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Retinoid Receptor

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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S1653 Retinoic acid (Tretinoin, Vitamin A acid) Retinoic acid (Tretinoin, Vitamin A acid) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), and can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells. Tretinoin (NSC 122758) can be used to induce animal models of osteoporosis.
Science Advances, October 20, 2021, eabe0834
Cancers, March 17, 2024, 1178
Nat Commun, 2025, 16(1):616
Verified customer review of Retinoic acid (Tretinoin, Vitamin A acid)
S2098 Bexarotene Bexarotene is a retinoid specifically selective for retinoid X receptors, used as an oral antineoplastic agent in the treatment of cutaneous T-cell lymphoma.
Cell Mol Immunol, 2025, 10.1038/s41423-025-01268-9
Nucleic Acids Res, 2025, 53(14)gkaf669
J Immunother Cancer, 2024, 12(11)e009805
Verified customer review of Bexarotene
S4627 TTNPB (Arotinoid acid) TTNPB is a potent RAR agonist, and inhibits binding of [3H]tRA with IC50 of 5.1 nM, 4.5 nM, and 9.3 nM for human RARα, β, and γ, respectively.
Environ Int, 2025, 204:109820
Cancer Lett, 2025, 610:217339
Nan Fang Yi Ke Da Xue Xue Bao, 2025, 45(2):322-330
S1368 Acitretin Acitretin (Etretin, RO 10-1670) is a second generation retinoid used for psoriasis.
Int J Mol Sci, 2022, 23(16)9366
Sci Rep, 2021, 11(1):9601
Biochemistry, 2021, 689-698
Verified customer review of Acitretin
S4260 Tamibarotene Tamibarotene(Am 80) is a synthetic retinoic acid receptor (RAR) agonist with high specificity for RARα and RARβ over RARγ.
iScience, 2024, 27(10):110862
Cancer Sci, 2024, 10.1111/cas.16280
Cancers (Basel), 2024, 16(7)1311
S2933 AM580 AM580 is a retinoic acid receptor agonist with Kd values of 8 nM, 131 nM and 450 nM for RARα, RARβ and RARγ.
Cell, 2025, S0092-8674(25)00807-4
Cell Rep, 2023, 42(6):112566
Cell Res, 2022, 10.1038/s41422-022-00668-0
S1276 Adapalene Adapalene (CD-271) is a dual RAR and RXR agonist, used in the treatment of acne.
Int J Mol Sci, 2022, 23(16)9366
Cancer Discov, 2020, 10(7):1058-1077
PLoS Pathog, 2020, 16;16(3):e1008341
S1569 Tazarotene Tazarotene (AGN190168) is a retinoid prodrug of tazarotenic acid, which is a RAR agonist, used to treat psoriasis, acne, and sun damaged skin.
Int J Mol Sci, 2022, 23(16)9366
Mol Pharm, 2015, 12(9):3399-407
J Clin Invest, 2013, 123(9):3941-51
S5233 Fenretinide Fenretinide is a synthetic derivative of retinoic acid that has a broad-spectrum of cytotoxic activity against primary tumor cells, cell lines, and/or xenografts of various cancers (including neuroblastoma). This compound (4-hydroxy(phenyl)retinamide; 4-HPR) is a synthetic derivative of retinoic acid, and it can bind to retinoic acid receptor (RAR) and retinoid X receptor (RXR) at concentrations necessary to induce cell death.
iScience, 2024, 27(10):110862
Acta Pharm Sin B, 2023, 13(1):142-156
Cancer Immunology Research, 2023, 1351-1366
S4699 Etretinate Etretinate (Tegison, Ethyl etrinoate, Retinoid, Etretinato,Ro 10-9359) is an oral aromatic retinoid acid which is effective in psoriasis and other dermatological syndromes. It activates retinoid receptors, causing an induction of cell differentiation, inhibition of cell proliferation, and inhibition of tissue infiltration by inflammatory cells.
Viruses, 2021, 1533
Scientific Reports, 2021, 9601
Viruses, 2021, 13(8)1533