HMG-CoA Reductase

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HMG-CoA Reductase Signaling Pathway Map

HMG-CoA Reductase Signaling Pathways

HMG-CoA Reductase Products

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Catalog No. Product Name Information Product Use Citations Product Validations
S1759 Pitavastatin (NK-104) calcium Pitavastatin Calcium (NK-104, P-872441, itavastatin, nisvastatin), a novel member of the medication class of statins, is a calcium salt formulation of pitavastatin which is a highly effective HMG-CoA reductase inhibitor. Pitavastatin Calcium attenuates AGEs-induced mitophagy via inhibition of ROS generation. Pitavastatin Calcium induces autophagy and apoptosis.
Autophagy, 2022, 1-19
Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4
Cancer Discov, 2021, candisc.0551.2021
S1792 Simvastatin (MK 733) Simvastatin (MK-0733, MK 733) is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis.
J Control Release, 2022, 346:98-109
Front Immunol, 2022, 13:865704
PLoS Pathog, 2022, 18(4):e1010468
S1909 Fluvastatin (XU-62-320) Sodium Fluvastatin Sodium (XU-62-320) inhibits HMG-CoA reductase activity with IC50 of 8 nM in a cell-free assay.
BMC Cancer, 2022, 22(1):282
Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4
Cancer Res, 2021, canres.0955.2021
S2061 Lovastatin (MK-803) Lovastatin (MK-803, Mevinolin) is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM in a cell-free assay, used for lowering cholesterol (hypolipidemic agent). Lovastatin triggers autophagy.
Sci Adv, 2022, 8(17):eabm3108
Cell Rep, 2022, 39(3):110712
Cancers (Basel), 2022, 14(9)2327
S2077 Atorvastatin Calcium Atorvastatin Calcium is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol. Atorvastatin Calcium induces apoptosis and autophagy.
Cancers (Basel), 2022, 14(9)2327
Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4
Oncol Lett, 2021, 21(2):82
S2169 Rosuvastatin (ZD4522) calcium Rosuvastatin Calcium (ZD4522) is a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM in a cell-free assay.
Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4
Cancers (Basel), 2021, 13(21)5543
Cell Death Dis, 2021, 12(1):78
S2664 Clinofibrate Clinofibrate inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR) with IC50 of 0.47 mM, is a lipid-lowering agent used for controlling high cholesterol and triacylglyceride levels in the blood.
Carcinogenesis, 2020, 7;bgaa036
S3036 Pravastatin sodium Pravastatin sodium (CS-514) is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.
Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4
J Cell Mol Med, 2020, 25
Cancer Sci, 2018, 109(10):3272-3284
S4223 Mevastatin Mevastatin (ML-236B) is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself.
Immunity, 2021, 54(10):2273-2287.e6
Front Pharmacol, 2020, 11:574068
Nature, 2018, 560(7718):372-376
S5713 Pravastatin Pravastatin is a lipoprotein-lowering drug via reversibly inhibiting hydroxymethylglutaryl-CoA (HMG-CoA) reductase and the synthesis of very-low-density lipoproteins.
EMBO Rep, 2022, e53373
J Cell Mol Med, 2020, 25
J Cell Physiol, 2019, 234(3):2058-2066
S5715 Atorvastatin Atorvastatin is a lipid lowering agent. It is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway. Atorvastatin activates autophagy.
Peptides, 2022, S0196-9781(22)00036-5
Acta Histochem, 2022, 124(4):151895
Cancers (Basel), 2021, 13(21)5543
S8302 SR-12813 SR-12813 is a pregnane X receptor (PXR) agonist and HMG-CoA reductase inhibitor with an IC50 of 850 nM.
Cell Death Dis, 2019, 10(10):777
S1759 Pitavastatin (NK-104) calcium Pitavastatin Calcium (NK-104, P-872441, itavastatin, nisvastatin), a novel member of the medication class of statins, is a calcium salt formulation of pitavastatin which is a highly effective HMG-CoA reductase inhibitor. Pitavastatin Calcium attenuates AGEs-induced mitophagy via inhibition of ROS generation. Pitavastatin Calcium induces autophagy and apoptosis.
Autophagy, 2022, 1-19
Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4
Cancer Discov, 2021, candisc.0551.2021
S1792 Simvastatin (MK 733) Simvastatin (MK-0733, MK 733) is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis.
J Control Release, 2022, 346:98-109
Front Immunol, 2022, 13:865704
PLoS Pathog, 2022, 18(4):e1010468
S1909 Fluvastatin (XU-62-320) Sodium Fluvastatin Sodium (XU-62-320) inhibits HMG-CoA reductase activity with IC50 of 8 nM in a cell-free assay.
BMC Cancer, 2022, 22(1):282
Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4
Cancer Res, 2021, canres.0955.2021
S2061 Lovastatin (MK-803) Lovastatin (MK-803, Mevinolin) is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM in a cell-free assay, used for lowering cholesterol (hypolipidemic agent). Lovastatin triggers autophagy.
Sci Adv, 2022, 8(17):eabm3108
Cell Rep, 2022, 39(3):110712
Cancers (Basel), 2022, 14(9)2327
S2077 Atorvastatin Calcium Atorvastatin Calcium is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol. Atorvastatin Calcium induces apoptosis and autophagy.
Cancers (Basel), 2022, 14(9)2327
Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4
Oncol Lett, 2021, 21(2):82
S2169 Rosuvastatin (ZD4522) calcium Rosuvastatin Calcium (ZD4522) is a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM in a cell-free assay.
Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4
Cancers (Basel), 2021, 13(21)5543
Cell Death Dis, 2021, 12(1):78
S2664 Clinofibrate Clinofibrate inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR) with IC50 of 0.47 mM, is a lipid-lowering agent used for controlling high cholesterol and triacylglyceride levels in the blood.
Carcinogenesis, 2020, 7;bgaa036
S3036 Pravastatin sodium Pravastatin sodium (CS-514) is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.
Nat Biotechnol, 2021, 10.1038/s41587-021-00860-4
J Cell Mol Med, 2020, 25
Cancer Sci, 2018, 109(10):3272-3284
S4223 Mevastatin Mevastatin (ML-236B) is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself.
Immunity, 2021, 54(10):2273-2287.e6
Front Pharmacol, 2020, 11:574068
Nature, 2018, 560(7718):372-376
S5713 Pravastatin Pravastatin is a lipoprotein-lowering drug via reversibly inhibiting hydroxymethylglutaryl-CoA (HMG-CoA) reductase and the synthesis of very-low-density lipoproteins.
EMBO Rep, 2022, e53373
J Cell Mol Med, 2020, 25
J Cell Physiol, 2019, 234(3):2058-2066
S5715 Atorvastatin Atorvastatin is a lipid lowering agent. It is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway. Atorvastatin activates autophagy.
Peptides, 2022, S0196-9781(22)00036-5
Acta Histochem, 2022, 124(4):151895
Cancers (Basel), 2021, 13(21)5543
S8302 SR-12813 SR-12813 is a pregnane X receptor (PXR) agonist and HMG-CoA reductase inhibitor with an IC50 of 850 nM.
Cell Death Dis, 2019, 10(10):777
Tags: HMG-CoA Reductase inhibitor|HMG-CoA Reductase agonist|HMG-CoA Reductase activator|HMG-CoA Reductase inducer|HMG-CoA Reductase antagonist|HMG-CoA Reductase signaling pathway|HMG-CoA Reductase assay kit