Verapamil HCl

Catalog No.S4202

Verapamil HCl Chemical Structure

Molecular Weight(MW): 491.06

Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent.

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Cited by 10 Publications

3 Customer Reviews

  • The proportion of SP cells in HepG2 and HCCLM3 cell lines were 0.16% and 32.2%, which reduced to 0% and 0.28% in the presence of verapamil.

    Front Pharmacol, 2018, 9:1298. Verapamil HCl purchased from Selleck.

    f, Cells were pretreated with or without 5 μM verapamil and then treated with the indicated concentrations of 17-DMAG for 6 h. The proteins involved in ALK-related signaling were detected by western blot analysis.

    BMC Cancer, 2015, 15:553.. Verapamil HCl purchased from Selleck.

  • J45.01 cells were suspended in a growth medium containing 0.1 μM 5-CFDA and kept on ice for 20 min to allow its uptake. The effects of verapamil (MDR1 inhibitor) and MK571 (MRP1 inhibitor) on the efflux of 5-CF at 37°C was determined by flow cytometry (B).

    Exp Hematol, 2017, 2.436. Verapamil HCl purchased from Selleck.

Purity & Quality Control

Choose Selective Calcium Channel Inhibitors

Biological Activity

Description Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent.
Targets
Calcium channel [2]
In vitro

The enzyme hydrolase activity of recombinant CES2 is substantially inhibited by diltiazem and verapamil (Ki = 0.25 ± 0.02 and 3.84 ± 0.99μM, respectively).

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MDA435/LCC6 cells MlPCSpVv[3Srb36gZZN{[Xl? NVPCV|FEWmW4ZYLzZYwhd2ZidnnuZoxie3SrbnWgdoV{cXO2YX7j[UBqdiCvdXz0bYRzfWdicnXzbZN1[W62IF3ERVQ{PS:OQ1O2JINmdGy|IHL5JG1VWyCjc4PhfUwhUUN3ME2wMlAxODJ3IN88US=> NH3XT5AyPzF3NEWwOS=>
HCT116/VM46 cell MnjDSpVv[3Srb36gZZN{[Xl? NXTNNZZQOSEQvF2= NWLY[JZSTW[oZXP0JI9vKH[rbnLsZZN1cW6nIFnDOVAh[WejaX7zeEBOTFJiaIXtZY4h[2G{Y3nuc41iKEiFVEGxOk9XVTR4IHPlcIwhdGmwZTDheEBiKGSxc3Wgc4YhOSC3TTDjc45k\W62cnH0bY9vNCCLQ{WwQVAvODB2IN88US=> MmnZNVI4Ojl4NkO=
KB-3-1 cells MXHGeY5kfGmxbjDhd5NigQ>? M{m1O|Uh|ryP NVXJTHhpPjhiaB?= NUT0O2hbWmW4ZYLzZYwhd2ZiUD3ndE1u\WSrYYTl[EBufWy2aXTyeYchemW|aYP0ZY5k\SC2bzDDfZRwfG:6aXPpeJkhd2ZiY3;sZ4hq[2mwZTDh[4FqdnO2IHj1cYFvKEuELUOtNUBk\WyuczDheEA2KHWPIHHmeIVzKDZ6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OC5yMES3JO69VQ>? MXSxO|Q5QDF{OB?=
human KBV20C cells NWXs[HVmS3m2b4TvfIlkyqCjc4PhfS=> MXXDfZRwfG:6aXPpeJkh[WejaX7zeEBufWy2aXTyeYchemW|aYP0ZY51KFBvZ4Cg[ZhxemW|c3nu[{BpfW2jbjDLRnYzOENiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkhcW5icILld4Vv[2Vib3[gdIFkdGm2YYjlcEBjgSCPVGOgZZN{[XluIFnDOVA:OC5yMTFOwG0> Mo\ZNVgzQTV2OUC=
human KB/VCR cells MkHER5l1d3SxeHnjxsBie3OjeR?= NUfZeZNPOjVizszN MkjhO|IhcA>? MnizR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT2IwXkOUIHPlcIx{KGG|c3Xzd4VlKGG|II\pcoNzcXO2aX7lJGlEPTBiYYSgNlUhfU1iYX\0[ZIhPzJiaILzJIJ6KFOUQjDt[ZRpd2RuIFnDOVA:OC5yMjFOwG0> NIGxXoUzPTV7N{CxNC=>
K562 cells NXH2cXhxTnWwY4Tpc44h[XO|YYm= NYH1XJdWOyEQvF2= M{SxS|czKGh? M2O3O21w\HWuYYTvdpkh[WO2aY\peJkh[XRiUD3ndEBie3Onc4Pl[EBieyCmb4jvdpVjcWOrbjDJR|UxKGmwIHj1cYFvKEt3NkKgZ4VtdHNiYYSgN{B2VSCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6KCiUdnKg[I95d3K3YnnjbY4h[WyxbnWgTWM2OCB;IECuNFI{KCtxLTCwMlAxPCC3TTmsJGlEPTB;MD6wNlkh|ryP M3O2flI2Ojh{Mk[z
CCRF-CEM cells MnzhSpVv[3Srb36gZZN{[Xl? NEfEbGg2KM7:TR?= NVrr[4ZpXGinIHXm[oVkfGm4ZTDkc5NmKHejczDt[YF{fXKnZDDh[4FqdnO2IGCt[4x6[2:ycn;0[YlvKGW6cILld5NqdmdiQ1PSSk1ETU1iY3XscJMhcW5idHjlJJBz\XOnbnPlJI9nKDVidV2g[IF2dm:veXPpckwhTUR3ME2wMlA1PSEQvF2= M4PDdVc3Ojl6MUe=
KB-C2 cells M2i5cWZ2dmO2aX;uJIF{e2G7 M3O0XlUh|ryP M1:wSlY5KGh? NFLpXG1T\X[ncoPhcEBw\iCSLXfwMY1m\GmjdHXkJI12dHSrZIL1[{Bz\XOrc4ThcoNmKHSxIFP5eI91d3irY3n0fUBw\iClb3zjbIlkcW6nIHHnZYlve3RiaIXtZY4hU0JvQ{KgZ4VtdHNiYYSgOUB2VSCjZoTldkA3QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvOSEQvF2= MmDENVc1QDhzMki=
CHO cells M4DGZmZ2dmO2aX;uJIF{e2G7 M2TrTmlvcGmkaYTpc44hd2ZiaIXtZY4hTVKJIHX4dJJme3OnZDDpckBEUE9iY3XscJMh[nlid3jvcIUh[2WubDDwZZRkcCClbHHtdEB1\WOqbnnxeYUtKEmFNUC9NE4yPDF{NTFOwG0> M1Lse|E5PDR6M{Sy
MCF7 cells NVe5eHh1TnWwY4Tpc44h[XO|YYm= NUO5SJc{UW6qaXLpeIlwdiCxZjDoeY1idiCHUlegbY4hVUOINzDj[YxteyxiSVO1NF0xNjF2NEW0JO69VQ>? Mn7TNVkyOTB|NEG=
NCI-H292 cells MVvGeY5kfGmxbjDhd5NigQ>? NHz2NVA2OCEQvF2= NGL6e5U4OiCq NXK2VGdnWG:2ZX70bYF1cW:wIH;mJIdm\mm2aX7pZk1qdmS3Y3XkJIN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5EUS2KMkmyJINmdGy|IHHzd4V{e2WmIHHzJIdm\mm2aX7pZkBKSzVyIHH0JFUxKHWPIHHmeIVzKDd{IHjyd{BjgSCVUlKgZZN{[XluIFnDOVA:OC5zODFOwG0> NFmyb5czPTJzNUi1Oi=>
human KBV20C cells M3vPeWN6fG:2b4jpZ:Kh[XO|YYm= MV;DfZRwfG:6aXPpeJkh[WejaX7zeEBufWy2aXTyeYchemW|aYP0ZY51KFBvZ4Cg[ZhxemW|c3nu[{BpfW2jbjDLRnYzOENiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkhcW5icILld4Vv[2Vib3[geolv[3Krc4TpcoUh[nliTWTTJIF{e2G7LDDJR|UxRTBwMjFOwG0> NV3wXFNkOTh{OUW0PVA>
human LCC6MDR cells NH:zdG1HfW6ldHnvckBie3OjeR?= MoLTOUBl[Xm| MlnYVoV3\XK|YXygc4YhWC2pcD3t[YRq[XSnZDDkc5hwenWkaXPpck1z\XOrc4ThcoNmKGmwIHj1cYFvKEyFQ{\NSHIh[2WubIOgZYZ1\XJiNTDkZZl{KGK7IF3UV{Bie3OjeTygSWM2OD1yLkK0OUDPxE1? M1vxNlIzOzJyNECy
rat A7R5 cells Mm\YSpVv[3Srb36gZZN{[Xl? M{H3d|E2KG2rboO= NVn1XoNrSW62YXfvcol{fCCjY4Tpeol1gSCjdDDjZYxkcXWvIHPoZY5v\WxiaX6gdoF1KEF5UkWgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCFYXPsNk9MS2xvaX7keYNm\CCrbnPy[YF{\SCrbjDpcpRz[WOnbHz1cIFzKEOjMjugbY5kfWKjdHXkJIZweiBzNTDtbY5{KHC{aX;yJJRwKEOjY3yyM2tEdCClaHHscIVv\2ViYomg[ox2d3Knc3PlcoNmKGG|c3H5MEBKSzVyPUCuN{DPxE1? MXyyOVMyOTV4NB?=
MDCK cells NEH4R|JHfW6ldHnvckBie3OjeR?= NWXLfnlJOzBibXnudy=> MVjJcohq[mm2aX;uJI9nKGi3bXHuJG1FWjFiZYjwdoV{e2WmIHnuJG1FS0tiY3XscJMh[XO|ZYPz[YQh[XNiY3HsZ4VqdiCDTTDhZ4N2dXWuYYTpc44h[W[2ZYKgN|AhdWmwczDifUBndHWxcnXzZ4Vv[2ViYYPzZZktKEmFNUC9NE42KM7:TR?= MX6yNlEyOjJyOB?=
human CEM/VLB500 cells MnHYSpVv[3Srb36gZZN{[Xl? MYOzJIRigXN? NIPLcZdT\X[ncoPhcEBw\iCSLXfwMY1m\GmjdHXkJI12dHSrZIL1[{Bz\XOrc4ThcoNmKHSxII\pcoJt[XO2aX7lJIlvKGi3bXHuJGNGVS:YTFK1NFAh[2WubIOgZYZ1\XJiMzDkZZl{KGK7IILld4F7fXKrbjDhd5NigSxiRVO1NF0yNjB2MTFOwG0> NV3aR3NLOTd|OUm5PVA>
human NCI-H292 cells MXTGeY5kfGmxbjDhd5NigQ>? M{izOVUxKM7:TR?= NV\CbVZlPzJiaB?= MUnQc5RmdnSrYYTpc44hd2ZiZYLsc5RqdmmkLXnu[JVk\WRiY4n0c5RwgGmlaYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWgzQTJiY3XscJMh[XO|ZYPz[YQh[XNiZYLsc5RqdmmkIFnDOVAh[XRiNUCgeW0h[W[2ZYKgO|IhcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME2xMlIh|ryP MWCyOVIyPTh3Nh?=
human KB/VCR cells MnP2SpVv[3Srb36gZZN{[Xl? M{XLSFczKGh? NUHGUVM1UW6qaXLpeIlwdiCxZjDwMYdxKGmwIHj1cYFvKEuEL2\DVkBk\WyuczDhd5Nme3OnZDDhd{Bxd3SnboTpZZRqd25ib3[gNVAxKG6PIHTvZ4V1[XinbD3pcoR2[2WmIHP5eI91d3irY3n0fUBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBGSzVyPUGuNlU{KM7:TR?= NUPFelRDOjN4OEO4N|Q>
human K562/DOX cells MlnYSpVv[3Srb36gZZN{[Xl? MkPrUY9lfWyjdH;yfUBi[3Srdnn0fUBifCCSLXfwJIlvKGi3bXHuJGs2PjJxRF;YJINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKG63Y3zlZZIh[2:wY3XueJJifGmxbjDv[kBxcXKjcoXibYNqdiCkeTDzdIVkfHKxZnz1c5JwdWW2cnnjJIF{e2G7LDDJR|UxRTFwNjFOwG0> MonNNlUzQDJ{NkO=
human KBV1 cells NH[0bm1EgXSxdH;4bYPDqGG|c3H5 NILXWmY1QCCq MWnDfZRwfG:6aXPpeJkh[WejaX7zeEB3cW6kbHHzeIlv\SC{ZYPpd5RidnRiaIXtZY4hU0KYMTDj[YxteyCjZoTldkA1QCCqcoOgbY4heHKnc3XuZ4Uhd2ZiMUCwJI5OKH[rbnLsZZN1cW6nIHL5JHNTSiCvZYToc4QtKEmFNUC9NU43KM7:TR?= MnTpNVA{PDZ7NEi=
A2780 cells MXXGeY5kfGmxbjDhd5NigQ>? M4DCTmlvcGmkaYTpc44hd2ZiUD3ndEBqdiCqdX3hckBi\HKrYX35Z4lvNXKnc3nzeIFvfCCDMke4NEBk\WyuczDifUBJd2WlaIP0JFM{OzR{IHHzd4F6NCCLQ{WwQVQvPTdyOEig{txO NGLQN3IyQDZ5OES5OS=>
human MCF7/ADR cells MVvGeY5kfGmxbjDhd5NigQ>? MYixNEDPxE1? M4LCSVQ5KGh? M2TIdmlvcGmkaYTpc44hd2ZiUD3ndEBqdiCqdX3hckBOS0Z5L1HEVkBk\WyuczDhd5Nme3OnZDDhd{Bz\X[ncoPhcEBw\iCvdXz0bYRzfWdicnXzbZN1[W6lZTDheEAyOCC3TTDifUBu\WG|dYLpcochTUN3MDDmc5Ih[WS{aXHtfYNqdi2rbnT1Z4VlKGO7dH;0c5hq[2m2eTDh[pRmeiB2ODDodpMh[nliU2LCJINwdG:{aX3leJJq[yCjc4PhfUwhTUN3ME20Mlg6KM7:TR?= MlTrNlU5PTZ3NEW=
MDCK2 cells MkTUSpVv[3Srb36gZZN{[Xl? NYj3TmVSOjBibXnudy=> Ml\6SY5p[W6lZX3lcpQhd2ZiY3HsZ4Vqdi2DTTD1dJRic2ViaX6gUWREUzJiY3XscJMhd3[ncjDlfJBz\XO|aX7nJG1FWjFiYX\0[ZIhOjBibXnud{whTUN3ME21MlEh|ryP M2K2TlE5QDR7MU[3
human 2008 cells MWDGeY5kfGmxbjDhd5NigQ>? MnPCTY5pcWKrdHnvckBw\iCqdX3hckBOWlBzIHnuJIh2dWGwIEKwNFgh[2WubIOsJGlEPTB;OT62OkDPxE1? NHn0RWoyQDdyN{i4OC=>
human H460 cells NYPhXWRYTnWwY4Tpc44h[XO|YYm= MX61NEDPxE1? NFTpbHA4OiCq MYfQc5RmdnSrYYTpc44hd2ZiZYLsc5RqdmmkLXnu[JVk\WRiY4n0c5RwgGmlaYT5JIFo[Wmwc4SgbJVu[W5iSES2NEBk\WyuczDhd5Nme3OnZDDhd{BmemyxdHnubYIhUUN3MDDheEA2OCC3TTDh[pRmeiB5MjDodpMh[nliU2LCJIF{e2G7LDDJR|UxRTFyLkOg{txO NUHhNphiOjV{MUW4OVY>
hamster BHK21 cells MkiyR5l1d3SxeHnjxsBie3OjeR?= NYSwN5RRQTZiaB?= MYPDfZRwfG:6aXPpeJkh[WejaX7zeEBp[W2|dHXyJGJJUzJzIHPlcIx{KGW6cILld5NqdmdiTWLQNUBi\nSncjC5OkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUGwMlYh|ryP NV3nOXB5OjB4OUG1PVk>
KB cells MUnGeY5kfGmxbjDhd5NigQ>? Mn\wO|IhcA>? Ml3lTY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JGtDKGOnbHygcIlv\SCjZoTldkA4OiCqIH;mJIRzfWdiZYjwc5N2emVuIFnDOVA:OTlwNjFOwG0> M2LvNlE2PDhzOUmx
Caco-2 cells MmjHSpVv[3Srb36gZZN{[Xl? Mn3ETY5pcWKrdHnvckBw\iCSZ4CgcYVie3W{ZXSgZZMhcW6qaXLpeIlwdiCxZjDbN2hefmmwYnzhd5RqdmViYnHzc4xifGW{YXygeI8h[XCrY3HsJJRz[W6|cH;yeEBqdiCFYXPvMVIh[2WubIOsJGVEPTB;MkCg{txO Mnr6NVcxPjRyN{m=
human KB31 cells M2HkOWN6fG:2b4jpZ:Kh[XO|YYm= MYe0PEBp NF[4ZpBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMSjNzIHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJibXX0bI9lNCCLQ{WwQVQ2NjJizszN Mlj0NVA{PDZ7NEi=

... Click to View More Cell Line Experimental Data

In vivo Verapamil confers an anti-arrhythmic effect via calcium influx inhibition, inhibition of oxygen consumption and accompanied by preservation of Cx43 protein in rat heart.

Protocol

Solubility (25°C)

In vitro DMSO 98 mg/mL (199.56 mM)
Water 50 mg/mL (101.82 mM)
Ethanol 12 mg/mL (24.43 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 491.06
Formula

C27H38N2O4.HCl

CAS No. 152-11-4
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04014634 Recruiting Drug: Methylprednisolone|Other: Placebo Cluster Headache Episodic|Greater Occipital Nerve Injection Leiden University Medical Center|Hersenstichting|Innovatiefonds Zorgverzekeraars August 1 2019 Phase 4
NCT02912663 Recruiting Drug: Verapamil and Magnesium Sulfate|Other: Placebo Ischemic Stroke Justin Fraser|University of Kentucky October 11 2017 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID