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Osunprotafib (ABBV-CLS-484) PTPN1/PTPN2 inhibitor

Name: Osunprotafib (ABBV-CLS-484)
Brand: Selleck Chemicals
SKU: E1207
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.E1207

Osunprotafib (ABBV-CLS-484) is a potent PTPN1 or PTPN2 inhibitor with a sub-nanomolar activity.

Chemical Structure

Molecular Weight: 385.46

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Quality Control

Batch: E120701 DMSO]77 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.84%

Cited in Nature Medicine for its top-tier quality
COA
NMR
HPLC
SDS/MSDS
Datasheet

99.84

Related Targets	Dehydrogenase HSP Transferase P450 (e.g. CYP17) PDE PPAR Vitamin Carbohydrate Metabolism Mitochondrial Metabolism Casein Kinase
Other phosphatase Inhibitors	SHP099 Hydrochloride RMC-4550 SHP099 Batoprotafib (TNO155) GSK2830371 β-Glycerophosphate sodium salt hydrate NSC87877 TPI-1 Suramin sodium salt Sanguinarine chloride

Solubility in DMSO or Water

In vitro
Batch:

DMSO : 77 mg/mL (199.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

The solubility data above are all experimental results (not literature values).

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	3.850mg/ml (9.99mM)	Taking the 1 mL working solution as an example, add 50 μL of 77 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.960mg/ml (2.49mM)	Taking the 1 mL working solution as an example, add 50 μL of 19.2 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Working Concentrations for Cell Culture Treatment

Working Concentrations for Animal Model Treatment

Mechanism of Action

Information	Osunprotafib (ABBV-CLS-484) is a potent, first-in-class, active-site competitive PTPN2 and PTPN1 inhibitor. It affects JAK-STAT and interferon signaling by preventing the dephosphorylation of key immune proteins, enhancing T cell activation and promoting robust anti-tumor immune responses.
Read more about Osunprotafib (ABBV-CLS-484) IC50 for cell-based and cell-free assays
Primary Applications and Mechanism of Action

Chemical Information, Storage & Stability

Molecular Weight	385.46	Formula	C₁₇H₂₄FN₃O₄S	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	2489404-97-7	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

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Handling Instructions

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