Hydroxylase
Signaling Pathway Map
Research Area
Inhibitory Selectivity
Isoform-specific Inhibitors
Hydroxylase Products
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S2695 |
Nepicastat (SYN-117) HClNepicastat (SYN-117) HCl is a potent and selective inhibitor of both bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors. Phase 2. |
||
| S4130 |
MildronateMildronate (Meldonium, MET-88, Quaterin) is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption. |
||
| S3273 |
HypericinHypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). |
||
| S4586 |
4-Chloro-DL-phenylalanine4-Chloro-DL-phenylalanine (Fenclonine, PCPA, CP-10188) is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). 4-Chloro-DL-phenylalanine acts pharmacologically to deplete endogenous levels of serotonin. |
||
| S7456 |
Osilodrostat (LCI699)LCI699(Osilodrostat) is a potent inhibitor of 11β-hydroxylase (CYP11B), an enzyme catalyzing the final step of cortisol synthesis. |
||
| S4926 |
(R)-Nepicastat HCl(R)-Nepicastat HCl (RS-25560-198), the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors. |
||
| S5797 |
MetyrosineMetyrosine (α-Methyltyrosine), an antihypertensive drug, is a tyrosine hydroxylase inhibitor. |
||
| S8172 |
Ro 61-8048Ro 61-8048 is a high-affinity kynurenine 3-hydroxylase (KMO) inhibitor with IC50 and Ki of 37 nM and 4.8 nM, respectively. |
||
| S6044 |
H-Tyr(3-I)-OHH-Tyr(3-I)-OH (3-Iodo-L-tyrosine) is responsible for catalyzing the first step of the noradrenergic biosynthesis pathway. H-Tyr(3-I)-OH is an effective tyrosine hydroxylase inhibitor. |
||
| S7483 |
DMOGDMOG (Dimethyloxalylglycine) is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolylhydroxylase, leading to stabilisation and accumulation of HIF-1α protein in the nucleus. DMOG enhances autophagy. |
Western blot was performed to analyze p65 signaling and the expression of Bcl2 and cleaved Caspase 3. GAPDH served as the loading control
|
|
| S2173 |
Telotristat Etiprate (LX 1606 Hippurate)Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity. Phase 3. |
||
| S2367 |
Tetrahydropapaverine HClTetrahydropapaverine (Norlaudanosine), one of the TIQs and an analogue of salsolinol and tetrahydropapaveroline, has been reported to have neurotoxic effects on dopamine neurons. |
||
| S1379 |
IsotretinoinIsotretinoin (13-cis retinoic acid) was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more. |
||
| S9568 |
Sapropterin DihydrochlorideSapropterin Dihydrochloride (Tetrahydrobiopterin, R-THBP), a synthetic preparation of the dihydrochloride salt of naturally occurring tetrahydrobiopterin (BH4), is a phenylalanine hydroxylase activator. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S2695 |
Nepicastat (SYN-117) HClNepicastat (SYN-117) HCl is a potent and selective inhibitor of both bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors. Phase 2. |
||
| S4130 |
MildronateMildronate (Meldonium, MET-88, Quaterin) is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption. |
||
| S3273 |
HypericinHypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). |
||
| S4586 |
4-Chloro-DL-phenylalanine4-Chloro-DL-phenylalanine (Fenclonine, PCPA, CP-10188) is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). 4-Chloro-DL-phenylalanine acts pharmacologically to deplete endogenous levels of serotonin. |
||
| S7456 |
Osilodrostat (LCI699)LCI699(Osilodrostat) is a potent inhibitor of 11β-hydroxylase (CYP11B), an enzyme catalyzing the final step of cortisol synthesis. |
||
| S4926 |
(R)-Nepicastat HCl(R)-Nepicastat HCl (RS-25560-198), the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors. |
||
| S5797 |
MetyrosineMetyrosine (α-Methyltyrosine), an antihypertensive drug, is a tyrosine hydroxylase inhibitor. |
||
| S8172 |
Ro 61-8048Ro 61-8048 is a high-affinity kynurenine 3-hydroxylase (KMO) inhibitor with IC50 and Ki of 37 nM and 4.8 nM, respectively. |
||
| S6044 |
H-Tyr(3-I)-OHH-Tyr(3-I)-OH (3-Iodo-L-tyrosine) is responsible for catalyzing the first step of the noradrenergic biosynthesis pathway. H-Tyr(3-I)-OH is an effective tyrosine hydroxylase inhibitor. |
||
| S7483 |
DMOGDMOG (Dimethyloxalylglycine) is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolylhydroxylase, leading to stabilisation and accumulation of HIF-1α protein in the nucleus. DMOG enhances autophagy. |
Western blot was performed to analyze p65 signaling and the expression of Bcl2 and cleaved Caspase 3. GAPDH served as the loading control
|
|
| S2173 |
Telotristat Etiprate (LX 1606 Hippurate)Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity. Phase 3. |
||
| S2367 |
Tetrahydropapaverine HClTetrahydropapaverine (Norlaudanosine), one of the TIQs and an analogue of salsolinol and tetrahydropapaveroline, has been reported to have neurotoxic effects on dopamine neurons. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S1379 |
IsotretinoinIsotretinoin (13-cis retinoic acid) was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more. |
||
| S9568 |
Sapropterin DihydrochlorideSapropterin Dihydrochloride (Tetrahydrobiopterin, R-THBP), a synthetic preparation of the dihydrochloride salt of naturally occurring tetrahydrobiopterin (BH4), is a phenylalanine hydroxylase activator. |
