Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S2695 Nepicastat (SYN-117) HCl <1 mg/mL 66 mg/mL <1 mg/mL
S4130 Mildronate 29 mg/mL <1 mg/mL 29 mg/mL
S4586 4-Chloro-DL-phenylalanine <1 mg/mL 2 mg/mL <1 mg/mL
S7456 Osilodrostat (LCI699) 15 mg/mL 45 mg/mL 45 mg/mL
S4926 (R)-Nepicastat HCl <1 mg/mL 66 mg/mL <1 mg/mL
S8172 Ro 61-8048 <1 mg/mL 84 mg/mL <1 mg/mL
S7483 DMOG 35 mg/mL 35 mg/mL 35 mg/mL
S2173 Telotristat Etiprate (LX 1606 Hippurate) <1 mg/mL 100 mg/mL <1 mg/mL
S2367 Tetrahydropapaverine HCl 76 mg/mL 7 mg/mL <1 mg/mL
S1379 Isotretinoin <1 mg/mL 60 mg/mL <1 mg/mL
S9568 Sapropterin Dihydrochloride -1 mg/mL 63 mg/mL -1 mg/mL
Catalog No. Information Product Use Citations Product Validations

Nepicastat (SYN-117) HCl

Nepicastat (SYN-117) HCl is a potent and selective inhibitor of both bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors. Phase 2.



Mildronate is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption.



4-Chloro-DL-phenylalanine is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). 4-Chloro-DL-phenylalanine acts pharmacologically to deplete endogenous levels of serotonin.


Osilodrostat (LCI699)

LCI699(Osilodrostat) is a potent inhibitor of 11β-hydroxylase, an enzyme catalyzing the final step of cortisol synthesis.


(R)-Nepicastat HCl

(R)-Nepicastat HCl, the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors.


Ro 61-8048

Ro 61-8048 is a high-affinity kynurenine 3-hydroxylase (KMO) inhibitor with IC50 and Ki of 37 nM and 4.8 nM, respectively.



DMOG is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolylhydroxylase.


Telotristat Etiprate (LX 1606 Hippurate)

Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity. Phase 3.


Tetrahydropapaverine HCl

Tetrahydropapaverine, one of the TIQs and an analogue of salsolinol and tetrahydropapaveroline, has been reported to have neurotoxic effects on dopamine neurons.



It was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.


Sapropterin Dihydrochloride

Sapropterin Dihydrochloride, a synthetic preparation of the dihydrochloride salt of naturally occurring tetrahydrobiopterin (BH4), is a phenylalanine hydroxylase activator.

Tags: Hydroxylase activity | Dopamine-β-Hydroxylase activity | Hydroxylase inhibitor review