Fatty Acid Synthase

Choose Selective Fatty Acid Synthase Inhibitors

Fatty Acid Synthase Products

  • All (19)
  • Fatty Acid Synthase Inhibitors (17)
  • Fatty Acid Synthase Antibodie (1)
  • Fatty Acid Synthase Modulator (1)
  • New Fatty Acid Synthase Products
Catalog No. Product Name Information Product Use Citations Product Validations
S1629 Orlistat (Ro 18-0647) Orlistat (Ro 18-0647, Tetrahydrolipstatin) is a general lipase inhibitor with IC50 of 122 ng/ml for PL from human duodenal juice. Orlistat treatment reduces proliferation, induces apoptosis and arrests cell cycle.
Nat Commun, 2021, 12(1):3830
Cell Rep, 2021, 36(12):109742
Sci Rep, 2021, 11(1):22085
S1937 Isoniazid Isoniazid is a prodrug that blocks the action of fatty acid synthase by interacting with KatG , used for the prevention and treatment of tuberculosis.
Front Immunol, 2021, 12:712021
Nat Metab, 2021, 10.1038/s42255-021-00479-4
Molecules, 2019, 25(1)
S2250 (-)-Epigallocatechin Gallate (-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.
Exp Cell Res, 2022, 411(1):113000
Int J Mol Med, 2022, 49(1)11
EMBO Rep, 2021, e53166
S2314 Kaempferol (NSC 407289) Kaempferol (NSC 407289, Robigenin), a natural flavonol, functions as an ERRα and ERRγ inverse agonist. It inhibits topoisomerase I catalyzed DNA religation and may also inhibit the activity of fatty acid synthase.
Molecules, 2021, 26(5)1210
Eur J Pharmacol, 2021, 907:174251
Nat Metab, 2021, 10.1038/s42255-021-00479-4
S2697 A-769662 A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM in cell-free assays, little effect on GPPase/FBPase activity.
Mol Cell, 2021, S1097-2765(21)00232-X
Mol Cell, 2021, 81(18):3803-3819.e7
Nat Commun, 2021, 12(1):5058
S3300 Desoxyrhaponticin Desoxyrhaponticin (DC, DES), a stilbene glycoside from Rheum tanguticum Maxim. ex Balf. (rhubarb) which is a traditional Chinese nutritional food, is a fatty acid synthase (FAS/FASN) inhibitor. Desoxyrhaponticin (DC, DES) is also a competitive inhibitor of glucose uptake with IC50 of 148.3 μM and 30.9 μM in rabbit intestinal membrane vesicles and in rat everted gut sleeves, respectively. Desoxyrhaponticin has apoptotic effect on human cancer cells.
Nat Metab, 2021, 10.1038/s42255-021-00479-4
S3576New TVB-3166 TVB-3166 is an orally-available, reversible, potent and selective inhibitor of fatty acid synthase (FASN) with IC50 of 0.042 μM in an in vitro biochemical assay. TVB-3166 induces apoptosis, and inhibits in-vivo xenograft tumor growth.
S4754 Betulin Betulin (BE, betulinol, betuline, betulinic alcohol), also known as betulinol, betuline, or betulinic alcohol, is a pentacyclic lupane-type triterpenoid naturally distributed in many plants and displays a broad spectrum of biological and pharmacological properties such as anticancer and chemopreventive activity. Betulin (Trochol), is a sterol regulatory element-binding protein (SREBP) inhibitor with an IC50 of 14.5 μM in K562 cell line.
Theranostics, 2021, 11(13):6560-6572
Nat Metab, 2021, 10.1038/s42255-021-00479-4
S6248New Fasnall Fasnall, a thiophenopyrimidine, is a selective fatty acid synthase (FASN) inhibitor that shows potent anti-tumor activity.
S6666 FT113 FT113 is a potent inhibitor of fatty acid synthase (FAS/FASN) with ic50 of 213 nM.
Nat Metab, 2021, 10.1038/s42255-021-00479-4
S8284 Fatostatin (125B11) HBr Fatostatin HBr (Fatostatin A, 125B11) is an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2.
EMBO Rep, 2021, e52537
Nat Metab, 2021, 10.1038/s42255-021-00479-4
Cell, 2020, S0092-8674(20)31626-3
S8563 TVB-3664 TVB-3664 is a potent, selective, orally active and reversible inhibitor of fatty acid synthase (FASN) with IC50 of 0.018 μM and 0.012 μM for human and mouse cell palmitate synthesis, respectively.
Sci Rep, 2021, 11(1):22085
Nat Metab, 2021, 10.1038/s42255-021-00479-4
S8588 ACSS2 inhibitor ACSS2 inhibitor is the most potent and specific inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2). ACSS2 inhibitor also inhibits the respiratory syncytial virus (RSV).
Proc Natl Acad Sci U S A, 2021, 118(22)e2014681118
EMBO Rep, 2021, e52023
Ecotoxicol Environ Saf, 2021, 224:112626
S8915 C75 trans C75 trans (trans-C75, (±)-C75) is a novel, potent synthetic inhibitor of fatty acid synthase (FAS/FASN) with IC50 of 35 μM and 50 μM in clonogenic assays and spheroid growth assay, respectively. C75 is used as a tool for studying fatty acid synthesis in metabolic disorders and cancer.
Nat Metab, 2021, 10.1038/s42255-021-00479-4
S9392 Praeruptorin B Praeruptorin B is an important compound isolated from Bai-hua Qian-hu and has been reported to exert multiple biochemical and pharmacological activities.praeruptorin B exerts lipid-lowering effects through inhibits SREBPs and could serve as a possible therapeutic option to improve hyperlipidemia and hyperlipidemia-induced comorbidities.
Nat Metab, 2021, 10.1038/s42255-021-00479-4
S9714 TVB-2640 TVB-2640 (ASC-40, FASN-IN-2) is an orally bioavailable, pharmacological fatty acid synthase (FAS/FASN) inhibitor with therapeutic potential in patients with NAFLD and nonalcoholic steatohepatitis.
Cancer Metab, 2021, 9(1):31
Nat Metab, 2021, 10.1038/s42255-021-00479-4
bioRxiv, 2021, 10.1101/2021.03.12.435005
S9785 Fatostatin

Fatostatin (125B11), a diarylthiazole derivative, is a specific inhibitor of Sterol regulatory element binding proteins (SREBPs) activation. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin suppresses growth and enhances apoptosis in cancer cells.

EMBO Rep, 2021, e52537
Reproduction, 2021, 162(6):397-410
A5181 ATP citrate lyase Rabbit Recombinant mAb ATP citrate lyase Rabbit Recombinant mAb detects endogenous level of total ATP citrate lyase.
S6466New Eicosapentaenoic acid ethyl ester Eicosapentaenoic acid ethyl ester (AMR101, EPA ethyl ester, Ethyl eicosapentaenoate) is an omega-3 fatty acid agent that significantly reduces the triglyceride (TG) levels and improves other lipid parameters without significantly increasing the low-density lipoprotein (LDL) cholesterol levels.
S1629 Orlistat (Ro 18-0647) Orlistat (Ro 18-0647, Tetrahydrolipstatin) is a general lipase inhibitor with IC50 of 122 ng/ml for PL from human duodenal juice. Orlistat treatment reduces proliferation, induces apoptosis and arrests cell cycle.
Nat Commun, 2021, 12(1):3830
Cell Rep, 2021, 36(12):109742
Sci Rep, 2021, 11(1):22085
S1937 Isoniazid Isoniazid is a prodrug that blocks the action of fatty acid synthase by interacting with KatG , used for the prevention and treatment of tuberculosis.
Front Immunol, 2021, 12:712021
Nat Metab, 2021, 10.1038/s42255-021-00479-4
Molecules, 2019, 25(1)
S2250 (-)-Epigallocatechin Gallate (-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.
Exp Cell Res, 2022, 411(1):113000
Int J Mol Med, 2022, 49(1)11
EMBO Rep, 2021, e53166
S2314 Kaempferol (NSC 407289) Kaempferol (NSC 407289, Robigenin), a natural flavonol, functions as an ERRα and ERRγ inverse agonist. It inhibits topoisomerase I catalyzed DNA religation and may also inhibit the activity of fatty acid synthase.
Molecules, 2021, 26(5)1210
Eur J Pharmacol, 2021, 907:174251
Nat Metab, 2021, 10.1038/s42255-021-00479-4
S2697 A-769662 A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM in cell-free assays, little effect on GPPase/FBPase activity.
Mol Cell, 2021, S1097-2765(21)00232-X
Mol Cell, 2021, 81(18):3803-3819.e7
Nat Commun, 2021, 12(1):5058
S3300 Desoxyrhaponticin Desoxyrhaponticin (DC, DES), a stilbene glycoside from Rheum tanguticum Maxim. ex Balf. (rhubarb) which is a traditional Chinese nutritional food, is a fatty acid synthase (FAS/FASN) inhibitor. Desoxyrhaponticin (DC, DES) is also a competitive inhibitor of glucose uptake with IC50 of 148.3 μM and 30.9 μM in rabbit intestinal membrane vesicles and in rat everted gut sleeves, respectively. Desoxyrhaponticin has apoptotic effect on human cancer cells.
Nat Metab, 2021, 10.1038/s42255-021-00479-4
S3576New TVB-3166 TVB-3166 is an orally-available, reversible, potent and selective inhibitor of fatty acid synthase (FASN) with IC50 of 0.042 μM in an in vitro biochemical assay. TVB-3166 induces apoptosis, and inhibits in-vivo xenograft tumor growth.
S4754 Betulin Betulin (BE, betulinol, betuline, betulinic alcohol), also known as betulinol, betuline, or betulinic alcohol, is a pentacyclic lupane-type triterpenoid naturally distributed in many plants and displays a broad spectrum of biological and pharmacological properties such as anticancer and chemopreventive activity. Betulin (Trochol), is a sterol regulatory element-binding protein (SREBP) inhibitor with an IC50 of 14.5 μM in K562 cell line.
Theranostics, 2021, 11(13):6560-6572
Nat Metab, 2021, 10.1038/s42255-021-00479-4
S6248New Fasnall Fasnall, a thiophenopyrimidine, is a selective fatty acid synthase (FASN) inhibitor that shows potent anti-tumor activity.
S6666 FT113 FT113 is a potent inhibitor of fatty acid synthase (FAS/FASN) with ic50 of 213 nM.
Nat Metab, 2021, 10.1038/s42255-021-00479-4
S8284 Fatostatin (125B11) HBr Fatostatin HBr (Fatostatin A, 125B11) is an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2.
EMBO Rep, 2021, e52537
Nat Metab, 2021, 10.1038/s42255-021-00479-4
Cell, 2020, S0092-8674(20)31626-3
S8563 TVB-3664 TVB-3664 is a potent, selective, orally active and reversible inhibitor of fatty acid synthase (FASN) with IC50 of 0.018 μM and 0.012 μM for human and mouse cell palmitate synthesis, respectively.
Sci Rep, 2021, 11(1):22085
Nat Metab, 2021, 10.1038/s42255-021-00479-4
S8588 ACSS2 inhibitor ACSS2 inhibitor is the most potent and specific inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2). ACSS2 inhibitor also inhibits the respiratory syncytial virus (RSV).
Proc Natl Acad Sci U S A, 2021, 118(22)e2014681118
EMBO Rep, 2021, e52023
Ecotoxicol Environ Saf, 2021, 224:112626
S8915 C75 trans C75 trans (trans-C75, (±)-C75) is a novel, potent synthetic inhibitor of fatty acid synthase (FAS/FASN) with IC50 of 35 μM and 50 μM in clonogenic assays and spheroid growth assay, respectively. C75 is used as a tool for studying fatty acid synthesis in metabolic disorders and cancer.
Nat Metab, 2021, 10.1038/s42255-021-00479-4
S9392 Praeruptorin B Praeruptorin B is an important compound isolated from Bai-hua Qian-hu and has been reported to exert multiple biochemical and pharmacological activities.praeruptorin B exerts lipid-lowering effects through inhibits SREBPs and could serve as a possible therapeutic option to improve hyperlipidemia and hyperlipidemia-induced comorbidities.
Nat Metab, 2021, 10.1038/s42255-021-00479-4
S9714 TVB-2640 TVB-2640 (ASC-40, FASN-IN-2) is an orally bioavailable, pharmacological fatty acid synthase (FAS/FASN) inhibitor with therapeutic potential in patients with NAFLD and nonalcoholic steatohepatitis.
Cancer Metab, 2021, 9(1):31
Nat Metab, 2021, 10.1038/s42255-021-00479-4
bioRxiv, 2021, 10.1101/2021.03.12.435005
S9785 Fatostatin

Fatostatin (125B11), a diarylthiazole derivative, is a specific inhibitor of Sterol regulatory element binding proteins (SREBPs) activation. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin suppresses growth and enhances apoptosis in cancer cells.

EMBO Rep, 2021, e52537
Reproduction, 2021, 162(6):397-410
A5181 ATP citrate lyase Rabbit Recombinant mAb ATP citrate lyase Rabbit Recombinant mAb detects endogenous level of total ATP citrate lyase.
S6466New Eicosapentaenoic acid ethyl ester Eicosapentaenoic acid ethyl ester (AMR101, EPA ethyl ester, Ethyl eicosapentaenoate) is an omega-3 fatty acid agent that significantly reduces the triglyceride (TG) levels and improves other lipid parameters without significantly increasing the low-density lipoprotein (LDL) cholesterol levels.
S3576New TVB-3166 TVB-3166 is an orally-available, reversible, potent and selective inhibitor of fatty acid synthase (FASN) with IC50 of 0.042 μM in an in vitro biochemical assay. TVB-3166 induces apoptosis, and inhibits in-vivo xenograft tumor growth.
S6248New Fasnall Fasnall, a thiophenopyrimidine, is a selective fatty acid synthase (FASN) inhibitor that shows potent anti-tumor activity.
S6466New Eicosapentaenoic acid ethyl ester Eicosapentaenoic acid ethyl ester (AMR101, EPA ethyl ester, Ethyl eicosapentaenoate) is an omega-3 fatty acid agent that significantly reduces the triglyceride (TG) levels and improves other lipid parameters without significantly increasing the low-density lipoprotein (LDL) cholesterol levels.
Tags: FASN inhibition | FASN activation | FASN activity | FASN inhibitors in clinical trials | FASN inhibitor review