Pioglitazone HCl

Catalog No.S2046 Synonyms: AD-4833, U-72107E

Pioglitazone HCl Chemical Structure

Molecular Weight(MW): 392.9

Pioglitazone HCl is a selective peroxisome proliferator-activated receptor-gamma (PPARgamma) agonist, used to treat diabetes.

Size Price Stock Quantity  
In DMSO USD 50 In stock
USD 40 In stock
USD 170 In stock
USD 370 In stock
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2 Customer Reviews

  • Primary hepatocytes were treated with or without 20μM Wy14643/Pioglitazone/Rosiglitazone for 24h followed by stimulation with or without 1μg/ml recombinant human FGF21 for 15min. FGF21 signaling was analyzed by phosphorylation of ERK1/2 and FRS2 examination.

    Mol Nutr Food Res, 2017, 61(9). Pioglitazone HCl purchased from Selleck.

    Accumulated 7-day BrdU labeling in representative sections of pancreatic islets from mice fed (A) normal chow, (B) HFD, (C) HFD+clodronate, and (D) HFD+pioglitazone. β-Cells were immunostained with anti-insulin Ab (green) and for replication with anti-BrdU Ab (red). Nuclei were stained in blue. Scale bar, 100 μm. The percentage of BrdU-positive β-cells was calculated. Values are means±SE with 5 pancreas samples in each experimental group analyzed and are shown in E. *P<0.05 where significant difference was detected between the HFD mice and other treatment groups. No significant difference was detected between the results of other groups.

    Endocrinology and Metabolism, 2016, 311(4): E763-E771.. Pioglitazone HCl purchased from Selleck.

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Biological Activity

Description Pioglitazone HCl is a selective peroxisome proliferator-activated receptor-gamma (PPARgamma) agonist, used to treat diabetes.
Targets
PPARgamma [1]
In vitro

Pioglitazone inhibits LPS-induced iNOS expression and NO generation, and inhibition of iNOS is sufficient to protect dopaminergic neurons against LPS insult. Pioglitazone protects dopaminergic neurons against LPS insult at least via inhibiting iNOS expression and NO generation, which is potentially mediated via inhibition of p38 MAPK activity. Pioglitazone inhibits LPS-induced phosphorylation of p38 MAPK. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
COS cells MVrGeY5kfGmxbjDhd5NigQ>? NWHwR5g4XHKjboPjdolxfGmxbnHsJIFkfGm4YYTpc44hcW5iQ1;TJINmdGy|IHX4dJJme3OrbnegVHBCWiCpYX3tZUBidmRiUmjSJIFteGijOzD2ZYx2\XNiaX6geIhmKHCjcnXueIhme2W|IHnu[Ilk[XSnczC5OUUh[2:wZnnk[Y5k\SCrboTldpZidCxiRVO1NF0xNjR7IN88US=> NGrPNYUyOTlyNkK5Ny=>
HepG2 cells NXnlbmNCTnWwY4Tpc44h[XO|YYm= MVXQ[ZJwgGm|b33lJJBzd2yrZnXyZZRweiCjY4TpeoF1\WRicnXj[ZB1d3JiZ3HtcYEh[WexbnnzeIlkKGGldHn2bZR6KGmwIFjldGczKGOnbHzzMEBGSzVyPUeuOkDPxE1? MYGxNFcyPDVyMx?=

... Click to View More Cell Line Experimental Data

In vivo Pioglitazone administered orally (0.3-3 mg/kg/d for 7 days) dose dependently reduces hyperglycemia, hyperlipidemia, and hyperinsulinemia in male fatty rats. Pioglitazone improves glucose tolerance and augmentes the glycemic response to exogenous insulin and clearance of plasma triglyceride in rats. [2] Pioglitazone-treated transgenic mice reveals improved muscle strength and body weight, exhibits a delayed disease onset, and survives significantly longer than nontreated SOD1-G93A mice. [3] Pioglitazone markedly decreases hyperglycemia, hyperlipidemia, hyperinsulinemia, and glucoseintolerance characterized as insulin resistant states in these rats and mice. Pioglitazone potentiates insulin-mediated glucose metabolism in the diaphragm and adipose tissues of yellow KK mice and enhanced the glycemic response to exogenous insulin in Zucker fatty rats. [4] Pioglitazone results in a reduction in the number of activated microglia and reactive astrocytes in the hippocampus and cortex of APPV717I transgenic mice. Pioglitazone decreases beta-secretase-1 (BACE1) mRNA and protein levels in APPV717I transgenic mice. [5]

Protocol

Solubility (25°C)

In vitro DMSO 79 mg/mL (201.06 mM)
Ethanol 4 mg/mL (10.18 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 392.9
Formula

C19H20N2O3S.HCl

CAS No. 112529-15-4
Storage powder
in solvent
Synonyms AD-4833, U-72107E

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01217073 Completed Type 2 Diabetes Mellitus Merck Sharp & Dohme Corp. October 8 2010 Phase 2
NCT03457597 Completed Healthy Corcept Therapeutics March 6 2018 Phase 1
NCT02787551 Active not recruiting Type 2 Diabetes Mellitus Sanofi July 6 2016 Phase 3
NCT00722371 Completed Type 2 Diabetes Mellitus Merck Sharp & Dohme Corp. September 5 2008 Phase 3
NCT01517165 Terminated Opioid-Related Disorders National Institute on Drug Abuse (NIDA)|National Institutes of Health Clinical Center (CC) January 4 2012 Phase 1
NCT00604578 Withdrawn Asthma|Airway Inflammation|Airflow Obstruction|Airway Hyperactivity National Heart Lung and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC) January 4 2008 Phase 2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID