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Mitochondrial Metabolism

Other Metabolism Related Inhibitors

Dehydrogenase Transferase DPP Aminopeptidase Procollagen C Proteinase P450 (e.g. CYP17) Phospholipase (e.g. PLA) Factor Xa PDE DHFR
Cat.No. Product Name Information Product Use Citations Product Validations
S9803 Elamipretide (SS-31, MTP-131) Elamipretide (MTP-131, SS-31) is a cytochrome c peroxidase inhibitor. Elamipretide improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice.
Ecotoxicol Environ Saf, 2025, 290:117622
Ecotoxicol Environ Saf, 2025, 296:118202
Neurotherapeutics, 2025, S1878-7479(25)00250-8
S3654 Tauroursodeoxycholic Acid (TUDCA) Tauroursodeoxycholic acid (TUDCA) is the taurine conjugate of ursodeoxycholic acid (UDCA) and acts as a mitochondrial stabilizer and anti-apoptotic agent in several models of neurodegenerative diseases, including AD, Parkinson's diseases (PD), and Huntington's diseases (HD).
Nat Commun, 2025, 16(1):50
Toxicol Appl Pharmacol, 2025, 499:117333
Cell Mol Life Sci, 2024, 81(1):299
S3375 Mitochondrial Fusion Promoter M1 Mitochondrial fusion promoter M1 is a mitochondrial dynamic modulator that increases the expression of mitofusin 2, a mitochondrial outer membrane fusion protein, reduces brain mitochondrial dysfunction. Mitochondrial fusion promoter M1 alleviates brain damage in rats with cardiac ischemia/reperfusion injury.
The FASEB Journal, 2025, e202503182RR
Vet Res, 2025, 56(1):175
Veterinary Research, 2025, 175
S2968 CTPI-2 CTPI-2 is an inhibitor of mitochondrial citrate carrier SLC25A1 with KD of 3.5 μM. This compound is a unique regulator of glycolysis that limits the metabolic plasticity of cancer stem cells (CSCs).
Cancers (Basel), 2024, 16(21)3606
Res Sq, 2024, rs.3.rs-5278203
J Immunol, 2022, 208(5):1085-1098
E1252 MitoPQ MitoPQ (MitoParaquat), a mitochondria-targeted redox cycler, enables the selective generation of superoxide within mitochondria and is a useful tool to investigate the many roles of mitochondrial superoxide in pathology and redox signaling in cells and in vivo.
Cell Reports, 2025, 116262
Immunity, 2022, 1370-1385.e8
S5874 D-Carnitine hydrochloride D-Carnitine hydrochloride ((S)-Carnitine hydrochloride, (+)-Carnitine hydrochloride) is biosynthesized from lysine. It might be associated with the energy production from branched chain amino acids.
Medical Science Monitor, 2020, e923251
Med Sci Monit, 2020, 26;26:e923251
S0767 NL-1 The mitochondrial mitoNEET ligand NL-1 is a mitoNEET inhibitor, which induces a concentration-dependent decrease in cell viability with an IC50 of 47.35 μM and 56.26 μM in REH and REH/Ara-C cells respectively. The docking studies using liver mitochondrial suspensions show the IC50 of this compound binding for [3H]-rosiglitazone is 0.9 μM and the Ki for this chemical site 1 and site 2 was 4.78 and 2.77, respectively.
J Transl Med, 2024, 22(1):593
E5826 MASM7 MASM7 is an activator of mitofusins that promotes mitochondrial fusion through mitofusins. It increases mitochondrial AR in MEFs in a concentration-dependent manner, with an EC50 value of 75 nM. This compound also directly binds to the HR2 domain of MFN2 with a dissociation constant (Kd) of 1.1 μM, effectively activating MFN2 or MFN to induce fusion.
J Adv Res, 2025, S2090-1232(25)00955-5
Journal of Advanced Research, 2025, S2090-1232(25)00955-5
E1823 Ninerafaxstat trihydrochloride Ninerafaxstat trihydrochloride (MB-1018972 trihydrochloride, IMB-101 trihydrochloride) acts as a competitive inhibitor of 3-ketoacyl-CoA thiolase (3-KAT) to partially suppress fatty acid oxidation. It is an orally active cardiac mitochondrial drug that restores myocardial energy homeostasis. This compound regulates myocardial substrate utilization and improves cardiac efficiency. It is also used in research of cardiovascular diseases.
E1583 MFI8 MFI8 is a small molecule inhibitor of mitofusin-1 (MFN1) and mitofusin-2 (MFN2). It significantly reduces mitochondrial aspect ratio, inhibiting mitochondrial fusion and subsequently promoting mitochondrial fission and can be used in research on disorders with impaired mitochondrial dynamics.