Verapamil HCl

Catalog No.S4202

Verapamil HCl Chemical Structure

Molecular Weight(MW): 491.06

Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent.

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Cited by 5 Publications

3 Customer Reviews

  • The proportion of SP cells in HepG2 and HCCLM3 cell lines were 0.16% and 32.2%, which reduced to 0% and 0.28% in the presence of verapamil.

    Front Pharmacol, 2018, 9:1298. Verapamil HCl purchased from Selleck.

    f, Cells were pretreated with or without 5 μM verapamil and then treated with the indicated concentrations of 17-DMAG for 6 h. The proteins involved in ALK-related signaling were detected by western blot analysis.

    BMC Cancer, 2015, 15:553.. Verapamil HCl purchased from Selleck.

  • J45.01 cells were suspended in a growth medium containing 0.1 μM 5-CFDA and kept on ice for 20 min to allow its uptake. The effects of verapamil (MDR1 inhibitor) and MK571 (MRP1 inhibitor) on the efflux of 5-CF at 37°C was determined by flow cytometry (B).

    Exp Hematol, 2017, 2.436. Verapamil HCl purchased from Selleck.

Purity & Quality Control

Choose Selective Calcium Channel Inhibitors

Biological Activity

Description Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent.
Targets
Calcium channel [2]
In vitro

The enzyme hydrolase activity of recombinant CES2 is substantially inhibited by diltiazem and verapamil (Ki = 0.25 ± 0.02 and 3.84 ± 0.99μM, respectively).

