Peroxidases
Inhibitory Selectivity
Isoform-specific Inhibitors
Peroxidases Products
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S1988 |
PropylthiouracilPropylthiouracil (NSC 6498, NSC 70461) is a thyroperoxidase and 5'-deiodinase inhibitor, used to treat hyperthyroidism. |
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| S0018 |
VerdiperstatVerdiperstat (AZD3241, BHV-3241) is a selective, orally active and irreversible inhibitor of myeloperoxidase (MPO) with IC50 of 630 nM. Verdiperstat (AZD3241) can be used in the research of neurodegenerative brain disorders. |
||
| S6648 |
PF-06282999PF-06282999 is an orally bioavailable, irreversible inactivator of myeloperoxidase enzyme and is currently in clinical trials for the potential treatment of cardiovascular diseases. |
||
| S0316 |
MPO-IN-28MPO-IN-28 (Compound 28) is an inhibitor of myeloperoxidase (MPO) with IC50 of 44 nM. |
||
| S9874New |
4-Aminobenzohydrazide4-Aminobenzohydrazide (4-Aminobenzhydrazide, 4-aminobenzoic acid hydrazide, 4-ABAH, Myeloperoxidase Inhibitor I, NSC 640) is an inhibitor of MPO (Myeloperoxidase) enzyme that enhances iNOS induction in MPO-positive cells, but not in MPO-KO cells. |
||
| S5977New |
3-Amino-1,2,4-triazole3-Amino-1,2,4-triazole (1,2,4-Triazol-3-amine, 3-AT, Aminotriazole, Amitrol, 3-Amino-1H-1,2,4-triazole, Trapidil impurity B) is a common irreversible inhibitor of catalase, induces a compensatory mechanism for the hydrogen peroxide detoxification, which includs a rise in glutathione peroxidase (GPX) and glutathione reductase activities. |
||
| S4452New |
ML162ML162 is a covalent inhibitor of cellular phospholipid glutathione peroxidase (GPX-4) that induces ferroptosis. |
||
| S9803New |
Elamipretide (MTP-131)Elamipretide (MTP-131, SS-31, D-Arg-Dmt-Lys-Phe-NH2) is a cytochrome c peroxidase inhibitor. Elamipretide improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice. |
||
| S0788 |
ML 210ML-210 (CID 49766530) is a selective covalent inhibitor of cellular glutathione peroxidase 4 (GPX4) with EC50 of 0.04 μM and induces ferroptosis. ML-210 can selectively kill cells induced to express mutant RAS. ML-210 exhibits anti-cancer activity. |
||
| S4966 |
4-Methylesculetin4-methylesculetin is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase (MPO) activity and reduces IL-6 level. |
||
| S8155 |
RSL3RSL3 ((1S,3R)-RSL3) is a ferroptosis activator in a VDAC-independent manner,exhibiting selectivity for tumor cells bearing oncogenic RAS. RSL3 binds, inactivates GPX4 and thus mediates GPX4-regulated ferroptosis. |
(D) Representative western blot and (E) densitometry showing protein levels of HO-1 in HO-1+/+ PTCs treated with RSL3 over time. Data shown represent the Mean ± SEM of three independent experiments performed each time in triplicate; * = p<0.05, ** = p<0.01 compared to lower concentration at each time point. |
|
| S3298 |
Caulophylline (N-Methylcytisine)Caulophylline (N-Methylcytisine, Caulophyllin, NMC) is a tricyclic quinolizidine alkaloid with anti-inflammatory activities. Caulophylline binds to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia with Kd of 50 nM. Caulophylline significantly reduces myeloperoxidase (MPO) activity, blocks the activation of NF-κB by inhibiting IκB and IKK phosphorylation. |
||
| S3274 |
Glucosyl-vitexinGlucosyl-vitexin (Glucosylvitexin), the major C-glycosylflavone present in millet, inhibits thyroid peroxidase (TPO) activity. |
||
| S3299 |
DemethyleneberberineDemethyleneberberine (DMB), a component of Cortex Phellodendri Chinensis (CPC), significantly alleviates the weight loss and diminishes myeloperoxidase (MPO) activity, while significantly reduces the production of pro-inflammatory cytokines, such as interleukin (IL)-6 and tumor necrosis factor-α (TNF-α), and inhibits the activation of NF-κB signaling pathway. Demethyleneberberine (DMB) potentially ameliorates NAFLD (Non-alcoholic fatty liver disease) by activating AMPK pathways. |
||
| S6822 |
TMB dihydrochlorideTMB dihydrochloride (3,3',5,5'-Tetramethylbenzidine dihydrochloride hydrate, TMB-d, BM blue, Sure Blue TMB) is an excellent colorimetric substrate for detection of horseradish peroxidase (HRP) labeled probes and is used in staining procedures in immunohistochemistry and in enzyme-linked immunosorbent assays (ELISA). |
||
| S6106 |
3-Chloro-L-tyrosine3-Chloro-L-tyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S1988 |
PropylthiouracilPropylthiouracil (NSC 6498, NSC 70461) is a thyroperoxidase and 5'-deiodinase inhibitor, used to treat hyperthyroidism. |
||
| S0018 |
VerdiperstatVerdiperstat (AZD3241, BHV-3241) is a selective, orally active and irreversible inhibitor of myeloperoxidase (MPO) with IC50 of 630 nM. Verdiperstat (AZD3241) can be used in the research of neurodegenerative brain disorders. |
||
| S6648 |
PF-06282999PF-06282999 is an orally bioavailable, irreversible inactivator of myeloperoxidase enzyme and is currently in clinical trials for the potential treatment of cardiovascular diseases. |
||
| S0316 |
MPO-IN-28MPO-IN-28 (Compound 28) is an inhibitor of myeloperoxidase (MPO) with IC50 of 44 nM. |
||
| S9874New |
4-Aminobenzohydrazide4-Aminobenzohydrazide (4-Aminobenzhydrazide, 4-aminobenzoic acid hydrazide, 4-ABAH, Myeloperoxidase Inhibitor I, NSC 640) is an inhibitor of MPO (Myeloperoxidase) enzyme that enhances iNOS induction in MPO-positive cells, but not in MPO-KO cells. |
||
| S5977New |
3-Amino-1,2,4-triazole3-Amino-1,2,4-triazole (1,2,4-Triazol-3-amine, 3-AT, Aminotriazole, Amitrol, 3-Amino-1H-1,2,4-triazole, Trapidil impurity B) is a common irreversible inhibitor of catalase, induces a compensatory mechanism for the hydrogen peroxide detoxification, which includs a rise in glutathione peroxidase (GPX) and glutathione reductase activities. |
||
| S4452New |
ML162ML162 is a covalent inhibitor of cellular phospholipid glutathione peroxidase (GPX-4) that induces ferroptosis. |
||
| S9803New |
Elamipretide (MTP-131)Elamipretide (MTP-131, SS-31, D-Arg-Dmt-Lys-Phe-NH2) is a cytochrome c peroxidase inhibitor. Elamipretide improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice. |
||
| S0788 |
ML 210ML-210 (CID 49766530) is a selective covalent inhibitor of cellular glutathione peroxidase 4 (GPX4) with EC50 of 0.04 μM and induces ferroptosis. ML-210 can selectively kill cells induced to express mutant RAS. ML-210 exhibits anti-cancer activity. |
||
| S4966 |
4-Methylesculetin4-methylesculetin is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase (MPO) activity and reduces IL-6 level. |
||
| S8155 |
RSL3RSL3 ((1S,3R)-RSL3) is a ferroptosis activator in a VDAC-independent manner,exhibiting selectivity for tumor cells bearing oncogenic RAS. RSL3 binds, inactivates GPX4 and thus mediates GPX4-regulated ferroptosis. |
(D) Representative western blot and (E) densitometry showing protein levels of HO-1 in HO-1+/+ PTCs treated with RSL3 over time. Data shown represent the Mean ± SEM of three independent experiments performed each time in triplicate; * = p<0.05, ** = p<0.01 compared to lower concentration at each time point. |
|
| S3298 |
Caulophylline (N-Methylcytisine)Caulophylline (N-Methylcytisine, Caulophyllin, NMC) is a tricyclic quinolizidine alkaloid with anti-inflammatory activities. Caulophylline binds to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia with Kd of 50 nM. Caulophylline significantly reduces myeloperoxidase (MPO) activity, blocks the activation of NF-κB by inhibiting IκB and IKK phosphorylation. |
||
| S3274 |
Glucosyl-vitexinGlucosyl-vitexin (Glucosylvitexin), the major C-glycosylflavone present in millet, inhibits thyroid peroxidase (TPO) activity. |
||
| S3299 |
DemethyleneberberineDemethyleneberberine (DMB), a component of Cortex Phellodendri Chinensis (CPC), significantly alleviates the weight loss and diminishes myeloperoxidase (MPO) activity, while significantly reduces the production of pro-inflammatory cytokines, such as interleukin (IL)-6 and tumor necrosis factor-α (TNF-α), and inhibits the activation of NF-κB signaling pathway. Demethyleneberberine (DMB) potentially ameliorates NAFLD (Non-alcoholic fatty liver disease) by activating AMPK pathways. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S6822 |
TMB dihydrochlorideTMB dihydrochloride (3,3',5,5'-Tetramethylbenzidine dihydrochloride hydrate, TMB-d, BM blue, Sure Blue TMB) is an excellent colorimetric substrate for detection of horseradish peroxidase (HRP) labeled probes and is used in staining procedures in immunohistochemistry and in enzyme-linked immunosorbent assays (ELISA). |
||
| S6106 |
3-Chloro-L-tyrosine3-Chloro-L-tyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima. |
