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Other Metabolism Related Inhibitors

Dehydrogenase Transferase DPP Aminopeptidase Procollagen C Proteinase P450 (e.g. CYP17) Phospholipase (e.g. PLA) Factor Xa PDE DHFR

Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S8155 RSL3 RSL3 ((1S,3R)-RSL3) is a ferroptosis activator in a VDAC-independent manner,exhibiting selectivity for tumor cells bearing oncogenic RAS. RSL3 binds, inactivates GPX4 and thus mediates GPX4-regulated ferroptosis.
Rockefeller University Digital Commons @ RU, 221, 670
Exp Cell Res, 2026, 454(1):114825
Nature, 2025, 10.1038/s41586-025-09222-5
Verified customer review of RSL3
S9803 Elamipretide (SS-31, MTP-131) Elamipretide (MTP-131, SS-31) is a cytochrome c peroxidase inhibitor. Elamipretide improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice.
Ecotoxicol Environ Saf, 2025, 290:117622
Ecotoxicol Environ Saf, 2025, 296:118202
Neurotherapeutics, 2025, S1878-7479(25)00250-8
S0788 ML 210 ML-210 (CID 49766530) is a selective covalent inhibitor of cellular glutathione peroxidase 4 (GPX4) with EC50 of 0.04 μM and induces ferroptosis. ML-210 can selectively kill cells induced to express mutant RAS. ML-210 exhibits anti-cancer activity.
Nature, 2025, 10.1038/s41586-025-09709-1
Cell Death Dis, 2025, 16(1):564
Cell Death Dis, 2025, 16(1):614
S1988 Propylthiouracil Propylthiouracil (NSC 6498, NSC 70461) is a thyroperoxidase and 5'-deiodinase inhibitor, used to treat hyperthyroidism.
J Biol Chem, 2020, jbc.RA120.015020
BMC Neurosci, 2015, 16:33
S4452 ML162 ML162 is a covalent inhibitor of cellular phospholipid glutathione peroxidase (GPX-4) that induces ferroptosis.
Nat Commun, 2025, 16(1):1982
J Adv Res, 2025, S2090-1232(25)00045-1
Cell Death Dis, 2025, 16(1):614
S0018 Verdiperstat Verdiperstat (AZD3241, BHV-3241) is a selective, orally active and irreversible inhibitor of myeloperoxidase (MPO) with IC50 of 630 nM. This compound can be used in the research of neurodegenerative brain disorders.
J Chromatogr B Analyt Technol Biomed Life Sci, 2021, 1181:122924
S6648 PF-06282999 PF-06282999 is an orally bioavailable, irreversible inactivator of myeloperoxidase enzyme and is currently in clinical trials for the potential treatment of cardiovascular diseases.
J Chromatogr B Analyt Technol Biomed Life Sci, 2021, 1181:122924
S9874 4-Aminobenzohydrazide 4-Aminobenzohydrazide (4-Aminobenzhydrazide, 4-aminobenzoic acid hydrazide, 4-ABAH, Myeloperoxidase Inhibitor I, NSC 640) is an inhibitor of MPO (Myeloperoxidase) enzyme that enhances iNOS induction in MPO-positive cells, but not in MPO-KO cells.
Parasit Vectors, 2025, 18(1):248
Front Bioeng Biotechnol, 2022, 10:855755
E4652 ZX703 ZX703 is a proteolysis targeting chimera (PROTAC), that is a degrader of GPX4 through the ubiquitin-proteasome and the autophagy-lysosome with a DC50 of 0.315 µM. It induces the accumulation of lipid reactive oxygen species (ROS), thereby inducing ferroptosis cancer cells.
E1244 FINO2 FINO2 is a potent ferroptosis inducer which inhibits GPX4 activity. This compound causes widespread lipid peroxidation.