Fatty Acid Synthase

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S2697 A-769662 <1 mg/mL 72 mg/mL <1 mg/mL
S1629 Orlistat <1 mg/mL 99 mg/mL 99 mg/mL
S1937 Isoniazid 27 mg/mL 27 mg/mL 27 mg/mL
S2250 (-)-Epigallocatechin Gallate 23 mg/mL 72 mg/mL 83 mg/mL
S8588 ACSS2 inhibitor <1 mg/mL 30 mg/mL 2 mg/mL
S2314 Kaempferol <1 mg/mL 57 mg/mL 3 mg/mL
Catalog No. Information Product Use Citations Product Validations


A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM in cell-free assays, little effect on GPPase/FBPase activity.



Orlistat is a general lipase inhibitor with IC50 of 122 ng/ml for PL from human duodenal juice.



Isoniazid is a prodrug that blocks the action of fatty acid synthase by interacting with KatG , used for the prevention and treatment of tuberculosis.


(-)-Epigallocatechin Gallate

(-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.


ACSS2 inhibitor

ACSS2 inhibitor is the most potent and specific inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2).



Kaempferol, a natural flavonol, functions as an ERRα and ERRγ inverse agonist. It inhibits topoisomerase I catalyzed DNA religation and may also inhibit the activity of fatty acid synthase.

Tags: FASN inhibition | FASN activation | FASN activity | FASN inhibitors in clinical trials | FASN inhibitor review