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Decarboxylase Products

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  • Decarboxylase Inhibitors (14)
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Catalog No. Product Name Information Product Use Citations Product Validations
S4582 Eflornithine (DFMO) hydrochloride hydrate Eflornithine (DFMO) hydrochloride hydrate inhibits polyamine biosynthesis by the selective, irreversible inhibition of ornithine decarboxylase (ODC). A chemoprotective agent that blocks angiogenesis. Its biological half-life is 8 hours.
Front Oncol, 2023, 13:1212604
mBio, 2022, 13(5):e0219422
iScience, 2022, 25(3):103881
S2453 Benserazide HCl Benserazide HCl (Ro-4-4602) is a peripherally-acting aromatic L-amino acid decarboxylase (AAAD) or DOPA decarboxylase inhibitor.Solutions are unstable and should be fresh-prepared.
Front Pharmacol, 2024, 15:1404532
Viruses, 2024, 16(10)1566
Elife, 2022, 11e72668
S1891 Carbidopa Carbidopa is an aromatic-L-amino-acid decarboxylase inhibitor with an IC50 of 29 ± 2 μM.
Signal Transduct Target Ther, 2021, 6(1):77
J Cell Physiol, 2021, 10.1002/jcp.30587
PLoS One, 2017, 12(3):e0173240
S0108 AZ-33 AZ-33 (LDHA Inhibitor 33) is a potent inhibitor of lactate dehydrogenase A (LDHA) with IC50 of 0.5 μM. LDHA is the key enzyme involved in anaerobic glycolysis which is frequently deregulated in human malignancies.
FASEB J, 2022, 36(3):e22229
Front Mol Biosci, 2021, 8:806650
F0074New GAD67 mAb GAD1,GAD67,GAD-67
F2532New GAD67/GAD1 Mouse mAb GAD1,GAD67,GAD-67
E8286New Ivospemin Ivospemin is a spermine analogue and polyamine inhibitor that lowers polyamine levels by inhibiting the activity of the polyamine biosynthetic enzyme ornithine decarboxylase (ODC) in cancer cell lines. It shows potential as a treatment for metastatic pancreatic adenocarcinoma.
S3086 Maleic acid

Maleic acid inhibits glutamate decarboxylase (GAD) activity, thus enhances acid sensitivity of Listeria monocytogenes. Maleic acid affects the extracellular GABA levels.
E2354 Valepotriate Valepotriate, an unstable iridoid isolated from Valeriana jatamansi Jones, has anti-epileptic by significantly increasing the expression of GABAA, glutamic acid decarboxylase 65, and Bcl-2 and reduce the expression of caspase-3.
S1642 Methyldopa Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg.
J Immunother Cancer, 2024, 12(11)e009805
E0654 D-Arginine D-Arginine is an inhibitor of arginine decarboxylase(ADC) to regulate putrescine biosynthesis.
S5448 S(-)-Carbidopa S(-)-Carbidopa is a peripheral decarboxylase inhibitor, used in combination with levodopa for treatment of Parkinsonism.
E1189 TES-1025 TES-1025 is a potent and selective human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) inhibitor with an IC50 of 13 nM.
S5444 4-Bromo-3-hydroxybenzoic acid 4-bromo-3-hydroxybenzoic acid is a potent inhibitor of the enzyme histidine decarboxylase with resultant inhibition of histamine formation in mammals.
S5579 Chelidonic acid Chelidonic acid (Jerva acid, Jervaic acid, γ-Pyrone-2,6-dicarboxylic acid) is a secondary metabolite found in several plants with therapeutic potential in allergic disorders in experimental animals. Chelidonic acid inhibits IL-6 production by blocking NF-κB and caspase-1 in HMC-1 cells. Chelidonic acid is also an inhibitor of glutamate decarboxylase with Ki of 1.2 μM.
S5409 Chelidamic acid hydrate Chelidamic acid is a pharmaceutical intermediate as well as a cosmetic material due to its anti-inflammatory and whitening effect. Chelidamic acid is also one of the most potent inhibitors of glutamate decarboxylase, with a Ki of 33 μM.
E7388New (S)-2-Allylglycine (S)-2-Allylglycine (L-Allylglycine) is a potent inhibitor of glutamic acid decarboxylase (GAD), the key enzyme in GABA biosynthesis, causing GABA depletion, seizures, and neuronal damage. It is used in research on treatment-resistant seizures in epilepsy.
S4582 Eflornithine (DFMO) hydrochloride hydrate Eflornithine (DFMO) hydrochloride hydrate inhibits polyamine biosynthesis by the selective, irreversible inhibition of ornithine decarboxylase (ODC). A chemoprotective agent that blocks angiogenesis. Its biological half-life is 8 hours.
Front Oncol, 2023, 13:1212604
mBio, 2022, 13(5):e0219422
iScience, 2022, 25(3):103881
S2453 Benserazide HCl Benserazide HCl (Ro-4-4602) is a peripherally-acting aromatic L-amino acid decarboxylase (AAAD) or DOPA decarboxylase inhibitor.Solutions are unstable and should be fresh-prepared.
Front Pharmacol, 2024, 15:1404532
Viruses, 2024, 16(10)1566
Elife, 2022, 11e72668
S1891 Carbidopa Carbidopa is an aromatic-L-amino-acid decarboxylase inhibitor with an IC50 of 29 ± 2 μM.
Signal Transduct Target Ther, 2021, 6(1):77
J Cell Physiol, 2021, 10.1002/jcp.30587
PLoS One, 2017, 12(3):e0173240
S0108 AZ-33 AZ-33 (LDHA Inhibitor 33) is a potent inhibitor of lactate dehydrogenase A (LDHA) with IC50 of 0.5 μM. LDHA is the key enzyme involved in anaerobic glycolysis which is frequently deregulated in human malignancies.
FASEB J, 2022, 36(3):e22229
Front Mol Biosci, 2021, 8:806650
E8286New Ivospemin Ivospemin is a spermine analogue and polyamine inhibitor that lowers polyamine levels by inhibiting the activity of the polyamine biosynthetic enzyme ornithine decarboxylase (ODC) in cancer cell lines. It shows potential as a treatment for metastatic pancreatic adenocarcinoma.
S3086 Maleic acid

Maleic acid inhibits glutamate decarboxylase (GAD) activity, thus enhances acid sensitivity of Listeria monocytogenes. Maleic acid affects the extracellular GABA levels.
S1642 Methyldopa Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg.
J Immunother Cancer, 2024, 12(11)e009805
E0654 D-Arginine D-Arginine is an inhibitor of arginine decarboxylase(ADC) to regulate putrescine biosynthesis.
S5448 S(-)-Carbidopa S(-)-Carbidopa is a peripheral decarboxylase inhibitor, used in combination with levodopa for treatment of Parkinsonism.
E1189 TES-1025 TES-1025 is a potent and selective human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) inhibitor with an IC50 of 13 nM.
S5444 4-Bromo-3-hydroxybenzoic acid 4-bromo-3-hydroxybenzoic acid is a potent inhibitor of the enzyme histidine decarboxylase with resultant inhibition of histamine formation in mammals.
S5579 Chelidonic acid Chelidonic acid (Jerva acid, Jervaic acid, γ-Pyrone-2,6-dicarboxylic acid) is a secondary metabolite found in several plants with therapeutic potential in allergic disorders in experimental animals. Chelidonic acid inhibits IL-6 production by blocking NF-κB and caspase-1 in HMC-1 cells. Chelidonic acid is also an inhibitor of glutamate decarboxylase with Ki of 1.2 μM.
S5409 Chelidamic acid hydrate Chelidamic acid is a pharmaceutical intermediate as well as a cosmetic material due to its anti-inflammatory and whitening effect. Chelidamic acid is also one of the most potent inhibitors of glutamate decarboxylase, with a Ki of 33 μM.
E7388New (S)-2-Allylglycine (S)-2-Allylglycine (L-Allylglycine) is a potent inhibitor of glutamic acid decarboxylase (GAD), the key enzyme in GABA biosynthesis, causing GABA depletion, seizures, and neuronal damage. It is used in research on treatment-resistant seizures in epilepsy.
E2354 Valepotriate Valepotriate, an unstable iridoid isolated from Valeriana jatamansi Jones, has anti-epileptic by significantly increasing the expression of GABAA, glutamic acid decarboxylase 65, and Bcl-2 and reduce the expression of caspase-3.
F0074New GAD67 mAb GAD1,GAD67,GAD-67
F2532New GAD67/GAD1 Mouse mAb GAD1,GAD67,GAD-67
E8286New Ivospemin Ivospemin is a spermine analogue and polyamine inhibitor that lowers polyamine levels by inhibiting the activity of the polyamine biosynthetic enzyme ornithine decarboxylase (ODC) in cancer cell lines. It shows potential as a treatment for metastatic pancreatic adenocarcinoma.
E7388New (S)-2-Allylglycine (S)-2-Allylglycine (L-Allylglycine) is a potent inhibitor of glutamic acid decarboxylase (GAD), the key enzyme in GABA biosynthesis, causing GABA depletion, seizures, and neuronal damage. It is used in research on treatment-resistant seizures in epilepsy.

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