Verapamil (CP-16533-1) HCl

For research use only.

Catalog No.S4202

14 publications

Verapamil (CP-16533-1) HCl Chemical Structure

CAS No. 152-11-4

Verapamil HCl (CP-16533-1) is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits both permeability-glycoprotein (P-gp) and CYP3A4.

Size Price Stock Quantity  
EUR 95 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Selleck's Verapamil (CP-16533-1) HCl has been cited by 14 publications

3 Customer Reviews

  • The proportion of SP cells in HepG2 and HCCLM3 cell lines were 0.16% and 32.2%, which reduced to 0% and 0.28% in the presence of verapamil.

    Front Pharmacol, 2018, 9:1298. Verapamil (CP-16533-1) HCl purchased from Selleck.

  • f, Cells were pretreated with or without 5 μM verapamil and then treated with the indicated concentrations of 17-DMAG for 6 h. The proteins involved in ALK-related signaling were detected by western blot analysis.

    BMC Cancer, 2015, 15:553.. Verapamil (CP-16533-1) HCl purchased from Selleck.

  • J45.01 cells were suspended in a growth medium containing 0.1 μM 5-CFDA and kept on ice for 20 min to allow its uptake. The effects of verapamil (MDR1 inhibitor) and MK571 (MRP1 inhibitor) on the efflux of 5-CF at 37°C was determined by flow cytometry (B).

    Exp Hematol, 2017, 2.436. Verapamil (CP-16533-1) HCl purchased from Selleck.

Purity & Quality Control

Choose Selective Calcium Channel Inhibitors

Biological Activity

Description Verapamil HCl (CP-16533-1) is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits both permeability-glycoprotein (P-gp) and CYP3A4.
Targets
Calcium channel [2]
In vitro

The enzyme hydrolase activity of recombinant CES2 is substantially inhibited by diltiazem and verapamil (Ki = 0.25 ± 0.02 and 3.84 ± 0.99μM, respectively).

