PTP Inhibitor II

Synonyms: NSC 129010, 4-(Bromoacetyl)anisole

PTP Inhibitor II (NSC 129010, 4-(Bromoacetyl)anisole) is a cell-permeable protein tyrosine phosphatase (PTP) inhibitor that covalently binds the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with Ki value of 128 μM.

PTP Inhibitor II Chemical Structure

PTP Inhibitor II Chemical Structure

CAS: 2632-13-5

Selleck's PTP Inhibitor II has been cited by 1 publication

Purity & Quality Control

Batch: S367801 DMSO] 45 mg/mL] false] Ethanol] 45 mg/mL] false] Water] Insoluble] false Purity: 99.56%
99.56

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Biological Activity

Description PTP Inhibitor II (NSC 129010, 4-(Bromoacetyl)anisole) is a cell-permeable protein tyrosine phosphatase (PTP) inhibitor that covalently binds the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with Ki value of 128 μM.
Targets
SHP-1(ΔSH2) [1]
(Cell-free)
128 μM(Ki)

Chemical Information & Solubility

Molecular Weight 229.07 Formula

C9H9BrO2

CAS No. 2632-13-5 SDF Download PTP Inhibitor II SDF
Smiles COC1=CC=C(C=C1)C(=O)CBr
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 45 mg/mL ( (196.44 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 45 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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