Serine/threonin kinase

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S8388 ML-7 HCl <1 mg/mL 90 mg/mL <1 mg/mL
S8465 GSK'872 (GSK2399872A) <1 mg/mL 76 mg/mL 40 mg/mL
S8215 BAY 1217389 <1 mg/mL 100 mg/mL 3 mg/mL
S8366 CRT0066101 82 mg/mL 25 mg/mL 2 mg/mL
S8358 WNK463 <1 mg/mL 92 mg/mL 92 mg/mL
S7188 CID755673 <1 mg/mL 43 mg/mL <1 mg/mL
Catalog No. Information Product Use Citations Product Validations

ML-7 HCl

ML-7 is an inhibitor of smooth muscle myosin light chain kinase (MLCK) with a Ki value of 0.3 µM and displays reversible, ATP-competitive inhibition of Ca2+-calmodulin-dependent and -independent smooth muscle MLCKs.


GSK'872 (GSK2399872A)

GSK'872 (GSK2399872A) is a potent and selective RIP3 kinase inhibitor which binds RIP3 kinase domain with high affinity (IC50=1.8 nM) and inhibits kinase activity with IC50 of 1.3 nM. It has minimal cross-reactivity.


BAY 1217389

BAY 1217389 is an orally bioavailable, selective inhibitor of the serine/threonine kinase monopolar spindle 1 (Mps1) with IC50 values below 10 nmol/L while showing an excellent selectivity profile.



CRT0066101 is a small molecule PKD family specific inhibitor which specifically blocks PKD1/2 activity and does not suppress PKCα/PKCβ/PKCε activity in multiple.



WNK463 is a pan-WNK-kinase inhibitor. It potently inhibits the in vitro kinase activity of all four WNK family members (WNK1, WNK2, WNK3, and WNK4).



CID755673 is a cell-active pan-PKD1/2/3 inhibitor with IC50 of 180 nM, 280nM, and 227 nM, respectively, about 200-fold selectivity over other CAMKs.

Tags: STK activation | STK kinase family | STK family kinases | STK activity | STK cancer | Serine/threonine kinase | STK phosphorylation | STK inhibition | STK inhibitors cancer | STK inhibitor review