- Inhibitory Selectivity
|Catalog No.||Product Name||Solubility(25°C)|
|S8388||ML-7 HCl||<1 mg/mL||90 mg/mL||<1 mg/mL|
|S8465||GSK'872 (GSK2399872A)||<1 mg/mL||76 mg/mL||40 mg/mL|
|S8215||BAY 1217389||<1 mg/mL||100 mg/mL||3 mg/mL|
|S5792||CID 2011756||<1 mg/mL||30 mg/mL||<1 mg/mL|
|S4956||Benzamidine HCl||31 mg/mL||31 mg/mL||31 mg/mL|
|S8775||HS-1371||<1 mg/mL||13 mg/mL||4 mg/mL|
|S8366||CRT0066101||82 mg/mL||25 mg/mL||2 mg/mL|
|S8358||WNK463||<1 mg/mL||92 mg/mL||92 mg/mL|
|S7188||CID755673||<1 mg/mL||43 mg/mL||<1 mg/mL|
- Serine/threonin kinase Inhibitors (9)
- New Serine/threonin kinase Products
|Catalog No.||Information||Product Use Citations||Product Validations|
ML-7 is an inhibitor of smooth muscle myosin light chain kinase (MLCK) with a Ki value of 0.3 µM and displays reversible, ATP-competitive inhibition of Ca2+-calmodulin-dependent and -independent smooth muscle MLCKs.
Representative Hoechst 33342 (blue) and phosphorylated MLC (red) stained images of SK-LMS-1 cells. Scale bar, 200 μm.
GSK'872 (GSK2399872A) is a potent and selective RIP3 kinase inhibitor which binds RIP3 kinase domain with high affinity (IC50=1.8 nM) and inhibits kinase activity with IC50 of 1.3 nM. It has minimal cross-reactivity.
BAY 1217389 is an orally bioavailable, selective inhibitor of the serine/threonine kinase monopolar spindle 1 (Mps1) with IC50 values below 10 nmol/L while showing an excellent selectivity profile.
CID 2011756 is an inhibitor of protein kinase D (PKD) with IC50 values of 3.2, 0.6, and 0.7 μM for PKD1, PKD2, and PKD3, respectively.
Benzamidine is an inhibitor of serine proteases with Ki values of 35, 350, and 220 µM for trypsin, plasmin, and thrombin, respectively.
HS-1371 is a potent RIP3 kinase inhibitor with an IC50 of 20.8 nM. It binds to the ATP binding pocket of RIP3 and inhibits ATP binding to prevent RIP3 enzymatic activity in vitro.
CRT0066101 is a small molecule PKD family specific inhibitor which specifically blocks PKD1/2 activity and does not suppress PKCα/PKCβ/PKCε activity in multiple.
WNK463 is a pan-WNK-kinase inhibitor. It potently inhibits the in vitro kinase activity of all four WNK family members (WNK1, WNK2, WNK3, and WNK4).
CID755673 is a cell-active pan-PKD1/2/3 inhibitor with IC50 of 180 nM, 280nM, and 227 nM, respectively, about 200-fold selectivity over other CAMKs.