HMG-CoA Reductase

Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S1792 Simvastatin <1 mg/mL 83 mg/mL 83 mg/mL
S2169 Rosuvastatin Calcium <1 mg/mL 100 mg/mL <1 mg/mL
S1759 Pitavastatin Calcium <1 mg/mL 51 mg/mL <1 mg/mL
S2061 Lovastatin <1 mg/mL 8 mg/mL 6 mg/mL
S1909 Fluvastatin Sodium 1 mg/mL 87 mg/mL <1 mg/mL
S5072 Rosuvastatin 96 mg/mL 96 mg/mL 23 mg/mL
S2077 Atorvastatin Calcium <1 mg/mL 100 mg/mL <1 mg/mL
S3036 Pravastatin sodium 89 mg/mL 89 mg/mL 12 mg/mL
S2664 Clinofibrate <1 mg/mL 94 mg/mL 94 mg/mL
S4223 Mevastatin <1 mg/mL 78 mg/mL <1 mg/mL
S8302 SR-12813 <1 mg/mL 100 mg/mL 100 mg/mL
Catalog No. Information Product Use Citations Product Validations


Simvastatin is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays.


Rosuvastatin Calcium

Rosuvastatin Calcium is a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM in a cell-free assay.


Pitavastatin Calcium

Pitavastatin calcium, a novel member of the medication class of statins, is a calcium salt formulation of pitavastatin which is a highly effective HMG-CoA reductase inhibitor.



Lovastatin is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM in a cell-free assay, used for lowering cholesterol (hypolipidemic agent).


Fluvastatin Sodium

Fluvastatin Sodium inhibits HMG-CoA reductase activity with IC50 of 8 nM in a cell-free assay.



Rosuvastatin is an inhibitor of HMG-CoA reductase, an enzyme that catalyzes the rate-limiting step in cholesterol biosynthesis, with Ki value (inhibition constant) of approximately 0.1 nM.


Atorvastatin Calcium

Atorvastatin Calcium is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol.


Pravastatin sodium

Pravastatin sodium is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.



Clinofibrate inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR) with IC50 of 0.47 mM, is a lipid-lowering agent used for controlling high cholesterol and triacylglyceride levels in the blood.



Mevastatin is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself.



SR-12813 is a pregnane X receptor (PXR) agonist and HMG-CoA reductase inhibitor with an IC50 of 850 nM.