Fatty Acid Synthase
- Inhibitory Selectivity
|Catalog No.||Product Name||Solubility(25°C)|
|S2697||A-769662||<1 mg/mL||72 mg/mL||<1 mg/mL|
|S1629||Orlistat||<1 mg/mL||99 mg/mL||99 mg/mL|
|S1937||Isoniazid||27 mg/mL||27 mg/mL||27 mg/mL|
|S2250||(-)-Epigallocatechin Gallate||23 mg/mL||72 mg/mL||83 mg/mL|
|S8588||ACSS2 inhibitor||<1 mg/mL||30 mg/mL||2 mg/mL|
|S2314||Kaempferol||<1 mg/mL||57 mg/mL||3 mg/mL|
- Fatty Acid Synthase Inhibitors (6)
|Catalog No.||Information||Product Use Citations||Product Validations|
A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM in cell-free assays, little effect on GPPase/FBPase activity.
Cells were treated with CP, DOXO, SRT1720 (100 nM), EX527 (100 nM), A769662 (10 μM) and Compound C (1 μM) under normoxic or hypoxic conditions for 48 hours, and then their viabilities were measured by MTT.
Orlistat is a general lipase inhibitor with IC50 of 122 ng/ml for PL from human duodenal juice.
Isoniazid is a prodrug that blocks the action of fatty acid synthase by interacting with KatG , used for the prevention and treatment of tuberculosis.
(-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.
(a) Huh7 cells were incubated with HCVcc of JFH-1 for 2 h before overlaying with 1% agarose dissolved in culture medium or with AR3A anti-E2 neutralizing antibodies, in the presence of 20 μg/ml SZA. EGCG (50 μM) was introduced as a positive control. At 48 h post-infection, infected cells were quantified by IF. Nuclei were stained with DAPI. (b) Numbers of cells per positive colony were determined in 15 foci.
ACSS2 inhibitor is the most potent and specific inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2).
Kaempferol, a natural flavonol, functions as an ERRα and ERRγ inverse agonist. It inhibits topoisomerase I catalyzed DNA religation and may also inhibit the activity of fatty acid synthase.
Total cellular protein was harvested after 8 days and the protein levels of adipogenic factors were measured using western blot analysis with specific antibodies (B).