Retinoid Receptor
Inhibitory Selectivity
Isoform-specific Inhibitors
Retinoid Receptor Products
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S5233 |
FenretinideFenretinide (4-hydroxy(phenyl)retinamide, 4-HPR, MK-4016) is a synthetic derivative of retinoic acid that has a broad-spectrum of cytotoxic activity against primary tumor cells, cell lines, and/or xenografts of various cancers (including neuroblastoma). Fenretinide (4-hydroxy(phenyl)retinamide; 4-HPR) is a synthetic derivative of retinoic acid, fenretinide can bind to retinoic acid receptor (RAR) and retinoid X receptor (RXR) at concentrations necessary to induce cell death. |
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| S6605 |
AR7AR7 is a retinoic acid receptor α (RARα) antagonist. |
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| S1653 |
Tretinoin (Retinoic acid)Tretinoin (Retinoic acid, All-trans Retinoic Acid, ATRA), which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells. |
HL60 differentiation measured by expression of CD11b (flow cytometry) after a single dose exposure to HH1 or MC180295 for 4 days. 1 mM ATRA and high concentrations of DMSO (1.25%) were used as positive controls.
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| S2098 |
BexaroteneBexarotene (Targretin, LGD1069) is a retinoid specifically selective for retinoid X receptors, used as an oral antineoplastic agent in the treatment of cutaneous T-cell lymphoma. |
Bexarotene inhibited microglia activation after SAH. Left, Representative immunofluorescent images of Iba1 (red) and DAPI (blue) in basal cortex at 24 h after SAH (N = 4/group, mean ± SD). Scale bar, 30 μm. Right, quantification of Iba1 positive cells per mm2. ***p < 0.001 compared with the Sham group, ###p < 0.001 compared with the SAH + vehicle group.
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| S1276 |
AdapaleneAdapalene (CD-271) is a dual RAR and RXR agonist, used in the treatment of acne. |
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| S1368 |
AcitretinAcitretin (Etretin, RO 10-1670) is a second generation retinoid used for psoriasis. |
Acitretin does not induce HIV reactivation in J-lat and ACH-2 cells. (a, b) HIV reactivation induced by acid retinoic (AR) derivative acitretin (25 – 1 μM) in J-Lat cells clone 8.4 (a) and 9.2(b). HDAC inhibitors (HDCAi) panobinostat (PNB, 0.16μM) and vorinostat (VOR, 4 – 0.16 μM) were used as controls. Reactivation was determined by the quantification of GFP+ cells (%) after culturing J-Lat with HDACi and acitretin for 24h. (c, d) HIV reactivation induced by acitretin and HDACi in ACH-2 cells. Reactivation was determined after 48h of incubation by quantification of CAp24 (c) and HIV RNA copy number (d) in the supernatant. Values represent mean±SD of at least three independent experiments performed in triplicate. UN, untreated. *P < 0.05; **P < 0.01; ***P < 0.001.
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| S1569 |
TazaroteneTazarotene (AGN190168) is a retinoid prodrug of tazarotenic acid, which is a RAR agonist, used to treat psoriasis, acne, and sun damaged skin. |
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| S4627 |
TTNPB (Arotinoid Acid)TTNPB (Arotinoid Acid) is a potent RAR agonist, and inhibits binding of [3H]tRA with IC50 of 5.1 nM, 4.5 nM, and 9.3 nM for human RARα, β, and γ, respectively. |
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| S4260 |
TamibaroteneTamibarotene is a synthetic retinoic acid receptor (RAR) agonist with high specificity for RARα and RARβ over RARγ. |
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| S6132 |
All trans-RetinalAll trans-Retinal, a component of the retinoid cycle, is converted to retinoic acid in vivo by the action of retinal dehydrogenase. Retinoic acid is a ligand for both RAR and RXR. All trans-retinal ias a potent photosensitizer. |
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| S2933 |
AM580AM580 is a retinoic acid receptor agonist with Kd values of 8 nM, 131 nM and 450 nM for RARα, RARβ and RARγ. |
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| S4699 |
EtretinateEtretinate is an oral aromatic retinoid acid which is effective in psoriasis and other dermatological syndromes. It activates retinoid receptors, causing an induction of cell differentiation, inhibition of cell proliferation, and inhibition of tissue infiltration by inflammatory cells. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S5233 |
FenretinideFenretinide (4-hydroxy(phenyl)retinamide, 4-HPR, MK-4016) is a synthetic derivative of retinoic acid that has a broad-spectrum of cytotoxic activity against primary tumor cells, cell lines, and/or xenografts of various cancers (including neuroblastoma). Fenretinide (4-hydroxy(phenyl)retinamide; 4-HPR) is a synthetic derivative of retinoic acid, fenretinide can bind to retinoic acid receptor (RAR) and retinoid X receptor (RXR) at concentrations necessary to induce cell death. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S6605 |
AR7AR7 is a retinoic acid receptor α (RARα) antagonist. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S1653 |
Tretinoin (Retinoic acid)Tretinoin (Retinoic acid, All-trans Retinoic Acid, ATRA), which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells. |
HL60 differentiation measured by expression of CD11b (flow cytometry) after a single dose exposure to HH1 or MC180295 for 4 days. 1 mM ATRA and high concentrations of DMSO (1.25%) were used as positive controls.
