2-Ketoglutaric acid

Catalog No.S6237 Synonyms: alpha-ketoglutarate, alpha-ketoglutaric acid, 2-oxoglutaric acid

For research use only.

2-Ketoglutaric acid (AKG, alpha-ketoglutarate, alpha-ketoglutaric acid, 2-oxoglutaric acid), is a key molecule in the TCA cycle, playing a fundamental role in determining the overall rate of this important metabolic process. In the TCA cycle, AKG is decarboxylated to succinyl-CoA and carbon dioxide by AKG dehydrogenase, which functions as a key control point of the TCA cycle. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase.

2-Ketoglutaric acid Chemical Structure

CAS No. 328-50-7

Selleck's 2-Ketoglutaric acid has been cited by 2 Publications

Purity & Quality Control

Choose Selective Tyrosinase Inhibitors

Biological Activity

Description 2-Ketoglutaric acid (AKG, alpha-ketoglutarate, alpha-ketoglutaric acid, 2-oxoglutaric acid), is a key molecule in the TCA cycle, playing a fundamental role in determining the overall rate of this important metabolic process. In the TCA cycle, AKG is decarboxylated to succinyl-CoA and carbon dioxide by AKG dehydrogenase, which functions as a key control point of the TCA cycle. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase.

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 29 mg/mL
(198.49 mM)
Ethanol '-1 mg/mL

Chemical Information

Molecular Weight 146.10
Formula

C5H6O5

CAS No. 328-50-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C(CC(=O)O)C(=O)C(=O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04560309 Completed Drug: L-alanyl-L-glutamine dipeptide|Drug: Placebo Coronary Artery Bypass|Cardiopulmonary Bypass|Coronary Artery Disease National Cardiovascular Center Harapan Kita Hospital Indonesia January 1 2021 Phase 3
NCT01880281 Completed Other: Meat and vegetable diet Acid Base Disorder Michel Burnier|Centre Hospitalier Universitaire Vaudois June 2013 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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