KB-0742 Dihydrochloride

Catalog No.S9901

For research use only.

KB-0742 Dihydrochloride is a potent, selective, and orally bioavailable small molecule inhibitor of the transcription elongation cofactor CDK9 with IC50 of 6 nM for CDK9/cyclin T1 inhibition at 10 μM ATP.

KB-0742 Dihydrochloride Chemical Structure

CAS No. 2416874-75-2

Purity & Quality Control

Choose Selective CDK Inhibitors

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Biological Activity

Description

KB-0742 Dihydrochloride is a potent, selective, and orally bioavailable small molecule inhibitor of the transcription elongation cofactor CDK9 with IC50 of 6 nM for CDK9/cyclin T1 inhibition at 10 μM ATP.

Targets
CDK9/cyclin T1 [1]
()
6 nM

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 72 mg/mL
(199.81 mM)
Water 72 mg/mL
(199.81 mM)
Ethanol 72 mg/mL
(199.81 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 360.33
Formula

C16H25N5.2ClH

CAS No. 2416874-75-2
Storage 3 years -20°C powder
2 years -80°C in solvent

In vivo Formulation Calculator (Clear solution)

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04718675 Recruiting Drug: KB-0742 Relapsed Solid Tumors|Refractory Solid Tumors|Non-Hodgkin Lymphoma Kronos Bio February 8 2021 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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