|
|
| S2098 |
BexaroteneBexarotene (Targretin, LGD1069) is a retinoid specifically selective for retinoid X receptors, used as an oral antineoplastic agent in the treatment of cutaneous T-cell lymphoma. |
Bexarotene inhibited microglia activation after SAH. Left, Representative immunofluorescent images of Iba1 (red) and DAPI (blue) in basal cortex at 24 h after SAH (N = 4/group, mean ± SD). Scale bar, 30 μm. Right, quantification of Iba1 positive cells per mm2. ***p < 0.001 compared with the Sham group, ###p < 0.001 compared with the SAH + vehicle group.
|
|
| S1276 |
AdapaleneAdapalene (CD-271) is a dual RAR and RXR agonist, used in the treatment of acne. |
||
| S1368 |
AcitretinAcitretin (Etretin, RO 10-1670) is a second generation retinoid used for psoriasis. |
Acitretin does not induce HIV reactivation in J-lat and ACH-2 cells. (a, b) HIV reactivation induced by acid retinoic (AR) derivative acitretin (25 – 1 μM) in J-Lat cells clone 8.4 (a) and 9.2(b). HDAC inhibitors (HDCAi) panobinostat (PNB, 0.16μM) and vorinostat (VOR, 4 – 0.16 μM) were used as controls. Reactivation was determined by the quantification of GFP+ cells (%) after culturing J-Lat with HDACi and acitretin for 24h. (c, d) HIV reactivation induced by acitretin and HDACi in ACH-2 cells. Reactivation was determined after 48h of incubation by quantification of CAp24 (c) and HIV RNA copy number (d) in the supernatant. Values represent mean±SD of at least three independent experiments performed in triplicate. UN, untreated. *P < 0.05; **P < 0.01; ***P < 0.001.
|
|
| S1569 |
TazaroteneTazarotene (AGN190168) is a retinoid prodrug of tazarotenic acid, which is a RAR agonist, used to treat psoriasis, acne, and sun damaged skin. |
||
| S4627 |
TTNPB (Arotinoid Acid)TTNPB (Arotinoid Acid) is a potent RAR agonist, and inhibits binding of [3H]tRA with IC50 of 5.1 nM, 4.5 nM, and 9.3 nM for human RARα, β, and γ, respectively. |
||
| S4260 |
TamibaroteneTamibarotene is a synthetic retinoic acid receptor (RAR) agonist with high specificity for RARα and RARβ over RARγ. |
||
| S6132 |
All trans-RetinalAll trans-Retinal, a component of the retinoid cycle, is converted to retinoic acid in vivo by the action of retinal dehydrogenase. Retinoic acid is a ligand for both RAR and RXR. All trans-retinal ias a potent photosensitizer. |
||
| S2933 |
AM580AM580 is a retinoic acid receptor agonist with Kd values of 8 nM, 131 nM and 450 nM for RARα, RARβ and RARγ. |
||
| S4699 |
EtretinateEtretinate is an oral aromatic retinoid acid which is effective in psoriasis and other dermatological syndromes. It activates retinoid receptors, causing an induction of cell differentiation, inhibition of cell proliferation, and inhibition of tissue infiltration by inflammatory cells. |
