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ACE

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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S9666 DX600 DX600 is a specific inhibitor of angiotensin-converting enzyme 2 (ACE2) that does not cross-react with ACE.
Commun Biol, 2023, 6(1):386
Communications Biology, 2023, 6(1)
S8940 MLN-4760 MLN-4760 (compound 16) is a potent and selective inhibitor of human angiotensin-converting enzyme 2 (ACE2) with IC50 of 0.44 nM. This compound also inhibits bovine carboxypeptidase A (CPDA) with IC50 of 27 μM.
Int J Biol Sci, 2023, 19(8):2613-2629
E2435 Perindopril L-Arginine Perindopril L-Argininel is a prodrug that is metabolized in the liver to its active diacid metabolite perindoprilat, which is rapidly and extensively absorbed, and become one of the highest tissue angiotensin-converting enzyme (ACE) affinities among the ACE inhibitors.
E6037 Perindopril Perindopril (S-9490) is a brain-penetrating inhibitor of angiotensin-converting enzyme (ACE) with an IC50 of 0.048 μM for ACE-1. It exhibits anti-hypertensive, anti-inflammatory, and anti-fibrotic properties.
S3562 Deserpidine Deserpidine (Harmonyl), an alkaloid isolated from the roots of Rauwolfia canescens, is a competitive angiotensin converting enzyme (ACE) inhibitor, also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex.
E4876 Lisinopril Lisinopril(MK-521) is a potent inhibitor of angiotensin-1 converting enzyme (sACE-1) with an IC50 of 1.9 nM. It demonstrates significant efficacy in the management of hypertension and heart failure, potentially improving cardiovascular outcomes.
E4900 Enalapril Enalapril(Eletriptan, Amprace, Vaseretic) is an inhibitor of angiotensin-converting enzyme (ACE), primarily used to treat hypertension, heart failure, and asymptomatic left ventricular dysfunction. It also attenuates frailty in aging mice.
Biochem Pharmacol, 2025, 240:117098
S2099 Temocapril HCl Temocapril HCl (CS-622) is the hydrochloride of Temocapril, which is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.
J Immunother Cancer, 2024, 12(11)e009805
J Pers Med, 2022, 12(2)258
Hum Cell, 2022, 10.1007/s13577-022-00671-y
S2051 Captopril Captopril (SQ 14225,Capoten) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 6 nM.
Nat Commun, 2025, 16(1):7347
J Neuroinflammation, 2025, 22(1):121
Toxicol Appl Pharmacol, 2025, 500:117375
S4104 Diminazene Aceturate Diminazene(Diminazene diaceturate) is a di-amidine also known as 4,4-(1-Triazene–1,3–diyl)bis(benzenecarboximidamide), used as an effective trypanocidal agent. The main biochemical mechanism of the trypanocidal actions of Diminazene aceturate is by binding to trypanosomal kinetoplast DNA (kDNA) in a non-intercalative manner through specific interaction with sites rich in adenine-thymine base pairs. Diminazene aceturate is also an angiotensin-converting enzyme 2 (ACE2) activator and has strong and potent anti-inflammatory properties.
Sci Rep, 2025, 15(1):18633
Cell, 2024, 187(15):4095-4112.e21
Cell, 2024, 187(15):4095-4112.e21