Home Metabolism Serine/threonin kinase

Serine/threonin kinase

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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S8358 WNK463 WNK463 is a pan-WNK-kinase inhibitor. It potently inhibits the in vitro kinase activity of all four WNK family members (WNK1, WNK2, WNK3, and WNK4) with IC50 of 5nM, 1nM, 6nM, and 9nM.
Nat Commun, 2025, 16(1):4945
bioRxiv, 2025, 2025.02.02.636139
PLoS Pathog, 2024, 20(8):e1012291
S1460 SP600125 SP600125 (Nsc75890) is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM in cell-free assays, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selectivity against ERK2, p38, Chk1, EGFR etc. This compound is also a broad‐spectrum inhibitor of serine/threonine kinases including Aurora kinase A，FLT3 and TRKA with of IC50 of 60 nM, 90 nM and 70 nM. It inhibits autophagy and activates apoptosis.
Nat Commun, 2025, 16(1):7156
Adv Sci (Weinh), 2025, 12(28):e2502634
Adv Sci (Weinh), 2025, 12(36):e00028
Verified customer review of SP600125
S8929 GCN2iB GCN2iB is an ATP-competitive serine/threonine-protein kinase general control nonderepressible 2 (GCN2) inhibitor with IC50 of 2.4 nM.
Immunity, 2025, 58(10):2489-2504.e8
EMBO J, 2025, 10.1038/s44318-025-00505-1
EMBO J, 2025, 44(4):1107-1130
S7270 SRPIN340 SRPIN340 is a selective SRPK inhibitor with Ki of 0.89 μM for SRPK1, showing no significant inhibitory activity against more than 140 other kinases.
Mol Cell, 2024, 84(23):4558-4575.e8
Cancers (Basel), 2022, 14(19)4695
Mol Cell, 2020, 80(6):1104-1122.e9
Verified customer review of SRPIN340
S4956 Benzamidine HCl Benzamidine is an inhibitor of serine proteases with Ki values of 35, 350, and 220 µM for trypsin, plasmin, and thrombin, respectively.
Sci Rep, 2019, 9(1):382
Nature, 2015, 519(7542):247-50
Nature, 2015, 12;519(7542):247-50.
S8810 SPHINX31 SPHINX31 is a SRPK1 inhibiror with an IC50 of 5.9 nM with highly selectivity for SRPK1 over SRPK2 (50-fold) and CLK1 (100-fold).
Leukemia, 2023, 37(8):1649-1659
Antiviral Res, 2023, 10.1016/j.antiviral.2023.105756
S8945 BAY-1816032 BAY-1816032 is a potent and oral available inhibitor of budding uninhibited by benzimidazoles 1 (BUB1) kinase with IC50 of 6.1 nM for recombinant catalytic domain of human BUB1. This compound has antitumor activity.
Mol Cell, 2024, 84(9):1783-1801.e7
S0431 ML281 ML281 is a potent and selective inhibitor of Serine/threonine kinase 33 (STK33) with IC50 of 0.014 μM. This compound is selectively toxic to KRAS-dependent cancer cell lines.
iScience, 2024, 27(3):109300
S8976 DCLK1-IN-1 DCLK1-IN-1 is a selective, in vivo-compatible chemical probe of the doublecortin like kinase 1 (DCLK1) domain that binds to DCLK1 and DCLK2 with IC50 of 9.5 nM and 31 nM, respectively. This compound inhibits DCLK1 and DCLK2 kinases with IC50 of 57.2 nM and 103 nM in kinase assay, respectively.
Clin Transl Med, 2022, 12(5):e743
S6710 SGC-GAK-1 SGC-GAK-1 is a potent, selective, and cell-active inhibitor of cyclin G-associated kinase (GAK) with Ki value of 3.1 nM and >50-fold selectivity over nearest kinase.
Cell Rep Med, 2025, S2666-3791(25)00231-9