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MDA435/LCC6 cells MnLLSpVv[3Srb36gZZN{[Xl? NFjXOmNT\X[ncoPhcEBw\iC4aX7icIF{fGmwZTDy[ZNqe3SjbnPlJIlvKG23bITp[JJ2\yC{ZYPpd5RidnRiTVTBOFM2N0yFQ{[gZ4VtdHNiYomgUXRUKGG|c3H5MEBKSzVyPUCuNFAxOjVizszN NUXMfoFqOTdzNUS1NFU>
HCT116/VM46 cell MnPBSpVv[3Srb36gZZN{[Xl? NFrXWYcyKM7:TR?= NITwXlZG\m[nY4Sgc44hfmmwYnzhd5RqdmViSVO1NEBi\2GrboP0JG1FWiCqdX3hckBk[XKlaX7vcYEhUEOWMUG2M3ZOPDZiY3XscEBtcW6nIHH0JIEh\G:|ZTDv[kAyKHWPIHPvcoNmdnS{YYTpc44tKEmFNUC9NE4xODRizszN NYSwOVhnOTJ5Mkm2OlM>
KB-3-1 cells M4XrfmZ2dmO2aX;uJIF{e2G7 NGHweoY2KM7:TR?= NWfMVox4PjhiaB?= M1nKWXJmfmW{c3HsJI9nKFBvZ4CtcYVlcWG2ZXSgcZVtfGmmcoXnJJJme2m|dHHuZ4UhfG9iQ4n0c5RwgGmlaYT5JI9nKGOxbHPobYNqdmViYXfhbY5{fCCqdX3hckBMSi1|LUGgZ4VtdHNiYYSgOUB2VSCjZoTldkA3QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvODB2NzFOwG0> MnLONVc1QDhzMki=
human KBV20C cells MmS1R5l1d3SxeHnjxsBie3OjeR?= NVG2[oZxS3m2b4TvfIlkcXS7IHHnZYlve3RibYXseIllenWpIILld4l{fGGwdDDQMYdxKGW6cILld5NqdmdiaIXtZY4hU0KYMkDDJINmdGy|IHHzd4V{e2WmIHHzJINmdGxidnnhZoltcXS7IHnuJJBz\XOnbnPlJI9nKHCjY3zpeIF5\WxiYomgUXRUKGG|c3H5MEBKSzVyPUCuNFEh|ryP MVGxPFI6PTR7MB?=
human KB/VCR cells NWHHT415S3m2b4TvfIlkyqCjc4PhfS=> M2rEd|I2KM7:TR?= NHvtcmE4OiCq MYLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLRk9XS1JiY3XscJMh[XO|ZYPz[YQh[XNidnnuZ5Jqe3SrbnWgTWM2OCCjdDCyOUB2VSCjZoTldkA4OiCqcoOgZpkhW1KEIH3leIhw\CxiSVO1NF0xNjB{IN88US=> NHjBXmszPTV7N{CxNC=>
K562 cells NU\nb4M1TnWwY4Tpc44h[XO|YYm= Mn;QN{DPxE1? MUO3NkBp NF:yZmFOd2S3bHH0c5J6KGGldHn2bZR6KGG2IGCt[5Ah[XO|ZYPz[YQh[XNiZH;4c5J2[mmlaX6gTWM2OCCrbjDoeY1idiCNNU[yJINmdGy|IHH0JFMhfU1iYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSBqUo\iJIRwgG:{dXLpZ4lvKGGub37lJGlEPTBiPTCwMlAzOyBtLz2gNE4xODRidV2pMEBKSzVyPUCuNFI6KM7:TR?= NITPbYozPTJ6MkK2Ny=>
CCRF-CEM cells NX;PXGFWTnWwY4Tpc44h[XO|YYm= NIWxc4o2KM7:TR?= NYP0S5JYXGinIHXm[oVkfGm4ZTDkc5NmKHejczDt[YF{fXKnZDDh[4FqdnO2IGCt[4x6[2:ycn;0[YlvKGW6cILld5NqdmdiQ1PSSk1ETU1iY3XscJMhcW5idHjlJJBz\XOnbnPlJI9nKDVidV2g[IF2dm:veXPpckwhTUR3ME2wMlA1PSEQvF2= NYXXRpRLPzZ{OUixOy=>
KB-C2 cells MXrGeY5kfGmxbjDhd5NigQ>? MlmzOUDPxE1? M134b|Y5KGh? NG\wNG5T\X[ncoPhcEBw\iCSLXfwMY1m\GmjdHXkJI12dHSrZIL1[{Bz\XOrc4ThcoNmKHSxIFP5eI91d3irY3n0fUBw\iClb3zjbIlkcW6nIHHnZYlve3RiaIXtZY4hU0JvQ{KgZ4VtdHNiYYSgOUB2VSCjZoTldkA3QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvOSEQvF2= M2\Y[|E4PDh6MUK4
CHO cells MkLrSpVv[3Srb36gZZN{[Xl? NGX2eZhKdmirYnn0bY9vKG:oIHj1cYFvKEWURzDlfJBz\XO|ZXSgbY4hS0iRIHPlcIx{KGK7IIfoc4xmKGOnbHygdIF1[2hiY3zhcZAhfGWlaH7pdZVmNCCLQ{WwQVAvOTRzMkWg{txO MnjkNVg1PDh|NEK=
MCF7 cells NFvaN5JHfW6ldHnvckBie3OjeR?= NYnrS5lGUW6qaXLpeIlwdiCxZjDoeY1idiCHUlegbY4hVUOINzDj[YxteyxiSVO1NF0xNjF2NEW0JO69VQ>? M{\UU|E6OTFyM{Sx
NCI-H292 cells NU\5[YJETnWwY4Tpc44h[XO|YYm= MoLwOVAh|ryP Mnn4O|IhcA>? MlrTVI91\W62aXH0bY9vKG:oIHfl[ol1cW6rYj3pcoR2[2WmIHP5eI91d3irY3n0fUBi\2GrboP0JIh2dWGwIF7DTU1JOjl{IHPlcIx{KGG|c3Xzd4VlKGG|IHfl[ol1cW6rYjDJR|UxKGG2IEWwJJVOKGGodHXyJFczKGi{czDifUBUWkJiYYPzZZktKEmFNUC9NE4yQCEQvF2= MlLKNlUzOTV6NU[=
human KBV20C cells M2npNmN6fG:2b4jpZ:Kh[XO|YYm= MoLpR5l1d3SxeHnjbZR6KGGpYXnud5QhdXWudHnkdpVoKHKnc3nzeIFvfCCSLXfwJIV5eHKnc4PpcochcHWvYX6gT2JXOjCFIHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwhfmmjYnnsbZR6KGmwIIDy[ZNmdmOnIH;mJJZqdmO{aYP0bY5mKGK7IF3UV{Bie3OjeTygTWM2OD1yLkKg{txO MWixPFI6PTR7MB?=
human LCC6MDR cells MWTGeY5kfGmxbjDhd5NigQ>? MljMOUBl[Xm| M2fKOnJmfmW{c3HsJI9nKFBvZ4CtcYVlcWG2ZXSg[I95d3K3YnnjbY4uemW|aYP0ZY5k\SCrbjDoeY1idiCOQ1O2UWRTKGOnbHzzJIFnfGW{IEWg[IF6eyCkeTDNWHMh[XO|YYmsJGVEPTB;MD6yOFUh|ryP NFPjfHQzOjN{MESwNi=>
rat A7R5 cells MnnySpVv[3Srb36gZZN{[Xl? NGX0fIYyPSCvaX7z Mn:zRY51[WexbnnzeEBi[3Srdnn0fUBifCClYXzjbZVuKGOqYX7u[YwhcW5icnH0JGE4WjViY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBE[WOuMj;LR4wucW6mdXPl[EBqdmO{ZXHz[UBqdiCrboTyZYNmdGy3bHHyJGNiOitiaX7jeYJifGWmIH\vdkAyPSCvaX7zJJBzcW:{IITvJGNi[2x{L1vDcEBkcGGubHXu[4Uh[nliZnz1c5Jme2OnbnPlJIF{e2G7LDDJR|UxRTBwMzFOwG0> MoHONlU{OTF3NkS=
MDCK cells NG[4[FNHfW6ldHnvckBie3OjeR?= MVGzNEBucW6| MmDnTY5pcWKrdHnvckBw\iCqdX3hckBOTFJzIHX4dJJme3OnZDDpckBOTEONIHPlcIx{KGG|c3Xzd4VlKGG|IHPhcINmcW5iQV2gZYNkfW23bHH0bY9vKGGodHXyJFMxKG2rboOgZpkh\my3b4Lld4NmdmOnIHHzd4F6NCCLQ{WwQVAvPSEQvF2= MUeyNlEyOjJyOB?=
human CEM/VLB500 cells M4HsbmZ2dmO2aX;uJIF{e2G7 NFjkOZM{KGSjeYO= NX35SZZ2WmW4ZYLzZYwhd2ZiUD3ndE1u\WSrYYTl[EBufWy2aXTyeYchemW|aYP0ZY5k\SC2bzD2bY5jdGG|dHnu[UBqdiCqdX3hckBETU1xVlzCOVAxKGOnbHzzJIFnfGW{IEOg[IF6eyCkeTDy[ZNignW{aX6gZZN{[XluIFXDOVA:OS5yNEGg{txO NWTOeohJOTd|OUm5PVA>
human NCI-H292 cells NFvEXWZHfW6ldHnvckBie3OjeR?= NIPYPYc2OCEQvF2= Ml\2O|IhcA>? MkC1VI91\W62aXH0bY9vKG:oIHXycI91cW6rYj3pcoR2[2WmIHP5eI91d3irY3n0fUBi\2GrboP0JIh2dWGwIF7DTU1JOjl{IHPlcIx{KGG|c3Xzd4VlKGG|IHXycI91cW6rYjDJR|UxKGG2IEWwJJVOKGGodHXyJFczKGi{czDifUBUWkJiYYPzZZktKEmFNUC9NU4zKM7:TR?= NEH3cmQzPTJzNUi1Oi=>
human KB/VCR cells NYnvNIlMTnWwY4Tpc44h[XO|YYm= NUToeGE1PzJiaB?= NV6wV4VuUW6qaXLpeIlwdiCxZjDwMYdxKGmwIHj1cYFvKEuEL2\DVkBk\WyuczDhd5Nme3OnZDDhd{Bxd3SnboTpZZRqd25ib3[gNVAxKG6PIHTvZ4V1[XinbD3pcoR2[2WmIHP5eI91d3irY3n0fUBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBGSzVyPUGuNlU{KM7:TR?= M2\aXlI{Pjh|OEO0
human K562/DOX cells M1vvWGZ2dmO2aX;uJIF{e2G7 NGqwRotOd2S3bHH0c5J6KGGldHn2bZR6KGG2IGCt[5AhcW5iaIXtZY4hUzV4Mj;EU3gh[2WubIOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iboXjcIVieiClb37j[Y51emG2aX;uJI9nKHCrcnHyeYJq[2mwIHL5JJNx\WO2cn;mcJVwem:vZYTybYMh[XO|YYmsJGlEPTB;MT62JO69VQ>? NYjCNGNlOjV{OEKyOlM>
human KBV1 cells NH\zWndEgXSxdH;4bYPDqGG|c3H5 Mmn6OFghcA>? NGfDXWZEgXSxdH;4bYNqfHliYXfhbY5{fCC4aX7icIF{fGmwZTDy[ZNqe3SjboSgbJVu[W5iS1LWNUBk\WyuczDh[pRmeiB2ODDodpMhcW5icILld4Vv[2Vib3[gNVAxKG6PII\pcoJt[XO2aX7lJIJ6KFOUQjDt[ZRpd2RuIFnDOVA:OS54IN88US=> MYexNFM1Pjl2OB?=
A2780 cells NU\YbIt2TnWwY4Tpc44h[XO|YYm= MoHTTY5pcWKrdHnvckBw\iCSLXfwJIlvKGi3bXHuJIFlemmjbYnjbY4uemW|aYP0ZY51KEF{N{iwJINmdGy|IHL5JGhw\WOqc4SgN|M{PDJiYYPzZZktKEmFNUC9OE42PzB6ODFOwG0> NIDDRmkyQDZ5OES5OS=>
