KS176

Catalog No.S0140

For research use only.

KS176 (compound 9) is a potent and selective inhibitor of the breast cancer resistance protein (BCRP, ABCG2) multidrug transporter with IC50 of 1.39 μM and 0.59 μM in Hoechst 33342 assay and Pheo A assay, respectively.

KS176 Chemical Structure

CAS No. 1253452-78-6

Purity & Quality Control

Choose Selective BCRP Inhibitors

Biological Activity

Description KS176 (compound 9) is a potent and selective inhibitor of the breast cancer resistance protein (BCRP, ABCG2) multidrug transporter with IC50 of 1.39 μM and 0.59 μM in Hoechst 33342 assay and Pheo A assay, respectively.
Targets
BCRP [1]
(in Pheo A assay)
BCRP [1]
(in Hoechst 33342 assay)
0.59 μM 1.39 μM

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 81 mg/mL
(199.8 mM)
Ethanol 3 mg/mL
(7.4 mM)
Water Insoluble

Chemical Information

Molecular Weight 405.40
Formula

C22H19N3O5

CAS No. 1253452-78-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC=C(C(=C1)C(=O)NC2=CC=C(C=C2)CCO)NC(=O)C3=CC=C(C=C3)[N+](=O)[O-]

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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