product Use Citations | Product Validations |
---|---|---|---|
S1921 |
PhenindionePhenindione (Rectadione, phenylindandione) is an anticoagulant which functions as a Vitamin K antagonist. |
||
S5668 |
ChlorindioneChlorindione is an antagonist of vitamin K. |
||
S4144 |
Amprolium HClAmprolium chloride is a thiamin antagonist, which prevents carbohydrate synthesis by blocking thiamine uptake. |
Catalog No. | Information | Product Use Citations | Product Validations |
---|---|---|---|
S6681New |
ParicalcitolParicalcitol (Paracalcin, Zemplar, 19-Nor-1-25-OH2D2, 19-Nor-colecalciferol) is a selective vitamin D receptor agonist. Paricalcitol suppresses parathyroid hormone mRNA expression and inhibits parathyroid cell proliferation. Pariccitol is used to treat secondary hyperparathyroidism in chronic kidney disease. |
Catalog No. | Information | Product Use Citations | Product Validations |
---|---|---|---|
S1466 |
CalcitriolCalcitriol (RO215535, Topitriol) is a nonselective vitamin D receptor activator/agonist(VDRA), exhibiting a 10-fold higher vitamin D receptor (VDR) binding affinity(IC50=0.4 nM) than the selective VDRA paricalcitol. |
![]() ![]() |
|
S3114 |
Vitamin CVitamin C (Ascorbic acid) is a water-soluble vitamin indicated for the prevention and treatment of scurvy. |
||
S1467 |
DoxercalciferolDoxercalciferol (1α-hydroxyvitamin D2) is a synthetic vitamin D2 analog, suppressing parathyroid synthesis and secretion, used to treat secondary hyperparathyroidism and metabolic bone disease. |
||
S3130 |
Biotin (Vitamin B7)Biotin is a water-soluble B-vitamin and is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids. |
||
S1902 |
Vitamin B12Vitamin B12 (Cobalamin, Cyanocobalamin) is a water soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood. |
||
S1744 |
Nicotinic AcidNicotinic Acid is a water-soluble vitamin belonging to the vitamin B family. |
||
S4063 |
cholecalciferol (Vitamin D3)Cholecalciferol (Vitamin D3) is a form of vitamin D, binds and activates a H305F/H397Y mutant vitamin D receptor (VDR) with EC50 of 300 nM. |
||
S1767 |
Beta CaroteneBeta Carotene is an organic compound and classified as a terpenoid. It is a precursor (inactive form) of vitamin A. |
||
S2540 |
RiboflavinRiboflavin (Vitamin B2) is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals. |
||
S3211 |
Thiamine HCl (Vitamin B1)Thiamine or vitamin B1 is a water-soluble vitamin of the B complex, its phosphate derivatives are involved in many cellular processes. |
||
S5082 |
Vitamin K2Vitamin K2 (Menaquinone) is an important fat-soluble vitamin that plays critical roles in protecting heart and brain, and building strong bones. It also plays an important role in cancer protection. |
||
S5592 |
Vitamin AVitamin A (Retinol) is a naturally occuring fat-soluble vitamin that is important for normal vision, the immune system, and reproduction. It also plays roles in normal functioning of heart, lungs, kidneys, and other organs. |
||
S4503 |
Calcium D-PanthotenateCalcium D-Panthotenate (D-Pantothenic Acid Calcium), also called vitamin B5 Calcium, is a water-soluble vitamin and an essential nutrient for many animals. |
||
S5568 |
TocofersolanTocofersolan (Tocophersolan) is a synthetic water-soluble version of vitamin E that is used in treatment of vitamin E deficiency. |
||
S5386 |
7-Dehydrocholesterol7-Dehydrocholesterol (7-DHC, Provitamin D3) is the direct precursor of free cholesterol in the cholesterol biosynthetic pathway in mammalian tissues and also a biosynthetic precursor to vitamin D3. |
||
S4126 |
Retinyl (Vitamin A) PalmitateRetinyl (Vitamin A) Palmitate is a more stable, synthetic version of the essential nutrient vitamin A joined to palmitic acid. |
||
S5474 |
Dibenzoyl ThiamineDibenzoyl Thiamine (Bentiamine, O,S-Dibenzoylthiamine), a lipophilic derivative of vitamin B (thiamine), is a kind of food additive that can be rapidly absorbed into the body and converted to thiamine. |
||
S6104 |
(±)-α-Tocopherol(±)-α-Tocopherol is a biologically active form of vitamin E, which is a lipid-soluble antioxidant that protects cellular membranes from oxidative damage. |
||
S5203 |
SulbutiamineSulbutiamine is a synthetic derivative of thiamine (vitamin B1), belonging to a class of supplements shown to help improve memory, learning capacity, decision-making, concentration, and focus. |
||
S4605 |
Folic acidFolic acid (Folacin, Vitamin B9, Vitamin M, Pteroylglutamic acid, Folate), a B vitamin, plays an important role in cell division and in the synthesis of amino acids and nucleic acids like DNA. |
||
S6102 |
Thiamine pyrophosphate hydrochlorideThiamine pyrophosphate hydrochloride (cocarboxylase) is a thiamine (vitamin B1) derivative which is produced by the enzyme thiamine diphosphokinase. It is a coenzyme of many enzymes, most of which occur in prokaryotes and is involved in the regulation of basic metabolism. |
||
S2297 |
ErgosterolErgosterol is a sterol and a biological precursor (a provitamin) to vitamin D2. |
||
S4871 |
Pyridoxal 5-phosphate monohydratePyridoxal 5-phosphate monohydrate is an active vitamin B6 metabolite, which is a cofactor in many reactions of amino acid metabolism. |
||
S6614 |
FursultiamineFursultiamine (Thiamine tetrahydrofurfuryl disulfide) is a nutritional supplement and vitamin B1 derivative, with potential antineoplastic activity. |
||
S4695 |
D panthenolD panthenol (Dexpanthenol, D-Panthenol, Pantothenol, Ilopan, D-Pantothenyl alcohol) is an alcoholic analogue of D-pantothenic acid and cholinergic agent. |
||
S4083 |
Vitamin A AcetateVitamin A Acetate (Retinyl, Retinol) is a group of unsaturated nutritional hydrocarbons, that includes retinol, retinal, retinoic acid, and several provitamin A carotenoids, among which beta-carotene is the most important. |
||
S3681 |
Vitamin E AcetateVitamin E Acetate (Tocopherol) is the stable form of Vitamin E most often used in cosmetic formulations for its skin care benefits. It protects the cells against free radicals and prevents the peroxidation of body fats as an in-vivo antioxidant. |
||
S3665 |
TroloxTrolox is a cell-permeable, water-soluble derivative of vitamin E with potent antioxidant properties. |
||
S4698 |
Vitamin K1Vitamin K1 (Phyllohydroquinone, Phylloquinone, Phytomenadione, Phytonadione), made by plants, is a major type of dietary vitamin K, which is well-known for its role in blood clotting. Vitamin K1 is directly involved in photosynthesis. |
||
S3739 |
CalcipotrieneCalcipotriene (Calcipotriol, MC903) is a synthetic derivative of calcitriol, a form of vitamin D. It can induce differentiation and suppresses proliferation of keratinocytes, reversing abnormal keratinocyte changes in psoriasis, and lead to normalization of epidermal growth. Calcipotriol is a synthetic VitD3 analogue with a high affinity for the vitamin D receptor. |
||
S4779 |
Menadiol DiacetateMenadiol Diacetate (Vitamin K4, Acetomenaphthone, Kapilin) is a synthetic hydrophilic menadione compound, which is clinically used as hemostasis medicine. It induces caspase-3-related apoptosis pathway via mitochondrial dysfunction and DNA fragmentation. |
||
S3113 |
Pyridoxine HClPyridoxine HCl (Vitamin B6) is a form of vitamin B6. |
||
S4994 |
MethylcobalaminMethylcobalamin (Mecobalamin, Vancomin, Methycobal, Cobametin) is one active form of vitamin B12 which can directly participate in homocysteine metabolism. It is used to treat some nutritional diseases and other diseases in clinic, such as Alzheimer's disease and rheumatoid arthritis. |
||
S5846 |
ApocarotenalApocarotenal is a carotenoid found in spinach and citrus fruits and plays a role as a precursor of vitamin A. |
||
S4245 |
Sodium ascorbateSodium Ascorbate is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement. |
||
S4987 |
Inositol niacinateInositol Niacinate (Inositol hexanicotinate, Myo-Inositol hexanicotinate) is a formulation of niacin, which is also called vitamin B3, an essential human nutrient. |
||
S3980 |
PyridoxinePyridoxine (Pyridoxol, Vitamin B6, Gravidox), also known as vitamin B6, is a form of vitamin B6 found commonly in food and used as dietary supplement. It is a cofactor for both glutamic acid decarboxylase and GABA transaminase. |
||
S5220 |
D-PantethinePantethine (Bis-pantethine, Pantetina, Pantomin, Pantosin) is a naturally occurring compound synthesized in the body from pantothenic acid (vitamin B5) via addition of cysteamine and used as a dietary supplement for lowering blood cholesterol and triglycerides. |
||
S5558 |
D-Pantothenate SodiumD-Pantothenate Sodium, the sodium salt of D-pantothenate, is a derivative of vitamin B5 which is an an essential nutrient and plays important roles in the oxidation of fats and carbohydrates and certain amino acids. |
||
S4811 |
VitaMin UVitamin U (Methylmethioninesulfonium Chloride, Cabagin-U, Smethylmethionine) is a vitamin found in green vegetables. It is used in the treatment of peptic ulcers, colitis, and gastritis and has an effect on secretory, acid-forming, and enzymatic functions of the intestinal tract. |
||
S5311 |
Pyridoxal phosphatePyridoxal phosphate (Pyridoxal 5'-phosphate, PAL-P, PLP, Vitamin B6), the active form of vitamin B6, acts as a coenzyme in all transamination reactions, and in certain decarboxylation, deamination, and racemization reactions of amino acids. |