Verapamil (CP-16533-1) HCl

Catalog No.S4202

For research use only.

Verapamil HCl (CP-16533-1) is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits both permeability-glycoprotein (P-gp) and CYP3A4.

Verapamil (CP-16533-1) HCl Chemical Structure

CAS No. 152-11-4

Selleck's Verapamil (CP-16533-1) HCl has been cited by 20 publications

Purity & Quality Control

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Biological Activity

Description Verapamil HCl (CP-16533-1) is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits both permeability-glycoprotein (P-gp) and CYP3A4.
Targets
Calcium channel [2]
In vitro

The enzyme hydrolase activity of recombinant CES2 is substantially inhibited by diltiazem and verapamil (Ki = 0.25 ± 0.02 and 3.84 ± 0.99μM, respectively).

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HCT116/VM46 cell NHHI[JNHfW6ldHnvckBie3OjeR?= NI\4elQyKM7:TR?= NGCyVpRG\m[nY4Sgc44hfmmwYnzhd5RqdmViSVO1NEBi\2GrboP0JG1FWiCqdX3hckBk[XKlaX7vcYEhUEOWMUG2M3ZOPDZiY3XscEBtcW6nIHH0JIEh\G:|ZTDv[kAyKHWPIHPvcoNmdnS{YYTpc44tKEmFNUC9NE4xODRizszN NE\qNm89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkeyPVY3Oyd-MUK3Nlk3PjN:L3G+
human MCF7/ADR cells MlzySpVv[3Srb36gZZN{[Xl? NEj1e2IyOCEQvF2= M2rWdlQ5KGh? NHHYNpRKdmirYnn0bY9vKG:oIGCt[5AhcW5iaIXtZY4hVUOINz;BSHIh[2WubIOgZZN{\XO|ZXSgZZMhemW4ZYLzZYwhd2ZibYXseIllenWpIILld4l{fGGwY3WgZZQhOTBidV2gZpkhdWWjc4XybY5oKEWFNUCg[o9zKGGmcnnhcZlkcW5vaX7keYNm\CCleYTveI95cWOrdImgZYZ1\XJiNEigbJJ{KGK7IGPSRkBkd2yxcnnt[ZRzcWNiYYPzZZktKEWFNUC9OE45QSEQvF2= NVezPFFkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4OVY2PDVpPkK1PFU3PTR3PD;hQi=>
NG108-15 MlvvSpVv[3Srb36gZZN{[Xl? MmiwWIhmKGOxbYDveY5lKHejczD0[ZN1\WRiZn;yJIlvcGmkaYTpc44hd2ZiY3HsZ4l2dSCrbn\seZghcW62bzDu[ZVzd26jbDCoUmcyODhvMUWpJINmdGy|LDDJR|UxRTZwNd88US=> M2XSWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{O1PFQoRjJyM{O1PFQ9N2F-
CCRF-CEM MX3GeY5kfGmxbjDhd5NigQ>? M1nGSnRp\SCnZn\lZ5RqfmViZH;z[UB4[XNibXXhd5Vz\WRiYXfhbY5{fCCSLXfsfYNweHKxdHXpckBmgHC{ZYPzbY5oKEOFUl[tR2VOKGOnbHzzJIlvKHSqZTDwdoV{\W6lZTDv[kA2KHWPIHTheY5wdXmlaX6sJGVFPTB;MD6wOFXPxE1? MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek84PjJ7OEG3K|44PjJ7OEG3QE9iRg>?
CCRF-CEM MlPDSpVv[3Srb36gZZN{[Xl? MoPpWIhmKGWoZnXjeIl3\SCmb4PlJJdieyCvZXHzeZJm\CCjZ3HpcpN1KFBvZ3z5Z49xem:2ZXnuJIV5eHKnc4PpcochS0OURj3DSW0h[2WubIOgbY4hfGinIIDy[ZNmdmOnIH;mJFUhfU1iZYTvdI9{cWSnLDDFSFUxRTNwNN88US=> MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek84PjJ7OEG3K|44PjJ7OEG3QE9iRg>?
MCF7/VP MlvXSpVv[3Srb36gZZN{[Xl? NX;EVJRUOjBidV2= NU\hOlhoPDhiaILz MUXJcohq[mm2aX;uJI9nKE2UUDDlfJBz\XO|ZXSgbY4hcHWvYX6gUWNHPy:YUDDj[YxteyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckB3cW6lcnnzeIlv\S2rbnT1Z4VlKGO7dH;0c5hq[2m2eTDheEAzOCC3TTDh[pRmeiB2ODDodpMh[nliU2LCJIJqdmSrbnegZZN{[Xl? MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek85Pzh4M{[0K|45Pzh4M{[0QE9iRg>?
MCF/ADR NHXwUoVHfW6ldHnvckBie3OjeR?= MVfS[ZZmenOjbDDv[kBRNWeyLX3l[IlifGWmIH31cJRq\HK3ZzDy[ZNqe3SjbnPlJIlvKGi3bXHuJG1ETi:DRGKgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hemixZHHtbY5mKD[JIHHjZ5VufWyjdHnvci=> M2DIe|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzh7OESxOVEoRjh7OESxOVE9N2F-
B16/F10 NHL1S4NHfW6ldHnvckBie3OjeR?= MkHMTY5pcWKrdHnvckBw\iCqdX3hckBOTFJzIHX4dJJme3OnZDDpckBud3W|ZTDCNVYwTjFyIHPlcIx{KGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIRwgG:{dXLpZ4lvKGGlY4XteYxifGmxbjDifUBndHWxcnnt[ZRzgSxiRVS1NF0{|ryP Mmn0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTR4MU[1PEc,QTR4MU[1PFww[T5?
HeLa NYTPPYluTnWwY4Tpc44h[XO|YYm= M2G4PHRRZ1SUQV7TVG9TXEWUOjDpcohq[mm2aX;uJI9nKFSHQTD1dJRic2ViaX6gU2NVOS2neIDy[ZN{cW6pIFjlUIEh[2WubIOsJGtqRTJwOd88US=> MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86PjV3OEiwK|46PjV3OEiwQE9iRg>?
K562/DOX MDR MWjDfZRwfG:6aXPpeJkh[XO|YYm= MoDoRYJqdGm2eTD0c{Bxd3SnboTpZZRmKESRWDDjfZRwfG:6aXPpeJkhd25iS{W2Nk9FV1hiTVTSJINmdGy|LjDD[YxtKHO3co\peoFtKHejczDhd5NigWWmIHL5JG1VXCClb372[ZJ{cW:wLDDJR|UxRTN5zszN MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86QTh4N{G4K|46QTh4N{G4QE9iRg>?
KBV1 MUHDfZRwfG:6aXPpeJkh[XO|YYm= NH;5cnk1QCCqcoO= M{OzbWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KH[rbnLsZZN1cW6nIILld4l{fGGwdDDoeY1idiCNQm[xJINmdGy|IHHmeIVzKDR6IHjyd{BqdiCycnXz[Y5k\SCxZjCxNFAhdk1idnnuZoxie3SrbnWgZpkhW1KEIH3leIhw\CxiSVO1NF0yNjcQvF2= MlXGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB|NE[5OFgoRjFyM{S2PVQ5RC:jPh?=
KBV1 NVfNW41KS3m2b4TvfIlkcXS7IHHzd4F6 MXi0PEBpenN? NYrlbms5S3m2b4TvfIlkcXS7IHHnZYlve3RidnnuZoxie3SrbnWgdoV{cXO2YX70JIh2dWGwIFvCWlEh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IGPSRkBu\XSqb3SsJGlEPTB;M{muNu69VQ>? NUPaOFRlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUCzOFY6PDhpPkGwN|Q3QTR6PD;hQi=>
KB31 Mn7JR5l1d3SxeHnjbZR6KGG|c3H5 NXXNTFRJPDhiaILz M3PSU2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGtDOzFiY3XscJMh[W[2ZYKgOFghcHK|IHL5JHNTSiCvZYToc4QtKEmFNUC9OFUvOs7:TR?= M{XKUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyM{S2PVQ5Lz5zMEO0Olk1QDxxYU6=
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Caco-2 M1fLWmZ2dmO2aX;uJIF{e2G7 NGXxeJNVWF:WUlHOV3BQWlSHUkqgbY5pcWKrdHnvckBw\iCGaXfvfIlvKHS{YX7z[ZBqfGinbHnhcEB1emGwc4DvdpQhMGKjc3HsJJRwKGGyaXPhcEkhMESrZ3;4bY47KDVidV2pJIlvKEOjY3:tNkBk\WyuczygTWM2OD1{LkJOwG0> NGHCVo09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEiyNFE{Pyd-MUC4NlAyOzd:L3G+
Caco-2 NWLCWHhNTnWwY4Tpc44h[XO|YYm= MYDUVH9VWkGQU2DPVnRGWjpiaX7obYJqfGmxbjDv[kBV[XixbDD0doFve2WyaYTo[Yxq[WxidILhcpNxd3K2IDjiZZNidCC2bzDhdIlk[WxrIHnuJGNi[29vMjDj[YxteyxiS3m9N:69VQ>? NUXpRVRqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUG0NFUzQDdpPkGxOFA2Ojh5PD;hQi=>
G185 NVzON4tYTnWwY4Tpc44h[XO|YYm= NFy4cmJVWF:WUlHOV3BQWlSHUkqgbY5pcWKrdHnvckBw\iCGYYXuc5J2[mmlaX6g[YZndHW6IDjEZZVvd3K3YnnjbY47KD9idV2pJIlvKEdzOEWgZ4VtdHNuIFnDOVA:PC5{zszN MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTR3NEeyOEc,OTF2NUS3NlQ9N2F-
NIH-3T3-G185 MkLRSpVv[3Srb36gZZN{[Xl? MoTGWHBgXFKDTmPQU3JVTVJ8IHnubIljcXSrb36gc4YhTGG3bn;yeYJq[2mwIHXm[ox2gCCrbjDOTWguO1R|LVexPFUh[2WubIOsJGlEPTB;ND6y{txO M3ryPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzN{G2OVE1Lz5zMUexOlUyPDxxYU6=
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NIH-3T3-G185 NETEUWFHfW6ldHnvckBie3OjeR?= NIPyXmNVWF:WUlHOV3BQWlSHUkqgbY5pcWKrdHnvckBw\iCFYXzj[YlvNUGPIHXm[ox2gCCrbjDOTWguO1R|LVexPFUh[2WubIOsJGlEPTB;MkiuPe69VQ>? NGHHS4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUexOlUyPCd-MUG3NVY2OTR:L3G+
NIH-3T3-G185 NUPzSHBHTnWwY4Tpc44h[XO|YYm= M2CzRXRRZ1SUQV7TVG9TXEWUOjDpcohq[mm2aX;uJI9nKFSndILhcYV1cHmucn;zZY1qdmViZX\mcJV5KGmwIF7JTE0{XDNvR{G4OUBk\WyuczygTWM2OD1|OD6y{txO M4jDSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzN{G2OVE1Lz5zMUexOlUyPDxxYU6=
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CAKI1 NVe2WGdUTnWwY4Tpc44h[XO|YYm= NYjCO4w{OC56IITvJFEzNjVidXevcWw> MmnEUY9lfWyjdHnvckBw\iCSLXfwJIlvKGi3bXHuJGNCU0lzIHPlcIx{KGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJGRKVkmELXnu[JVk\WRiY4n0c5RwgGmlaYT5JIF1KDBwODD0c{AyOi53IIXnM41N M{Ppc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzN{W0OlAzLz5zMUe1OFYxOjxxYU6=
MDA-435/LCC6 and MDA-435/LCC6-MDRI cells MXPGeY5kfGmxbjDhd5NigQ>? MXrDc45k\W62cnH0bY9vKHSqYYSgdoVlfWOnczDkbYZn\XKnbnPlJIlvKHKndnXyd4FtKG:oIGuzTH1XSkxiYXPjeY12dGG2aX;uJIJmfHenZX6gUWRCNTR|NT;MR2M3KGGwZDDNSGEuPDN3L1zDR|YuVUSUSTDj[YxteyCkeTC1NEUtKEWFNUC9NU4z|ryP NVzySo1GRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUG3PFQyPDNpPkGxO|g1OTR|PD;hQi=>
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MDA435/LCC6 MDR1 M1jJUGZ2dmO2aX;uJIF{e2G7 MULUVH9VWkGQU2DPVnRGWjpicnX2[ZJ{[Wxib3[gWolv[myjc4TpcoUh[WOldX31cIF1cW:wIDjWbY5jdGG|dHnu[VohOC5yMEWgeW0qKGmwIF3ERVQ{PS:OQ1O2JG1FWjFiY3XscJMtKEWFNUC9N{4y|ryP M1HBZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzN{i0NVQ{Lz5zMUe4OFE1OzxxYU6=
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In vivo Verapamil confers an anti-arrhythmic effect via calcium influx inhibition, inhibition of oxygen consumption and accompanied by preservation of Cx43 protein in rat heart.

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 98 mg/mL
(199.56 mM)
Water 50 mg/mL
(101.82 mM)
Ethanol ''12 mg/mL

Chemical Information

Molecular Weight 491.06
Formula

C27H38N2O4.HCl

CAS No. 152-11-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC.Cl

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04406259 Not yet recruiting Drug: Verapamil Cluster Headache Centre Hospitalier Universitaire de Nice September 1 2020 Phase 4
NCT04014634 Unknown status Drug: Methylprednisolone|Other: Placebo Cluster Headache Episodic|Greater Occipital Nerve Injection Leiden University Medical Center|Netherlands Brain Foundation|Innovatiefonds Zorgverzekeraars August 1 2019 Phase 4
NCT02912663 Completed Drug: Verapamil and Magnesium Sulfate|Other: Placebo Ischemic Stroke Justin Fraser|University of Kentucky October 11 2017 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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