For research use only.

Catalog No.S6527

Kobe2602 Chemical Structure

Molecular Weight(MW): 419.31

Kobe2602 is a selective Ras inhibitor that blocks H-Ras GTP binding to c-Raf-1 (Ki = 149 µM).

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Biological Activity

Description Kobe2602 is a selective Ras inhibitor that blocks H-Ras GTP binding to c-Raf-1 (Ki = 149 µM).
Ras [1]
149 μM(Ki)


Cell Research:


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  • Cell lines: NIH 3T3 cells
  • Concentrations: 20 μM
  • Incubation Time: 1 h
  • Method:

    NIH 3T3 cells are transfected with pEF-BOS-HA-K-Ras(G12V) or an empty vector and treated with 20 μM Kobe0065, 20 μM Kobe2602, or the vehicle (DMSO) in the presence of 2% (vol/vol) FBS for 1 h. Cell lysate is subjected to detection of c-Raf-1 coimmunoprecipitated with K-Ras(G12V) by an anti-HA antibody and total c-Raf-1 by Western blotting with an anti-c-Raf-1 antibody.

    (Only for Reference)
Animal Research:


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  • Animal Models: Female athymic nude mice implanted with SW480 cells
  • Dosages: 80 mg/kg
  • Administration: oral
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 84 mg/mL (200.32 mM)
Ethanol 40 mg/mL (95.39 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 419.31


CAS No. 454453-49-7
Storage powder
in solvent
Synonyms N/A
Smiles [O-][N+](=O)C1=CC(=CC(=C1NNC(=S)NC2=CC=C(F)C=C2)[N+]([O-])=O)C(F)(F)F

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)
% DMSO % % Tween 80 % ddH2O

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Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Rho Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID