K03861

Catalog No.S8100 Synonyms: AUZ 454,AUZ454

For research use only.

K03861 (AUZ 454,AUZ454) is a type II CDK2 inhibitor with Kd of 50 nM, 18.6 nM, 15.4 nM, and 9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely.

K03861 Chemical Structure

CAS No. 853299-07-7

Selleck's K03861 has been cited by 8 Publications

Purity & Quality Control

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Biological Activity

Description K03861 (AUZ 454,AUZ454) is a type II CDK2 inhibitor with Kd of 50 nM, 18.6 nM, 15.4 nM, and 9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely.
Targets
CDK2(C118L/A144C) [1]
(Cell-free assay)
CDK2(A144C) [1]
(Cell-free assay)
CDK2(C118L) [1]
(Cell-free assay)
CDK2(WT) [1]
(Cell-free assay)
9.7 nM(Kd) 15.4 nM(Kd) 18.6 nM(Kd) 50 nM(Kd)
In vitro

K03861 inhibits CDK2 activity by competing with binding of activating cyclins. [1]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 100 mg/mL
(199.4 mM)
Ethanol 15 mg/mL
(29.91 mM)
Water Insoluble

Chemical Information

Molecular Weight 501.50
Formula

C24H26F3N7O2

CAS No. 853299-07-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)NC3=CC=C(C=C3)OC4=NC(=NC=C4)N)C(F)(F)F

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO % % Tween 80 % ddH2O
%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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