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Decarboxylase

Other Metabolism Related Inhibitors

Dehydrogenase Transferase DPP Aminopeptidase Procollagen C Proteinase P450 (e.g. CYP17) Phospholipase (e.g. PLA) Factor Xa PDE DHFR
Cat.No. Product Name Information Product Use Citations Product Validations
S4582 Eflornithine (DFMO) Hydrochloride Hydrate Eflornithine (DFMO) hydrochloride hydrate inhibits polyamine biosynthesis by the selective, irreversible inhibition of ornithine decarboxylase (ODC). A chemoprotective agent that blocks angiogenesis. Its biological half-life is 8 hours.
Cancer Lett, 2025, 630:217887
Front Oncol, 2023, 13:1212604
mBio, 2022, 13(5):e0219422
S2453 Benserazide HCl Benserazide HCl (Ro-4-4602) is a peripherally-acting aromatic L-amino acid decarboxylase (AAAD) or DOPA decarboxylase inhibitor.Solutions are unstable and should be fresh-prepared.
Front Pharmacol, 2024, 15:1404532
Viruses, 2024, 16(10)1566
Elife, 2022, 11e72668
S1891 Carbidopa Carbidopa is an aromatic-L-amino-acid decarboxylase inhibitor with an IC50 of 29 ± 2 μM.
Signal Transduct Target Ther, 2021, 6(1):77
J Cell Physiol, 2021, 10.1002/jcp.30587
PLoS One, 2017, 12(3):e0173240
S1642 Methyldopa Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg.
J Immunother Cancer, 2024, 12(11)e009805
E8286New Ivospemin Ivospemin is a spermine analogue and polyamine inhibitor that lowers polyamine levels by inhibiting the activity of the polyamine biosynthetic enzyme ornithine decarboxylase (ODC) in cancer cell lines. It shows potential as a treatment for metastatic pancreatic adenocarcinoma.
S3086 Maleic acid

Maleic acid inhibits glutamate decarboxylase (GAD) activity, thus enhances acid sensitivity of Listeria monocytogenes. This compound affects the extracellular GABA levels.
E0654 D-Arginine D-Arginine is an inhibitor of arginine decarboxylase(ADC) to regulate putrescine biosynthesis.
S5448 S(-)-Carbidopa S(-)-Carbidopa is a peripheral decarboxylase inhibitor, used in combination with levodopa for treatment of Parkinsonism.
E1189 TES-1025 TES-1025 is a potent and selective human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) inhibitor with an IC50 of 13 nM.
S5444 4-Bromo-3-hydroxybenzoic acid 4-bromo-3-hydroxybenzoic acid is a potent inhibitor of the enzyme histidine decarboxylase with resultant inhibition of histamine formation in mammals.