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Mitochondrial Metabolism

Other Metabolism Related Inhibitors

Dehydrogenase Transferase DPP Aminopeptidase Procollagen C Proteinase P450 (e.g. CYP17) Phospholipase (e.g. PLA) Factor Xa PDE DHFR
Cat.No. Product Name Information Product Use Citations Product Validations
S9803 Elamipretide (SS-31, MTP-131) Elamipretide (MTP-131, SS-31) is a cytochrome c peroxidase inhibitor. Elamipretide improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice.
Ecotoxicol Environ Saf, 2025, 290:117622
Ecotoxicol Environ Saf, 2025, 296:118202
Neurotherapeutics, 2025, S1878-7479(25)00250-8
S3654 Tauroursodeoxycholic Acid (TUDCA) Tauroursodeoxycholic acid (TUDCA) is the taurine conjugate of ursodeoxycholic acid (UDCA) and acts as a mitochondrial stabilizer and anti-apoptotic agent in several models of neurodegenerative diseases, including AD, Parkinson's diseases (PD), and Huntington's diseases (HD).
Nat Commun, 2025, 16(1):50
Toxicol Appl Pharmacol, 2025, 499:117333
Cell Mol Life Sci, 2024, 81(1):299
S3375 Mitochondrial Fusion Promoter M1 Mitochondrial fusion promoter M1 is a mitochondrial dynamic modulator that increases the expression of mitofusin 2, a mitochondrial outer membrane fusion protein, reduces brain mitochondrial dysfunction. Mitochondrial fusion promoter M1 alleviates brain damage in rats with cardiac ischemia/reperfusion injury.
Stem Cell Research & Therapy, March 25, 2022, 127
Nature, January 2026, 1-11
Environmental Science & Technology, 2025, nan
S2968 CTPI-2 CTPI-2 is an inhibitor of mitochondrial citrate carrier SLC25A1 with KD of 3.5 μM. This compound is a unique regulator of glycolysis that limits the metabolic plasticity of cancer stem cells (CSCs).
Cancers (Basel), 2024, 16(21)3606
Res Sq, 2024, rs.3.rs-5278203
J Immunol, 2022, 208(5):1085-1098
E1252 MitoPQ MitoPQ (MitoParaquat), a mitochondria-targeted redox cycler, enables the selective generation of superoxide within mitochondria and is a useful tool to investigate the many roles of mitochondrial superoxide in pathology and redox signaling in cells and in vivo.
Cell Reports, 2025, 116262
Immunity, 2022, 1370-1385.e8
S5874 D-Carnitine hydrochloride D-Carnitine hydrochloride ((S)-Carnitine hydrochloride, (+)-Carnitine hydrochloride) is biosynthesized from lysine. It might be associated with the energy production from branched chain amino acids.
Medical Science Monitor, 2020, e923251
Med Sci Monit, 2020, 26;26:e923251
S0767 NL-1 The mitochondrial mitoNEET ligand NL-1 is a mitoNEET inhibitor, which induces a concentration-dependent decrease in cell viability with an IC50 of 47.35 μM and 56.26 μM in REH and REH/Ara-C cells respectively. The docking studies using liver mitochondrial suspensions show the IC50 of this compound binding for [3H]-rosiglitazone is 0.9 μM and the Ki for this chemical site 1 and site 2 was 4.78 and 2.77, respectively.
J Transl Med, 2024, 22(1):593
E5826 MASM7 MASM7 is an activator of mitofusins that promotes mitochondrial fusion through mitofusins. It increases mitochondrial AR in MEFs in a concentration-dependent manner, with an EC50 value of 75 nM. This compound also directly binds to the HR2 domain of MFN2 with a dissociation constant (Kd) of 1.1 μM, effectively activating MFN2 or MFN to induce fusion.
J Adv Res, 2025, S2090-1232(25)00955-5
Journal of Advanced Research, 2025, S2090-1232(25)00955-5
E6583New Atpenin A5 Atpenin A5 is a potent and specific mitochondrial complex II inhibitor with an IC50 of ~10 nM. It also acts as an mKATP channel agonist and confers cardioprotection in models of ischemia–reperfusion injury.
E1851New Succinyl phosphonate trisodium salt Succinyl phosphonate trisodium salt, a trisodium salt of succinyl phosphonate, is a selective inhibitor of the α‑ketoglutarate dehydrogenase complex (KGDHC). By reducing KGDHC activity and succinyl‑CoA–dependent protein succinylation, it modulates mitochondrial metabolism and protects neurons from glutamate‑ and β‑amyloid‑induced injury.