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Lipoxygenase

Other Metabolism Related Inhibitors

Dehydrogenase Transferase DPP Aminopeptidase Procollagen C Proteinase P450 (e.g. CYP17) Phospholipase (e.g. PLA) Factor Xa PDE DHFR
Cat.No. Product Name Information Product Use Citations Product Validations
S1396 Resveratrol (trans-Resveratrol) Resveratrol has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases（LOX, IC50=2.7 μM）, kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Resveratrol induces mitophagy/autophagy and autophagy-dependent apoptosis.
Aging Cell, 2025, e70075
Biomed Pharmacother, 2025, 190:118393
Breast Cancer Res, 2025, 27(1):186
Verified customer review of Resveratrol (trans-Resveratrol)
S1443 Zileuton Zileuton is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation, used to decrease the symptoms of asthma. This compound induces apoptosis while inhibits ferroptosis.
Biomolecules & Therapeutics, May 15 2023, 599-610
bioRxiv, July 13 2023, nan
Frontiers in Immunology, August 08 2019, 1904
Verified customer review of Zileuton
S6557 ML355 ML355 is a potent and selective inhibitor of human 12-Lipoxygenase with an IC50 of 290 nM and shows excellent selectivity over related lipoxygenases and cyclooxygenases.
Vaccines (Basel), 2023, 11(2)205
Redox Biol, 2022, 55:102421
Arteriosclerosis, Thrombosis, and Vascular Biology, 2021 Jan, e33-e45
E4977 Zileuton sodium Zileuton sodium (A 64077 sodium) is a potent, selective, and specific inhibitor of 5-lipoxygenase, exhibiting inflammatory activities. This compound prevents polyp formation efficiently by reducing tumor-associated and systemic inflammation in in vivo models. It also acts as a potential chemo-preventive agent in patients that are at high risk of developing colon cancer.
Cancer Science, 2023 Oct 26, 197-210
Biomolecules & Therapeutics, 2023 May 15, 599-610
Frontiers in Microbiology, 2020 May 8, 845
S3984 Nordihydroguaiaretic acid (NDGA) Nordihydroguaiaretic acid (NDGA) is a phenolic antioxidant found in the leaves and twigs of the evergreen desert shrub, Larrea tridentata (Sesse and Moc. ex DC) Coville (creosote bush). It is a recognized inhibitor of lipoxygenase (LOX) and has antioxidant and free radical scavenging properties. Nordihydroguaiaretic acid (NDGA) is a cytotoxic insulin-like growth factor-I receptor (IGF-1R)/HER2 inhibitor and induces apoptosis.
Gut Microbes, July 1, 2025, 2518338
npj Breast Cancer, August 6, 2024, 74
Gut Microbes, 2025, 17(1):2518338
S1137 Malotilate Malotilate (NKK105) is a drug used for the treatment of liver cirrhosis. This compound is a liver protein metabolism improved compound, which selectively inhibit the 5-lipoxygenase.
Journal of Cachexia, Sarcopenia and Muscle, 2022, 3062-3077
J Cachexia Sarcopenia Muscle, 2022, 13(6):3062-3077
S3387 ML351 ML351 is a selective inhibitor of 15-Lipoxygenase-1 (15-LOX-1 or 12/15-LOX) with IC50 of 200 nM.
Kyushu University Institutional Repository, 2019, nan
S6956 PD146176

PD146176 (NSC168807) is a potent inhibitor of 15-lipoxygenase (15-LO) with Ki of 197 nM for rabbit reticulocyte 15-LO.
Br J Cancer, 2023, 129(4):601-611
S9378 4',5-Dihydroxyflavone 4',5-Dihydroxyflavone inhibits soybean LOX-1 and yeast α-glucosidase.
Medical University of Bialystok, 2022, Vol. 79 No. 6 pp. 835-840, 2022
S9024 AKBA (3-O-Acetyl-11-keto-β-boswellic acid) AKBA (3-O-Acetyl-11-keto-β-boswellic acid), the major active ingredient of the gum resin from Boswellia serrata and Boswellia carteri Birdw., exerts anti-inflammatory therapeutic effects and noncompetitively inhibits 5-lipoxygenase, topoisomerase, and leukocyte elastase.
Nature Cancer, 2022, 629-648
Nat Cancer, 2022, 3(5):629-648