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Catalog No. Product Name Information Product Use Citations Product Validations
S1629 Orlistat (Ro 18-0647) Orlistat (Ro 18-0647, Tetrahydrolipstatin) is a general lipase inhibitor with IC50 of 122 ng/ml for PL from human duodenal juice. Orlistat treatment reduces proliferation, induces apoptosis and arrests cell cycle.
Nat Cell Biol, 2022, 24(3):364-372
Oncogenesis, 2022, 11(1):24
Nat Commun, 2021, 12(1):3830
S2365 Tanshinone IIA Tanshinone IIA (Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardiovascular and inflammatory diseases; A natural monoacylglycerol lipase inhibitor.
Vet Med Sci, 2022, 10.1002/vms3.811
Biochem Biophys Res Commun, 2021, 575:1-7
Mol Med Rep, 2021, 23(5)371
S4904 JZL184 JZL 184 is the first selective inhibitor of monoacylglycerol lipase (MAGL) with IC50 of 8 nM.
Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7
Biomed Pharmacother, 2022, 149:112798
Open Biol, 2021, 11(2):200306
S4930 Cetilistat Cetilistat (ATL962) is a novel highly lipophilic benzoxazinone that inhibits gastrointestinal and pancreatic lipases. It shows a good safety and tolerability profile in vivo
S6550 URB602 URB602 is an inhibitor of monoacylglycerol lipase (MGL), a serine hydrolase involved in the biological deactivation of the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG).
S6609 JZL195 JZL195 is a potent inhibitor of both FAAH and MAGL with IC50s of 2 and 4 nM respectively.
S7364 Atglistatin Atglistatin is a highly potent, and selective inhibitor of adipose triglyceride lipase (ATGL) with IC50 of 0.7 μM, high selectivity over other key metabolic lipases.
Nat Commun, 2021, 12(1):3493
EMBO Rep, 2020, 21(12):e49634
J Cardiovasc Pharmacol Ther, 2020, 1074248420971113
S7457 XEN445 XEN445 is a potent and selective endothelial lipase inhibitor with IC50 of 0.237 μM.
S8823 ABX-1431 ABX-1431 is a highly potent, selective, and CNS-penetrant Monoacylglycerol lipase (MGLL) inhibitor with IC50 values of 14 nM and 27 nM for hMGLL and mMGLL respectively.
S9234 Schaftoside Schaftoside, a bioactive compound found in the Herba Desmodii Styracifolii, exhibits pancreatic lipase inhibitory activity. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission.
S9404 Pristimerin Pristimerin is a naturally occurring triterpenoid that has been shown to suppress the proliferation of various cancer cell lines at the concentration (IC50) range of 0.2-4 μM, including those of breast, glioma, prostate, pancreatic, ovarian, colon. Pristimerin can inhibits monoacylglycerol lipase(MGL) with an IC50 of 93 nM through a reversible mechanism.
Cell Death Dis, 2020, 14;11(4):232
S4825 Pancreatin Pancreatin (Pancrelipase, Pancreatic enzymes), are commercial mixtures of amylase, lipase, and protease. They are used to treat malabsorption syndrome due to pancreatic problems.
S1629 Orlistat (Ro 18-0647) Orlistat (Ro 18-0647, Tetrahydrolipstatin) is a general lipase inhibitor with IC50 of 122 ng/ml for PL from human duodenal juice. Orlistat treatment reduces proliferation, induces apoptosis and arrests cell cycle.
Nat Cell Biol, 2022, 24(3):364-372
Oncogenesis, 2022, 11(1):24
Nat Commun, 2021, 12(1):3830
S2365 Tanshinone IIA Tanshinone IIA (Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardiovascular and inflammatory diseases; A natural monoacylglycerol lipase inhibitor.
Vet Med Sci, 2022, 10.1002/vms3.811
Biochem Biophys Res Commun, 2021, 575:1-7
Mol Med Rep, 2021, 23(5)371
S4904 JZL184 JZL 184 is the first selective inhibitor of monoacylglycerol lipase (MAGL) with IC50 of 8 nM.
Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7
Biomed Pharmacother, 2022, 149:112798
Open Biol, 2021, 11(2):200306
S4930 Cetilistat Cetilistat (ATL962) is a novel highly lipophilic benzoxazinone that inhibits gastrointestinal and pancreatic lipases. It shows a good safety and tolerability profile in vivo
S6550 URB602 URB602 is an inhibitor of monoacylglycerol lipase (MGL), a serine hydrolase involved in the biological deactivation of the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG).
S6609 JZL195 JZL195 is a potent inhibitor of both FAAH and MAGL with IC50s of 2 and 4 nM respectively.
S7364 Atglistatin Atglistatin is a highly potent, and selective inhibitor of adipose triglyceride lipase (ATGL) with IC50 of 0.7 μM, high selectivity over other key metabolic lipases.
Nat Commun, 2021, 12(1):3493
EMBO Rep, 2020, 21(12):e49634
J Cardiovasc Pharmacol Ther, 2020, 1074248420971113
S7457 XEN445 XEN445 is a potent and selective endothelial lipase inhibitor with IC50 of 0.237 μM.
S8823 ABX-1431 ABX-1431 is a highly potent, selective, and CNS-penetrant Monoacylglycerol lipase (MGLL) inhibitor with IC50 values of 14 nM and 27 nM for hMGLL and mMGLL respectively.
S9234 Schaftoside Schaftoside, a bioactive compound found in the Herba Desmodii Styracifolii, exhibits pancreatic lipase inhibitory activity. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission.
S9404 Pristimerin Pristimerin is a naturally occurring triterpenoid that has been shown to suppress the proliferation of various cancer cell lines at the concentration (IC50) range of 0.2-4 μM, including those of breast, glioma, prostate, pancreatic, ovarian, colon. Pristimerin can inhibits monoacylglycerol lipase(MGL) with an IC50 of 93 nM through a reversible mechanism.
Cell Death Dis, 2020, 14;11(4):232
Tags: Lipase inhibitor|Lipase agonist|Lipase activator|Lipase inducer|Lipase antagonist|Lipase signaling pathway|Lipase assay kit