phosphatase

Inhibitory Selectivity
Solubility

Catalog No.	Product Name	Solubility(25°C)
Catalog No.	Product Name	Water	DMSO	Alcohol
S1949	Menadione	<1 mg/mL	34 mg/mL	34 mg/mL
S1857	Etidronate	41 mg/mL	<1 mg/mL	<1 mg/mL
S1514	Cyclosporine	<1 mg/mL	100 mg/mL	100 mg/mL
S4007	Pentamidine isethionate	100 mg/mL	100 mg/mL	<1 mg/mL
S7437	Sal003	<1 mg/mL	93 mg/mL	<1 mg/mL
S8718	RMC-4550	-1 mg/mL	100 mg/mL	-1 mg/mL
S5452	Sanguinarine chloride	<1 mg/mL	5 mg/mL	<1 mg/mL
S5431	L-Homoarginine hydrochloride	44 mg/mL	<1 mg/mL	-1 mg/mL
S5441	1-Naphthyl phosphate potassium salt	-1 mg/mL	20 mg/mL	-1 mg/mL
S4013	Sodium Monofluorophosphate	29 mg/mL	<1 mg/mL	<1 mg/mL
S7639	3PO	<1 mg/mL	42 mg/mL	42 mg/mL
S3696	PTP Inhibitor I	<1 mg/mL	43 mg/mL	43 mg/mL
S3678	PTP Inhibitor II	<1 mg/mL	45 mg/mL	45 mg/mL
S7485	CCT007093	<1 mg/mL	1 mg/mL	<1 mg/mL
S7537	LB-100	53 mg/mL	<1 mg/mL	<1 mg/mL
S7383	(-)-p-Bromotetramisole Oxalate	30 mg/mL	74 mg/mL	<1 mg/mL
S8278	SHP099 HCl	2 mg/mL	77 mg/mL	<1 mg/mL
S7573	GSK2830371	<1 mg/mL	92 mg/mL	92 mg/mL
S3670	Cefsulodin sodium	100 mg/mL	100 mg/mL	<1 mg/mL
S3620	β-Glycerophosphate sodium salt hydrate	61 mg/mL	<1 mg/mL	<1 mg/mL
S8182	NSC87877	100 mg/mL	100 mg/mL	<1 mg/mL
S8248	IQ-1	<1 mg/mL	72 mg/mL	7 mg/mL

phosphatase Inhibitors (22)
New phosphatase Products

Catalog No.	Information	Product Use Citations	Product Validations
S1949	Menadione Menadione(Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.
S1857	Etidronate Etidronate is a non-aminobisphosphonate, show protein tyrosine phosphatase (PTP) inhibitory activity, used for the treatment of Paget's disease and the prevention of heterotopic ossification.
S1514	Cyclosporine Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.
S4007	Pentamidine isethionate Pentamidine is an inhibitor of PRL Phosphatases and also inhibits synthesis of DNA, RNA and protein.
S7437	Sal003 Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor.
S8718^New	RMC-4550 RMC-4550 is a potent SHP-2inhibitor with an IC50 of 1.55 nM and it has no significant activity vs. 468 kinases, the catalytic domain of 15 phosphatases and other cellular targets including GPCRs, transporters and ion channels.
S5452^New	Sanguinarine chloride Sanguinarine, a plant alkaloid, is a potent and specific protein phosphatase (PP) 2C inhibitor.
S5431^New	L-Homoarginine hydrochloride L-Homoarginine is a specific inhibitor of liver-type alkaline phosphatase.
S5441^New	1-Naphthyl phosphate potassium salt 1-Naphthyl phosphate potassium salt is a non-specific phosphatase inhibitor which acts on acid, alkaline, and protein phosphatases.
S4013	Sodium Monofluorophosphate Sodium Monofluorophosphate is a competitive inhibitor of pyruvate kinase and alkaline phosphatase with K_i of 3.4 mM and 69 μM, respectively, which also irreversibly inhibits phosphorylase phosphatase with K_i of 0.5 mM.
S7639	3PO 3PO is a small-molecule inhibitor of PFKFB3 with an IC50 of 22.9 μM for recombinant human PFKFB3 protein and does not inhibit PFK-1 activity. It suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.
S3696	PTP Inhibitor I PTP Inhibitor I is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor with Ki values of 43 and 42 μM for SHP-1(ΔSH2) and PTP1B, respectively.
S3678	PTP Inhibitor II PTP Inhibitor II is a cell-permeable protein tyrosine phosphatase (PTP) inhibitor that covalently binds the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with Ki value of 128 μM.
S7485	CCT007093 CCT007093 is a potent PPM1D (WIP1) inhibitor with IC50 of 8.4 μM.	Oncogene, 2016, 35(42):5552-5564	(A-B)Twenty-four hours after plating 1×105 shh-EGFP cells, media was changed to serum-free media containing vehicle (Vh), DMSO, CCT007093 (CCT, 5µM), and/or Shh (3µg/mL). Cells were also transduced with LentiORF-RFP-CTRL or LentiORF-YFP-WIP1 lentivirus. 48 hours later, cells were fixed in 4% paraformaldehyde, permeabilized, incubated with α-WIP1 or α-Ki-67 antibody, and mounted using media containing DAPI (left-hand panels). Quantification of cells, per high power field (HPF), that express green fluorescent protein (GFP) or Ki-67 (right-hand panels). Bars, mean of cell counts from 10 representative fields for each experimental condition.
S7537	LB-100 LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor with IC50s of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells.	Mol Cancer, 2018, 17(1):44 Exp Mol Med, 2018, 50(7):83 Anticancer Res, 2018, 38(10):5791-5798	LB-100 (a protein phosphatase-2A inhibitor) induces a significant increase for hypoxia-inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF)-C expression by enhancing phosphatidylinositol 3-kinase (PI3K)p85/AKT/ mechanistic target of rapamycin (mTOR) signaling. Western blot analysis results for phosphorylated and total PI3Kp85/AKT/mTOR, HIF-1α, and VEGF-C with or without monocyte chemoattractant protein (MCP)-1 or LB-100 treatment. Bar graphs show quantitative results by densitometric analysis. n = 3 or more independent replications. ∗P < 0.05, ∗∗P < 0.01. Gapdh, glyceraldehyde-3-phosphate dehydrogenase; p, phosphorylated.
S7383	(-)-p-Bromotetramisole Oxalate (-)-p-Bromotetramisole Oxalate is a potent and non-specific alkaline phosphatase inhibitor.
S8278	SHP099 HCl SHP099 is a highly potent, selective and orally bioavailable small-molecule SHP2 inhibitor with an IC50 value of 0.071 μM and shows no activity against SHP1.
S7573	GSK2830371 GSK2830371 is an orally active, allosteric Wip1 phosphatase inhibitor with IC50 of 6 nM.
S3670	Cefsulodin sodium Cefsulodin is a β-lactam antibiotic and inhibits mPTPB with the IC50 of 16 μM.
S3620	β-Glycerophosphate sodium salt hydrate β-Glycerophosphate (sodium salt hydrate) is a potent protein phosphatase inhibitor.
S8182	NSC87877 NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. It also inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.	Front Immunol, 2018, 9:2643
S8248	IQ-1 IQ-1 enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation, Maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells and prevents PP2A/Nkd interaction.

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By Signaling Pathways

By product type

phosphatase

Menadione

Etidronate

Cyclosporine

Pentamidine isethionate

Sal003

RMC-4550

Sanguinarine chloride

L-Homoarginine hydrochloride

1-Naphthyl phosphate potassium salt

Sodium Monofluorophosphate

3PO

PTP Inhibitor I

PTP Inhibitor II

CCT007093

LB-100

(-)-p-Bromotetramisole Oxalate

SHP099 HCl

GSK2830371

Cefsulodin sodium

β-Glycerophosphate sodium salt hydrate

NSC87877

IQ-1