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P450 (e.g. CYP17)

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Dehydrogenase Transferase DPP Aminopeptidase Procollagen C Proteinase Phospholipase (e.g. PLA) Factor Xa PDE DHFR Carbonic Anhydrase

Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S2246 Abiraterone Acetate Abiraterone Acetate is an acetate salt form of Abiraterone which is a steroidal cytochrome CYP17 inhibitor with IC50 of 72 nM in a cell-free assay. Abiraterone acetate is an oral androgen biosynthesis inhibitor.
Adv Sci (Weinh), 2025, 12(31):e01284
Cancer Med, 2025, 14(9):e70855
Cells, 2024, 13(19)1622
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S1123 Abiraterone Abiraterone is a potent CYP17 inhibitor with IC50 of 2 nM in a cell-free assay. This compound is an androgen biosynthesis inhibitor.
Cancer Res, 2023, 83(8):1361-1380
Cancer Cell, 2021, S1535-6108(21)00659-0
Cancers (Basel), 2021, 13(16)3959
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S2262 Apigenin Apigenin is a potent P450 inhibitor for CYP2C9 with Ki of 2 μM.
Phytomedicine, 2024, 135:156024
Antioxidants (Basel), 2024, 13(5)611
bioRxiv, 2024, 2024.04.04.588167
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S1442 Voriconazole Voriconazole is a new triazole derivative similar to fluconazole and itraconazole that acts by inhibiting fungal cytochrome P-450-dependent, 14-alpha-sterol demethylase-mediated synthesis of ergosterol.
J Adv Res, 2025, S2090-1232(25)00065-7
PLoS Pathog, 2025, 21(5):e1013220
mSphere, 2025, 10(1):e0070324
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S1257 Posaconazole Posaconazole is an inhibitor primarily of CYP3A4, but it does not inhibit the activity of other CYP enzymes; Also an inhibitor of sterol C14ɑ demethylase inhibitor with IC50 of 0.25 μM. This compound has a median terminal elimination half-life of 15-35 hours.
Infect Drug Resist, 2025, 18:783-789
Front Cell Infect Microbiol, 2023, 13:1131641
Front Cell Infect Microbiol, 2022, 12:1074903
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S1331 Fluconazole Fluconazole is a fungal lanosterol 14 alpha-demethylase inhibitor, which thereby prevents the formation of ergosterol, used in the treatment and prevention of superficial and systemic fungal infections.
J Infect, 2025, 91(3):106595
PLoS Pathog, 2025, 21(5):e1013220
Antimicrob Agents Chemother, 2025, 69(9):e0042725
S2268 Baicalein Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor.
SLAS Discov, 2024, S2472-5552(24)00007-8
Redox Rep, 2023, 28(1):2152607
Microbiol Spectr, 2023, 11(3):e0470222
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S2187 Avasimibe Avasimibe inhibits ACAT with IC50 of 3.3 μM, also inhibits human P450 isoenzymes CYP2C9, CYP1A2 and CYP2C19 with IC50 of 2.9 μM, 13.9 μM and 26.5 μM, respectively.
J Lipid Res, 2025, 66(8):100854
Hepatol Commun, 2025, 9(6)e0714
Nat Commun, 2024, 15(1):8301
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S1353 Ketoconazole Ketoconazole inhibits cyclosporine oxidase and testosterone 6 beta-hydroxylase with IC50 of 0.19 mM and 0.22 mM, respectively. This compound is an androgen biosynthesis inhibitor.
Nature, 2025, 10.1038/s41586-025-09755-9
Mol Oncol, 2025, 10.1002/1878-0261.13799
Discov Oncol, 2024, 15(1):709
S1712 Deferasirox (ICL670) Deferasirox is an iron chelator, also a cytochrome P450 3A4 inducer, Cytochrome P450 2C8 inhibitor, and Cytochrome P450 1A2 inhibitor. Deferasirox-induced iron depletion promotes BclxL downregulation and cell death.
Front Immunol, 2025, 16:1502094
Elife, 2023, 12RP88745
J Transl Med, 2023, 21(1):50
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