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Retinoid Receptor

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Catalog No. Product Name Information Product Use Citations Product Validations
S5233 Fenretinide (NSC 374551) Fenretinide (4-hydroxy(phenyl)retinamide, 4-HPR, MK-4016) is a synthetic derivative of retinoic acid that has a broad-spectrum of cytotoxic activity against primary tumor cells, cell lines, and/or xenografts of various cancers (including neuroblastoma). Fenretinide (4-hydroxy(phenyl)retinamide; 4-HPR) is a synthetic derivative of retinoic acid, fenretinide can bind to retinoic acid receptor (RAR) and retinoid X receptor (RXR) at concentrations necessary to induce cell death.
S6605 AR7 AR7 is a retinoic acid receptor α (RARα) antagonist.
S1276 Adapalene Adapalene (CD-271) is a dual RAR and RXR agonist, used in the treatment of acne.
PLoS Pathog, 2020, 16;16(3):e1008341
Cancer Discov, 2020, 10(7):1058-1077
S1368 Acitretin Acitretin (Etretin, RO 10-1670) is a second generation retinoid used for psoriasis.
Antimicrob Agents Chemother, 2017, 61(11). pii: e01368-17
Saudi Pharm J, 2017, 25(4):620-624
S1569 Tazarotene Tazarotene (AGN190168) is a retinoid prodrug of tazarotenic acid, which is a RAR agonist, used to treat psoriasis, acne, and sun damaged skin.
Mol Pharm, 2015, 12(9):3399-407
J Clin Invest, 2013, 123(9):3941-51
S1653 Tretinoin (NSC 122758) Tretinoin (NSC 122758, Retinoic acid, All-trans Retinoic Acid, ATRA, Vitamin A acid, Vesanoid, Airol, Renova, Atralin, Retin-A, Avita, Stieva-A), which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.
Cell Signal, 2022, 93:110304
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Sci Adv, 2021, 7(43):eabe0834
S2098 Bexarotene (LGD1069) Bexarotene (Targretin, LGD1069) is a retinoid specifically selective for retinoid X receptors, used as an oral antineoplastic agent in the treatment of cutaneous T-cell lymphoma.
J Cell Mol Med, 2021, 25(5):2404-2417
J Cell Mol Med, 2021, 10.1111/jcmm.16074
Sci Adv, 2020, 6(42)eabb8543
S2933 AM580 AM580 is a retinoic acid receptor agonist with Kd values of 8 nM, 131 nM and 450 nM for RARα, RARβ and RARγ.
Cell Res, 2022, 10.1038/s41422-022-00668-0
J Leukoc Biol, 2022, 111(5):1107-1121
Stem Cells Int, 2018, 2018:5965727
S4260 Tamibarotene Tamibarotene is a synthetic retinoic acid receptor (RAR) agonist with high specificity for RARα and RARβ over RARγ.
PLoS One, 2019, 14(1):e0211071
S4627 TTNPB (Arotinoid Acid) TTNPB (Arotinoid Acid, Ro 13-7410, AGN-191183) is a potent RAR agonist, and inhibits binding of [3H]tRA with IC50 of 5.1 nM, 4.5 nM, and 9.3 nM for human RARα, β, and γ, respectively.
Int J Mol Sci, 2022, 23(8)4213
Cell Signal, 2022, 93:110304
Sci Rep, 2021, 11(1):10931
S4699 Etretinate Etretinate (Tegison, Ethyl etrinoate, Retinoid, Etretinato) is an oral aromatic retinoid acid which is effective in psoriasis and other dermatological syndromes. It activates retinoid receptors, causing an induction of cell differentiation, inhibition of cell proliferation, and inhibition of tissue infiltration by inflammatory cells.
Viruses, 2021, 13(8)1533
S6132 All trans-Retinal All trans-Retinal (Retinaldehyde, Vitamin A aldehyde, Retinene), a component of the retinoid cycle, is converted to retinoic acid in vivo by the action of retinal dehydrogenase. Retinoic acid is a ligand for both RAR and RXR. All trans-retinal ias a potent photosensitizer.
S5233 Fenretinide (NSC 374551) Fenretinide (4-hydroxy(phenyl)retinamide, 4-HPR, MK-4016) is a synthetic derivative of retinoic acid that has a broad-spectrum of cytotoxic activity against primary tumor cells, cell lines, and/or xenografts of various cancers (including neuroblastoma). Fenretinide (4-hydroxy(phenyl)retinamide; 4-HPR) is a synthetic derivative of retinoic acid, fenretinide can bind to retinoic acid receptor (RAR) and retinoid X receptor (RXR) at concentrations necessary to induce cell death.
S6605 AR7 AR7 is a retinoic acid receptor α (RARα) antagonist.
S1276 Adapalene Adapalene (CD-271) is a dual RAR and RXR agonist, used in the treatment of acne.
PLoS Pathog, 2020, 16;16(3):e1008341
Cancer Discov, 2020, 10(7):1058-1077
S1368 Acitretin Acitretin (Etretin, RO 10-1670) is a second generation retinoid used for psoriasis.
Antimicrob Agents Chemother, 2017, 61(11). pii: e01368-17
Saudi Pharm J, 2017, 25(4):620-624
S1569 Tazarotene Tazarotene (AGN190168) is a retinoid prodrug of tazarotenic acid, which is a RAR agonist, used to treat psoriasis, acne, and sun damaged skin.
Mol Pharm, 2015, 12(9):3399-407
J Clin Invest, 2013, 123(9):3941-51
S1653 Tretinoin (NSC 122758) Tretinoin (NSC 122758, Retinoic acid, All-trans Retinoic Acid, ATRA, Vitamin A acid, Vesanoid, Airol, Renova, Atralin, Retin-A, Avita, Stieva-A), which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.
Cell Signal, 2022, 93:110304
Hum Cell, 2022, 10.1007/s13577-022-00671-y
Sci Adv, 2021, 7(43):eabe0834
S2098 Bexarotene (LGD1069) Bexarotene (Targretin, LGD1069) is a retinoid specifically selective for retinoid X receptors, used as an oral antineoplastic agent in the treatment of cutaneous T-cell lymphoma.
J Cell Mol Med, 2021, 25(5):2404-2417
J Cell Mol Med, 2021, 10.1111/jcmm.16074
Sci Adv, 2020, 6(42)eabb8543
S2933 AM580 AM580 is a retinoic acid receptor agonist with Kd values of 8 nM, 131 nM and 450 nM for RARα, RARβ and RARγ.
Cell Res, 2022, 10.1038/s41422-022-00668-0
J Leukoc Biol, 2022, 111(5):1107-1121
Stem Cells Int, 2018, 2018:5965727
S4260 Tamibarotene Tamibarotene is a synthetic retinoic acid receptor (RAR) agonist with high specificity for RARα and RARβ over RARγ.
PLoS One, 2019, 14(1):e0211071
S4627 TTNPB (Arotinoid Acid) TTNPB (Arotinoid Acid, Ro 13-7410, AGN-191183) is a potent RAR agonist, and inhibits binding of [3H]tRA with IC50 of 5.1 nM, 4.5 nM, and 9.3 nM for human RARα, β, and γ, respectively.
Int J Mol Sci, 2022, 23(8)4213
Cell Signal, 2022, 93:110304
Sci Rep, 2021, 11(1):10931
S4699 Etretinate Etretinate (Tegison, Ethyl etrinoate, Retinoid, Etretinato) is an oral aromatic retinoid acid which is effective in psoriasis and other dermatological syndromes. It activates retinoid receptors, causing an induction of cell differentiation, inhibition of cell proliferation, and inhibition of tissue infiltration by inflammatory cells.
Viruses, 2021, 13(8)1533
S6132 All trans-Retinal All trans-Retinal (Retinaldehyde, Vitamin A aldehyde, Retinene), a component of the retinoid cycle, is converted to retinoic acid in vivo by the action of retinal dehydrogenase. Retinoic acid is a ligand for both RAR and RXR. All trans-retinal ias a potent photosensitizer.
Tags: Retinoid Receptor inhibitor|Retinoid Receptor agonist|Retinoid Receptor activator|Retinoid Receptor inducer|Retinoid Receptor antagonist|Retinoid Receptor signaling pathway|Retinoid Receptor assay kit