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phosphatase Inhibitors

Other Metabolism Related Inhibitors

Dehydrogenase Transferase DPP Aminopeptidase Procollagen C Proteinase P450 (e.g. CYP17) Phospholipase (e.g. PLA) Factor Xa PDE DHFR

Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
E1207 Osunprotafib (ABBV-CLS-484) Osunprotafib (ABBV-CLS-484) is a potent PTPN1 or PTPN2 inhibitor with a sub-nanomolar activity.
S5003 FK506 (Tacrolimus) Tacrolimus (FK506) is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity in T cells by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex. Tacrolimus also inhibits the phosphatase activity of calcineurin. Tacrolimus induces vascular endothelial autophagy.
Proc Natl Acad Sci U S A, 2025, 122(4):e2418317122
J Nanobiotechnology, 2025, 23(1):32
PLoS Pathog, 2025, 21(1):e1012872
Verified customer review of FK506 (Tacrolimus)
S2286 Cyclosporin A Cyclosporin A, a non-polar cyclic oligopeptide, is an immunosuppressive agent that binds to cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay. Cyclosporin A is generally given following transplant surgery to prevent rejection and has been used to test its toxic effect on a perfused 3D proximal tubule model.Cyclosporin A (NSC 290193) can be used to induce animal models of Chronic Rejection of Liver Transplantation.
Signal Transduct Target Ther, 2025, 10(1):81
Signal Transduct Target Ther, 2025, 10(1):167
Adv Sci (Weinh), 2025, 12(36):e06150
Verified customer review of Cyclosporin A
S8278 SHP099 Hydrochloride SHP099 is a highly potent, selective and orally bioavailable small-molecule SHP2 inhibitor with an IC50 value of 0.071 μM and shows no activity against SHP1.
Cancers (Basel), 2025, 17(7)1152
EMBO Mol Med, 2024, 10.1038/s44321-024-00106-1
Pharmacol Res, 2024, 201:107096
S8718 RMC-4550 RMC-4550 is a potent SHP-2inhibitor with an IC50 of 1.55 nM and this compound has no significant activity vs. 468 kinases, the catalytic domain of 15 phosphatases and other cellular targets including GPCRs, transporters and ion channels.
Nat Cancer, 2025, 10.1038/s43018-025-00960-z
Cancer Res, 2025, 10.1158/0008-5472.CAN-24-3819
iScience, 2025, 28(9):113374
S6388 SHP099 SHP099 is a highly potent, selective and orally bioavailable small-molecule SHP2 inhibitor with an IC50  value of  71 nM and shows no activity against SHP1.
iScience, 2025, 28(2):111662
Res Sq, 2025, rs.3.rs-7032881
bioRxiv, 2025, 2025.06.11.659120
S1514 Cyclosporine Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.
J Adv Res, 2024, S2090-1232(24)00499-5
Cells, 2023, 12(23)2696
Int J Mol Sci, 2023, 24(11)9708
S3620 β-Glycerophosphate sodium salt hydrate β-Glycerophosphate (sodium salt hydrate) is a potent protein phosphatase inhibitor.
Nat Commun, 2024, 15(1):2384
Discover Oncology, 2024, 338
Discov Oncol, 2024, 15(1):338
S4007 Pentamidine isethionate Pentamidine is an inhibitor of PRL Phosphatases and also inhibits synthesis of DNA, RNA and protein.
Nat Commun, 2022, 13(1):6323
Biomed Chromatogr, 2022, e5519.
Cell Prolif, 2020, 53(1):e12718
S7573 GSK2830371 GSK2830371 is an orally active, allosteric Wip1 phosphatase inhibitor with IC50 of 6 nM.
J Biomed Sci, 2025, 32(1):88
Cancer Res, 2022, canres.4145.2021
Cancer Res, 2022, 82 (12): 2313–2326.