Kobe2602

Catalog No.S6527

Kobe2602 Chemical Structure

Molecular Weight(MW): 419.31

Kobe2602 is a selective Ras inhibitor that blocks H-Ras GTP binding to c-Raf-1 (Ki = 149 µM).

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Biological Activity

Description Kobe2602 is a selective Ras inhibitor that blocks H-Ras GTP binding to c-Raf-1 (Ki = 149 µM).
Targets
Ras [1]
()
149 μM(Ki)

Protocol

Cell Research:

[1]

+ Expand
  • Cell lines: NIH 3T3 cells
  • Concentrations: 20 μM
  • Incubation Time: 1 h
  • Method:

    NIH 3T3 cells are transfected with pEF-BOS-HA-K-Ras(G12V) or an empty vector and treated with 20 μM Kobe0065, 20 μM Kobe2602, or the vehicle (DMSO) in the presence of 2% (vol/vol) FBS for 1 h. Cell lysate is subjected to detection of c-Raf-1 coimmunoprecipitated with K-Ras(G12V) by an anti-HA antibody and total c-Raf-1 by Western blotting with an anti-c-Raf-1 antibody.


    (Only for Reference)
Animal Research:

[1]

+ Expand
  • Animal Models: Female athymic nude mice implanted with SW480 cells
  • Formulation: --
  • Dosages: 80 mg/kg
  • Administration: oral
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 84 mg/mL (200.32 mM)
Ethanol 40 mg/mL (95.39 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 419.31
Formula

C14H9F4N5O4S

CAS No. 454453-49-7
Storage powder
in solvent
Synonyms N/A

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Rho Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID