Lipase
Inhibitory Selectivity
Lipase Products
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S1629 |
OrlistatOrlistat (Ro 18-0647, Tetrahydrolipstatin) is a general lipase inhibitor with IC50 of 122 ng/ml for PL from human duodenal juice. Orlistat treatment reduces proliferation, induces apoptosis and arrests cell cycle. |
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| S4904 |
JZL184JZL 184 is the first selective inhibitor of monoacylglycerol lipase (MAGL) with IC50 of 8 nM. |
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| S7364 |
AtglistatinAtglistatin is a highly potent, and selective inhibitor of adipose triglyceride lipase (ATGL) with IC50 of 0.7 μM, high selectivity over other key metabolic lipases. |
C, G0s2-null MEFs were transfected with HRAS and the following day treated with either 40 mmol/L of ATGL inhibitor atglistatin or DMSO (Vehicle) every 2 days. Left, representative plates. Right, the average of biologic triplicate determinations. Error bars, SD. The experiment was repeated twice with similar results.
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| S7457 |
XEN445XEN445 is a potent and selective endothelial lipase inhibitor with IC50 of 0.237 μM. |
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| S9234 |
SchaftosideSchaftoside, a bioactive compound found in the Herba Desmodii Styracifolii, exhibits pancreatic lipase inhibitory activity. |
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| S6609 |
JZL195JZL195 is a potent inhibitor of both FAAH and MAGL with IC50s of 2 and 4 nM respectively. |
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| S6550 |
URB602URB602 is an inhibitor of monoacylglycerol lipase (MGL), a serine hydrolase involved in the biological deactivation of the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG). |
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| S9404 |
PristimerinPristimerin is a naturally occurring triterpenoid that has been shown to suppress the proliferation of various cancer cell lines at the concentration (IC50) range of 0.2-4 μM, including those of breast, glioma, prostate, pancreatic, ovarian, colon. Pristimerin can inhibits monoacylglycerol lipase(MGL) with an IC50 of 93 nM through a reversible mechanism. |
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| S8823 |
ABX-1431ABX-1431 is a highly potent, selective, and CNS-penetrant Monoacylglycerol lipase (MGLL) inhibitor with IC50 values of 14 nM and 27 nM for hMGLL and mMGLL respectively. |
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| S2365 |
Tanshinone IIATanshinone IIA (Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardiovascular and inflammatory diseases; A natural monoacylglycerol lipase inhibitor. |
Western blotting analysis of b-catenin, TCF3 and LEF1 levels in HT-29 cells. b-actin is the loading control.
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| S4930 |
CetilistatCetilistat is a novel highly lipophilic benzoxazinone that inhibits gastrointestinal and pancreatic lipases. It shows a good safety and tolerability profile in vivo |
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| S4825 |
PancreatinPancreatic enzymes also known as pancrelipase and pancreatin, are commercial mixtures of amylase, lipase, and protease. They are used to treat malabsorption syndrome due to pancreatic problems. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S1629 |
OrlistatOrlistat (Ro 18-0647, Tetrahydrolipstatin) is a general lipase inhibitor with IC50 of 122 ng/ml for PL from human duodenal juice. Orlistat treatment reduces proliferation, induces apoptosis and arrests cell cycle. |
||
| S4904 |
JZL184JZL 184 is the first selective inhibitor of monoacylglycerol lipase (MAGL) with IC50 of 8 nM. |
||
| S7364 |
AtglistatinAtglistatin is a highly potent, and selective inhibitor of adipose triglyceride lipase (ATGL) with IC50 of 0.7 μM, high selectivity over other key metabolic lipases. |
C, G0s2-null MEFs were transfected with HRAS and the following day treated with either 40 mmol/L of ATGL inhibitor atglistatin or DMSO (Vehicle) every 2 days. Left, representative plates. Right, the average of biologic triplicate determinations. Error bars, SD. The experiment was repeated twice with similar results.
|
|
| S7457 |
XEN445XEN445 is a potent and selective endothelial lipase inhibitor with IC50 of 0.237 μM. |
||
| S9234 |
SchaftosideSchaftoside, a bioactive compound found in the Herba Desmodii Styracifolii, exhibits pancreatic lipase inhibitory activity. |
||
| S6609 |
JZL195JZL195 is a potent inhibitor of both FAAH and MAGL with IC50s of 2 and 4 nM respectively. |
||
| S6550 |
URB602URB602 is an inhibitor of monoacylglycerol lipase (MGL), a serine hydrolase involved in the biological deactivation of the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG). |
||
| S9404 |
PristimerinPristimerin is a naturally occurring triterpenoid that has been shown to suppress the proliferation of various cancer cell lines at the concentration (IC50) range of 0.2-4 μM, including those of breast, glioma, prostate, pancreatic, ovarian, colon. Pristimerin can inhibits monoacylglycerol lipase(MGL) with an IC50 of 93 nM through a reversible mechanism. |
||
| S8823 |
ABX-1431ABX-1431 is a highly potent, selective, and CNS-penetrant Monoacylglycerol lipase (MGLL) inhibitor with IC50 values of 14 nM and 27 nM for hMGLL and mMGLL respectively. |
||
| S2365 |
Tanshinone IIATanshinone IIA (Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardiovascular and inflammatory diseases; A natural monoacylglycerol lipase inhibitor. |
Western blotting analysis of b-catenin, TCF3 and LEF1 levels in HT-29 cells. b-actin is the loading control.
|
|
| S4930 |
CetilistatCetilistat is a novel highly lipophilic benzoxazinone that inhibits gastrointestinal and pancreatic lipases. It shows a good safety and tolerability profile in vivo |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S4825 |
PancreatinPancreatic enzymes also known as pancrelipase and pancreatin, are commercial mixtures of amylase, lipase, and protease. They are used to treat malabsorption syndrome due to pancreatic problems. |
