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Fatty Acid Synthase

Other Metabolism Related Inhibitors

Dehydrogenase Transferase DPP Aminopeptidase Procollagen C Proteinase P450 (e.g. CYP17) Phospholipase (e.g. PLA) Factor Xa PDE DHFR
Cat.No. Product Name Information Product Use Citations Product Validations
S9714 Denifanstat (TVB-2640) Denifanstat (TVB-2640) is an orally bioavailable, pharmacological fatty acid synthase (FAS/FASN) inhibitor with therapeutic potential in patients with NAFLD and nonalcoholic steatohepatitis.
Nat Genet, 2024, 10.1038/s41588-024-01891-8
Cell Rep, 2023, 42(9):113034
J Transl Med, 2023, 21(1):32
S1937 Isoniazid Isoniazid is a prodrug that blocks the action of fatty acid synthase by interacting with KatG, used for the prevention and treatment of tuberculosis.
mBio, 2022, e0302422.
Nat Metab, 2021, 10.1038/s42255-021-00479-4
Front Immunol, 2021, 12:712021
S4754 Betulin Betulin (BE, betulinol, betuline, betulinic alcohol), also known as betulinol, betuline, or betulinic alcohol, is a pentacyclic lupane-type triterpenoid naturally distributed in many plants and displays a broad spectrum of biological and pharmacological properties such as anticancer and chemopreventive activity. This compound (Trochol), is a sterol regulatory element-binding protein (SREBP) inhibitor with an IC50 of 14.5 μM in K562 cell line.
Acta Biochim Biophys Sin -Shanghai), 2023, 55(9):1479-1486
Acta Biochim Biophys Sin (Shanghai), 2023, 55(9):1479-1486
Nat Metab, 2021, 10.1038/s42255-021-00479-4
S8563 TVB-3664 TVB-3664 is a potent, selective, orally active and reversible inhibitor of fatty acid synthase (FASN) with IC50 of 0.018 μM and 0.012 μM for human and mouse cell palmitate synthesis, respectively.
bioRxiv, 2025, 2025.02.02.636110
Nat Commun, 2023, 14(1):1362
bioRxiv, 2023, 2023.07.05.547848
S6666 FT113 FT113 is a potent inhibitor of fatty acid synthase (FAS/FASN) with ic50 of 213 nM.
Oncotarget, 2025, 16:532-544
Nat Cancer, 2023, 4(10):1508-1525
Nat Cancer, 2023, 10.1038/s43018-023-00635-7
S9785 Fatostatin

Fatostatin (125B11), a diarylthiazole derivative, is a specific inhibitor of Sterol regulatory element binding proteins (SREBPs) activation. This compound binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. It suppresses growth and enhances apoptosis in cancer cells.
J Transl Med, 2025, 23(1):1055
iScience, 2025, 28(8):113097
Oncol Lett, 2025, 29(4):175
S8915 C75 trans C75 trans (trans-C75, (±)-C75) is a novel, potent synthetic inhibitor of fatty acid synthase (FAS/FASN) with IC50 of 35 μM and 50 μM in clonogenic assays and spheroid growth assay, respectively. C75 is used as a tool for studying fatty acid synthesis in metabolic disorders and cancer.
Biol Sex Differ, 2025, 16(1):9
Signal Transduct Target Ther, 2022, 7(1):46
Nat Metab, 2021, 10.1038/s42255-021-00479-4
S3300 Desoxyrhaponticin Desoxyrhaponticin (DC, DES), a stilbene glycoside from Rheum tanguticum Maxim. ex Balf. (rhubarb) which is a traditional Chinese nutritional food, is a fatty acid synthase (FAS/FASN) inhibitor. This compound is also a competitive inhibitor of glucose uptake with IC50 of 148.3 μM and 30.9 μM in rabbit intestinal membrane vesicles and in rat everted gut sleeves, respectively. It has apoptotic effect on human cancer cells.
Nat Metab, 2021, 10.1038/s42255-021-00479-4
E2641 trans-Chalcone Trans-Chalcone, the backbone of flavonoids, also is a potent fatty acid synthase (FAS) with IC50 of 17.1 μg/mL, and α-amylase inhibitor, causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7, exerting antifungal and anticancer activities.
E2667 IPI-9119 IPI-9119 is a potent, selective, and irreversible inhibitor of fatty acid synthase (FASN), which can inhibit the FASN thioesterase domain by promoting acylation of the catalytic serine with an IC50 of 0.3 nM.