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Catalog No.S7917

3 publications

Kenpaullone Chemical Structure

CAS No. 142273-20-9

Kenpaullone is an ATP-competitive inhibitor of cyclin-dependent kinases (CDKs). It also inhibit glycogen synthase kinase 3β (GSK3β) with IC50 of 0.23 µM.

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Selleck's Kenpaullone has been cited by 3 publications

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  • Effect of Kenpaullone on GSK-3β and CDKs. (A and B) Naïve CD4+ T cells were stimulated with anti-CD3/CD28 (TCR), TGF-β (5 ng/ml) and IL-6 (20 ng/ml) in the presence of the indicated Kenpaullone (Kenp) concentrations for 30 min (A) or 24 h (A and B).

    Biochem Biophys Res Commun, 2013, 435(3):378-84. . Kenpaullone purchased from Selleck.

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Biological Activity

Description Kenpaullone is an ATP-competitive inhibitor of cyclin-dependent kinases (CDKs). It also inhibit glycogen synthase kinase 3β (GSK3β) with IC50 of 0.23 µM.
GSK-3β [1]
(Cell-free assay)
CDK1/CyclinB [1]
(Cell-free assay)
CDK2/CyclinA [1]
(Cell-free assay)
CDK5/p35 [1]
(Cell-free assay)
CDK2/CyclinE [1]
(Cell-free assay)
0.23μM 0.4μM 0.68μM 0.85μM 7.5μM
In vitro

In HEK-293 cells, phosphorylation of the endogenous GSK3α on Tyr279 is greatly decreased after prolonged incubation with Kenpaullone. Also, the Phosphorylation of the endogenous GSK3β also decreases, although less markedly. Kenpaullone also induces the dephosphorylation of both GSK3 isoforms in SH-SY5Y cells and PC12 cells. Kenpaullone (20µM) strongly suppresses the autophosphorylation of GSK3β at Tyr216 in vitro whether GSK3 is expressed in Sf21 cells or in E. coli[2][3].


Solubility (25°C)

In vitro DMSO 65 mg/mL (198.66 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+50% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 327.18


CAS No. 142273-20-9
Storage powder
in solvent
Synonyms N/A
Smiles C1C2=C(C3=CC=CC=C3NC1=O)NC4=C2C=C(C=C4)Br

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID