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phosphatase Inhibitors

Other Metabolism Related Inhibitors

Dehydrogenase Transferase DPP Aminopeptidase Procollagen C Proteinase P450 (e.g. CYP17) Phospholipase (e.g. PLA) Factor Xa PDE DHFR

Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
E1207 Osunprotafib (ABBV-CLS-484) Osunprotafib (ABBV-CLS-484) is a potent PTPN1 or PTPN2 inhibitor with a sub-nanomolar activity.
S5003 FK506 (Tacrolimus) Tacrolimus (FK506) is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity in T cells by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex. Tacrolimus also inhibits the phosphatase activity of calcineurin. Tacrolimus induces vascular endothelial autophagy.
Proc Natl Acad Sci U S A, 2025, 122(4):e2418317122
J Nanobiotechnology, 2025, 23(1):32
PLoS Pathog, 2025, 21(1):e1012872
Verified customer review of FK506 (Tacrolimus)
S2286 Cyclosporin A Cyclosporin A, a non-polar cyclic oligopeptide, is an immunosuppressive agent that binds to cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay. Cyclosporin A is generally given following transplant surgery to prevent rejection and has been used to test its toxic effect on a perfused 3D proximal tubule model.Cyclosporin A (NSC 290193) can be used to induce animal models of Chronic Rejection of Liver Transplantation.
Frontiers in Immunology, May 25, 2022, 861292
Circulation Research, March 27, 2026, e327680
Anticancer Research, March 2023, 1103-1112
Verified customer review of Cyclosporin A
S8278 SHP099 Hydrochloride SHP099 is a highly potent, selective and orally bioavailable small-molecule SHP2 inhibitor with an IC50 value of 0.071 μM and shows no activity against SHP1.
Cancers (Basel), 2025, 17(7)1152
EMBO Mol Med, 2024, 10.1038/s44321-024-00106-1
Pharmacol Res, 2024, 201:107096
S8718 RMC-4550 RMC-4550 is a potent SHP-2inhibitor with an IC50 of 1.55 nM and this compound has no significant activity vs. 468 kinases, the catalytic domain of 15 phosphatases and other cellular targets including GPCRs, transporters and ion channels.
Nat Cancer, 2025, 10.1038/s43018-025-00960-z
Cancer Res, 2025, 10.1158/0008-5472.CAN-24-3819
iScience, 2025, 28(9):113374
S6388 SHP099 SHP099 is a highly potent, selective and orally bioavailable small-molecule SHP2 inhibitor with an IC50  value of  71 nM and shows no activity against SHP1.
iScience, 2025, 28(2):111662
Res Sq, 2025, rs.3.rs-7032881
bioRxiv, 2025, 2025.06.11.659120
S1514 Cyclosporine Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.
J Adv Res, 2024, S2090-1232(24)00499-5
Cells, 2023, 12(23)2696
Int J Mol Sci, 2023, 24(11)9708
S8987 Batoprotafib (TNO155) Batoprotafib (TNO155) is an inhibitor of protein tyrosine phosphatase (PTP) non-receptor type 11 (SHP2 /src homology region 2 domain phosphatase /PTPN11) with IC50 of 0.011 µM, and has potential antineoplastic activity.
bioRxiv, March 11 2026, nan
Molecular Cancer Therapeutics, December 01 2023, 1479-1492
Journal of Thoracic Oncology, August 2021, 1321-1332
S7573 GSK2830371 GSK2830371 is an orally active, allosteric Wip1 phosphatase inhibitor with IC50 of 6 nM.
J Biomed Sci, 2025, 32(1):88
Journal of Biomedical Science, 2025, 88
Cell Death & Disease, 2025, 864
S1949 Menadione (Vitamin K3) Menadione (Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.
mSphere, 2025, 10(1):e0070324
Med -N Y, 2022, S2666-6340-2200365-8
Mol Cell, 2021, S1097-2765(21)00269-0