phosphatase

Inhibitory Selectivity

phosphatase Products

All (24) phosphatase Inhibitors (23) phosphatase Activators (1) New phosphatase Products

Catalog No.	Information	Product Use Citations	Product Validations
S1949	Menadione Menadione(Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.	Mol Cell, 2017, 66(4):503-516
S1857	Etidronate Etidronate is a non-aminobisphosphonate, show protein tyrosine phosphatase (PTP) inhibitory activity, used for the treatment of Paget's disease and the prevention of heterotopic ossification.
S1514	Cyclosporine Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.	Oncotarget, 2019, 10(18):1669-1687 Acta Biomater, 2018, 83:414-424 Oxid Med Cell Longev, 2018, 2018:1725191
S4007	Pentamidine isethionate Pentamidine is an inhibitor of PRL Phosphatases and also inhibits synthesis of DNA, RNA and protein.	Cell Chem Biol, 2019, 10.1016/j.chembiol.2019.03.012 Mol Cancer Ther, 2018, 17(12):2495-2506
S7437	Sal003 Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor.
S6109^New	H-HoArg-OH H-HoArg-OH (L-Homoarginine) is an organ-specific, uncompetitive inhibitor of human liver and bone alkaline phosphohydrolases.
S8718^New	RMC-4550 RMC-4550 is a potent SHP-2inhibitor with an IC50 of 1.55 nM and it has no significant activity vs. 468 kinases, the catalytic domain of 15 phosphatases and other cellular targets including GPCRs, transporters and ion channels.
S4013	Sodium Monofluorophosphate Sodium Monofluorophosphate is a competitive inhibitor of pyruvate kinase and alkaline phosphatase with K_i of 3.4 mM and 69 μM, respectively, which also irreversibly inhibits phosphorylase phosphatase with K_i of 0.5 mM.
S5452	Sanguinarine chloride Sanguinarine, a plant alkaloid, is a potent and specific protein phosphatase (PP) 2C inhibitor.
S7639	3PO 3PO is a small-molecule inhibitor of PFKFB3 with an IC50 of 22.9 μM for recombinant human PFKFB3 protein and does not inhibit PFK-1 activity. It suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.	Lab Chip, 2016, 16(21):4189-4199
S3696	PTP Inhibitor I PTP Inhibitor I is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor with Ki values of 43 and 42 μM for SHP-1(ΔSH2) and PTP1B, respectively.
S3678	PTP Inhibitor II PTP Inhibitor II is a cell-permeable protein tyrosine phosphatase (PTP) inhibitor that covalently binds the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with Ki value of 128 μM.
S7485	CCT007093 CCT007093 is a potent PPM1D (WIP1) inhibitor with IC50 of 8.4 μM.	Oncogene, 2016, 35(42):5552-5564	(A-B)Twenty-four hours after plating 1×105 shh-EGFP cells, media was changed to serum-free media containing vehicle (Vh), DMSO, CCT007093 (CCT, 5µM), and/or Shh (3µg/mL). Cells were also transduced with LentiORF-RFP-CTRL or LentiORF-YFP-WIP1 lentivirus. 48 hours later, cells were fixed in 4% paraformaldehyde, permeabilized, incubated with α-WIP1 or α-Ki-67 antibody, and mounted using media containing DAPI (left-hand panels). Quantification of cells, per high power field (HPF), that express green fluorescent protein (GFP) or Ki-67 (right-hand panels). Bars, mean of cell counts from 10 representative fields for each experimental condition.
S7537	LB-100 LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor with IC50s of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells.	Eur J Pharmacol, 2019, 852:99-106 Mol Cancer, 2018, 17(1):44 Exp Mol Med, 2018, 50(7):83	LB-100 induced HDAC2 S394 phosphorylation.
S7383	(-)-p-Bromotetramisole Oxalate (-)-p-Bromotetramisole Oxalate is a potent and non-specific alkaline phosphatase inhibitor.
S8278	SHP099 HCl SHP099 is a highly potent, selective and orally bioavailable small-molecule SHP2 inhibitor with an IC50 value of 0.071 μM and shows no activity against SHP1.	Nat Commun, 2019, 10(1):1444 Cell Rep, 2019, 26(1):65-78
S7573	GSK2830371 GSK2830371 is an orally active, allosteric Wip1 phosphatase inhibitor with IC50 of 6 nM.	Mol Cell, 2019, 74(4):651-663.e8
S3670	Cefsulodin sodium Cefsulodin is a β-lactam antibiotic and inhibits mPTPB with the IC50 of 16 μM.
S3620	β-Glycerophosphate sodium salt hydrate β-Glycerophosphate (sodium salt hydrate) is a potent protein phosphatase inhibitor.
S5441	1-Naphthyl phosphate potassium salt 1-Naphthyl phosphate potassium salt is a non-specific phosphatase inhibitor which acts on acid, alkaline, and protein phosphatases.
S8182	NSC87877 NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. It also inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.	Cells, 2019, 8(4) Front Immunol, 2018, 9:2643	BMDMs and BMDCs were pretreated with NSC87877 (1 μM) for 1 h followed by stimulation with anti-CD180 Ab (0.2 μg/ml). Then the cells were stimulated with R837 (1 μg/ml) and CpG 1826 (0.5 μM). ELISA analysis of the levels of IL-6 and IL-12 secreted by BMDMs (E) and BMDCs (F) at 24 h.
S5431	L-Homoarginine hydrochloride L-Homoarginine is a specific inhibitor of liver-type alkaline phosphatase.
S8248	IQ-1 IQ-1 enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation, Maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells and prevents PP2A/Nkd interaction.
S8774^New	DT-061(SMAP) DT-061(SMAP) is a bioavailable PP2A activator. It decreases cell viability in HCC827 and HCC3255 cell lines, with IC50 values of 14.3 μM and 12.4 μM respectively.

Catalog No.	Information	Product Use Citations	Product Validations
S1949	Menadione Menadione(Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.	Mol Cell, 2017, 66(4):503-516
S1857	Etidronate Etidronate is a non-aminobisphosphonate, show protein tyrosine phosphatase (PTP) inhibitory activity, used for the treatment of Paget's disease and the prevention of heterotopic ossification.
S1514	Cyclosporine Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.	Oncotarget, 2019, 10(18):1669-1687 Acta Biomater, 2018, 83:414-424 Oxid Med Cell Longev, 2018, 2018:1725191
S4007	Pentamidine isethionate Pentamidine is an inhibitor of PRL Phosphatases and also inhibits synthesis of DNA, RNA and protein.	Cell Chem Biol, 2019, 10.1016/j.chembiol.2019.03.012 Mol Cancer Ther, 2018, 17(12):2495-2506
S7437	Sal003 Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor.
S6109^New	H-HoArg-OH H-HoArg-OH (L-Homoarginine) is an organ-specific, uncompetitive inhibitor of human liver and bone alkaline phosphohydrolases.
S8718^New	RMC-4550 RMC-4550 is a potent SHP-2inhibitor with an IC50 of 1.55 nM and it has no significant activity vs. 468 kinases, the catalytic domain of 15 phosphatases and other cellular targets including GPCRs, transporters and ion channels.
S4013	Sodium Monofluorophosphate Sodium Monofluorophosphate is a competitive inhibitor of pyruvate kinase and alkaline phosphatase with K_i of 3.4 mM and 69 μM, respectively, which also irreversibly inhibits phosphorylase phosphatase with K_i of 0.5 mM.
S5452	Sanguinarine chloride Sanguinarine, a plant alkaloid, is a potent and specific protein phosphatase (PP) 2C inhibitor.
S7639	3PO 3PO is a small-molecule inhibitor of PFKFB3 with an IC50 of 22.9 μM for recombinant human PFKFB3 protein and does not inhibit PFK-1 activity. It suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.	Lab Chip, 2016, 16(21):4189-4199
S3696	PTP Inhibitor I PTP Inhibitor I is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor with Ki values of 43 and 42 μM for SHP-1(ΔSH2) and PTP1B, respectively.
S3678	PTP Inhibitor II PTP Inhibitor II is a cell-permeable protein tyrosine phosphatase (PTP) inhibitor that covalently binds the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with Ki value of 128 μM.
S7485	CCT007093 CCT007093 is a potent PPM1D (WIP1) inhibitor with IC50 of 8.4 μM.	Oncogene, 2016, 35(42):5552-5564	(A-B)Twenty-four hours after plating 1×105 shh-EGFP cells, media was changed to serum-free media containing vehicle (Vh), DMSO, CCT007093 (CCT, 5µM), and/or Shh (3µg/mL). Cells were also transduced with LentiORF-RFP-CTRL or LentiORF-YFP-WIP1 lentivirus. 48 hours later, cells were fixed in 4% paraformaldehyde, permeabilized, incubated with α-WIP1 or α-Ki-67 antibody, and mounted using media containing DAPI (left-hand panels). Quantification of cells, per high power field (HPF), that express green fluorescent protein (GFP) or Ki-67 (right-hand panels). Bars, mean of cell counts from 10 representative fields for each experimental condition.
S7537	LB-100 LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor with IC50s of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells.	Eur J Pharmacol, 2019, 852:99-106 Mol Cancer, 2018, 17(1):44 Exp Mol Med, 2018, 50(7):83	LB-100 induced HDAC2 S394 phosphorylation.
S7383	(-)-p-Bromotetramisole Oxalate (-)-p-Bromotetramisole Oxalate is a potent and non-specific alkaline phosphatase inhibitor.
S8278	SHP099 HCl SHP099 is a highly potent, selective and orally bioavailable small-molecule SHP2 inhibitor with an IC50 value of 0.071 μM and shows no activity against SHP1.	Nat Commun, 2019, 10(1):1444 Cell Rep, 2019, 26(1):65-78
S7573	GSK2830371 GSK2830371 is an orally active, allosteric Wip1 phosphatase inhibitor with IC50 of 6 nM.	Mol Cell, 2019, 74(4):651-663.e8
S3670	Cefsulodin sodium Cefsulodin is a β-lactam antibiotic and inhibits mPTPB with the IC50 of 16 μM.
S3620	β-Glycerophosphate sodium salt hydrate β-Glycerophosphate (sodium salt hydrate) is a potent protein phosphatase inhibitor.
S5441	1-Naphthyl phosphate potassium salt 1-Naphthyl phosphate potassium salt is a non-specific phosphatase inhibitor which acts on acid, alkaline, and protein phosphatases.
S8182	NSC87877 NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. It also inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.	Cells, 2019, 8(4) Front Immunol, 2018, 9:2643	BMDMs and BMDCs were pretreated with NSC87877 (1 μM) for 1 h followed by stimulation with anti-CD180 Ab (0.2 μg/ml). Then the cells were stimulated with R837 (1 μg/ml) and CpG 1826 (0.5 μM). ELISA analysis of the levels of IL-6 and IL-12 secreted by BMDMs (E) and BMDCs (F) at 24 h.
S5431	L-Homoarginine hydrochloride L-Homoarginine is a specific inhibitor of liver-type alkaline phosphatase.
S8248	IQ-1 IQ-1 enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation, Maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells and prevents PP2A/Nkd interaction.

Catalog No.	Information	Product Use Citations	Product Validations
S8774^New	DT-061(SMAP) DT-061(SMAP) is a bioavailable PP2A activator. It decreases cell viability in HCC827 and HCC3255 cell lines, with IC50 values of 14.3 μM and 12.4 μM respectively.

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Information

Product Use Citations

Product Validations

S8774^New

DT-061(SMAP)

DT-061(SMAP) is a bioavailable PP2A activator. It decreases cell viability in HCC827 and HCC3255 cell lines, with IC50 values of 14.3 μM and 12.4 μM respectively.

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Inhibitory Selectivity

phosphatase Products