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FXR

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Cat.No. Product Name Information Product Use Citations Product Validations
S2782 GW4064 GW4064 is an agonist of farnesoid X receptor (FXR) with EC50 of 65 nM in CV1 cell line and displays no activity at other nuclear receptors at concentrations up to 1 μM. This compound stimulates autophagy in MCF-7 cells.
Life Metab, 2025, 4(2):loaf004
Gut Microbes, 2024, 16(1):2379566
Mol Metab, 2024, 79:101841
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S2449 Forskolin (Colforsin) Forskolin (Colforsin) is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology. Forskolin also activates PXR and FXR activity. Forskolin stimulates autophagy.
Molecules, September 27, 2021, 5858
The FASEB Journal, June 30, 2025, e70762
Cell Reports, January 10, 2017, 468-481
Verified customer review of Forskolin (Colforsin)
S7660 Obeticholic Acid (INT-747) Obeticholic Acid (INT-747) is a potent and selective farnesoid X receptor (FXR) agonist with EC50 of 99 nM, and it inhibits autophagy. This compound is in Phase 3.
Nat Commun, 2025, 16(1):2093
Cell Commun Signal, 2025, 23(1):236
Am J Physiol Gastrointest Liver Physiol, 2025, 328(5):G558-G577
Verified customer review of Obeticholic Acid (INT-747)
S3792 Guggulsterone E&Z Guggulsterone is one of the active constituent of Commiphora mukul. It occurs in two isomeric forms, namely Z-GS and E-GS. Guggulsterone act as antagonist ligands for the bile acid receptor, farnesoid X receptor, and as active ingredients responsible for the hypolipidemic activity.
Journal of Natural Products, October 4, 2024, 2393-2397
Nature Communications, October 30, 2023, 6908
Gut Microbes, 2024, 16(1):2379566
S2694 Turofexorate Isopropyl (XL335) Turofexorate Isopropyl (XL335, Fxr 450) is a potent, selective FXR agonist with EC50 of 4 nM, highly selective versus other nuclear receptors, such as LXR, PPAR, ER and etc. Phase 1.
Cell Cycle, 2019 Aug, 1784-1797
Cell Cycle, 2019, 1784-1797
Cell Cycle, 2019, 18(15):1784-1797
Verified customer review of Turofexorate Isopropyl (XL335)
S1843 Chenodeoxycholic Acid Chenodeoxycholic Acid (Chenodiol, Chenodesoxycholic acid, Chenocholic acid,CDCA) is a naturally occurring human bile acid, and inhibits production of cholesterol in the liver and absorption in the intestines. This compound is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.
Acta Pharm Sin B, 2024, 14(8):3513-3527
World J Gastroenterol, 2024, 30(5):485-498
Food Funct, 2021, 10.1039/d1fo01272j
S4003 Lithocholic acid Lithocholic acid is a toxic secondary bile acid, causes intrahepatic cholestasis, has tumor-promoting activity, its toxic effect can be protected after it activates the vitamin D receptor, PXR and FXR.
FEBS Open Bio, 2023, 13(9):1789-1806
Biomed Pharmacother, 2022, 149:112825
International Journal of Stem Cells, 2021, 119-126
S6413 fexaramine Fexaramine is a potent, selective farnesoid X receptor (FXR) agonist with an EC50 of 25 nM and it displays no activity at hRXRα, hPPARα, hPPARγ, hPPARδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ and hVDR receptors.
Mol Med, 2025, 31(1):258
Molecular Medicine, 2025, 258
S4129 Sevelamer HCl Sevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption.
S0033 BAR502 BAR502 (Compound 30) is a dual FXR and GPBAR1 agonist with IC50 values of 2 μM and 0.4 μM, respectively.