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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S8172 Ro 61-8048 Ro 61-8048 is a high-affinity kynurenine 3-hydroxylase (KMO) inhibitor with IC50 and Ki of 37 nM and 4.8 nM, respectively.
Frontiers in Molecular Neuroscience, 2021, 659576
J Neurosci Res, 2020, 98(1):155-167
Leukemia, 2019, 10.1038/s41375-019-0558-x
S7483 DMOG (Dimethyloxallyl Glycine) DMOG (Dimethyloxalylglycine) is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolylhydroxylase, leading to stabilisation and accumulation of HIF-1α protein in the nucleus. DMOG enhances autophagy.Solutions are unstable and should be fresh-prepared.
Nucleic Acids Res, 2025, 53(14)gkaf669
Cell Commun Signal, 2025, 23(1):364
Front Pharmacol, 2025, 16:1502269
Verified customer review of DMOG (Dimethyloxallyl Glycine)
S1379 Isotretinoin (13-cis retinoic acid) Isotretinoin (13-cis retinoic acid) was developed as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.
Science Advances, October 20, 2021, eabe0834
Journal of Virology, 2026, e01620-25
Cell Death Discov, 2025, 11(1):363
S4130 Meldonium Meldonium (MET-88, Quaterin) is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption.
Cancer Research, October 1, 2025, 3651-3670
Cancer Discovery, November 2020, 1706-1721
Drug Resist Updat, 2025, 84:101313
S4586 4-Chloro-DL-phenylalanine 4-Chloro-DL-phenylalanine (Fenclonine, PCPA, CP-10188) is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). This compound acts pharmacologically to deplete endogenous levels of serotonin.
Proc Natl Acad Sci U S A, 2024, 121(11):e2317658121
Proceedings of the National Academy of Sciences of the United States of America, 2024, e2317658121
Med Sci Sports Exerc, 2022, 54(4):566-581
S5797 Metyrosine Metyrosine (α-Methyltyrosine), an antihypertensive drug, is a tyrosine hydroxylase inhibitor.
Cancer Cell, 2025, 776-796.e14
Cancer Cell, 2025, 43(4):776-796.e14
S9568 Sapropterin (Tetrahydrobiopterin) Dihydrochloride Sapropterin (Tetrahydrobiopterin) Dihydrochloride, a synthetic preparation of the dihydrochloride salt of naturally occurring tetrahydrobiopterin (BH4), is a phenylalanine hydroxylase activator.
Cancer Cell, 2025, 43(4):776-796.e14
Cancer Cell, 2025, 776-796.e14
S2173 Telotristat Etiprate (LX 1606 Hippurate) Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity, currently in Phase 3.
Cancers (Basel), 2021, 13(21)5305
S2695 Nepicastat (SYN-117) HCl Nepicastat (SYN-117) HCl is a potent and selective inhibitor of both bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors. Phase 2.
S4926 (R)-Nepicastat HCl (R)-Nepicastat HCl (RS-25560-198), the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors.

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