- Inhibitory Selectivity
|Catalog No.||Product Name||Solubility(25°C)|
|S8388||ML-7 HCl||<1 mg/mL||90 mg/mL||<1 mg/mL|
|S8465||GSK'872 (GSK2399872A)||<1 mg/mL||76 mg/mL||40 mg/mL|
|S8215||BAY 1217389||<1 mg/mL||100 mg/mL||3 mg/mL|
|S8366||CRT0066101||82 mg/mL||25 mg/mL||2 mg/mL|
|S8358||WNK463||<1 mg/mL||92 mg/mL||92 mg/mL|
|S7188||CID755673||<1 mg/mL||43 mg/mL||<1 mg/mL|
- Serine/threonin kinase Inhibitors (6)
|Catalog No.||Information||Product Use Citations||Product Validations|
ML-7 is an inhibitor of smooth muscle myosin light chain kinase (MLCK) with a Ki value of 0.3 µM and displays reversible, ATP-competitive inhibition of Ca2+-calmodulin-dependent and -independent smooth muscle MLCKs.
Representative Hoechst 33342 (blue) and phosphorylated MLC (red) stained images of SK-LMS-1 cells. Scale bar, 200 μm.
GSK'872 (GSK2399872A) is a potent and selective RIP3 kinase inhibitor which binds RIP3 kinase domain with high affinity (IC50=1.8 nM) and inhibits kinase activity with IC50 of 1.3 nM. It has minimal cross-reactivity.
BAY 1217389 is an orally bioavailable, selective inhibitor of the serine/threonine kinase monopolar spindle 1 (Mps1) with IC50 values below 10 nmol/L while showing an excellent selectivity profile.
CRT0066101 is a small molecule PKD family specific inhibitor which specifically blocks PKD1/2 activity and does not suppress PKCα/PKCβ/PKCε activity in multiple.
WNK463 is a pan-WNK-kinase inhibitor. It potently inhibits the in vitro kinase activity of all four WNK family members (WNK1, WNK2, WNK3, and WNK4).
CID755673 is a cell-active pan-PKD1/2/3 inhibitor with IC50 of 180 nM, 280nM, and 227 nM, respectively, about 200-fold selectivity over other CAMKs.