human MCF7/ADR cells MULGeY5kfGmxbjDhd5NigQ>? NHX6fogyOCEQvF2= MmTaOFghcA>? M4rRTmlvcGmkaYTpc44hd2ZiUD3ndEBqdiCqdX3hckBOS0Z5L1HEVkBk\WyuczDhd5Nme3OnZDDhd{Bz\X[ncoPhcEBw\iCvdXz0bYRzfWdicnXzbZN1[W6lZTDheEAyOCC3TTDifUBu\WG|dYLpcochTUN3MDDmc5Ih[WS{aXHtfYNqdi2rbnT1Z4VlKGO7dH;0c5hq[2m2eTDh[pRmeiB2ODDodpMh[nliU2LCJINwdG:{aX3leJJq[yCjc4PhfUwhTUN3ME20Mlg6KM7:TR?= M1PWdVI2QDV4NUS1
MDCK2 cells M3TkU2Z2dmO2aX;uJIF{e2G7 NFK2XXAzOCCvaX7z MXPFcohidmOnbXXueEBw\iClYXzj[YlvNUGPIIXweIFs\SCrbjDNSGNMOiClZXzsd{BwfmW{IHX4dJJme3OrbnegUWRTOSCjZoTldkAzOCCvaX7zMEBGSzVyPUWuNUDPxE1? NIrINGMyQDh2OUG2Oy=>
human 2008 cells Mm\SSpVv[3Srb36gZZN{[Xl? MYPJcohq[mm2aX;uJI9nKGi3bXHuJG1TWDFiaX6gbJVu[W5iMkCwPEBk\WyuczygTWM2OD17Lk[2JO69VQ>? NI\tUHAyQDdyN{i4OC=>
human H460 cells MojWSpVv[3Srb36gZZN{[Xl? M2DG[VUxKM7:TR?= NHj0RlA4OiCq NIrhZotRd3SnboTpZZRqd25ib3[g[ZJtd3SrbnniMYlv\HWlZXSgZ5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTFQ3OCClZXzsd{Bie3Onc4Pl[EBieyCncnzveIlvcWJiSVO1NEBifCB3MDD1UUBi\nSncjC3NkBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUGwMlMh|ryP NGKzcGgzPTJzNUi1Oi=>
hamster BHK21 cells NEXBPYZEgXSxdH;4bYPDqGG|c3H5 MUC5OkBp NGXNUGVEgXSxdH;4bYNqfHliYXfhbY5{fCCqYX3zeIVzKEKKS{KxJINmdGy|IHX4dJJme3OrbnegUXJROSCjZoTldkA6PiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVExNjZizszN M4jZXFIxPjlzNUm5
KB cells MWjGeY5kfGmxbjDhd5NigQ>? NEfmepg4OiCq NEnnNFVKdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QhU0JiY3XscEBtcW6nIHHmeIVzKDd{IHigc4Yh\HK3ZzDlfJBwe3W{ZTygTWM2OD1zOT62JO69VQ>? MmL5NVU1QDF7OUG=
Caco-2 cells NUfPVmVJTnWwY4Tpc44h[XO|YYm= NYDCUY17UW6qaXLpeIlwdiCxZjDQ[5AhdWWjc4Xy[YQh[XNiaX7obYJqfGmxbjDv[kBcO0ifdnnuZoxie3SrbnWgZoF{d2yjdHXyZYwhfG9iYYDpZ4FtKHS{YX7zdI9zfCCrbjDDZYNwNTJiY3XscJMtKEWFNUC9NlAh|ryP MnLXNVcxPjRyN{m=
human KB31 cells M1rqcWN6fG:2b4jpZ:Kh[XO|YYm= M4TGbFQ5KGh? MkPKR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT2I{OSClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKG2ndHjv[EwhUUN3ME20OU4zKM7:TR?= MVyxNFM1Pjl2OB?=

... Click to View More Cell Line Experimental Data

In vivo Verapamil confers an anti-arrhythmic effect via calcium influx inhibition, inhibition of oxygen consumption and accompanied by preservation of Cx43 protein in rat heart.

Protocol

Solubility (25°C)

In vitro DMSO 98 mg/mL (199.56 mM)
Water 50 mg/mL (101.82 mM)
Ethanol 12 mg/mL (24.43 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 491.06
Formula

C27H38N2O4.HCl

CAS No. 152-11-4
Storage powder
in solvent
Synonyms N/A

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04014634 Recruiting Drug: Methylprednisolone|Other: Placebo Cluster Headache Episodic|Greater Occipital Nerve Injection Leiden University Medical Center|Hersenstichting|Innovatiefonds Zorgverzekeraars August 1 2019 Phase 4
NCT02912663 Recruiting Drug: Verapamil and Magnesium Sulfate|Other: Placebo Ischemic Stroke Justin Fraser|University of Kentucky October 11 2017 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Calcium Channel Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID