Glucokinase

Other Metabolism Related Inhibitors

Dehydrogenase Transferase DPP Aminopeptidase Procollagen C Proteinase P450 (e.g. CYP17) Phospholipase (e.g. PLA) Factor Xa PDE DHFR

Cat.No.	Product Name	Information	Product Use Citations
S7443	AP-III-a4 (ENOblock)	AP-III-a4 (ENOblock) is the first nonsubstrate analogue inhibitor of enolase with IC50 of 0.576 μM.	International Journal of Molecular Sciences, 2025, 8340 Cell Division, 2025, 23 Cell Div, 2025, 20(1):23
E1703	SF2312	SF2312 is a highly potent inhibitor of Enolase with IC50s of 37.9 nM and 42.5 nM for human recombinant ENO1 and ENO2, respectively, and also is a natural phosphonate antibiotic. SF2312 displays activity against bacteria under anaerobic conditions.
E1028	POMHEX	POMHEX, is a potent ENO2 -specific inhibitor of enolase and a racemic mixture, a cell-permeable pivaloyloxymethyl (POM) prodrug of HEX. It is also glycolysis inhibitor and can be used for the research of cancer.
S7289	PFK-015	PFK15 (PFK-015) is a potent and selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM.	Nature, 2025, 10.1038/s41586-025-09328-w Adv Healthc Mater, 2025, e2501417. Cell Commun Signal, 2025, 23(1):104
S7639	3PO	3PO (3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one) is a small-molecule inhibitor of PFKFB3 with an IC50 of 22.9 μM for recombinant human PFKFB3 protein and does not inhibit PFK-1 activity. It suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.	Atherosclerosis, 2025, 405:119223 bioRxiv, 2025, nan J Transl Med, 2024, 22(1):954
S8807	PFK158	PFK158 is a potent and selective inhibitor of PFKFB3. It has improved PK properties and causes ~80% growth inhibition in several mouse models of human-derived tumors.	Cancer & Metabolism, September 23, 2021, 33 eLife, September 09, 2025, 107536 Frontiers in Cellular and Infection Microbiology, October 08, 2025, 1648576
S6921	Dorzagliatin	Dorzagliatin (HMS-5552, RO-5305552, Sinogliatin) is a dual-acting glucokinase (GK) activator that improves glycaemic control and pancreatic β-cell function in patients with type 2 diabetes.	Pharmaceuticals (Basel), 2025, 18(6)927 bioRxiv, 2025, 2025.04.03.647023 bioRxiv, 2025, 2023.08.11.552890
S1830	Oxfendazole	Oxfendazole (RS-8858,Fenbendazole sulfoxide) is a broad spectrum benzimidazole anthelmintic.	bioRxiv, 2023, 2023.07.12.548707 Nature Cell Biology, 2019, 203-213 Molecular Medicine Reports, 2019, 2921-2926
S0400	KAN0438757	KAN0438757 is a potent and selective inhibitor of the metabolic kinase PFKFB3 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3) with IC50 of 0.19 μM and 3.6 μM for PFKFB3 and PFKFB4, respectively.	Current Issues in Molecular Biology, 2025, 892 Molecular & Cellular Proteomics, 2023, 100649 Mol Cell Proteomics, 2023, 22(11):100649
S2155	LY2608204	LY2608204 activates glucokinase (GK) with EC50 of 42 nM. Phase 2.	Scientific Reports, 2017, 44681 Sci Rep, 2017, 7:44681 Nat Commun, 2016, 7:11463
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