For research use only.

Catalog No.S7125

7 publications

KPT-185 Chemical Structure

CAS No. 1333151-73-7

KPT-185 is a selective CRM1 inhibitor that induces growth inhibition and apoptosis in a panel of NHL cell lines with a median IC50 ~25 nM.

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Selleck's KPT-185 has been cited by 7 publications

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  • (D)Western blot analysis of RNF146 in cytoplasmic and nuclear fraction after KPT-185 treatment. Data represented mean ± s.e.m., n = 5; *P < 0.05, **P < 0.01. NES, nuclear export signal. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

    Biochem Biophys Res Commun, 2018, 503(3):1544-1549. KPT-185 purchased from Selleck.

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Choose Selective CRM1 Inhibitors

Biological Activity

Description KPT-185 is a selective CRM1 inhibitor that induces growth inhibition and apoptosis in a panel of NHL cell lines with a median IC50 ~25 nM.
CRM1 [1]
In vitro

KPT-185 significantly inhibits leukemia cell proliferation with IC50 ranging from 100 nM to 500 nM, and induces cell-cycle arrest and apoptosis of AML cell lines and primary AML blasts. KPT-185 reduces CRM1 protein protein level and shows a significant nuclear accumulation of CRM1 cargo proteins. [1] KPT-185 also inhibits proliferation and promotes apoptosis of pancreatic cancer cells without affecting human pancreatic ductal epithelial cells. [2]


Cell Research:


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  • Cell lines: AML cell lines (MV4-11, Kasumi-1, OCI/AML3, MOLM-13, KG1a, and THP-1)
  • Concentrations: ~10 μM
  • Incubation Time: 72 hours
  • Method:

    Cells are seeded into 96-well plates and treated for 24, 48, and 72 hours with KPT-SINE at various concentrations ranging from 10 nM to 10 μM. Cell viability is evaluated using the cell proliferation reagent WST-1 according to the manufacturer's protocol. The absorbance of wells at 450 nm (reference wavelength, 650 nm) is measured with a microplate reader.

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Solubility (25°C)

In vitro DMSO 71 mg/mL (199.82 mM)
Ethanol 71 mg/mL (199.82 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 355.31


CAS No. 1333151-73-7
Storage powder
in solvent
Synonyms N/A
Smiles CC(C)OC(=O)C=CN1C=NC(=N1)C2=CC(=CC(=C2)OC)C(F)(F)F

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID