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Catalog No.	Product Name	Information	Product Use Citations
E0140	PRL-3 Inhibitor (Compound 5e)	PRL-3 Inhibitor (Compound 5e) is a potent PRL-3 inhibitor with an IC50 of 0.9 μM.
E0758^New	Silydianin	Silydianin is an active constituent of Silybium marianum, with exhibit anti-collagenase, antitumor and anti-elastase activities.
E1171^New	SBI-425	SBI-425, a potent, selective and oral bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor, effectively inhibits TNAP in the vasculature, improving cardiovascular parameters and survival.
E1191^New	GDC-1971	GDC-1971 (compound 199) is a SHP2 inhibitor.
E3790^New	Sambucus Adnata Extract	Sambucus Adnata Extract is drawed from Sambucus Adnata, which has shown significant protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity.
S0056	(E/Z)-BCI	(E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells.
S0119	PTP1B-IN-2	PTP1B-IN-2 (MDK3465, Ptp1B-In-2, Compound P6) is a potent and selective protein tyrosine phosphatase-1B (PTP1B) inhibitor with IC50 of 50 nM. PTP1B-IN-2 enhances insulin-mediated insulin receptor β (IRβ) phosphorylation and insulin-stimulated glucose uptake.
S0136	KY-226	KY-226 is a potent, selective, orally active and allosteric inhibitor of protein tyrosine phosphatase 1B (PTP1B) with IC50 of 0.28 μM for human PTP1B activity. KY-226 exerts anti-diabetic and anti-obesity effects by enhancing insulin and leptin signaling, respectively.
S0244	SPI-112	SPI-112 is a not cell permeable inhibitor of Src homology region 2 domain-containing phosphatase 2 (SHP-2, PTPN11) with IC50 of 1 μM in cell-free assay.
S0302	F1063-0967	F1063-0967 is an inhibitor of Dual-specificity phosphatase 26 (DUSP26) with IC50 of 11.62 μM.
S0528	Raphin1	Raphin1 is an orally bioavailable, selective inhibitor of R15B (PPP1R15B, a regulatory subunit of protein phosphatase 1). Raphin1 binds strongly to the R15B-PP1c holophosphatase with Kd of 33 nM.	Cell Stem Cell, 2022, 29(7):1119-1134.e7
S0744	Raphin1 acetate	Raphin1 acetate is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 acetate binds strongly to the R15B-PP1c holophosphatase with Kd of 0.033 μM.
S1514	Cyclosporine (NSC-290193)	Cyclosporine (NSC-290193) is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.	Cell Rep, 2021, 34(10):108832 Eur J Pharmacol, 2021, 898:173999 Nat Microbiol, 2019, 4(11):1840-1850
S1857	Etidronate	Etidronate is a non-aminobisphosphonate, show protein tyrosine phosphatase (PTP) inhibitory activity, used for the treatment of Paget's disease and the prevention of heterotopic ossification.	J Immunother Cancer, 2020, 8(2)e001037
S1949	Menadione (NSC 4170)	Menadione (NSC 4170, Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.	Mol Cell, 2021, S1097-2765(21)00269-0 DNA Repair (Amst), 2021, 105:103152 BMC Urol, 2021, 21(1):96
S2286	Cyclosporin A (NSC 290193)	Cyclosporin A (Cyclosporine A, Cyclosporine, Ciclosporin, CsA,NSC 290193) is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection.	Theranostics, 2022, 12(4): 1621-1638 Theranostics, 2022, 12(3):1148-1160 Cell Death Dis, 2022, 13(4):413
S2435	Sodium stibogluconate	Sodium stibogluconate (SSG, Stibogluconate trisodium nonahydrate, Lenocta, VQD-001), a pentavalent antimony derivative, is a potent and selective inhibitor of protein tyrosine phosphatase (PTPase). Sodium stibogluconate inhibits 99% of Src homology 2 domain-containing phosphatase 1 (SHP-1) activity at 10 μg/ml and similar degrees of inhibition of SHP-2 and PTP1B requires 100 μg/ml. Sodium stibogluconate is a drug used in treatment of leishmaniasis.
S2837	BCI	BCI ((E)-BCI, compound 1) is an allosteric dual specificity phosphatase (DUSP) inhibitor with EC50 of 13.3 μM and 8.0 μM in cells for DUSP6 and DUSP1, respectively.
S3245	Nodakenetin	Nodakenetin (NANI), a plant-derived coumarin isolated from Angelica decursiva, inhibits α-glucosidase, PTP1B, rat lens aldose reductase (RLAR), AChE, BChE, and β-site amyloid precursor protein cleaving enzyme 1 (BACE1). Nodakenetin alters the protein expression of Bax and Bcl-2, and prompts mitochondrial apoptosis. Nodakenetin exhibits anti-tumor activity.
S3284	Tracheloside	Tracheloside is a lignan glycoside isolated from seeds of Carthamus tinctorius with anti-estrogenic effects. Tracheloside significantly decreases the activity of alkaline phosphatase (AP) (an estrogen-inducible marker enzyme) with IC50 of 0.31 μg/ml. Tracheloside promotes keratinocyte proliferation through ERK1/2 stimulation.
S3620	β-Glycerophosphate sodium salt hydrate	β-Glycerophosphate (sodium salt hydrate) is a potent protein phosphatase inhibitor.	Sci Rep, 2022, 12(1):7 Immunopharmacol Immunotoxicol, 2022, 1-11 Front Med (Lausanne), 2021, 8:777507
S3678	PTP Inhibitor II	PTP Inhibitor II (NSC 129010, 4-(Bromoacetyl)anisole) is a cell-permeable protein tyrosine phosphatase (PTP) inhibitor that covalently binds the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with Ki value of 128 μM.	Fish Shellfish Immunol, 2020, 99:562-571
S3696	PTP Inhibitor I	PTP Inhibitor I is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor with Ki values of 43 and 42 μM for SHP-1(ΔSH2) and PTP1B, respectively.
S4007	Pentamidine isethionate	Pentamidine is an inhibitor of PRL Phosphatases and also inhibits synthesis of DNA, RNA and protein.	Cell Prolif, 2020, 53(1):e12718 Cell Chem Biol, 2019, 10.1016/j.chembiol.2019.03.012 Tissue Eng Regen Med, 2019, 16(3):265-273
S4013	Sodium Monofluorophosphate	Sodium Monofluorophosphate (NSC248) is a competitive inhibitor of pyruvate kinase and alkaline phosphatase with K_i of 3.4 mM and 69 μM, respectively, which also irreversibly inhibits phosphorylase phosphatase with K_i of 0.5 mM.
S4451	NSC45586	NSC45586 is an inhibitor of PHLPP (Pleckstrin homology domain and leucine-rich repeat protein phosphatase), which is selective for PHLPP1 and PHLPP2.
S5003	Tacrolimus (FK506)	Tacrolimus (FK506, FR900506, Fujimycin, Prograf) is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity in T cells by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex. Tacrolimus also inhibits the phosphatase activity of calcineurin. Tacrolimus induces vascular endothelial autophagy.	EMBO J, 2022, 41(14):e110655 Cancer Commun (Lond), 2022, 10.1002/cac2.12332 PLoS Pathog, 2022, 18(4):e1010453
S5198	Sodium Etidronate	Sodium Etidronate (Didronel, EHDP, Etidronic acid) is a non-aminobisphosphonate that exhibits protein tyrosine phosphatase (PTP) inhibitory activity.
S5431	L-Homoarginine hydrochloride	L-Homoarginine is a specific inhibitor of liver-type alkaline phosphatase.
S5441	1-Naphthyl phosphate potassium salt	1-Naphthyl phosphate potassium salt (α-Naphthyl acid phosphate monopotassium salt) is a non-specific phosphatase inhibitor which acts on acid, alkaline, and protein phosphatases.
S5452	Sanguinarine chloride	Sanguinarine, a plant alkaloid, is a potent and specific protein phosphatase (PP) 2C inhibitor. Sanguinarine chloride can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.	Front Pharmacol, 2021, 12:638215
S5595	3-Carene	3-Carene (Carene, Delta-3-Carene) is a bicyclic monoterpene in essential oils extracted from pine trees. 3-Carene have potent pharmacological effects on COX-2 overexpression and LPS-induced migration of Raw264.7 macrophages. 3‐carene is shown to significantly stimulate the activity and expression of alkaline phosphatase, an early phase marker of osteoblastic differentiation.	Phytomedicine, 2021, 91:153707
S5953	Menadione bisulfite sodium	Menadione(Vitamin K3) bisulfite sodium, a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.	Life Sci, 2020, 242:117159
S6109	H-HoArg-OH	H-HoArg-OH (L-Homoarginine) is an organ-specific, uncompetitive inhibitor of serum "bone and liver" alkaline phosphatase.
S6388	SHP099	SHP099 is a highly potent, selective and orally bioavailable small-molecule SHP2 inhibitor with an IC50 value of 71 nM and shows no activity against SHP1.	Cell Chem Biol, 2022, S2451-9456(22)00127-1 Am J Cancer Res, 2022, 12(1):247-264 Toxicol Appl Pharmacol, 2022, 441:115988
S6391	Sephin-1	Sephin-1 (NSC-65390) is a selective inhibitor of a holophosphatase, a small molecule that safely and selectively inhibits a regulatory subunit of protein phosphatase 1 in vivo. Sephin-1 (NSC-65390) selectively bounds and inhibits the stress-induced PPP1R15A.
S6570	TPI-1	TPI-1 (Tyrosine Phosphatase Inhibitor 1) is a potent inhibitor of SHP-1 with IC50 of 40 nM for recombinant SHP-1. TPI-1 exhibits anticancer activity.	J Extracell Vesicles, 2021, 10(5):e12078
S6777	NSC95397	NSC 95397 is a potent, selective Cdc25 dual specificity phosphatase inhibitor with Ki of 32 nM, 96 nM, 40 nM for Cdc25A, Cdc25B and Cdc25C, respectively. NSC 95397 has IC50 of 22.3 nM, 56.9 nM and 125 nM for human Cdc25A, human Cdc25C and Cdc25B, respectively. NSC 95397 inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) and suppresses proliferation and induces apoptosis in colon cancer cells through MKP-1 and ERK1/2 pathway.	Phytomedicine, 2022, 104:154283
S7383	(-)-p-Bromotetramisole Oxalate	(-)-p-Bromotetramisole Oxalate (L-p-Bromotetramisole Oxalate) is a potent and non-specific alkaline phosphatase inhibitor.
S7437	Sal003	Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor.
S7485	CCT007093	CCT007093 is a potent PPM1D (WIP1) inhibitor with IC50 of 8.4 μM.	Oncogene, 2016, 35(42):5552-5564
S7573	GSK2830371	GSK2830371 is an orally active, allosteric Wip1 phosphatase inhibitor with IC50 of 6 nM.	Cancer Res, 2022, canres.4145.2021 Cell Death Dis, 2021, 13(1):9 Oncogene, 2020,
S8182	NSC87877	NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. It also inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.	Oncotarget, 2020, 21;11(3):265-281 Cells, 2019, 8(4) J Mol Neurosci, 2019, 69(3):360-370
S8278	SHP099 HCl	SHP099 is a highly potent, selective and orally bioavailable small-molecule SHP2 inhibitor with an IC50 value of 0.071 μM and shows no activity against SHP1.	Cancer Res, 2022, 82(10):1991-2002 Breast Cancer Res, 2022, 24(1):23 Am J Cancer Res, 2022, 12(1):247-264
S8718	RMC-4550	RMC-4550 is a potent SHP-2inhibitor with an IC50 of 1.55 nM and it has no significant activity vs. 468 kinases, the catalytic domain of 15 phosphatases and other cellular targets including GPCRs, transporters and ion channels.	Cell Rep, 2022, 39(12):110993 Front Pharmacol, 2022, 13:841308 Mol Cancer Ther, 2021, molcanther.0965.2020
S8987	TNO155	TNO155 is an inhibitor of protein tyrosine phosphatase (PTP) non-receptor type 11 (SHP2 /src homology region 2 domain phosphatase /PTPN11) with IC50 of 0.011 µM. TNO155 has potential antineoplastic activity.	J Thorac Oncol, 2021, 16(8):1321-1332
S9703	IACS-13909	IACS-13909 (BBP-398) is a specific and potent allosteric inhibitor of SHP2 (Src homology 2 domain-containing phosphatase) that suppresses signaling through the MAPK pathway.
S9829^New	BVT-948	BVT 948 is a irreversible, noncompetitive and cell-permeable protein tyrosine phosphatase（PTP） inhibitor with IC50s of 0.9 μM, 1.7 μM, 0.09 μM, 1.5 μM and 0.7 μM for PTP1B, TCPTP, SHP-2, LAR and YopH respectively.
S9913^New	PHPS1	PHPS1 (PTP Inhibitor V), a potent and cell-permeable inhibitor, is specific for Shp2 with Ki value of 0.73 μM.
A5111	Alkaline Phosphatase Rabbit Recombinant mAb	Alkaline Phosphatase Rabbit Recombinant mAb detects endogenous levels of total alkaline phosphatase.
A5133	Cdc25C Rabbit Recombinant mAb	Cdc25C Rabbit Recombinant mAb detects endogenous level of total Cdc25C.	Front Oncol, 2021, 11:666589 Arch Biochem Biophys, 2021, 700:108774
A5178	CD45 Rabbit Recombinant mAb	CD45 Rabbit Recombinant mAb detects endogenous level of CD45.
A5255	PP2A alpha/beta Rabbit Recombinant mAb	PP2A alpha/beta Rabbit Recombinant mAb detects endogenous level of total PP2A alpha/beta.	Cell Rep, 2019, 28(8):2004-2011 Cell Rep, 2019, 28(8):2004-2011.e4
A5278	Phospho-SHP2 (Y542) Rabbit Recombinant mAb	Phospho-SHP2 (Y542) Rabbit Recombinant mAb detects endogenous level of total Phospho-SHP2 (Y542).	Mol Cancer Ther, 2021, molcanther.MCT-21-0395-A.2021
E0956^New	MP07-66	MP07-66, a FTY720 analogue, is devoid of immunosuppressive effects and shows promising antitumor effects in chronic lymphocytic leukemia by disruption of the SET-PP2A complex leading to PP2A reactivation.
E2692^New	L-Ascorbic acid 2-phosphate sesquimagnesium salt	L-Ascorbic acid 2-phosphate sesquimagnesium salt (2-Phospho-L-ascorbic acid magnesium), a long-acting vitamin C derivative that can stimulate collagen formation and expression, can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs), which increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation.
S0918	Ginkgolic acid C17:1	Ginkgolic acid C17:1 (GAC 17:1) inhibits constitutive activation of STAT3 through the abrogation of upstream JAK2 and Src. Ginkgolic acid C17:1 can induce the substantial expression of PTEN and SHP-1. Ginkgolic acid C17:1 induces apoptosis of tumor cells.
S0445	SC-43	SC-43, a sorafenib derivative, is an agonist of Src-homology protein tyrosine phosphatase-1 (SHP-1/PTPN6) and reduces liver fibrosis. SC-43 reduces p-STAT3 and induces apoptosis with anti-tumor activity.
E0140	PRL-3 Inhibitor (Compound 5e)	PRL-3 Inhibitor (Compound 5e) is a potent PRL-3 inhibitor with an IC50 of 0.9 μM.
E0758^New	Silydianin	Silydianin is an active constituent of Silybium marianum, with exhibit anti-collagenase, antitumor and anti-elastase activities.
E1171^New	SBI-425	SBI-425, a potent, selective and oral bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor, effectively inhibits TNAP in the vasculature, improving cardiovascular parameters and survival.
E1191^New	GDC-1971	GDC-1971 (compound 199) is a SHP2 inhibitor.
E3790^New	Sambucus Adnata Extract	Sambucus Adnata Extract is drawed from Sambucus Adnata, which has shown significant protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity.
S0056	(E/Z)-BCI	(E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells.
S0119	PTP1B-IN-2	PTP1B-IN-2 (MDK3465, Ptp1B-In-2, Compound P6) is a potent and selective protein tyrosine phosphatase-1B (PTP1B) inhibitor with IC50 of 50 nM. PTP1B-IN-2 enhances insulin-mediated insulin receptor β (IRβ) phosphorylation and insulin-stimulated glucose uptake.
S0136	KY-226	KY-226 is a potent, selective, orally active and allosteric inhibitor of protein tyrosine phosphatase 1B (PTP1B) with IC50 of 0.28 μM for human PTP1B activity. KY-226 exerts anti-diabetic and anti-obesity effects by enhancing insulin and leptin signaling, respectively.
S0244	SPI-112	SPI-112 is a not cell permeable inhibitor of Src homology region 2 domain-containing phosphatase 2 (SHP-2, PTPN11) with IC50 of 1 μM in cell-free assay.
S0302	F1063-0967	F1063-0967 is an inhibitor of Dual-specificity phosphatase 26 (DUSP26) with IC50 of 11.62 μM.
S0528	Raphin1	Raphin1 is an orally bioavailable, selective inhibitor of R15B (PPP1R15B, a regulatory subunit of protein phosphatase 1). Raphin1 binds strongly to the R15B-PP1c holophosphatase with Kd of 33 nM.	Cell Stem Cell, 2022, 29(7):1119-1134.e7
S0744	Raphin1 acetate	Raphin1 acetate is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 acetate binds strongly to the R15B-PP1c holophosphatase with Kd of 0.033 μM.
S1514	Cyclosporine (NSC-290193)	Cyclosporine (NSC-290193) is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.	Cell Rep, 2021, 34(10):108832 Eur J Pharmacol, 2021, 898:173999 Nat Microbiol, 2019, 4(11):1840-1850
S1857	Etidronate	Etidronate is a non-aminobisphosphonate, show protein tyrosine phosphatase (PTP) inhibitory activity, used for the treatment of Paget's disease and the prevention of heterotopic ossification.	J Immunother Cancer, 2020, 8(2)e001037
S1949	Menadione (NSC 4170)	Menadione (NSC 4170, Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.	Mol Cell, 2021, S1097-2765(21)00269-0 DNA Repair (Amst), 2021, 105:103152 BMC Urol, 2021, 21(1):96
S2286	Cyclosporin A (NSC 290193)	Cyclosporin A (Cyclosporine A, Cyclosporine, Ciclosporin, CsA,NSC 290193) is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection.	Theranostics, 2022, 12(4): 1621-1638 Theranostics, 2022, 12(3):1148-1160 Cell Death Dis, 2022, 13(4):413
S2435	Sodium stibogluconate	Sodium stibogluconate (SSG, Stibogluconate trisodium nonahydrate, Lenocta, VQD-001), a pentavalent antimony derivative, is a potent and selective inhibitor of protein tyrosine phosphatase (PTPase). Sodium stibogluconate inhibits 99% of Src homology 2 domain-containing phosphatase 1 (SHP-1) activity at 10 μg/ml and similar degrees of inhibition of SHP-2 and PTP1B requires 100 μg/ml. Sodium stibogluconate is a drug used in treatment of leishmaniasis.
S2837	BCI	BCI ((E)-BCI, compound 1) is an allosteric dual specificity phosphatase (DUSP) inhibitor with EC50 of 13.3 μM and 8.0 μM in cells for DUSP6 and DUSP1, respectively.
S3245	Nodakenetin	Nodakenetin (NANI), a plant-derived coumarin isolated from Angelica decursiva, inhibits α-glucosidase, PTP1B, rat lens aldose reductase (RLAR), AChE, BChE, and β-site amyloid precursor protein cleaving enzyme 1 (BACE1). Nodakenetin alters the protein expression of Bax and Bcl-2, and prompts mitochondrial apoptosis. Nodakenetin exhibits anti-tumor activity.
S3284	Tracheloside	Tracheloside is a lignan glycoside isolated from seeds of Carthamus tinctorius with anti-estrogenic effects. Tracheloside significantly decreases the activity of alkaline phosphatase (AP) (an estrogen-inducible marker enzyme) with IC50 of 0.31 μg/ml. Tracheloside promotes keratinocyte proliferation through ERK1/2 stimulation.
S3620	β-Glycerophosphate sodium salt hydrate	β-Glycerophosphate (sodium salt hydrate) is a potent protein phosphatase inhibitor.	Sci Rep, 2022, 12(1):7 Immunopharmacol Immunotoxicol, 2022, 1-11 Front Med (Lausanne), 2021, 8:777507
S3678	PTP Inhibitor II	PTP Inhibitor II (NSC 129010, 4-(Bromoacetyl)anisole) is a cell-permeable protein tyrosine phosphatase (PTP) inhibitor that covalently binds the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with Ki value of 128 μM.	Fish Shellfish Immunol, 2020, 99:562-571
S3696	PTP Inhibitor I	PTP Inhibitor I is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor with Ki values of 43 and 42 μM for SHP-1(ΔSH2) and PTP1B, respectively.
S4007	Pentamidine isethionate	Pentamidine is an inhibitor of PRL Phosphatases and also inhibits synthesis of DNA, RNA and protein.	Cell Prolif, 2020, 53(1):e12718 Cell Chem Biol, 2019, 10.1016/j.chembiol.2019.03.012 Tissue Eng Regen Med, 2019, 16(3):265-273
S4013	Sodium Monofluorophosphate	Sodium Monofluorophosphate (NSC248) is a competitive inhibitor of pyruvate kinase and alkaline phosphatase with K_i of 3.4 mM and 69 μM, respectively, which also irreversibly inhibits phosphorylase phosphatase with K_i of 0.5 mM.
S4451	NSC45586	NSC45586 is an inhibitor of PHLPP (Pleckstrin homology domain and leucine-rich repeat protein phosphatase), which is selective for PHLPP1 and PHLPP2.
S5003	Tacrolimus (FK506)	Tacrolimus (FK506, FR900506, Fujimycin, Prograf) is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity in T cells by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex. Tacrolimus also inhibits the phosphatase activity of calcineurin. Tacrolimus induces vascular endothelial autophagy.	EMBO J, 2022, 41(14):e110655 Cancer Commun (Lond), 2022, 10.1002/cac2.12332 PLoS Pathog, 2022, 18(4):e1010453
S5198	Sodium Etidronate	Sodium Etidronate (Didronel, EHDP, Etidronic acid) is a non-aminobisphosphonate that exhibits protein tyrosine phosphatase (PTP) inhibitory activity.
S5431	L-Homoarginine hydrochloride	L-Homoarginine is a specific inhibitor of liver-type alkaline phosphatase.
S5441	1-Naphthyl phosphate potassium salt	1-Naphthyl phosphate potassium salt (α-Naphthyl acid phosphate monopotassium salt) is a non-specific phosphatase inhibitor which acts on acid, alkaline, and protein phosphatases.
S5452	Sanguinarine chloride	Sanguinarine, a plant alkaloid, is a potent and specific protein phosphatase (PP) 2C inhibitor. Sanguinarine chloride can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.	Front Pharmacol, 2021, 12:638215
S5595	3-Carene	3-Carene (Carene, Delta-3-Carene) is a bicyclic monoterpene in essential oils extracted from pine trees. 3-Carene have potent pharmacological effects on COX-2 overexpression and LPS-induced migration of Raw264.7 macrophages. 3‐carene is shown to significantly stimulate the activity and expression of alkaline phosphatase, an early phase marker of osteoblastic differentiation.	Phytomedicine, 2021, 91:153707
S5953	Menadione bisulfite sodium	Menadione(Vitamin K3) bisulfite sodium, a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.	Life Sci, 2020, 242:117159
S6109	H-HoArg-OH	H-HoArg-OH (L-Homoarginine) is an organ-specific, uncompetitive inhibitor of serum "bone and liver" alkaline phosphatase.
S6388	SHP099	SHP099 is a highly potent, selective and orally bioavailable small-molecule SHP2 inhibitor with an IC50 value of 71 nM and shows no activity against SHP1.	Cell Chem Biol, 2022, S2451-9456(22)00127-1 Am J Cancer Res, 2022, 12(1):247-264 Toxicol Appl Pharmacol, 2022, 441:115988
S6391	Sephin-1	Sephin-1 (NSC-65390) is a selective inhibitor of a holophosphatase, a small molecule that safely and selectively inhibits a regulatory subunit of protein phosphatase 1 in vivo. Sephin-1 (NSC-65390) selectively bounds and inhibits the stress-induced PPP1R15A.
S6570	TPI-1	TPI-1 (Tyrosine Phosphatase Inhibitor 1) is a potent inhibitor of SHP-1 with IC50 of 40 nM for recombinant SHP-1. TPI-1 exhibits anticancer activity.	J Extracell Vesicles, 2021, 10(5):e12078
S6777	NSC95397	NSC 95397 is a potent, selective Cdc25 dual specificity phosphatase inhibitor with Ki of 32 nM, 96 nM, 40 nM for Cdc25A, Cdc25B and Cdc25C, respectively. NSC 95397 has IC50 of 22.3 nM, 56.9 nM and 125 nM for human Cdc25A, human Cdc25C and Cdc25B, respectively. NSC 95397 inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) and suppresses proliferation and induces apoptosis in colon cancer cells through MKP-1 and ERK1/2 pathway.	Phytomedicine, 2022, 104:154283
S7383	(-)-p-Bromotetramisole Oxalate	(-)-p-Bromotetramisole Oxalate (L-p-Bromotetramisole Oxalate) is a potent and non-specific alkaline phosphatase inhibitor.
S7437	Sal003	Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor.
S7485	CCT007093	CCT007093 is a potent PPM1D (WIP1) inhibitor with IC50 of 8.4 μM.	Oncogene, 2016, 35(42):5552-5564
S7573	GSK2830371	GSK2830371 is an orally active, allosteric Wip1 phosphatase inhibitor with IC50 of 6 nM.	Cancer Res, 2022, canres.4145.2021 Cell Death Dis, 2021, 13(1):9 Oncogene, 2020,
S8182	NSC87877	NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. It also inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.	Oncotarget, 2020, 21;11(3):265-281 Cells, 2019, 8(4) J Mol Neurosci, 2019, 69(3):360-370
S8278	SHP099 HCl	SHP099 is a highly potent, selective and orally bioavailable small-molecule SHP2 inhibitor with an IC50 value of 0.071 μM and shows no activity against SHP1.	Cancer Res, 2022, 82(10):1991-2002 Breast Cancer Res, 2022, 24(1):23 Am J Cancer Res, 2022, 12(1):247-264
S8718	RMC-4550	RMC-4550 is a potent SHP-2inhibitor with an IC50 of 1.55 nM and it has no significant activity vs. 468 kinases, the catalytic domain of 15 phosphatases and other cellular targets including GPCRs, transporters and ion channels.	Cell Rep, 2022, 39(12):110993 Front Pharmacol, 2022, 13:841308 Mol Cancer Ther, 2021, molcanther.0965.2020
S8987	TNO155	TNO155 is an inhibitor of protein tyrosine phosphatase (PTP) non-receptor type 11 (SHP2 /src homology region 2 domain phosphatase /PTPN11) with IC50 of 0.011 µM. TNO155 has potential antineoplastic activity.	J Thorac Oncol, 2021, 16(8):1321-1332
S9703	IACS-13909	IACS-13909 (BBP-398) is a specific and potent allosteric inhibitor of SHP2 (Src homology 2 domain-containing phosphatase) that suppresses signaling through the MAPK pathway.
S9829^New	BVT-948	BVT 948 is a irreversible, noncompetitive and cell-permeable protein tyrosine phosphatase（PTP） inhibitor with IC50s of 0.9 μM, 1.7 μM, 0.09 μM, 1.5 μM and 0.7 μM for PTP1B, TCPTP, SHP-2, LAR and YopH respectively.
S9913^New	PHPS1	PHPS1 (PTP Inhibitor V), a potent and cell-permeable inhibitor, is specific for Shp2 with Ki value of 0.73 μM.
A5111	Alkaline Phosphatase Rabbit Recombinant mAb	Alkaline Phosphatase Rabbit Recombinant mAb detects endogenous levels of total alkaline phosphatase.
A5133	Cdc25C Rabbit Recombinant mAb	Cdc25C Rabbit Recombinant mAb detects endogenous level of total Cdc25C.	Front Oncol, 2021, 11:666589 Arch Biochem Biophys, 2021, 700:108774
A5178	CD45 Rabbit Recombinant mAb	CD45 Rabbit Recombinant mAb detects endogenous level of CD45.
A5255	PP2A alpha/beta Rabbit Recombinant mAb	PP2A alpha/beta Rabbit Recombinant mAb detects endogenous level of total PP2A alpha/beta.	Cell Rep, 2019, 28(8):2004-2011 Cell Rep, 2019, 28(8):2004-2011.e4
A5278	Phospho-SHP2 (Y542) Rabbit Recombinant mAb	Phospho-SHP2 (Y542) Rabbit Recombinant mAb detects endogenous level of total Phospho-SHP2 (Y542).	Mol Cancer Ther, 2021, molcanther.MCT-21-0395-A.2021
E0956^New	MP07-66	MP07-66, a FTY720 analogue, is devoid of immunosuppressive effects and shows promising antitumor effects in chronic lymphocytic leukemia by disruption of the SET-PP2A complex leading to PP2A reactivation.
E2692^New	L-Ascorbic acid 2-phosphate sesquimagnesium salt	L-Ascorbic acid 2-phosphate sesquimagnesium salt (2-Phospho-L-ascorbic acid magnesium), a long-acting vitamin C derivative that can stimulate collagen formation and expression, can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs), which increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation.
S0918	Ginkgolic acid C17:1	Ginkgolic acid C17:1 (GAC 17:1) inhibits constitutive activation of STAT3 through the abrogation of upstream JAK2 and Src. Ginkgolic acid C17:1 can induce the substantial expression of PTEN and SHP-1. Ginkgolic acid C17:1 induces apoptosis of tumor cells.
S0445	SC-43	SC-43, a sorafenib derivative, is an agonist of Src-homology protein tyrosine phosphatase-1 (SHP-1/PTPN6) and reduces liver fibrosis. SC-43 reduces p-STAT3 and induces apoptosis with anti-tumor activity.
E0758^New	Silydianin	Silydianin is an active constituent of Silybium marianum, with exhibit anti-collagenase, antitumor and anti-elastase activities.
E1171^New	SBI-425	SBI-425, a potent, selective and oral bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor, effectively inhibits TNAP in the vasculature, improving cardiovascular parameters and survival.
E1191^New	GDC-1971	GDC-1971 (compound 199) is a SHP2 inhibitor.
E3790^New	Sambucus Adnata Extract	Sambucus Adnata Extract is drawed from Sambucus Adnata, which has shown significant protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity.
S9829^New	BVT-948	BVT 948 is a irreversible, noncompetitive and cell-permeable protein tyrosine phosphatase（PTP） inhibitor with IC50s of 0.9 μM, 1.7 μM, 0.09 μM, 1.5 μM and 0.7 μM for PTP1B, TCPTP, SHP-2, LAR and YopH respectively.
S9913^New	PHPS1	PHPS1 (PTP Inhibitor V), a potent and cell-permeable inhibitor, is specific for Shp2 with Ki value of 0.73 μM.
E0956^New	MP07-66	MP07-66, a FTY720 analogue, is devoid of immunosuppressive effects and shows promising antitumor effects in chronic lymphocytic leukemia by disruption of the SET-PP2A complex leading to PP2A reactivation.
E2692^New	L-Ascorbic acid 2-phosphate sesquimagnesium salt	L-Ascorbic acid 2-phosphate sesquimagnesium salt (2-Phospho-L-ascorbic acid magnesium), a long-acting vitamin C derivative that can stimulate collagen formation and expression, can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs), which increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation.