Lipase

Other Metabolism Related Inhibitors

Dehydrogenase Transferase DPP Aminopeptidase Procollagen C Proteinase P450 (e.g. CYP17) Phospholipase (e.g. PLA) Factor Xa PDE DHFR

Cat.No.	Product Name	Information	Product Use Citations
S2365	Tanshinone IIA	Tanshinone IIA (Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardiovascular and inflammatory diseases; this compound is a natural monoacylglycerol lipase inhibitor.	Phytomedicine, 2024, 128:155431 J Cancer, 2023, 14(13):2481-2490 Kaohsiung J Med Sci, 2023, 10.1002/kjm2.12663
S1629	Orlistat	Orlistat is a general lipase inhibitor with IC50 of 122 ng/ml for PL from human duodenal juice. This compound treatment reduces proliferation, induces apoptosis and arrests cell cycle.	Cell Rep, 2025, 44(7):115901 Acta Pharmacol Sin, 2025, 10.1038/s41401-025-01477-y J Cell Sci, 2024, 137(20)jcs262162
S7364	Atglistatin	Atglistatin is a highly potent, and selective inhibitor of adipose triglyceride lipase (ATGL) with IC50 of 0.7 μM, high selectivity over other key metabolic lipases.	Nat Commun, 2025, 16(1):4432 Int J Nanomedicine, 2025, 20:9019-9030 J Cell Mol Med, 2025, 29(14):e70693
S4904	JZL184	JZL 184 is the first selective inhibitor of monoacylglycerol lipase (MAGL) with IC50 of 8 nM.	Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7 Biomed Pharmacother, 2022, 149:112798 J Cardiovasc Transl Res, 2022, 10.1007/s12265-022-10323-z
S9234	Schaftoside	Schaftoside, a bioactive compound found in the Herba Desmodii Styracifolii, exhibits pancreatic lipase inhibitory activity. This compound inhibits the expression of TLR4 and Myd88. It also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission.	Journal of Pharmacological Sciences, 2019, 15-22
S9404	Pristimerin	Pristimerin is a naturally occurring triterpenoid that has been shown to suppress the proliferation of various cancer cell lines at the concentration (IC50) range of 0.2-4 μM, including those of breast, glioma, prostate, pancreatic, ovarian, colon. This compound can inhibit monoacylglycerol lipase(MGL) with an IC50 of 93 nM through a reversible mechanism.	Cell Death & Disease, April 14, 2020, 232 Cell Death & Disease, 2020, 232 Cell Death Dis, 2020, 14;11(4):232
S8823	ABX-1431	ABX-1431 is a highly potent, selective, and CNS-penetrant Monoacylglycerol lipase (MGLL) inhibitor with IC50 values of 14 nM and 27 nM for hMGLL and mMGLL respectively.	Cell Death & Disease, 2022, 1067
S7457	XEN445	XEN445 is a potent and selective endothelial lipase inhibitor with IC50 of 0.237 μM.
S7543	JW642	JW642 is a potent inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively.
S0536	Ibrolipim	Ibrolipim (NO-1886) is an effective lipoprotein lipase (LPL) activator that increases LPL mRNA and LPL activity in adipose tissue, myocardium, and skeletal muscle.
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