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HCT116/VM46 cell NH73NJJHfW6ldHnvckBie3OjeR?= MkHVNUDPxE1? MXvF[oZm[3Rib36geolv[myjc4TpcoUhUUN3MDDh[4FqdnO2IF3EVkBpfW2jbjDjZZJkcW6xbXGgTGNVOTF4L2\NOFYh[2WubDDsbY5mKGG2IHGg[I9{\SCxZjCxJJVOKGOxbnPlcpRz[XSrb36sJGlEPTB;MD6wNFQh|ryP NI\pVHg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkeyPVY3Oyd-MUK3Nlk3PjN:L3G+
human MCF7/ADR cells NEfYdXdHfW6ldHnvckBie3OjeR?= MUSxNEDPxE1? MVS0PEBp MnfmTY5pcWKrdHnvckBw\iCSLXfwJIlvKGi3bXHuJG1ETjdxQVTSJINmdGy|IHHzd4V{e2WmIHHzJJJmfmW{c3HsJI9nKG23bITp[JJ2\yC{ZYPpd5RidmOnIHH0JFExKHWPIHL5JI1m[XO3cnnu[{BGSzVyIH\vdkBi\HKrYX35Z4lvNWmwZIXj[YQh[3m2b4TvfIlkcXS7IHHmeIVzKDR6IHjyd{BjgSCVUlKgZ49td3KrbXX0dolkKGG|c3H5MEBGSzVyPUSuPFkh|ryP MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh3NkW0OUc,OjV6NU[1OFU9N2F-
NG108-15 NWC2OmhETnWwY4Tpc44h[XO|YYm= NIHycHRVcGViY3;tdI92dmRid3HzJJRme3SnZDDmc5IhcW6qaXLpeIlwdiCxZjDjZYxkcXWvIHnu[ox2gCCrboTvJI5mfXKxbnHsJEhPTzFyOD2xOUkh[2WubIOsJGlEPTB;Nj61{txO MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODN|NUi0K|4zODN|NUi0QE9iRg>?
CCRF-CEM MXrGeY5kfGmxbjDhd5NigQ>? NVr6Rop{XGinIHXm[oVkfGm4ZTDkc5NmKHejczDt[YF{fXKnZDDh[4FqdnO2IGCt[4x6[2:ycn;0[YlvKGW6cILld5NqdmdiQ1PSSk1ETU1iY3XscJMhcW5idHjlJJBz\XOnbnPlJI9nKDVidV2g[IF2dm:veXPpckwhTUR3ME2wMlA1Pc7:TR?= M3jNR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzd4Mkm4NVcoRjd4Mkm4NVc9N2F-
CCRF-CEM Mm\uSpVv[3Srb36gZZN{[Xl? M4CyWHRp\SCnZn\lZ5RqfmViZH;z[UB4[XNibXXhd5Vz\WRiYXfhbY5{fCCSLXfsfYNweHKxdHXpckBmgHC{ZYPzbY5oKEOFUl[tR2VOKGOnbHzzJIlvKHSqZTDwdoV{\W6lZTDv[kA2KHWPIHX0c5Bwe2mmZTygSWQ2OD1|LkVOwG0> MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek84PjJ7OEG3K|44PjJ7OEG3QE9iRg>?
MCF7/VP MXfGeY5kfGmxbjDhd5NigQ>? MlmwNlAhfU1? NWm3PVZSPDhiaILz MX\Jcohq[mm2aX;uJI9nKE2UUDDlfJBz\XO|ZXSgbY4hcHWvYX6gUWNHPy:YUDDj[YxteyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckB3cW6lcnnzeIlv\S2rbnT1Z4VlKGO7dH;0c5hq[2m2eTDheEAzOCC3TTDh[pRmeiB2ODDodpMh[nliU2LCJIJqdmSrbnegZZN{[Xl? M4X3fFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzh5OE[zOlQoRjh5OE[zOlQ9N2F-
MCF/ADR NITjZVFHfW6ldHnvckBie3OjeR?= MmftVoV3\XK|YXygc4YhWC2pcD3t[YRq[XSnZDDteYx1cWS{dXegdoV{cXO2YX7j[UBqdiCqdX3hckBOS0ZxQVTSJINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKHKqb3ThcYlv\SB4RzDhZ4N2dXWuYYTpc44> NFjLT2g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi96OUi0NVUyLz56OUi0NVUyRC:jPh?=
B16/F10 NYjqcppyTnWwY4Tpc44h[XO|YYm= MknLTY5pcWKrdHnvckBw\iCqdX3hckBOTFJzIHX4dJJme3OnZDDpckBud3W|ZTDCNVYwTjFyIHPlcIx{KGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIRwgG:{dXLpZ4lvKGGlY4XteYxifGmxbjDifUBndHWxcnnt[ZRzgSxiRVS1NF0{|ryP MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86PDZzNkW4K|46PDZzNkW4QE9iRg>?
HeLa NHezSFRHfW6ldHnvckBie3OjeR?= NXTMXGYxXFChVGLBUnNRV1KWRWK6JIlvcGmkaYTpc44hd2ZiVFXBJJVxfGGtZTDpckBQS1RzLXX4dJJme3OrbnegTIVN[SClZXzsd{whU2l;Mj65{txO MmXlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTZ3NUi4NEc,QTZ3NUi4NFww[T5?
K562/DOX MDR Mmn3R5l1d3SxeHnjbZR6KGG|c3H5 NGnsTXlC[mmuaYT5JJRwKHCxdHXueIlifGViRF;YJIN6fG:2b4jpZ4l1gSCxbjDLOVYzN0SRWDDNSHIh[2WubIOuJGNmdGxic4Xyeol3[Wxid3HzJIF{e2G7ZXSgZpkhVVSWIHPvcpZmenOrb36sJGlEPTB;M{hOwG0> MoHQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTl6NkexPEc,QTl6NkexPFww[T5?
KBV1 MnPSR5l1d3SxeHnjbZR6KGG|c3H5 NE\BZ4g1QCCqcoO= MUPDfZRwfG:6aXPpeJkh[WejaX7zeEB3cW6kbHHzeIlv\SC{ZYPpd5RidnRiaIXtZY4hU0KYMTDj[YxteyCjZoTldkA1QCCqcoOgbY4heHKnc3XuZ4Uhd2ZiMUCwJI5OKH[rbnLsZZN1cW6nIHL5JHNTSiCvZYToc4QtKEmFNUC9NU43|ryP MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODN2Nkm0PEc,OTB|NE[5OFg9N2F-
KBV1 NUT2cXBsS3m2b4TvfIlkcXS7IHHzd4F6 M2fxb|Q5KGi{cx?= M{TSVWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KH[rbnLsZZN1cW6nIILld4l{fGGwdDDoeY1idiCNQm[xJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCVUlKgcYV1cG:mLDDJR|UxRTN7LkNOwG0> M3izN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyM{S2PVQ5Lz5zMEO0Olk1QDxxYU6=
KB31 M2fMWWN6fG:2b4jpZ4l1gSCjc4PhfS=> Mo\YOFghcHK| Mm[yR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT2I{OSClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKG2ndHjv[EwhUUN3ME20OU4z|ryP MlnFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB|NE[5OFgoRjFyM{S2PVQ5RC:jPh?=
S1-B1-20 NXrVb|AyTnWwY4Tpc44h[XO|YYm= M3vXcWlvKH[rdILvJINwdmOnboTyZZRqd25icnXxeYlz\WRidH:gbY5pcWKrdDD0eY1weiCjY4Tpeol1gSCxbjDzeYJkdG:wZTDv[kBpfW2jbjDjc4xwdiClYYLjbY5wdWFiY3XscJMhMFNzLVKxMVIxMSC{ZYPpd5RidnRidH:gZol{[W62cnXu[UwhUUN3ME2xO{4zP87:TR?= MniwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB|N{eyNlAoRjFyM{e3NlIxRC:jPh?=
P388 M4XNN2Z2dmO2aX;uJIF{e2G7 Ml7uUZVtfGmmcoXnMZJme2m|dHHueEBz\X[ncoPhcEBi[3Srdnn0fUB2e2mwZzDQN|g5N1[PRGLDMlA1KGOnbHzzJEhiKHO3YnzpcoUhd2ZiUEO4PEBufXKrbnWgcIV2c2WvaXGgZ4VtdHNiZYjwdoV{e2mwZzDoeY1idiC{ZXPvcYJqdmGwdDDoeY1idiCSLXfsfYNweHKxdHXpckkhcW5idHjlJJBz\XOnbnPlJI9nKDFyIH7NJJZqdmO{aYP0bY5mNCCLQ{WwQVMvOc7:TR?= M1uycFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyM{i2PVMzLz5zMEO4Olk{OjxxYU6=
Caco-2 NVzEOoh7TnWwY4Tpc44h[XO|YYm= MV;UVH9VWkGQU2DPVnRGWjpiaX7obYJqfGmxbjDv[kBFcWexeHnuJJRz[W6|ZYDpeIhmdGmjbDD0doFve3CxcoSgLIJie2GuIITvJIFxcWOjbDmgLGRq\2:6aX66JFUhfU1rIHnuJGNi[29vMjDj[YxteyxiSVO1NF0zNjIQvF2= MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODh{MEGzO{c,OTB6MkCxN|c9N2F-
Caco-2 MWTGeY5kfGmxbjDhd5NigQ>? MXvUVH9VWkGQU2DPVnRGWjpiaX7obYJqfGmxbjDv[kBV[XixbDD0doFve2WyaYTo[Yxq[WxidILhcpNxd3K2IDjiZZNidCC2bzDhdIlk[WxrIHnuJGNi[29vMjDj[YxteyxiS3m9N:69VQ>? NIXwVlA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUSwOVI5Pyd-MUG0NFUzQDd:L3G+
G185 NEjGXm1HfW6ldHnvckBie3OjeR?= M1j5UnRRZ1SUQV7TVG9TXEWUOjDpcohq[mm2aX;uJI9nKESjdX7vdpVjcWOrbjDl[oZtfXhiKFTheY5wenWkaXPpclohRyC3TTmgbY4hTzF6NTDj[YxteyxiSVO1NF01NjMQvF2= MoC5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF2NUS3NlQoRjFzNEW0O|I1RC:jPh?=
NIH-3T3-G185 NGrvRYJHfW6ldHnvckBie3OjeR?= Mn\vWHBgXFKDTmPQU3JVTVJ8IHnubIljcXSrb36gc4YhTGG3bn;yeYJq[2mwIHXm[ox2gCCrbjDOTWguO1R|LVexPFUh[2WubIOsJGlEPTB;ND6y{txO MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTdzNkWxOEc,OTF5MU[1NVQ9N2F-
NIH-3T3-G185 M3y3dGZ2dmO2aX;uJIF{e2G7 MnSzWHBgXFKDTmPQU3JVTVJ8IHnubIljcXSrb36gc4YhVESVLUe1NUBm\m[udYigbY4hVkmKLUPUN{1IOTh3IHPlcIx{NCCLQ{WwQVQvP87:TR?= M{fScVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzN{G2OVE1Lz5zMUexOlUyPDxxYU6=
NIH-3T3-G185 NETxdHpHfW6ldHnvckBie3OjeR?= M4LmSnRRZ1SUQV7TVG9TXEWUOjDpcohq[mm2aX;uJI9nKFKqb3ThcYlv\SBzMkOg[YZndHW6IHnuJG5KUC1|VEOtS|E5PSClZXzsd{whUUN3ME22MlXPxE1? NGnPO2g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUexOlUyPCd-MUG3NVY2OTR:L3G+
NIH-3T3-G185 M3rF[mZ2dmO2aX;uJIF{e2G7 NUfJ[5h5XFChVGLBUnNRV1KWRWK6JIlvcGmkaYTpc44hd2ZiQ3HsZ4Vqdi2DTTDl[oZtfXhiaX6gUmlJNTOWMz3HNVg2KGOnbHzzMEBKSzVyPUK4MlnPxE1? M2rkRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzN{G2OVE1Lz5zMUexOlUyPDxxYU6=
NIH-3T3-G185 Ml3YSpVv[3Srb36gZZN{[Xl? NUS4Woh4XFChVGLBUnNRV1KWRWK6JIlvcGmkaYTpc44hd2ZiVHX0doFu\XSqeXzyc5NidWmwZTDl[oZtfXhiaX6gUmlJNTOWMz3HNVg2KGOnbHzzMEBKSzVyPUO4MlLPxE1? MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTdzNkWxOEc,OTF5MU[1NVQ9N2F-
NIH-3T3-G185 MmnZSpVv[3Srb36gZZN{[Xl? MUnUVH9VWkGQU2DPVnRGWjpiaX7obYJqfGmxbjDv[kBLSy1zIHXm[ox2gCCrbjDOTWguO1R|LVexPFUh[2WubIOsJGlEPTB;NENOwG0> MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOTdzNkWxOEc,OTF5MU[1NVQ9N2F-
HCT15 NYDye4xqTnWwY4Tpc44h[XO|YYm= MUmwMlghfG9iMUKuOUB2\y:vTB?= MUfNc4R2dGG2aX;uJI9nKFBvZ4CgbY4hcHWvYX6gTGNVOTViY3XscJMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gSGlPUUJvaX7keYNm\CCleYTveI95cWOrdImgZZQhOC56IITvJFEzNjVidXevcWw> NX24WWR6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUG3OVQ3ODJpPkGxO|U1PjB{PD;hQi=>
UO31 NEnNbldHfW6ldHnvckBie3OjeR?= Ml3FNE45KHSxIEGyMlUhfWdxbVy= NH3wPJROd2S3bHH0bY9vKG:oIGCt[5AhcW5iaIXtZY4hXU9|MTDj[YxteyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBFUU6LQj3pcoR2[2WmIHP5eI91d3irY3n0fUBifCByLkigeI8hOTJwNTD1[{9uVA>? MlzWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF5NUS2NFIoRjFzN{W0OlAzRC:jPh?=
CAKI1 M4D6RmZ2dmO2aX;uJIF{e2G7 M4DXSVAvQCC2bzCxNk42KHWpL33M NHLDWIVOd2S3bHH0bY9vKG:oIGCt[5AhcW5iaIXtZY4hS0GNSUGgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hTEmQSVKtbY5lfWOnZDDjfZRwfG:6aXPpeJkh[XRiMD64JJRwKDF{LkWgeYcwdUx? NE\nOnY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMUe1OFYxOid-MUG3OVQ3ODJ:L3G+
MDA-435/LCC6 and MDA-435/LCC6-MDRI cells M1;NV2Z2dmO2aX;uJIF{e2G7 Mk\ER49v[2WwdILheIlwdiC2aHH0JJJm\HWlZYOg[Iln\mW{ZX7j[UBqdiC{ZY\ldpNidCCxZjDbN2heXkKOIHHjZ5VufWyjdHnvckBj\XS5ZXXuJG1FSS12M{WvUGNEPiCjbnSgUWRCNTR|NT;MR2M3NU2GUlmgZ4VtdHNiYomgOVAmNCCHQ{WwQVEvOs7:TR?= NXzuRoE1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUG3PFQyPDNpPkGxO|g1OTR|PD;hQi=>
MDA-435/LCC6 and MDA-435/LCC6-MDRI cells M3vlb2Z2dmO2aX;uJIF{e2G7 MmfXR49v[2WwdILheIlwdiC2aHH0JJJm\HWlZYOgeIhmKGSrZn\ldoVv[2ViaX6gdoV3\XK|YXygc4YhTE:[IHHjZ5VufWyjdHnvckBj\XS5ZXXuJG1FSS12M{WvUGNEPiCjbnSgUWRCNTR|NT;MR2M3NU2GUlmgZ4VtdHNiYomgOVAmNixiRVO1NF0zNjUQvF2= NUi5c2NsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUG3PFQyPDNpPkGxO|g1OTR|PD;hQi=>
MDA-435/LCC6 MVvGeY5kfGmxbjDhd5NigQ>? M3vBcGVn\mWldDDvckBz\X[ncoPhcEBw\iCdM1jdMUBXSkxiYXPjeY12dGG2aX;uJIlvKE2GQT20N|UwVEOFNjCoVIdxNW6nZ3H0bZZmMSClZXzsd{4tKEWFNUC9N{4y|ryP M2THU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzN{i0NVQ{Lz5zMUe4OFE1OzxxYU6=
MDA435/LCC6 MDR1 MV7GeY5kfGmxbjDhd5NigQ>? MYjUVH9VWkGQU2DPVnRGWjpicnX2[ZJ{[Wxib3[gWolv[myjc4TpcoUh[WOldX31cIF1cW:wIDjWbY5jdGG|dHnu[VohOC5yMEWgeW0qKGmwIF3ERVQ{PS:OQ1O2JG1FWjFiY3XscJMtKEWFNUC9N{4y|ryP M{G4S|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzN{i0NVQ{Lz5zMUe4OFE1OzxxYU6=
MDA-435/LCC6 MmWySpVv[3Srb36gZZN{[Xl? NFS5R3FG\m[nY4Sgc44hemW4ZYLzZYwhd2ZiRF;YJIFk[3WvdXzheIlwdiCrbjDNSGEuPDN3L1zDR|YhMFCpcD3u[YdifGm4ZTmgZ4VtdHNwLDDFR|UxRTRwMd88US=> NXKyPWxWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUG3PFQyPDNpPkGxO|g1OTR|PD;hQi=>
BTI-TN5B1-4 MWnGeY5kfGmxbjDhd5NigQ>? NWO5dYtoXFChVGLBUnNRV1KWRWK6JGFVWCCqeXTyc4x6e2m|IHnuJI1mdWK{YX7lJIZz[WO2aX;uJIZzd21iSHnnbEBHcX[nIDjCWGkuXE53QkGtOEkh[2WubIOsJGtuRTRwMEdOwG0> M1z0SlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFzN{i1Olg1Lz5zMUe4OVY5PDxxYU6=
MDCK NWXrPIdqTnWwY4Tpc44h[XO|YYm= M2nyc3RRZ1SUQV7TVG9TXEWUOjDpcohq[mm2aX;uJI9nKESrZ3;4bY4hfHKjboPldIl1cGWuaXHsJJRz[W6|cH;yeEAp[mG|YXygeI8h[XCrY3HsLUBqdiCPRGKxMYV5eHKnc4PpcochVUSFSzDj[YxteyxiS3m9NVUvOc7:TR?= MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjF|NEm0OUc,OTJzM{S5OFU9N2F-
human embryonic kidney cells NVzOSVJuTnWwY4Tpc44h[XO|YYm= MWrLL{BkcGGwbnXsJIJtd2OtaX7nJIFkfGm4aYT5JIlvKGi3bXHuJIVu[nK7b37pZ{BscWSwZYmgZ4VtdHNiZYjwdoV{e2mwZzDISXJIKEu4MUGuNUwhUUN3ME2wMlE1O87:TR?= M3HLZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{MUmwN|A5Lz5zMkG5NFMxQDxxYU6=
HCT15/CL02 M3;sNWZ2dmO2aX;uJIF{e2G7 NWDmd5ViXFChVGLBUnNRV1KWRWK6JIRzfWdicnXzbZN1[W6lZTCodIFkdGm2YYjlcEkhcW5iSFPUNVUwS0xyMjDj[YxteyxiSVO1NF0zNjJzzszN NHTw[|c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkW2PVMxPSd-MUK1Olk{ODV:L3G+
MES-SA/DX5 Mn7SSpVv[3Srb36gZZN{[Xl? M3S0TXRRZ1SUQV7TVG9TXEWUOjDkdpVoKHKnc3nzeIFv[2ViKIDhZ4xqfGG6ZXypJIlvKE2HUz3TRU9FYDViY3XscJMtKEmFNUC9OE44QM7:TR?= NFLvR209[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkW2PVMxPSd-MUK1Olk{ODV:L3G+
Caco-2 MVLGeY5kfGmxbjDhd5NigQ>? NHKzUY1VWF:WUlHOV3BQWlSHUkqgeJJidnOncHn0bIVtcWGuIITyZY5{eG:{dDDv[kBlcWexeHnuJEhj[XOjbDD0c{BieGmlYXypJIlvKEOjY3:tNkBk\WyuczygT4k:OC56ON88US=> M17Eb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{NkO2NVU{Lz5zMk[zOlE2OzxxYU6=
L-MDR1 NHLSeIhHfW6ldHnvckBie3OjeR?= MkPsWHBgXFKDTmPQU3JVTVJ8IHPlcIwh[WOldX31cIF1cW:wIH;mJINidGOnaX6gbY4hVC2PRGKxJINmdGy|LDDJR|UxRTF6LkpOwG0> MkDhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ4NEmzOlkoRjF{NkS5N|Y6RC:jPh?=
LLC-PK1 M{P2[WZ2dmO2aX;uJIF{e2G7 M3ex[GlvcGmkaYTpc44hd2ZiUD3ncJlkd3C{b4TlbY4tKG2xdYPlJGwudWS{MXKg[ZhxemW|c3XkJIlvKEyOQz3QT|Eh\XCrdHjlcIlidCClZXzsd{B2e2mwZzDjZYxk\WmwLVHNJJBwdGG{aYPheIlwdiCjc4PhfUwhUUN3ME2y{txO MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjZ7OUO4PUc,OTJ4OUmzPFk9N2F-
LLC-PK1 NFHTUWJHfW6ldHnvckBie3OjeR?= NF;YW4RVWF:WUlHOV3BQWlSHUkqgbY5pcWKrdHnvckBw\iCFYXzj[YlvNUGPIHXm[ox2gCCrbjDN[JIy[i2neIDy[ZN{cW6pIFzMR{1RUzFiY3XscJMtKEmFNUC9Nu69VQ>? NFXuNpg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMk[5PVM5QSd-MUK2PVk{QDl:L3G+
LLC-PK1 NG\GRoRHfW6ldHnvckBie3OjeR?= NFzXOI9KdmirYnn0bY9vKG:oIGCt[4x6[2:ycn;0[YlvNCCqdX3hckBNNU2GUkGg[ZhxemW|c3XkJIlvKEyOQz3QT|Eh\XCrdHjlcIlidCClZXzsd{B2e2mwZzDjZYxk\WmwLVHNJJBwdGG{aYPheIlwdiCjc4PhfUwhUUN3ME22MlPPxE1? NUf4fm5wRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK2PVk{QDlpPkGyOlk6Ozh7PD;hQi=>
LLC-PK1 MnjESpVv[3Srb36gZZN{[Xl? MWXUVH9VWkGQU2DPVnRGWjpiaX7obYJqfGmxbjDv[kBE[WylZXnuMWFOKGWoZnz1fEBqdiCPRGKxMYV5eHKnc4PpcochVEyFLWDLNUBk\WyuczygTWM2OD14LkROwG0> MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjZ7OUO4PUc,OTJ4OUmzPFk9N2F-
LLC-PK1 MkO2SpVv[3Srb36gZZN{[Xl? NYHEZlY4UW6qaXLpeIlwdiCxZjDQMYdtgWOxcILveIVqdixibX;1d4UhVC2vZIKxZUBmgHC{ZYPz[YQhcW5iTFzDMXBMOSCncHn0bIVtcWGuIHPlcIx{KHW|aX7nJINidGOnaX6tRW0heG:uYYLpd4F1cW:wIHHzd4F6NCCLQ{WwQVEx|ryP NVryZZRORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUK2PVk{QDlpPkGyOlk6Ozh7PD;hQi=>
LLC-PK1 M17LemZ2dmO2aX;uJIF{e2G7 MVTUVH9VWkGQU2DPVnRGWjpiaX7obYJqfGmxbjDv[kBE[WylZXnuMWFOKGWoZnz1fEBqdiCPZIKxZU1mgHC{ZYPzbY5oKEyOQz3QT|Eh[2WubIOsJGlEPTB;MUFOwG0> M1HEXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{Nkm5N|g6Lz5zMk[5PVM5QTxxYU6=
CHO Ml3ySpVv[3Srb36gZZN{[Xl? Ml3ITY5pcWKrdHnvckBw\iCNKzDjbIFvdmWuIHHjeIl3cXS7IHnuJGNJVyClZXzsd{BmgHC{ZYPzbY5oKEiHUlegT5YyOS5zLDDJR|UxRTBwMUSz{txO MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjd{OU[3OUc,OTJ5Mkm2O|U9N2F-
mammalian cells MknrSpVv[3Srb36gZZN{[Xl? M2TJWmlvcGmkaYTpc44hd2ZiaIXtZY4hWG:2YYPzbZVuKGOqYX7u[YwhUEWURzDlfJBz\XO|ZXSgbY4hdWGvbXHsbYFvKGOnbHzzMEBKSzVyPUCuNVQyOjYQvF2= Ml\jQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ6N{O1NVIoRjF{OEezOVEzRC:jPh?=
AML-2/D100 MoLUSpVv[3Srb36gZZN{[Xl? MnfkWHBgXFKDTmPQU3JVTVJ8IHTyeYchemW|aYP0ZY5k\SBqdnnuZ5Jqe3SrbnWpJIlvKEGPTD2yM2QyODBiY3XscJMtKEmFNUC9NE41|ryP MnfzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV{NECxNFAoRjF3MkSwNVAxRC:jPh?=
Caco-2 M1f3dWZ2dmO2aX;uJIF{e2G7 NVnxRVA{XFChVGLBUnNRV1KWRWK6JJRz[W6|ZYDpeIhmdGmjbDD0doFve3CxcoSgc4Yh\mW6b3\lcoFlcW6nIHnuJGNi[29vMjDj[YxteyxiSVO1NF05NjR2zszN NGO0cos9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUO1PVU4PCd-MUWzOVk2PzR:L3G+
KB/MDR M3XHcWZ2dmO2aX;uJIF{e2G7 NHvzTYgyKGh? MnTUR49v[2WwdILheIlwdiC2aHH0JINifXOnczC1NEUhd2ZibXH4bY12dSC4aX7icIF{fGmwZTDhZ4N2dXWuYYTpc44hcW5iS1KvUWRTKGOnbHzzJIlvKDFiaDygSWM2OD1zNN88US=> MmC0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV2OEG5PVEoRjF3NEixPVkyRC:jPh?=
Sf9 M1TadGZ2dmO2aX;uJIF{e2G7 NXTVUolxVWmlaHHlcIl{NU2nboTlckBkd26|dHHueEBnd3JiaIXtZY4hWC2pbInjc5Bzd3SnaX6g[ZhxemW|c3XkJIlvKFOoOTDj[YxteyxiS329Nu69VQ>? MlHtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV6NkOzNlUoRjF3OE[zN|I2RC:jPh?=
K562 MVvGeY5kfGmxbjDhd5NigQ>? NEnWc3VT\X[ncoPhcEBw\iCSLXfwMY1m\GmjdHXkJI12dHSrZIL1[{Bz\XOrc4ThcoNmKGmwIHTvfI9zfWKrY3nuMZJme2m|dHHueEBpfW2jbjDLOVYzKGOnbHzzJIF{e2W|c3XkJIF{KGS{dXegZ49v[2WwdILheIlwdiClYYXzbY5oKGijbH[tcYF5cW2jbDDpcoNz\WG|ZTDpckBvfWOuZXHyJJBqemG{dXLpZ4lvKGOxbnPlcpRz[XSrb36sJGFkfGm4aYT5QVEvPs7:TR?= MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjJ5OUiwNkc,OTZ{N{m4NFI9N2F-
Caco-2 Mn3USpVv[3Srb36gZZN{[Xl? NETiUFJKdmirYnn0bY9vKG:oIGDndEBu\WG|dYLl[EBieyCrbnjpZol1cW:wIH;mJHs{UF24aX7icIF{fGmwZTDiZZNwdGG2ZYLhcEB1dyCjcHnjZYwhfHKjboPwc5J1KGmwIFPhZ48uOiClZXzsd{whTUN3ME2yNO69VQ>? NEPhdGc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{C2OFA4QSd-MUewOlQxPzl:L3G+
MDA435/LCC6 MX;GeY5kfGmxbjDhd5NigQ>? NF63XIxT\X[ncoPhcEBw\iC4aX7icIF{fGmwZTDy[ZNqe3SjbnPlJIlvKG23bITp[JJ2\yC{ZYPpd5RidnRiTVTBOFM2N0yFQ{[gZ4VtdHNiYomgUXRUKGG|c3H5MEBKSzVyPUCuNFAxOjYQvF2= MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF3NEWwOUc,OTdzNUS1NFU9N2F-
MDA435/LCC6 NH3lZlVHfW6ldHnvckBie3OjeR?= NUL2TXF7WmW4ZYLzZYwhd2ZicHHjcIl1[XinbDDy[ZNqe3SjbnPlJIlvKG23bITp[JJ2\yC{ZYPpd5RidnRiTVTBOFM2N0yFQ{[gZ4VtdHNiYomgUXRUKGG|c3H5MEBKSzVyPUCuNFA2Os7:TR?= MmTaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzNUS1NFUoRjF5MUW0OVA2RC:jPh?=
MDA435/LCC6 NUTaRpBbTnWwY4Tpc44h[XO|YYm= MYnS[ZZmenOjbDDv[kBx[WOuaYThfIVtKHKnc3nzeIFv[2ViaX6gcZVtfGmmcoXnJJJme2m|dHHueEBOTEF2M{WvUGNEPiClZXzsd{BjgSCPVGOgZZN{[XluIFXDOVA:OC55zszN M{jx[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUW0OVA2Lz5zN{G1OFUxPTxxYU6=
K562 NXfUWpdqTnWwY4Tpc44h[XO|YYm= MXvJcohq[mm2aX;uJI9nKGi3bXHuJHBoeCCrbjDhcpRpemGleXPsbY5mNXKnc3nzeIFvfCCNNU[yJINmdGy|IHHzd4V{e2WmIHHzJIRzfWdibHX2[Ywh[2G3c3nu[{Bp[WyoIH3hfIlu[WxiaX7jdoVie2ViaX6gcpVkdGWjcjDjc45k\W62cnH0bY9vKG:oIIDpdoFzfWKrY3nuMEBC[3Srdnn0fV0yNjcQvF2= M2TZcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MkW2PFM4Lz5zN{K1Olg{PzxxYU6=
Caco-2 M3K0dmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MUm0PEBpenN? NXyzNpVRSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDDZYNwNTJiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkh[nliTWTUJIF{e2G7IHHmeIVzKDR6IHjyd{whUUNzME2yOE46|ryP M4jnOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5Mke2NFc3Lz5zN{K3OlA4PjxxYU6=
CEM/VLB500 M1nmdmZ2dmO2aX;uJIF{e2G7 NIi2c4s{KGSjeYO= NXzrfWRtWmW4ZYLzZYwhd2ZiUD3ndE1u\WSrYYTl[EBufWy2aXTyeYchemW|aYP0ZY5k\SC2bzD2bY5jdGG|dHnu[UBqdiCqdX3hckBETU1xVlzCOVAxKGOnbHzzJIFnfGW{IEOg[IF6eyCkeTDy[ZNignW{aX6gZZN{[XluIFXDOVA:OS5yNEJOwG0> M33yVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5M{m5PVkxLz5zN{O5PVk6ODxxYU6=
A549 Mo[wSpVv[3Srb36gZZN{[Xl? M3jVOmlvcGmkaYTpc44hd2ZiUD3ndEBqdiCDNUS5JINmdGy|IHHzd4V{e2WmIHHzJIRzfWdiY3;uZ4VvfHKjdHnvckBz\XG3aYLl[EB1dyCmb4XicIUh[mG|ZXzpcoUh\my3b4Lld4NmdmOnIHzleoVtKGK7IHPhcINmcW5vQV2geZB1[WunIHHzd4F6NCCDY4Tpeol1gT15zszN NE\MeWQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{SxPVYxPid-MUe0NVk3ODZ:L3G+
THP1 MVjBcpRqdGWrc3jtZY5q[WxiYYPzZZk> MV;BcpRqdGWrc3jtZY5q[WxiYXP0bZZqfHliYXfhbY5{fCC5aXzkMZR6eGViTHXpd4hu[W6rYTDhcYF7d26nboPpd{BOUE:PL1LSM|E6PzNxTV2yNlY6KHC{b33hd5Rq\2:2ZYOgbY5n\WO2ZXSgbY4hcHWvYX6gWGhROSClZXzsd{BjgSCudXPp[oVz[XOnIHLhd4VlKGG|c3H5MEBKSzVyPUG5MlHPxE1? NXPWcJh{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0OVI1QDBpPkG3OFUzPDhyPD;hQi=>
THP1 M2jScWFvfGmuZXnzbI1idmmjbDDhd5NigQ>? MWjBcpRqdGWrc3jtZY5q[WxiYXP0bZZqfHliYXfhbY5{fCC5aXzkMZR6eGViTHXpd4hu[W6rYTDtZYpweiCOVkO5JJBzd22jc4Tp[491\XNiaX7m[YN1\WRiaX6gbJVu[W5iVFjQNUBk\WyuczDifUBtfWOrZnXyZZNmKGKjc3XkJIF{e2G7LDDJR|UxRTRyLkROwG0> MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR3MkS4NEc,OTd2NUK0PFA9N2F-
THP1 NIHk[nJCdnSrbHXpd4hu[W6rYXygZZN{[Xl? MULBcpRqdGWrc3jtZY5q[WxiYXP0bZZqfHliYXfhbY5{fCC5aXzkMZR6eGViTHXpd4hu[W6rYTDpcoZidnS3bTDNTG9ON02DL{[3M2lVVUGSLUK2N{Bxem:vYYP0bYdwfGW|IHnu[oVkfGWmIHnuJIh2dWGwIGTIVFEh[2WubIOgZpkhdHWlaX\ldoF{\SCkYYPl[EBie3OjeTygTWM2OD12Mz6y{txO M17OT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEWyOFgxLz5zN{S1NlQ5ODxxYU6=
KB-3-1 M1rFeGN6fG:2b4jpZ4l1gSCjc4PhfS=> M2W0flUhfU1? MVS2PEBpenN? NX:1U|lpWmW4ZYLzZYwhd2ZiUD3ndE1u\WSrYYTl[EBufWy2aXTyeYchemW|aYP0ZY5k\SC2bzDDfZRwfG:6aXPpeJkhd2ZiY3;sZ4hq[2mwZTDh[4FqdnO2IHj1cYFvKEuELUOtNUBk\WyuczDheEA2KHWPIHHmeIVzKDZ6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OC5yMES3{txO MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR6OEGyPEc,OTd2OEixNlg9N2F-
KB-C2 MmXZR5l1d3SxeHnjbZR6KGG|c3H5 MYS1JJVO M1mwdlY5KGi{cx?= NXHTR2x[WmW4ZYLzZYwhd2ZiUD3ndE1u\WSrYYTl[EBufWy2aXTyeYchemW|aYP0ZY5k\SC2bzDDfZRwfG:6aXPpeJkhd2ZiY3;sZ4hq[2mwZTDh[4FqdnO2IHj1cYFvKEuELVOyJINmdGy|IHH0JFUhfU1iYX\0[ZIhPjhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0xNjIQvF2= M3\xZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEi4NVI5Lz5zN{S4PFEzQDxxYU6=
BHK21 M2nTN2N6fG:2b4jpZ4l1gSCjc4PhfS=> NYjrR2huOTBidH:gNlAhfU1? MknKR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUXJROSCneIDy[ZN{cW6pIHjhcZN1\XJiQljLNlEh[2WubIOgZZQhOTBidH:gNlAhfU1iYomgUXRVKGG|c3H5 NEDURVA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[0OlE3QSd-MUe2OFYyPjl:L3G+
BHK21 NH[5fo9HfW6ldHnvckBie3OjeR?= MoHqTY5pcWKrdHnvckBw\iCqdX3hckBOWlBzIH3l[IlifGWmIFzUR|QhfHKjboPwc5J1KGmwIHjhcZN1\XJiQljLNlEh[2WubIOgbY4heHKnc3XuZ4Uhd2ZiZ3z1eIF1cGmxbnWgZpkhemGyaXSg[oltfHKjdHnvckB1\WOqbnnxeYU> MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzZ2NkG2PUc,OTd4NE[xOlk9N2F-
A2780/ADR MX7GeY5kfGmxbjDhd5NigQ>? NITp[|dKdmirYnn0bY9vKG:oIGCt[4x6[2:ycn;0[YlvKGW6cILld5Nm\CCrbjDBNlc5OC:DRGKgZ4VtdHNiYomgZ4Ft[2WrbjDBUUBie3OjeTygTWM2OD12LkW3NFg5|ryP Mnq5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd6OUCwPVQoRjF5OEmwNFk1RC:jPh?=
Caco-2 NW\EW3F4TnWwY4Tpc44h[XO|YYm= NHXS[4xKdmirYnn0bY9vKG:oIHj1cYFvKFCpcDDt[YRq[XSnZDDbN2hefmmwYnzhd5RqdmVidILhcpNxd3K2IHnuJIh2dWGwIFPhZ48uOiClZXzsd{whTUN3ME2yNO69VQ>? NX23elhrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe5N|Y3OzNpPkG3PVM3PjN|PD;hQi=>
MDCK2 NXn4eGxmTnWwY4Tpc44h[XO|YYm= NXXzNYtjOTBidV2= MXu0NEBucW6| NX74dWV4UW6qaXLpeIlwdiCxZjDoeY1idiC5aXzkJJR6eGViUHfwJIV5eHKnc4Pl[EBqdiCPRFPLNkBk\WyuczDhd5Nme3OnZDDhd{Bk[WylZXnuMWFOKGGlY4XteYxifGmxbjDheEAyOCC3TTDh[pRmeiB2MDDtbY5{ NWP6b2xERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe5OlQyPzBpPkG3PVY1OTdyPD;hQi=>
A2780 MXvGeY5kfGmxbjDhd5NigQ>? NF3hNm4{OCCvaX7z MmDPTY5pcWKrdHnvckBw\iCqdX3hckBR\3BiaX6gRVI4QDBiY3XscJMh[W[2ZYKgN|AhdWmwczDifUBk[WylZXnuJGFOKGG|c3H5MEBKSzVyPUSuOVcxQDkQvF2= MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDB6M{CzOEc,OThyOEOwN|Q9N2F-
A2780 NEXQbGZHfW6ldHnvckBie3OjeR?= MUCzNEBucW6| MXHJcohq[mm2aX;uJI9nKGi3bXHuJHBoeCCrbjDBNlc5OCClZXzsd{Bi\nSncjCzNEBucW6|IHL5JGhw\WOqc4SgN|M{PDJiYYPzZZktKEmFNUC9Ok43ODZ7M988US=> NEfG[JU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEC4N|A{PCd-MUiwPFMxOzR:L3G+
Caco-2 M3zGTGZ2dmO2aX;uJIF{e2G7 MYjJcohq[mm2aX;uJI9nKGi3bXHuJHAu\2y7Y3;wdo91\WmwIH3l[IlifGWmIGuzTH13cW6kbHHzeIlv\SC2cnHud5BwenRiaX6gbJVu[W5iQ3Hjc{0zKGOnbHzzMEBGSzVyPUKw{txO NWfIbGNPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUiyOVc2PDVpPkG4NlU4PTR3PD;hQi=>
Caco-2 NWXNc|dRTnWwY4Tpc44h[XO|YYm= Mn7yNVAxKHWP NVPmVpFZSWO2aY\heIlwdiCxZjDoeY1idiCSLXfsfYNweHKxdHXpckBCXFCjc3WgbY4hS2Glbz2yJINmdGy|IHHzd4V{e2WmIHHzJGFVWCCmZYDs[ZRqd25iYYSgNVAxKHWP MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDJ3N{W0OUc,OTh{NUe1OFU9N2F-
Caco-2 NXTwSVlVTnWwY4Tpc44h[XO|YYm= MnjyTY5pcWKrdHnvckBw\iCqdX3hckBRNWeyIH3l[IlifGWmIGuzTH13cW6kbHHzeIlv\SC2cnHud5BwenRiYXP0bZZqfHliaX6gbJVu[W5iQ3Hjc{0zKGOnbHzzMEBGSzVyPUKw{txO MmXUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh{N{[xOFUoRjF6Mke2NVQ2RC:jPh?=
KBV20C NF7idIlEgXSxdH;4bYNqfHliYYPzZZk> NX\acG1NS3m2b4TvfIlkcXS7IHHnZYlve3RibYXseIllenWpIILld4l{fGGwdDDQMYdxKGW6cILld5NqdmdiaIXtZY4hU0KYMkDDJINmdGy|IHHzd4V{e2WmIHHzJINmdGxidnnhZoltcXS7IHnuJJBz\XOnbnPlJI9nKHCjY3zpeIF5\WxiYomgUXRUKGG|c3H5MEBKSzVyPUCuNFHPxE1? NX3TOJVZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUiyPVU1QTBpPkG4Nlk2PDlyPD;hQi=>
KBV20C MVnDfZRwfG:6aXPpeJkh[XO|YYm= NIfSNVdEgXSxdH;4bYNqfHliYXfhbY5{fCCvdXz0bYRzfWdicnXzbZN1[W62IGCt[5Ah\XiycnXzd4lv\yCqdX3hckBMSlZ{MFOgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliaX6gdJJme2WwY3Wgc4YhfmmwY4Lpd5RqdmViYomgUXRUKGG|c3H5MEBKSzVyPUCuNu69VQ>? NILC[pI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEK5OVQ6OCd-MUiyPVU1QTB:L3G+
KBV20C MXvGeY5kfGmxbjDhd5NigQ>? NE\nd5hKdmirYnn0bY9vKG:oIGDndEBqdiCvdXz0bYRzfWdicnXzbZN1[W62IHj1cYFvKEuEVkKwR{Bk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCrboTyZYNmdGy3bHHyJIFk[3WvdXzheIlwdiCxZjDSbFEzOw>? NYThOIliRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUiyPVU1QTBpPkG4Nlk2PDlyPD;hQi=>
K562 MYXGeY5kfGmxbjDhd5NigQ>? NEPSemRC[3Srdnn0fUBw\iCSZ4CtRXRR[XOnIHnuJIRwgG:{dXLpZ4lvNXKnc3nzeIFvfCCqdX3hckBMPTZ{IHPlcIx{NCCNbU2wMlfPxE1? NXf5S5FNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUizNVM{ODdpPkG4N|E{OzB5PD;hQi=>
K562 NFXLfppHfW6ldHnvckBie3OjeR?= M2PJWmlvcGmkaYTpc44hd2ZiVnXyZZBidWmuLYP0bY12dGG2ZXSgbJVu[W5iUHfwMWFVWGG|ZTDhZ5Rqfmm2eTDpckBld3ixcoXibYNqdi2{ZYPpd5RidnRiS{W2NkBk\WyuczygT40:OC56Od88US=> NXn1fW0yRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUizNVM{ODdpPkG4N|E{OzB5PD;hQi=>
K562 M{i2emZ2dmO2aX;uJIF{e2G7 M1zYZWlvcGmkaYTpc44hd2ZiVnXyZZBidWmuLYP0bY12dGG2ZXSgbJVu[W5iUHfwMWFVWGG|ZTDhZ5Rqfmm2eTDpckBld3ixcoXibYNqdi2{ZYPpd5RidnRiS{W2NkBk\WyuczygWo1igD1{Mj6zPe69VQ>? M1XOZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6M{GzN|A4Lz5zOEOxN|MxPzxxYU6=
K562 MU\GeY5kfGmxbjDhd5NigQ>? NUTX[Ic6SWO2aY\peJkhd2ZiUHfwMWFVWGG|ZTDpckBld3ixcoXibYNqdi2{ZYPpd5RidnRiaIXtZY4hUzV4MjDj[YxteyxiVn3hfF0{Pi57M988US=> M4\VVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6M{GzN|A4Lz5zOEOxN|MxPzxxYU6=
PC12 NITFOZZCfXSxcHjh[5kh[XO|YYm= NFPTXo8yKHWP Mn7oNlQhcHK| NULMcmRQUW6mdXP0bY9vKG:oIHH1eI9xcGGpeTDpckBz[XRic4ThZoxmKGmwZIXjbYJt\SCSQ{GyJINmdGy|IHX4dJJme3OrbnegRVU{XCCjbIDoZU1{gW63Y3zlbY4h[XO|ZYPz[YQh[XNiQUWzWEBidHCqYT3zfY52[2ynaX6gZ4xm[XKjbnPlJIF1KDFidV2gZYZ1\XJiMkSgbJJ{KGK7IHTlcpNqfG:vZYTybYMh[W6jbInzbZM> MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDN7MUm0PUc,OTh|OUG5OFk9N2F-
PC12 MXPBeZRweGijZ4mgZZN{[Xl? MUGxJJVO MXG5OkBpenN? NGKzR5FKdmS3Y4Tpc44hd2ZiYYX0c5Bp[We7IHnuJJJifCC|dHHicIUhcW6mdXPpZoxmKFCFMUKgZ4VtdHNiZYjwdoV{e2mwZzDFS2ZRNUiGUUe0JIF{e2W|c3XkJIF{KHOxbIXicIUhTUeIUD3ISHE4PCClbHXhdoFv[2ViYYSgNUB2VSCjZoTldkA6PiCqcoOgZpkh\GWwc3n0c41mfHKrYzDhcoFtgXOrcx?= NFO1PWQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEO5NVk1QSd-MUizPVE6PDl:L3G+
SK-N-MC MV;BeZRweGijZ4mgZZN{[Xl? Ml24NUB2VQ>? NXvqU2ppPDhiaILz MXrJcoR2[3Srb36gc4Yh[XW2b4DoZYd6KGmwIHj1cYFvKFONLV6tUWMh[2WubIOg[ZhxemW|c3nu[{BGT0[SLVjEVVc1KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBGT0[SLVjEVVc1KGGpZ4Ll[4F1cW:wIHH0JFEhfU1iYX\0[ZIhPDhiaILzJIJ6KGSnboPpeI9u\XS{aXOgZY5idHm|aYO= MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDN7MUm0PUc,OTh|OUG5OFk9N2F-
SK-N-MC NV;SVY9wSXW2b4DoZYd6KGG|c3H5 NULwWG9rOC5|MzD1US=> M4\p[|I1KGi{cx?= M4HNUmlv\HWldHnvckBw\iCjdYTvdIhi\3liaX6gbJVu[W5iU1utUk1OSyClZXzsd{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDMR|MuOiCuZY\lcEBifCByLkOzJJVOKGGodHXyJFI1KGi{czDifUBqdW23bn;icI91fGmwZzDhcoFtgXOrcx?= MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDN7MUm0PUc,OTh|OUG5OFk9N2F-
SK-N-MC NXzF[4ZnSXW2b4DoZYd6KGG|c3H5 NUXPdXhkOSC3TR?= M{jLTFQ5KGi{cx?= M3vIOmlv\HWldHnvckBw\iCjdYTvdIhi\3liaX6gRZRoKHCxc3n0bZZmKGi3bXHuJHNMNU5vTVOgZ4VtdHNiZYjwdoV{e2mwZzDFS2ZRNUiGUUe0JIF1KDFidV2gZYZ1\XJiNEigbJJ{ MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDN7MUm0PUc,OTh|OUG5OFk9N2F-
PC12 MlPkRZV1d3CqYXf5JIF{e2G7 NFTEfooyKHWP NXHxSlJ{OjRiaILz M1TnOmlv\HWldHnvckBw\iCjdYTvdIhi\3liaX6gdJJmfHKnYYTl[EBz[XRic4ThZoxmKGmwZIXjbYJt\SCSQ{GyJINmdGy|IHX4dJJme3OrbnegSWdHWC2KRGG3OEBie3Onc4Pl[EBieyClYXzwZYlvKGGldHn2ZZRqd25iYYSgNUB2VSCob3zsc5dm\CCkeTDkc5h6[3muaX7lJJRz\WG2bXXueEBu\WG|dYLl[EBi\nSncjCyOEBpenN? M2m5W|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6M{mxPVQ6Lz5zOEO5NVk1QTxxYU6=
SK-N-SH MlHnRZV1d3CqYXf5JIF{e2G7 MWGxJJVO NFPqdYo1QCCqcoO= MlrqTY5lfWO2aX;uJI9nKGG3dH;wbIFogSCrbjDoeY1idiCVSz3OMXNJKGOnbHzzJIV5eHKnc4PpcochTUeIUD3ISHE4PCCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEKjeTDLPFY1PC2rbnT1Z4VlKEWJRmCtTGRSPzRiYXfndoVo[XSrb36gZZQhOSC3TTDh[pRmeiB2ODDodpM> Mkj5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh|OUG5OFkoRjF6M{mxPVQ6RC:jPh?=
PC12 NGGxXJRCfXSxcHjh[5kh[XO|YYm= NH74docyKHWP MYnJcoR2[3Srb36gc4Yh[XW2b4DoZYd6KGmwIHTp[oZmemWwdHnheIVlKHKjdDDzeIFjdGViaX7keYNq[mynIGDDNVIh[2WubIOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iTFOzMVIhdGW4ZXygZ4VtdCCycnX0doVifGWmIHH0JFEhfU1iaX6gdJJme2WwY3Wgc4YhPDByIH7NJIJi\mmub335Z4lvKEFz MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDN7MUm0PUc,OTh|OUG5OFk9N2F-
CHO NGrSTWtHfW6ldHnvckBie3OjeR?= NYHJeFV6UW6qaXLpeIlwdiCxZjDoeY1idiCHUleg[ZhxemW|c3XkJIlvKEOKTzDj[YxteyCkeTD3bI9t\SClZXzsJJBifGOqIHPsZY1xKHSnY3jubZF2\SxiSVO1NF0xNjF2MUK1{txO M3P6flxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NES4N|QzLz5zOES0PFM1OjxxYU6=
RBMEC MojJSpVv[3Srb36gZZN{[Xl? MYKxNEB2dW:uL1y= MXy5NEBucW6| MkPFTY5pcWKrdHnvckBw\iCSZ4CtcYVlcWG2ZXSgcZVtfGmmcoXnJJJme2m|dHHuZ4Uh[WO2aY\peJkhcW5icnH0JHJDVUWFIHPlcIx{KGG|c3Xzd4VlKGG|IGLoNVI{KGGlY4XteYxifGmxbjDheEAyOCC3bX;sM2wh[W[2ZYKgPVAhdWmwcx?= MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDVyMkGyOUc,OTh3MEKxNlU9N2F-
Caco-2 NWXwU2w2TnWwY4Tpc44h[XO|YYm= MWHJcohq[mm2aX;uJI9nKFBvZ3z5Z49xem:2ZXnuMY1m\GmjdHXkJHs{UF24aX7icIF{fGmwZTD0doFve3CxcoSgbY4hcHWvYX6gR4Fkdy1{IHPlcIx{NCCHQ{WwQVIx|ryP NFjFSGE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEWyOFU6Oid-MUi1NlQ2QTJ:L3G+
A2780 NYDrPZZJTnWwY4Tpc44h[XO|YYm= MUjJcohq[mm2aX;uJI9nKFBvZ4CgbY4hcHWvYX6gZYRzcWGveXPpck1z\XOrc4ThcpQhSTJ5OECgZ4VtdHNiYomgTI9m[2i|dDCzN|M1OiCjc4PhfUwhUUN3ME20MlU4ODh6zszN NV7wbIpURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi2O|g1QTVpPkG4Olc5PDl3PD;hQi=>
A2780 NVv5TXhMTnWwY4Tpc44h[XO|YYm= MXXJcohq[mm2aX;uJI9nKFBvZ4CgbY4hcHWvYX6gRVI4QDBiY3XscJMtKEmFNUC9OU41Os7:TR?= NEHZ[FU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEewO|g5PCd-MUi3NFc5QDR:L3G+
2008 MnPISpVv[3Srb36gZZN{[Xl? MorLTY5pcWKrdHnvckBw\iCqdX3hckBOWlBzIHnuJIh2dWGwIEKwNFgh[2WubIOsJGlEPTB;OT62Ou69VQ>? M3jjeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6N{C3PFg1Lz5zOEewO|g5PDxxYU6=
HEK293 NXfVeZIyTnWwY4Tpc44h[XO|YYm= MoXjTY5pcWKrdHnvckBw\iB2LTi0MUhlcW2ndHj5cIFucW6xKYP0fZJ6dClvTj3t[ZRpgWyyeYLp[IlvcXWvIIXweIFs\SCjdDDoeY1idiCRQ2SxJIV5eHKnc4Pl[EBqdiCKRVuyPVMh[2WubIOgZpkh[2:wZn;jZYwhdWmlcn;zZ49xgSxiSVO1NF03NjkQvF2= MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDd6OEeyOUc,OTh5OEi3NlU9N2F-
MDCK2 NEnhdWxHfW6ldHnvckBie3OjeR?= MU[yNEBucW6| NVnvRWJKTW6qYX7j[Y1mdnRib3[gZ4Ft[2Wrbj3BUUB2eHSja3WgbY4hVUSFS{KgZ4VtdHNib4\ldkBmgHC{ZYPzbY5oKE2GUkGgZYZ1\XJiMkCgcYlveyxiRVO1NF02NjIQvF2= M13k[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6OES5NVY4Lz5zOEi0PVE3PzxxYU6=
MCF7 MX7GeY5kfGmxbjDhd5NigQ>? Mn;QTY5pcWKrdHnvckBw\iCqdX3hckBGWkdiaX6gUWNHPyClZXzsd{whUUN3ME2wMlE1PDV2zszN MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTFzMEO0NUc,OTlzMUCzOFE9N2F-
K562 M1LVWWZ2dmO2aX;uJIF{e2G7 Ml21VoV3\XK|YXygc4YhWC2pbInjc5Bzd3SnaX6tcYVlcWG2ZXSgcZVtfGmmcoXnJJJme2m|dHHuZ4UhcW5iaIXtZY4h\G:6b4L1ZolkcW5vcnXzbZN1[W62IFu1OlIh[2WubIOgZZN{\XO|ZXSgZZMh\HK3ZzDs[ZZmdCClYYXzbY5oKG2jeHnteY0hcW6lcnXhd4UhcW5iboXjcIVieiClb37j[Y51emG2aX;uJI9nKHCrcnHyeYJq[2mwIHL5JJNx\WO2cn;mcJVwemmvZYTyfUBz\WyjdHn2[UB1dyClb370do9tNCCDbIDoZUBu[Xh;MD63{txO MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTF2ME[2OUc,OTlzNEC2OlU9N2F-
K562 MoLMSpVv[3Srb36gZZN{[Xl? MoHFVoV3\XK|YXygc4YhWC2pbInjc5Bzd3SnaX6tcYVlcWG2ZXSgcZVtfGmmcoXnJJJme2m|dHHuZ4UhcW5iaIXtZY4h\G:6b4L1ZolkcW5vcnXzbZN1[W62IFu1OlIh[2WubIOgZZN{\XO|ZXSgZZMh\HK3ZzDs[ZZmdCClYYXzbY5oKDVyJTDpcoNz\WG|ZTDpckBvfWOuZXHyJINwdmOnboTyZZRqd25ib3[gdIlz[XK3YnnjbY4h[nlic4DlZ5Rzd2[udX;ybY1mfHK7LDDBZ5Rqfmm2eU2xMlbPxE1? MnjLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlzNEC2OlUoRjF7MUSwOlY2RC:jPh?=
K562 M{PRRmZ2dmO2aX;uJIF{e2G7 MYexJJVO M{DIPFczKGi{cx?= NGrleFBRd3SnboTpZZRqd25ib3[g[I95d3K3YnnjbY4ucW6mdXPl[EBoem:5dHigbY5pcWKrdHnvckBqdiCqdX3hckBld3ixcoXibYNqdi2{ZYPpd5RidnRiS{W2NkBk\WyuczDlfJBz\XO|aX7nJHBoeCCjdDCxJJVOKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZk> Mlv5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlzNEC2OlUoRjF7MUSwOlY2RC:jPh?=
K562 MV3GeY5kfGmxbjDhd5NigQ>? NVPnOmFbOyC3TR?= M2\6eFczKGi{cx?= MVXQc5RmdnSrYYTpc44hd2ZiZH;4c5J2[mmlaX6tbY5lfWOnZDDndo94fGhiaX7obYJqfGmxbjDpckBpfW2jbjDkc5hwenWkaXPpck1z\XOrc4ThcpQhUzV4MjDj[YxteyCneIDy[ZN{cW6pIGDndEBifCB|IIXNJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYm= NFjycoM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUG0NFY3PSd-MUmxOFA3PjV:L3G+
smooth skeletal cells M1e4dWZ2dmO2aX;uJIF{e2G7 MXPEbZNxdGGlZX3lcpQhd2ZiKD2pMXs{UF2mZY\hdIFucWxiZoLvcUBNNXS7cHWgZ4Ft[2m3bTDjbIFvdmWuIHnuJJJi[mKrdDDzcY9wfGhic3vlcIV1[WxiY3XscJMhemWuYYTpeoUhfG9idnXyZZBidWmuLDDJR|UxRTBwME[wNu69VQ>? MnTHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl{MEOyO|IoRjF7MkCzNlczRC:jPh?=
A2780/ADR MUTGeY5kfGmxbjDhd5NigQ>? MWTJcohq[mm2aX;uJI9nKFBvZ3z5Z49xem:2ZXnuMY1m\GmjdHXkJI12dHSrZIL1[{Bz\XOrc4ThcoNmKGmwIHHkdolidXmlaX6tdoV{cXO2YX70JIh2dWGwIFGyO|gxN0GGUjDj[YxteyCkeTDjZYxk\WmwIFHNJIF{e2G7LDDJR|UxRTVwMt88US=> NULGcYJURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmyOVA5OzRpPkG5NlUxQDN2PD;hQi=>
MDCK2 MoPSSpVv[3Srb36gZZN{[Xl? NFrnWVAzOCCvaX7z MnTLTY5pcWKrdHnvckBw\iCqdX3hckBOTFJzIHX4dJJme3OnZDDpckBOTEONMjDj[YxteyCjc4Pld5Nm\CCjczDlcohidmOnbXXueEBw\iCFYXzj[YlvNUGPIIXweIFs\SC2cnXheIVlKDNyIH3pcpMh[mWob4LlJGNidGOnaX6tRW0h[2ijbHzlcodmKG2nYYP1doVlKGGodHXyJFIxKG2rboOsJGlEPTB;MUVOwG0> MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTRyMk[2OUc,OTl2MEK2OlU9N2F-
BHK MXfGeY5kfGmxbjDhd5NigQ>? MVjJcoR2[3Srb36gc4YhcHWvYX6gbIl{fGmmaX7lNVAufGGpZ3XkJG1FWjFiQWTQZZNmKGGldHn2bZR6KGW6cILld5Nm\CCrbjDCTGsh[2WubIOgZpkh[XCyYYLlcpQhVWmlaHHlcIl{NU2nboTlckBkd26|dHHueEwhU21;MkVOwG0> NIrnXno9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUSwNlY3PSd-MUm0NFI3PjV:L3G+
2008/MRP1 MWXGeY5kfGmxbjDhd5NigQ>? MmrBVoV3\XK|YXygc4YhVVKSMT3t[YRq[XSnZDDkc5hwenWkaXPpck1z\XOrc4ThcoNmKGmwIHj1cYFvKDJyMEivUXJROSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25ib3[g[I95d3K3YnnjbY4hUUN3MDDw[ZJk\W62IHL5JIhidGZuIFHjeIl3cXS7PUKuOu69VQ>? MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTd{NUW3PEc,OTl5MkW1O|g9N2F-
2008/MRP1 MXfGeY5kfGmxbjDhd5NigQ>? NW\wdlFsUW6qaXLpeIlwdiCxZjDNVnAyKGmwIHj1cYFvKDJyMEivUXJROSClZXzsd{BjgSCOaX7le4VifmW{LVL1dotmKHCub4SgZY5idHm|aYOsJGtqRTF|LkNOwG0> MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTd{NUW3PEc,OTl5MkW1O|g9N2F-
2008/MRP1 MX;GeY5kfGmxbjDhd5NigQ>? MY\Jcohq[mm2aX;uJI9nKE2UUEGgbY4hcHWvYX6gNlAxQC:PUmCxJINmdGy|IHL5JIRqgG:wIIDsc5Qh[W6jbInzbZMtKEurPUGzMlTPxE1? M2LTZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7N{K1OVc5Lz5zOUeyOVU4QDxxYU6=
2008/MRP1 M4nlc2Z2dmO2aX;uJIF{e2G7 NIDwNIQyOjBibXnudy=> MWLS[ZZmenOjbDDv[kBOWlBzLX3l[IlifGWmIHTvfI9zfWKrY3nuJJJme2m|dHHuZ4UhcW5iZH;4c5J2[mmlaX6gZ48ucW6ldXLheIVlKGi3bXHuJFIxODhxTWLQNUBk\WyuczDhd5Nme3OnZDDhd{BucW6rbYXtJINwdmOnboTyZZRqd25icnXxeYlz\WRiZn;yJJJme3SxcnH0bY9vKG:oIHTvfI9zfWKrY3nuJIFk[3WvdXzheIlwdiCjZoTldkAyOjBibXnud{BjgSC|cHXjeJJw\my3b4LpcYV1enlicnXsZZRqfmVidH:gZYNkfW23bHH0bY9vKGmwIHj1cYE> M3XuZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7N{K1OVc5Lz5zOUeyOVU4QDxxYU6=
K562 M3LGdmZ2dmO2aX;uJIF{e2G7 NXK4ZnNKUW6qaXLpeIlwdiCxZjDQMYdtgWOxcILveIVqdi2vZXTpZZRm\CCvdXz0bYRzfWdicnXzbZN1[W6lZTDpckBpfW2jbjDkc5hwenWkaXPpck1z\XOrc4ThcpQhUzV4MjDj[YxteyCjc4Pld5Nm\CCjczDkdpVoKGyndnXsJINifXOrbnegOVAmKGmwY4LlZZNmKGmwIH71Z4xm[XJiY3;uZ4VvfHKjdHnvckBw\iCyaYLhdpVjcWOrbjDifUB{eGWldILv[ox2d3KrbXX0dpktKEmQSE2xMlbPxE1? NG\zZW49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEGwOFg2OSd-MkCxNFQ5PTF:L3G+
MDCK MnTXSpVv[3Srb36gZZN{[Xl? NWTj[Gd2OzBidV2= NXqzU|Q3OS53IHjydy=> MYXJcohq[mm2aX;uJI9nKGi3bXHuJG1FWjFiZYjwdoV{e2WmIHnuJG1FS0tiY3XscJMh[XO|ZYPz[YQh[XNiZnz1c5Jme2OnbnPlJIFkfGm4aYT5JIF1KDNyIIXNJIFnfGW{IEGuOUBpenNiYomgdohw\GGvaX7lJFEzOyCnZn\seZghfGW|dB?= MlXPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB|NkO2N|UoRjJyM{[zOlM2RC:jPh?=
BHK21 MkjmR5l1d3SxeHnjbZR6KGG|c3H5 NIDjVoM6PiCqcoO= NYHVcnpvS3m2b4TvfIlkcXS7IHHnZYlve3RiaHHtd5RmeiCESFuyNUBk\WyuczDlfJBz\XO|aX7nJG1TWDFiYX\0[ZIhQTZiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0yOC54zszN NFjSOoY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{ME[5NVU6QSd-MkC2PVE2QTl:L3G+
K562 MVLGeY5kfGmxbjDhd5NigQ>? M3LmdmlvcGmkaYTpc44hd2ZiUHfwMY1m\GmjdHXkJI12dHSrZIL1[{Bz\XOrc4ThcoNmKGmwIHTvfI9zfWKrY3nuMZJme2m|dHHueEBpfW2jbjDLOVYzKGOnbHzzJIF{e2W|c3XkJIF{KGS{dXegcIV3\WxicnXxeYlz\WRiZn;yJI1igGmvdX2gbY5kemWjc3WgbY4hdnWlbHXhdkBkd26lZX70doF1cW:wIH;mJJBqemG{dXLpZ4lvKGK7IH\seY9z\XOlZX7j[UBie3OjeTygRYxxcGFibXH4QVAvP87:TR?= NFHhOmU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUG0OVc{QSd-MkGxOFU4Ozl:L3G+
K562 NYLne28{TnWwY4Tpc44h[XO|YYm= NXLnTnpxUW6qaXLpeIlwdiCxZjDQ[5AudWWmaXH0[YQhdXWudHnkdpVoKHKnc3nzeIFv[2ViaX6g[I95d3K3YnnjbY4uemW|aYP0ZY51KGi3bXHuJGs2PjJiY3XscJMh[XO|ZYPz[YQh[XNiZIL1[{Bt\X[nbDDy[ZF2cXKnZDDmc5IhPTBnIHnuZ5Jm[XOnIHnuJI52[2ynYYKgZ49v[2WwdILheIlwdiCxZjDwbZJienWkaXPpckBjgSCobIXvdoV{[2WwY3WgZZN{[XluIFnDOVA:OS54zszN NH;ieIo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUG0OVc{QSd-MkGxOFU4Ozl:L3G+
HEK-293 MYfGeY5kfGmxbjDhd5NigQ>? MkTyTY5pcWKrdHnvckBw\iC|b3TpeY0h[3W{cnXueEBu\WG|dYLl[EB2e2mwZzD3bI9t\S2lZXzsJJBifGOqIHPsZY1xKGW6cHXybY1mdnS|IHnuJGhGUy1{OUOgZ4VtdHNic4ThZox6KHS{YX7z[oVkfGWmIIfpeIghcE6jVkGuOUBkTE6DLDDJR|UxRTRzLkZOwG0> NE\CblM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUOwNFczOSd-MkGzNFA4OjF:L3G+
HCT15 M4H3TGZ2dmO2aX;uJIF{e2G7 NH7Fb4NKdmirYnn0bY9vKG:oIFHCR{B1emGwc4DvdpRmeiCrbjDoeY1idiCKQ2SxOUBk\WyuczDhd5Nme3OnZDDhd{Bk[WylZXnuMWFOKGWoZnz1fEB2eCC2bzCxNFAhfU1? MlvrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF|NEi0OlEoRjJzM{S4OFYyRC:jPh?=
HCT15 M1rIXGN6fG:2b4jpZ4l1gSCjc4PhfS=> NEPYdGFEgXSxdH;4bYNqfHliYXfhbY5{fCCPRGKxJIV5eHKnc4PpcochcHWvYX6gTGNVOTViY3XscJM> NEnKNGw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUO0PFQ3OSd-MkGzOFg1PjF:L3G+
HCT15 MVjGeY5kfGmxbjDhd5NigQ>? MVu0NEB2VQ>? MYjJcohq[mm2aX;uJI9nKE2GUkGgbY4hcHWvYX6gTGNVOTViY3XscJMh[XO|ZYPz[YQh[XNiY3HsZ4Vqdi2DTTDl[oZtfXhiYYSgOFAhfU1iYomg[ox2d3Knc3PlcoNmKGG|c3H5 MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTN2OES2NUc,OjF|NEi0OlE9N2F-
A2780adr MWLGeY5kfGmxbjDhd5NigQ>? MonOTY5pcWKrdHnvckBw\iCSLXfwJIV5eHKnc4Pl[EBqdiCDMke4NIFleiClZXzsd{BjgSClYXzj[YlvKEGPIHHjZ5VufWyjdHnvckBie3OjeTygTWM2OD13LkVOwG0> NGD4Slg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUO1OFgxOCd-MkGzOVQ5ODB:L3G+
MDCK NEfX[lNHfW6ldHnvckBie3OjeR?= MVTJcohq[mm2aX;uJI9nKE2GUkGg[ZhxemW|c3XkJIlvKE2GQ1ugZ4VtdHNidYPpcochemixZHHtbY5mKDF{MzDzeIFqdmmwZzDifUBndG:5IHP5eI9u\XS{eTygTWM2OD17LklOwG0> M1vrT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzM{W0PFAxLz5{MUO1OFgxODxxYU6=
NIH-3T3 MmLmSpVv[3Srb36gZZN{[Xl? MXexNEB2VQ>? MVOzNEBucW6| NX;i[WVvUW6qaXLpeIlwdiCxZjDoeY1idiCPRGKxJIV5eHKnc4Pl[EBqdiCvb4Xz[UBPUUhvM2SzJINmdGy|IHHzd4V{e2WmIHHzJIRifW6xbYnjbY4h\W[obIX4JIF1KDFyIIXNJIFnfGW{IEOwJI1qdnNiYomg[oxwfyCleYTvcYV1enl? MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTh3NkC0PUc,OjF6NU[wOFk9N2F-
MDCK MWDGeY5kfGmxbjDhd5NigQ>? NF\YZ2M{OCCvaX7z MljrTY5pcWKrdHnvckBw\iCqdX3hckBOTFJzIHX4dJJme3OnZDDpckBOTEONIHPlcIx{KGG|c3Xzd4VlKGG|IHPhcINmcW5iQV2gZYNkfW23bHH0bY9vKGGodHXyJFMxKG2rboOgZpkh\my3b4Lld4NmdmOnIHHzd4F6NCCLQ{WwQVAvPc7:TR?= MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjFzMkKwPEc,OjJzMUKyNFg9N2F-
MDCK NIH2W4xHfW6ldHnvckBie3OjeR?= NW\GVVdiOzBibXnudy=> NUjNfIpkUW6qaXLpeIlwdiCxZjDNVnAyKGW6cILld5Nm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KGOjbHPlbY4hSU1iYXPjeY12dGG2aX;uJIFnfGW{IEOwJI1qdnNiYomg[ox2d3Knc3PlcoNmKGG|c3H5MEBKSzVyPU[uPO69VQ>? Ml;wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzMUKyNFgoRjJ{MUGyNlA5RC:jPh?=
Caco2 MlPkSpVv[3Srb36gZZN{[Xl? M2fkfVUhfG9iMkWgeW0> NYXGfVRzOS53IHjydy=> MnPrTY5pcWKrdHnvckBw\iCSLXfsfYNweHKxdHXpckBwfmW{ZYjwdoV{e2WmIHnuJIh2dWGwIFPhZ48zKGOnbHzzJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHTp[495cW5iYXPjeY12dGG2aX;uJIF1KDVidH:gNlUhfU1iaX7jeYJifGWmIH\vdkAyNjViaILzJJBzcW:{IITvJIRq\2:6aX6geJJm[XSvZX70JI1m[XO3cnXkJIFnfGW{IEGuOUBpenNiYomgUGMwVVNxTWOgZY5idHm|aYO= MmHtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{MEm0PFYoRjJ{MkC5OFg3RC:jPh?=
LCC6MDR NVy3N2NWTnWwY4Tpc44h[XO|YYm= M{Xpd|Uh\GG7cx?= MWXS[ZZmenOjbDDv[kBRNWeyLX3l[IlifGWmIHTvfI9zfWKrY3nuMZJme2m|dHHuZ4UhcW5iaIXtZY4hVEOFNl3EVkBk\WyuczDh[pRmeiB3IHThfZMh[nliTWTTJIF{e2G7LDDFR|UxRTBwMkS1{txO M2\2UlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{KwOFAzLz5{MkOyNFQxOjxxYU6=
LCC6MDR M1TNZWZ2dmO2aX;uJIF{e2G7 NYW3NGl4PSCmYYnz M1LNdnJmfmW{c3HsJI9nKFBvZ4CtcYVlcWG2ZXSgeolv[3Krc4TpcoUuemW|aYP0ZY5k\SCrbjDoeY1idiCOQ1O2UWRTKGOnbHzzJIFnfGW{IEWg[IF6eyCkeTDNWHMh[XO|YYmsJGVEPTB;MD6zPFXPxE1? MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN{MESwNkc,OjJ|MkC0NFI9N2F-
LCC6MDR Mmj5SpVv[3Srb36gZZN{[Xl? MkHCOUBl[Xm| MmfhVoV3\XK|YXygc4YhWC2pcD3t[YRq[XSnZDDwZYNtcXSjeHXsMZJme2m|dHHuZ4UhcW5iaIXtZY4hVEOFNl3EVkBk\WyuczDh[pRmeiB3IHThfZMh[nliTWTTJIF{e2G7LDDFR|UxRTBwNEK4{txO M1zhTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{KwOFAzLz5{MkOyNFQxOjxxYU6=
LCC6MDR MUDGeY5kfGmxbjDhd5NigQ>? NWHye2oxPSCmYYnz NIDDWHNT\X[ncoPhcEBw\iCSLXfwMY1m\GmjdHXkJJZqdmKuYYP0bY4uemW|aYP0ZY5k\SCrbjDoeY1idiCOQ1O2UWRTKGOnbHzzJIFnfGW{IEWg[IF6eyCkeTDNWHMh[XO|YYmsJGVEPTB;MD61NFPPxE1? NVjxRnI2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKzNlA1ODJpPkKyN|IxPDB{PD;hQi=>
MDA435/LCC6MDR NXfDOVVtTnWwY4Tpc44h[XO|YYm= NVvk[oJGS2:vcHX0bZRqfmViaX7obYJqfGmxbjDv[kBRNWeyIH;2[ZJmgHC{ZYPz[YQhcW5iaIXtZY4hVUSDNEO1M2xESz[PRGKgZ4VtdHNiYYPz[ZN{\WRiYYOgZYNkfW23bHH0bY9vKG:oIHTvfI9zfWKrY3nuJIJ6KEyrbnX3[YF3\XJvQoXyb{BxdG:2IHHuZYx6e2m|LDDLbV0yNjd3zszN NFXVbHg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkOyNFQxOid-MkKzNlA1ODJ:L3G+
MDA435/LCC6MDR NYLaTmR5TnWwY4Tpc44h[XO|YYm= MVvDc41x\XSrdHn2[UBqdmirYnn0bY9vKG:oIGCt[5Ahd3[ncnX4dJJme3OnZDDpckBpfW2jbjDNSGE1OzVxTFPDOm1FWiClZXzsd{Bie3Onc4Pl[EBieyCjY3P1cZVt[XSrb36gc4Yh\G:6b4L1ZolkcW5iYomgSIl5d25icHzveEBidmGueYPpd{whU2l;MT63Oe69VQ>? MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN{MESwNkc,OjJ|MkC0NFI9N2F-
MDA435/LCC6MDR NWrQZmgxTnWwY4Tpc44h[XO|YYm= MU[xOVAhdWmwcx?= MlXnTY5pcWKrdHnvckBw\iCSLXfwJI93\XKneIDy[ZN{\WRiaX6gbJVu[W5iTVTBOFM2N0yFQ{\NSHIh[2WubIOgZZN{\XO|ZXSgZZMh[WOldX31cIF1cW:wIH;mJIRwgG:{dXLpZ4lvKGGodHXyJFE2OCCvaX7zJIJ6KG[udX;y[ZNk\W6lZTDzdIVkfHKxcHjveI9u\XS{aXOgZY5idHm|aYOsJG1KSz16zszN MkXIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|MkC0NFIoRjJ{M{KwOFAzRC:jPh?=
K562/A02 NGHETXJHfW6ldHnvckBie3OjeR?= NYnjXXByOTBidV2= MVHS[ZZmenOjbDDv[kBxNWeueXPvdJJwfGWrbj3t[YRq[XSnZDDteYx1cWS{dXetdoV{cXO2YX70JIlvKGi3bXHuJGs2PjJxQUCyJINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGGmcnnhcZlkcW5vaX7keYNm\CCleYTveI95cWNiZX\m[YN1KGG2IEGwJJVOKHS{ZXH0[YQhOjRiaILzJIJm\m:{ZTDh[JJq[W27Y3nuJINp[WyuZX7n[UBnd2yub4fl[EBjgSCmcoXnJJdie2ixdYSgZpkhVVSVIHHzd4F6NCCLQ{WwQVEzNjl{zszN MlT1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2MEW2OFYoRjJ{NEC1OlQ3RC:jPh?=
K562/A02 NHiybpNHfW6ldHnvckBie3OjeR?= MnrBNVAhfU1? NXfQSYZvOjRiaILz NYXvN29{WmW4ZYLzZYwhd2ZicD3ncJlkd3C{b4TlbY4udWWmaXH0[YQhdXWudHnkdpVoNXKnc3nzeIFvfCCrbjDoeY1idiCNNU[yM2ExOiClZXzsd{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCxZjDh[JJq[W27Y3nuMYlv\HWlZXSgZ5l1d3SxeHnjJIVn\mWldDDheEAyOCC3TTD0doVifGWmIH\vdkAzPCCqcoOg[o9tdG:5ZXSgZpkh[WS{aXHtfYNqdiC2cnXheIVlKDZiaILzJIFnfGW{IHTyeYchf2G|aH;1eEBjgSCPVGOgZZN{[XluIFnDOVA:OjZwMEdOwG0> MmXvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2MEW2OFYoRjJ{NEC1OlQ3RC:jPh?=
K562/A02 M1HoNmZ2dmO2aX;uJIF{e2G7 NFLoRnAxNjJ3IITvJFUh[W[2ZYK= MVe2NEBucW6| M121d2lvcGmkaYTpc44hd2ZicD3ncJlkd3C{b4TlbY4udWWmaXH0[YQhemixZHHtbY5mKDF{MzDl[oZtfXhiaX6gbJVu[W5iS{W2Nk9CODJiY3XscJMh[XRiMD6yOUB1dyB3IHHmeIVzKDZyIH3pcpMh[nliZnz1c5Jme2OnbnPlJI1q[3Kxc3PvdIlkKGGwYXz5d4l{ M{nxOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEC1OlQ3Lz5{MkSwOVY1PjxxYU6=
K562/A02 MX;GeY5kfGmxbjDhd5NigQ>? MVGxNEB2VQ>? M1G5S|MxKG2rboO= MVXJcohq[mm2aX;uJI9nKFCpcD3t[YRq[XSnZDDybI9l[W2rbnWgNVI{KGWoZnz1fEBqdiCqdX3hckBMPTZ{L1GwNkBk\WyuczDhd5Nme3OnZDDhd{BqdnS{YXPlcIx2dGG{IILoc4RidWmwZTCxNlMh[WOldX31cIF1cW:wIHH0JFExKHWPIIDy[Ylv[3WkYYTl[EBnd3JiM{CgcYlveyCvZXHzeZJm\CCjZoTldkA3OCCvaX7zJIJ6KG[udX;y[ZNk\W6lZTDtbYNzd3Olb4D5JJJmdGG2aY\lJJRwKGOxboTyc4w> NFmyNFM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSyPVUxQSd-MkK0Nlk2ODl:L3G+
K562/A02 MVfGeY5kfGmxbjDhd5NigQ>? NFHLfXoyOCC3TR?= M3;NUlI1KGi{cx?= M4HVdGlvcGmkaYTpc44hd2ZiUD3ncJlkd3C{b4TlbY4hcW5iaIXtZY4hUzV4Mj;BNFIh[2WubIOgZZN{\XO|ZXSgZZMheG:2ZX70bYF1cW:wIH;mJIFlemmjbYnjbY4ucW6mdXPl[EBkgXSxdH;4bYNqfHliYYSgNVAhfU1icILlbY5kfWKjdHXkJIZweiB{NDDodpMh\m:ubH;3[YQh[nlid3HzbI92fCCkZX\vdoUh[WSmaYTpc44hd2ZiYXTybYFugWOrbjDt[YF{fXKnZDDh[pRmeiB5MjDodpMh[nliTWTTJIF{e2G7IDjSeoIhRSB|Mz61PUB2VSl? M3zic|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEK5OVA6Lz5{MkSyPVUxQTxxYU6=
K562/A02 NXjPcWxHTnWwY4Tpc44h[XO|YYm= M3ThXVExKHWP M3HUdFI1KGi{cx?= Mn\UTY5pcWKrdHnvckBw\iCSLXfsfYNweHKxdHXpckBqdiCqdX3hckBMPTZ{L1GwNkBk\WyuczDhd5Nme3OnZDDhd{Bxd3SnboTpZZRqd25ib3[gZYRzcWGveXPpck1qdmS3Y3XkJIN6fG:2b4jpZ4l1gSCjdDCxNEB2VSCycnXpcoN2[mG2ZXSg[o9zKDJ2IHjyd{Bnd2yub4fl[EBjgSC5YYPoc5V1KGGmZHn0bY9vKG:oIHHkdolidXmlaX6gZZQhPiCqcoOgdI9{fCC5YYPoc5V1KG2nYYP1doVlKGGodHXyJFczKGi{czDifUBOXFNiYYPzZZkhMFK4YjC9JFM2 MnqyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2Mkm1NFkoRjJ{NEK5OVA6RC:jPh?=
K562/A02 NE\vSZZHfW6ldHnvckBie3OjeR?= MmHpNVAhfU1? M{HnTVI1KGi{cx?= MXTJcohq[mm2aX;uJI9nKFBvZ3z5Z49xem:2ZXnuJIlvKGi3bXHuJGs2PjJxQUCyJINmdGy|IHHzd4V{e2WmIHHzJJBwfGWwdHnheIlwdiCxZjDh[JJq[W27Y3nuMYlv\HWlZXSgZ5l1d3SxeHnjbZR6KGG2IEGwJJVOKHC{ZXnuZ5Vj[XSnZDDmc5IhOjRiaILzJIZwdGyxd3XkJIJ6KHejc3jveZQh[WSmaYTpc44hd2ZiYXTybYFugWOrbjDheEAyOiCqcoOgdI9{fCC5YYPoc5V1KG2nYYP1doVlKGGodHXyJFczKGi{czDifUBOXFNiYYPzZZkhMFK4YjC9JFU> MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR{OUWwPUc,OjJ2Mkm1NFk9N2F-
K562/A02 MnOySpVv[3Srb36gZZN{[Xl? MU[xNEB2VQ>? MXSyOEBpenN? NUHFS5NoUW6qaXLpeIlwdiCxZjDQMYdtgWOxcILveIVqdiCrbjDoeY1idiCNNU[yM2ExOiClZXzsd{Bie3Onc4Pl[EBieyCyb4TlcpRq[XSrb36gc4Yh[WS{aXHtfYNqdi2rbnT1Z4VlKGO7dH;0c5hq[2m2eTDheEAyOCC3TTDwdoVqdmO3YnH0[YQh\m:{IEK0JIhzeyCob3zsc5dm\CCkeTD3ZZNpd3W2IHHk[Il1cW:wIH;mJIFlemmjbYnjbY4h[XRiMkSgbJJ{KHCxc4Sge4F{cG:3dDDt[YF{fXKnZDDh[pRmeiB5MjDodpMh[nliTWTTJIF{e2G7IDjSeoIhRSB3 MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR{OUWwPUc,OjJ2Mkm1NFk9N2F-
K562/A02 NEPufYhHfW6ldHnvckBie3OjeR?= M{H2NVAvOzNidH:gNVAhfU1? M4\yOFYxKG2rboO= NH7rUWlKdmirYnn0bY9vKG:oIGDndE1u\WSrYYTl[EBzcG:mYX3pcoUuOTJ|IHXm[ox2gCCrbjDteYx1cWS{dXetdoV{cXO2YX7j[UBpfW2jbjDLOVYzN0FyMjDj[YxteyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBqdnS{YXPlcIx2dGG{IHHjZ5VufWyjdHnvckBw\iC{aH;kZY1qdmVvMUKzJIF1KDBwM{OgeI8hOTBidV2gZYZ1\XJiNkCgcYlveyCkeTDmcI94KGO7dH;t[ZRzgSCjbnHsfZNqew>? NGXRZ3Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkS1NFE{PCd-MkK0OVAyOzR:L3G+
K562/A02 NYj2UnJ6TnWwY4Tpc44h[XO|YYm= NV;BUpN{OC5|MzD0c{AyOCC3TR?= MoL1OlAhdWmwcx?= NFLCSnFKdmirYnn0bY9vKG:oIGDndE1u\WSrYYTl[EBzcG:mYX3pcoUuOTJ|IHXm[ox2gCCrbjDteYx1cWS{dXetdoV{cXO2YX7j[UBpfW2jbjDLOVYzN0FyMjDj[YxteyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDpckBqdnS{YXPlcIx2dGG{IHHjZ5VufWyjdHnvckBw\iC{aH;kZY1qdmVvMUKzJIF1KDBwM{OgeI8hOTBidV2gZYZ1\XJiNkCgcYlveyCkeTDmcJVwemW|Y3XuZ4UhdWmlcn;zZ49xcWNiYX7hcJl{cXN? MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR3MEGzOEc,OjJ2NUCxN|Q9N2F-
K562/A02 MojtSpVv[3Srb36gZZN{[Xl? M2rrVlAvOzNidH:gNVAhfU1? MoPCOlAhdWmwcx?= NGHpW3NKdmirYnn0bY9vKG:oIGDndE1u\WSrYYTl[EBi\HKrYX35Z4lvKGWoZnz1fEBqdiCvdXz0bYRzfWdvcnXzbZN1[W6lZTDoeY1idiCNNU[yM2ExOiClZXzsd{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDpcpRz[WOnbHz1cIFzKGGlY4XteYxifGmxbjDv[kBi\HKrYX35Z4lvKGG2IECuN|MhfG9iMUCgeW0h[W[2ZYKgOlAhdWmwczDifUBHSUOVIH\sc5ch[3m2b33leJJ6 MlLlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2NUCxN|QoRjJ{NEWwNVM1RC:jPh?=
CCRF-CEM/VCR1000 MmDKSpVv[3Srb36gZZN{[Xl? Mn:xNlQxKHOnY4O= MWDJcohq[mm2aX;uJI9nKFBvZ3z5Z49xem:2ZXnuMY1m\GmjdHXkJIRifW6xcoXibYNqdiCnZn\seZgh\nKxbTDoeY1idiCFQ2LGMWNGVS:YQ2KxNFAxKGOnbHzzJIFnfGW{IEK0NEB{\WO|IHL5JGZCS1NiZnzve{BkgXSxbXX0dolkKGGwYXz5d4l{NCCLQ{WwQVAvPTd3NEVOwG0> M{W0ZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEWyOFEzLz5{MkS1NlQyOjxxYU6=
BHK NYK3bYc3TnWwY4Tpc44h[XO|YYm= NHj3UnU{OCCvaX7z NFz1XmpKdmS3Y4Tpc44hd2ZiQWTQZZNmKGGldHn2bZR6KG:oIHj1cYFvKEirc{GwMZRi\2enZDDQMYdxKGW6cILld5Nm\CCrbjDCTGsh[2WubIOgZZN{\XO|ZXSgZZMhcW6xcnfhcolkKHCqb4PwbIF1\SC{ZXzlZZNmKGGodHXyJFMxKG2rboOgZpkhVWmlaHHlcIl{NU2nboTlckBidmGueYPpd{whU21;MkVOwG0> MlfpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ3M{O5NFUoRjJ{NUOzPVA2RC:jPh?=
HEK293 M3zCUGZ2dmO2aX;uJIF{e2G7 NGjKU4lKdmirYnn0bY9vKG:oIF;BWHAySjFiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gTGVMOjl|IHPlcIx{KHW|aX7nJIV{fHKjZHnvcE0yP2KndHGt[4x2[3W{b37p[IUhe3Wkc4TyZZRmNCCLQ{WwQVMz|ryP MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV6N{m4Okc,OjJ3OEe5PFY9N2F-
KBVIN NHzt[WxHfW6ldHnvckBie3OjeR?= NEHJSmgyOCC3TR?= MYW3NkBpenN? NF;OWFVKdmirYnn0bY9vKG:oIGCt[5AudWWmaXH0[YQhdXWudHnkdpVoNXKnc3nzeIFv[2ViaX6gbJVu[W5iS1LWTW4h[2WubIOgZZN{\XO|ZXSgZZMheGGlbHn0ZZhmdC2rbnT1Z4VlKGO7dH;0c5hq[2m2eTDheEAyOCC3TTDh[pRmeiB5MjDodpMh[nliU2LCJIF{e2G7 NH;ZeFM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mk[xNlY2Oid-MkK2NVI3PTJ:L3G+
KBVIN MkTlSpVv[3Srb36gZZN{[Xl? NETJO4gyOCC3TR?= NEjZS3A4OiCqcoO= NFH6b5FKdmirYnn0bY9vKG:oIGCt[5AudWWmaXH0[YQhdXWudHnkdpVoNXKnc3nzeIFv[2ViaX6gbJVu[W5iS1LWTW4h[2WubIOgZZN{\XO|ZXSgZZMhfmmwY4Lpd5RqdmVvaX7keYNm\CCleYTveI95cWOrdImgZZQhOTBidV2gZYZ1\XJiN{KgbJJ{KGK7IGPSRkBie3OjeR?= MlK2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ4MUK2OVIoRjJ{NkGyOlUzRC:jPh?=
KBVIN Mk[zSpVv[3Srb36gZZN{[Xl? Mm\ENVAhfU1? NWHHc3B1PzJiaILz MYLJcohq[mm2aX;uJI9nKFBvZ4CtcYVlcWG2ZXSgcZVtfGmmcoXnMZJme2m|dHHuZ4UhcW5iaIXtZY4hU0KYSV6gZ4VtdHNiYYPz[ZN{\WRiYYOg[I95d3K3YnnjbY4ucW6mdXPl[EBkgXSxdH;4bYNqfHliYYSgNVAhfU1iYX\0[ZIhPzJiaILzJIJ6KFOUQjDhd5NigQ>? NX36OIQyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK2NVI3PTJpPkKyOlEzPjV{PD;hQi=>
C1-6-37-3 NEL5eIxHfW6ldHnvckBie3OjeR?= Mkn5N|AhdWmwcx?= Mn7MTY5pcWKrdHnvckBw\iCqdX3hckB3d2y2YXflMYRmeGWwZHXueEBNNXS7cHWgZ4Ft[2m3bTDjbIFvdmWuIIP1ZpVvcXRiYXzwbIEySy:jbIDoZVJl\Wy2YT;i[ZRiOmFiZYjwdoV{e2WmIHnuJGMyNTZvM{etN{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFurMYlv\HWlZXSgZ4Ft[2m3bTDpcoZtfXhiaX7jeYJifGWmIH\vdkA{OCCvaX7zJJBzcW:{IITvJGssNWmwZIXjeIlwdiCkeTDGcJVwNTRvQV2gZoF{\WRiRlzJVHIh[XO|YYmsJGlEPTB;MD65{txO MmnjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ4OUSyO|AoRjJ{Nkm0NlcxRC:jPh?=
BHK MY\GeY5kfGmxbjDhd5NigQ>? MnnURolv\GmwZzDh[oZqdmm2eTD0c{BpfW2jbjDIbZMyOC22YXfn[YQhWC2pcDDlfJBz\XO|ZXSgbY4hSkiNIHPlcIx{KGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBCXFCjc3WgZYN1cX[rdImgcYVie3W{ZXSgZZMhcW6xcnfhcolkKHCqb4PwbIF1\SC{ZXzlZZNmKGK7IIPw[YN1em:yaH;0c41mfHKrYzDhcoFtgXOrczygT40:OjUQvF2= NWD0S4hVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK3Nlc4QDBpPkKyO|I4PzhyPD;hQi=>
ovary cells NXjXfJVvTnWwY4Tpc44h[XO|YYm= M2DKeWlvcGmkaYTpc44hd2ZiTD30fZBmKGOjbHPpeY0h[2ijbn7lcEBu\WG|dYLl[EB2e2mwZzCyMYVt\WO2cn;k[UB3d2y2YXflMYNt[W2yIHnuJGNpcW6nc3WgbIFue3SncjDveoFzgSClZXzsd{Bp\XSncn;sc4dq[2GubImg[ZhxemW|c3nu[{BidHCqYT2xR{B{fWK3bnn0MEBKSzVyPUKzMlXPxE1? MojRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ5NkGwNFAoRjJ{N{[xNFAxRC:jPh?=
embryonic kidney cells MnTiSpVv[3Srb36gZZN{[Xl? NV3xUG0zUW6qaXLpeIlwdiCxZjDMMZR6eGViY3HsZ4l2dSClaHHucoVtKG2nYYP1doVlKHW|aX7nJFIu\WynY4Tyc4RmKH[xbITh[4Uu[2yjbYCgbY4hcHWvYX6g[Y1jenmxbnnjJItq\G6neTDj[YxteyCqZYTldo9td2erY3HscJkh\XiycnXzd4lv\yCjbIDoZU0ySyC|dXL1col1NCCLQ{WwQVI1|ryP M3vw[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{N{[xNFAxLz5{Mke2NVAxODxxYU6=
embryonic kidney cells M2[ycmZ2dmO2aX;uJIF{e2G7 MlnlTY5pcWKrdHnvckBw\iCOLYT5dIUh[2GuY3n1cUBkcGGwbnXsJI1m[XO3cnXkJJV{cW6pIEKt[Yxm[3S{b3TlJJZwdHSjZ3WtZ4xidXBiaX6gbJVu[W5iZX3idplwdmmlIHvp[I5mgSClZXzsd{Bp\XSncn;sc4dq[2GubImg[ZhxemW|c3nu[{BidHCqYT2xR{B{fWK3bnn0MEBKSzVyPUS3{txO NGXTc|k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mke2NVAxOCd-MkK3OlExODB:L3G+
L929 MVHGeY5kfGmxbjDhd5NigQ>? NIC5WGtKdmirYnn0bY9vKG:oIFv2NU4{KGW6cILld5Nm\CCrbjDtc5V{\SCOOUK5JINmdGy|IHX4dI9{\WRidH:g[IVxd2yjcnn6bY5oKHO2ZYCgdJVte2W|IH\yc40hNThyIH3WJJRwKCt2MDDtWkBjgSC5aH;s[UBk\WyuIIDheINpKGOuYX3wJI1mfGixZDygTWM2OD16zszN NWDudY93RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwPFQzPzhpPkKzNFg1Ojd6PD;hQi=>
K562 NU\VPHZNTnWwY4Tpc44h[XO|YYm= NG\oW4VKdmirYnn0bY9vKG:oIGCt[4x6[2:ycn;0[YlvKGmwIHj1cYFvKGSxeH;yeYJq[2mwLYLld4l{fGGwdDDLOVYzKGOnbHzzJIF{e2W|c3XkJIF{KGijbH[gcYF5cW2jbDDpcoNz\WG|ZTDv[kBxcXKjcoXibYNqdiCjY3P1cZVt[XSrb36gZpkhe3CnY4Tyc4ZtfW:{b33leJJq[yCjbnHsfZNqeyxiSVO1NF0yNjcQvF2= NVLN[pBlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyOFU2PzFpPkKzNlQ2PTdzPD;hQi=>
KB/VCR M3XZfWZ2dmO2aX;uJIF{e2G7 MYi3NkBpenN? MXjJcohq[mm2aX;uJI9nKHBvZ4CgbY4hcHWvYX6gT2IwXkOUIHPlcIx{KGG|c3Xzd4VlKGG|IIDveIVvfGmjdHnvckBw\iBzMECgcm0h\G:lZYThfIVtNWmwZIXj[YQh[3m2b4TvfIlkcXS7IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFXDOVA:OS5{NUROwG0> Ml\tQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4OEO4N|QoRjJ|NkizPFM1RC:jPh?=
KB/VCR NFT1V4dHfW6ldHnvckBie3OjeR?= NHvuV3g2KHWP NYHDOWVMPzJiaILz NIDT[IJKdmirYnn0bY9vKG:oIICt[5AhcW5iaIXtZY4hU0JxVlPSJINmdGy|IHHzd4V{e2WmIHHzJJBwfGWwdHnheIlwdiCxZjDh[JJq[W27Y3nuMYlv\HWlZXSgZ5l1d3SxeHnjbZR6KGG2IEWgeW0h[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfS=> NFf0TYo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[4N|g{PCd-MkO2PFM5OzR:L3G+
KB/VCR NVO4NW44TnWwY4Tpc44h[XO|YYm= M2C0[VUhfU1? Ml\mO|IhcHK| MUTJcohq[mm2aX;uJI9nKHBvZ4CgbY4hcHWvYX6gT2IwXkOUIHPlcIx{KGG|c3Xzd4VlKGG|IIDveIVvfGmjdHnvckBw\iC4aX7jdol{fGmwZT3pcoR2[2WmIHP5eI91d3irY3n0fUBifCB3IIXNJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYm= MljWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4OEO4N|QoRjJ|NkizPFM1RC:jPh?=
CHO NFvqSGZHfW6ldHnvckBie3OjeR?= NWH2d|hiUW6qaXLpeIlwdiCxZjDDZZYyNjJiY4XydoVvfCCvZXHzeZJm\CC3c3nu[{BSWGG2Y3igZZV1d22jdHnjJJBifGhiY3zhcZAhe3m|dHXtJIlvKEOKTzDj[YxteyCneIDy[ZN{cW6pIFPhelEvOixiYnX0ZU0zKGGwZDDhcJBp[S1{L3TlcJRiNTFic4XieY5qfHNuIFnDOVA:OC5{zszN M37K[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OEGyOVA{Lz5{M{ixNlUxOzxxYU6=
MDA435/LCC6MDR M4PjO2Z2dmO2aX;uJIF{e2G7 M4PTbm1w\HWuYYTpc44hd2ZicD3ndEApfW6tbn;3ckBwemmpaX6pJJRz[W6|ZnXjeIVlKGmwIHj1cYFvKE2GQUSzOU9NS0N4TVTSJINmdGy|IHHzd4V{e2WmIHHzJJJmfmW{c3HsJI9nKHCjY3zpeIF5\WxicnXzbZN1[W6lZTygSWM2OD1yLkS0OVfPxE1? MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDF5MUS3PEc,OjRzN{G0O|g9N2F-
MDCK MYLGeY5kfGmxbjDhd5NigQ>? MVyzNEBucW6| NV;HNGFbUW6qaXLpeIlwdiCxZjDQMYdtgWOxcILveIVqdiBqdX7rco94diCxcnnnbY4qKGW6cILld5Nm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCxZjDjZYxk\WmwLVHNJJRz[W6|cH;yeEBi\nSncjCzNEBucW6|IHL5JIZtfW:{ZYPj[Y5k\SCjc4PhfUwhTUN3ME2yNO69VQ>? M3zSUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkC3PVk6Lz5{NE[wO|k6QTxxYU6=
MDCK NH7vb4xHfW6ldHnvckBie3OjeR?= M1y2T|ExOCC3TR?= MnTINkBpenN? MVjBZ5RqfmG2aX;uJI9nKEGWUHHz[UBi[3Srdnn0fUBw\iCPRGKxJEh2dmuwb4fuJI9zcWerbjmg[ZhxemW|c3XkJIlvKE2GQ1ugZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKHKnZIXjeIlwdiCxZjDBWHAhdGW4ZXygZZQhOTByIIXNJIFnfGW{IEKgbJJ{KGK7IHz1cYlv\XOlZX7j[U9CXFCuaYTlJIF{e2G7 MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZyN{m5PUc,OjR4MEe5PVk9N2F-
NCI/ADR-RES NYHvTYhlTnWwY4Tpc44h[XO|YYm= M1[xeFIxKG2rboO= NFPLTVRKdmirYnn0bY9vKG:oIHj1cYFvKFBvZ3z5Z49xem:2ZXnuJIV5eHKnc4Pl[EBqdiCQQ1mvRWRTNVKHUzDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4Yh[2GuY3Xpck1CVSC2cnHud5BwenRiYX\0[ZIhOjBibXnud{BjgSCobIXvdoV{[2WwY3WgZZN{[Xl? MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDl7MkG1N{c,OjR7OUKxOVM9N2F-
MDCK M1fBd2Z2dmO2aX;uJIF{e2G7 M4P0UlMxKG2rboO= NFjJVVhKdmirYnn0bY9vKG:oIF3SVFEhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5iTVTDT{Bk\WyuczDh[pRmeiB|MDDtbY5{KGK7IFPhcINmcW5vQV2gZZN{[XluIFnDOVA:Oy53zszN NUnPWGd7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWwPVM6OzFpPkK1NFk{QTNzPD;hQi=>
NCI-H292 MUTDfZRwfG:6aXPpeJkh[XO|YYm= NWHU[3FUPTBidV2= Mon3O|IhcHK| MXrQc5RmdnSrYYTpc44hd2ZiZ3XmbZRqdmmkLXnu[JVk\WRiY4n0c5RwgGmlaYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWgzQTJiY3XscJMh[XO|ZYPz[YQh[XNiZ3XmbZRqdmmkIFnDOVAh[XRiNUCgeW0h[W[2ZYKgO|IhcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME2wMlE5|ryP NVPlNJByRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyNVU5PTZpPkK1NlE2QDV4PD;hQi=>
NCI-H292 MonhR5l1d3SxeHnjbZR6KGG|c3H5 NFvJWpQ2OCC3TR?= MXO3NkBpenN? NY\6fnlRWG:2ZX70bYF1cW:wIH;mJIVzdG:2aX7pZk1qdmS3Y3XkJIN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5EUS2KMkmyJINmdGy|IHHzd4V{e2WmIHHzJIVzdG:2aX7pZkBKSzVyIHH0JFUxKHWPIHHmeIVzKDd{IHjyd{BjgSCVUlKgZZN{[XluIFnDOVA:OS5{zszN MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTJzNUi1Okc,OjV{MUW4OVY9N2F-
H460 MnvCR5l1d3SxeHnjbZR6KGG|c3H5 MXG1NEB2VQ>? MWK3NkBpenN? NXz6[lVyWG:2ZX70bYF1cW:wIH;mJIVzdG:2aX7pZk1qdmS3Y3XkJIN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGg1PjBiY3XscJMh[XO|ZYPz[YQh[XNiZYLsc5RqdmmkIFnDOVAh[XRiNUCgeW0h[W[2ZYKgO|IhcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME2xNE4{|ryP NG\DV409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUKxOVg2Pid-MkWyNVU5PTZ:L3G+
H460/Vbl M{HMdmN6fG:2b4jpZ4l1gSCjc4PhfS=> MlfnOVAhfU1? MUm3NkBpenN? MmDYVI91\W62aXH0bY9vKG:oIHXycI91cW6rYj3pcoR2[2WmIHP5eI91d3irY3n0fUBi\2GrboP0JIh2dWGwIFi0OlAwXmKuIHPlcIx{KGG|c3Xzd4VlKGG|IHXycI91cW6rYjDJR|UxKGG2IEWwJJVOKGGodHXyJFczKGi{czDifUBUWkJiYYPzZZktKEmFNUC9NVMvO87:TR?= M1PndFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MkG1PFU3Lz5{NUKxOVg2PjxxYU6=
H460 MYPDfZRwfG:6aXPpeJkh[XO|YYm= MXO1NEB2VQ>? NHL6PXE4OiCqcoO= Mn7ZVI91\W62aXH0bY9vKG:oIHfl[ol1cW6rYj3pcoR2[2WmIHP5eI91d3irY3n0fUBi\2GrboP0JIh2dWGwIFi0OlAh[2WubIOgZZN{\XO|ZXSgZZMh\2WoaYTpcoljKEmFNUCgZZQhPTBidV2gZYZ1\XJiN{KgbJJ{KGK7IGPSRkBie3OjeTygTWM2OD1zOT62{txO MlvpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{MUW4OVYoRjJ3MkG1PFU3RC:jPh?=
H460/Vbl NIPmeXBEgXSxdH;4bYNqfHliYYPzZZk> MmHUOVAhfU1? NXPCNGEzPzJiaILz NX\IZZhSWG:2ZX70bYF1cW:wIH;mJIdm\mm2aX7pZk1qdmS3Y3XkJIN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGg1PjBxVnLsJINmdGy|IHHzd4V{e2WmIHHzJIdm\mm2aX7pZkBKSzVyIHH0JFUxKHWPIHHmeIVzKDd{IHjyd{BjgSCVUlKgZZN{[XluIFnDOVA:OjVwN988US=> NGCxXWQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUKxOVg2Pid-MkWyNVU5PTZ:L3G+
K562 NF25cG1HfW6ldHnvckBie3OjeR?= MmTEN{B2VQ>? MYW3NkBpenN? NHy4PXJOd2S3bHH0c5J6KGGldHn2bZR6KGG2IGCt[5Ah[XO|ZYPz[YQh[XNiZH;4c5J2[mmlaX6gTWM2OCCrbjDoeY1idiCNNU[yJINmdGy|IHH0JFMhfU1iYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSBqUo\iJIRwgG:{dXLpZ4lvKGGub37lJGlEPTBiPTCwMlAzOyBtLz2gNE4xODRidV2pMEBKSzVyPUCuNFI6|ryP M2fXd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MkiyNlY{Lz5{NUK4NlI3OzxxYU6=
K562/DOX NUD4TYVZTnWwY4Tpc44h[XO|YYm= MV2zJJVO Mli5O|IhcHK| NYHzelg5VW:mdXzheI9zgSCjY4Tpeol1gSCjdDDQMYdxKGG|c3Xzd4VlKGG|IHTvfI9zfWKrY3nuJGlEPTBiaX6gbJVu[W5iS{W2Nk9FV1hiY3XscJMh[XRiMzD1UUBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5JEhTfmJiZH;4c5J2[mmlaX6gZYxwdmViSVO1NEA:KDJwMECgL{8uKDBwMkSgeW0qNCCLQ{WwQVAvPzUQvF2= MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTJ6MkK2N{c,OjV{OEKyOlM9N2F-
K562/DOX MlfFSpVv[3Srb36gZZN{[Xl? MmfMUY9lfWyjdH;yfUBi[3Srdnn0fUBifCCSLXfwJIlvKGi3bXHuJGs2PjJxRF;YJINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKG63Y3zlZZIh[2:wY3XueJJifGmxbjDv[kBxcXKjcoXibYNqdiCkeTDzdIVkfHKxZnz1c5JwdWW2cnnjJIF{e2G7LDDJR|UxRTFwNt88US=> NX\NdmlYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyPFIzPjNpPkK1NlgzOjZ|PD;hQi=>
A7R5 NFzEfpRHfW6ldHnvckBie3OjeR?= NVvZemI3OTVibXnudy=> MYLBcpRi\2:waYP0JIFkfGm4aYT5JIF1KGOjbHPpeY0h[2ijbn7lcEBqdiC{YYSgRVdTPSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGNi[2x{L1vDcE1qdmS3Y3XkJIlv[3KnYYPlJIlvKGmwdILhZ4VtdHWuYYKgR4EzMyCrbnP1ZoF1\WRiZn;yJFE2KG2rboOgdJJqd3JidH:gR4FkdDJxS1PsJINp[WyuZX7n[UBjgSCobIXvdoV{[2WwY3WgZZN{[XluIFnDOVA:OC5|zszN MnfWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV|MUG1OlQoRjJ3M{GxOVY1RC:jPh?=
MES-SA NH\FNXdHfW6ldHnvckBie3OjeR?= M{S5WFE2KG2rboO= Mn3XUY9lfWyjdHnvckBw\iCSLXfwJI1m\GmjdHXkJIRzfWdiZX\mcJV5KGmwIHj1cYFvKE2HUz3TRUBk\WyuczDhd5Nme3OnZDDhd{Bi[2O3bYXsZZRqd25ib3[gdohw\GGvaX7lMVEzOyCrbnP1ZoF1\WRiZn;yJFE2KG2rboOgdJJqd3JidH:gdohw\GGvaX7lMVEzOyCjZHTpeIlwdiCvZXHzeZJm\CCjZoTldkAyKGi{IHL5JIZtfW:{ZYPj[Y5k\SCjbnHsfZNqeyxiRVO1NF04NjIQvF2= NYPVcXdoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWzNVE2PjRpPkK1N|EyPTZ2PD;hQi=>
H69 NHnET2FHfW6ldHnvckBie3OjeR?= NEX5UlQyPSCvaX7z NHvsVJZOd2S3bHH0bY9vKG:oIF3SVFEhdWWmaXH0[YQh\HK3ZzDl[oZtfXhiaX6g[I95d3K3YnnjbY4uemW|aYP0ZY51KGi3bXHuJGg3QSClZXzsd{Bie3Onc4Pl[EBieyCjY3P1cZVt[XSrb36gc4Yh[2GuY3XpckBCVSCrbnP1ZoF1\WRiZn;yJFE2KG2rboOgdJJqd3JidH:gZ4Ft[2WrbjDBUUBi\GSrdHnvckBu\WG|dYLl[EBi\nSncjCzNEBucW6|IHL5JIZtfW:{ZYPj[Y5k\SCjbnHsfZNqeyxiRVO1NF0zPy56zszN M4Oxb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3M{GxOVY1Lz5{NUOxNVU3PDxxYU6=
MES-SA NECyPY5HfW6ldHnvckBie3OjeR?= NXXFbW5YOTVibXnudy=> NISyW3ZOd2S3bHH0bY9vKG:oIFLDVnAyKG2nZHnheIVlKGS{dXeg[YZndHW6IHnuJI1qfG:6YX70do9v\S2{ZYPpd5RidnRiaIXtZY4hVUWVLWPBJINmdGy|IHHzd4V{e2WmIHHzJIFk[3WvdXzheIlwdiCxZjDoc4VkcHO2IEOzN|QzKGmwY4XiZZRm\CCob4KgNVUhdWmwczDwdolweiC2bzDybI9l[W2rbnWtNVI{KGGmZHn0bY9vKG2nYYP1doVlKGGodHXyJFkxKG2rboOgZpkh\my3b4Lld4NmdmOnIHHuZYx6e2m|LDDFR|UxRTN5LkROwG0> NF3F[IQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUOxNVU3PCd-MkWzNVE2PjR:L3G+
K562/ADR NXLzU21GTnWwY4Tpc44h[XO|YYm= MV6xNEB2VQ>? NVG5O5lxOi53IHjydy=> NVLTcYtEUW6lcnXhd4UhcW5iYXTybYFugWOrbjD1dJRic2ViaX6gbJVu[W5iS{W2Nk9CTFJiY3XscJMh[XRiMUCgeW0h[W[2ZYKgNk42KGi{czDifUBndHWxcnXzZ4Vv[2VibXnjdo9{[2:yeR?= MnP3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2NkKyOlQoRjJ3NE[yNlY1RC:jPh?=
K562/ADR M2jmbWZ2dmO2aX;uJIF{e2G7 NFX6PXYyOCC3TR?= NUTaS2FOOi53IHjydy=> NH;FWG9KdmO{ZXHz[UBqdiCjZILpZY16[2mwIIXweIFs\SCrbjDoeY1idiCNNU[yM2FFWiClZXzsd{BifCBzMDD1UUBi\nSncjCyMlUhcHK|IHL5JIZtfW:{ZYPj[Y5k\SC|cHXjeJJweGixdH;t[ZRzgQ>? M1PUT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NE[yNlY1Lz5{NUS2NlI3PDxxYU6=
K562/ADR NXfLWFZKS3m2b4TvfIlkcXS7IHHzd4F6 NULNd4RMOTBidV2= MXO0PEBpenN? MYnQc5RmdnSrYYTpc44hd2ZiYXTybYFugWOrbj3pcoR2[2WmIHP5eI91d3irY3n0fUBi\2GrboP0JIh2dWGwIFu1OlIwSUSUIHPlcIx{KGG2IEGwJJVOKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZk> M3njXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NE[yNlY1Lz5{NUS2NlI3PDxxYU6=
K562/A02 NGCw[4dHfW6ldHnvckBie3OjeR?= MWO1JJVO NVzYWG9GPDhiaILz M{f1VXJmfmW{c3HsJI9nKFBvZ4CtcYVlcWG2ZXSgcZVtfGmmcoXnJJJme2m|dHHuZ4UhcW5iaIXtZY4hUzV4Mj;BNFIh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oIHHkdolidXmlaX6gTWM2OCCjdDC1JJVOKGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUC9Ok45|ryP MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR4NEi4OEc,OjV2NkS4PFQ9N2F-
K562/A02 NVr6eFZNTnWwY4Tpc44h[XO|YYm= MXO1JJVO M1S5fVI1KGi{cx?= Mm\RVoV3\XK|YXygc4YhWC2pcD3t[YRq[XSnZDDteYx1cWS{dXegdoV{cXO2YX7j[UBqdiCqdX3hckBMPTZ{L1GwNkBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2ZiYXTybYFugWOrbjDJR|UxKGG2IEWgeW0hcW6ldXLheIVlKG[xcjCyOEBpenNicILpc5IhfG9iYXTybYFugWOrbjD0doVifG2nboSgcYVie3W{ZXSgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD17LkdOwG0> M1O1W|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NE[0PFg1Lz5{NUS2OFg5PDxxYU6=
K562/A02 NYLwbIdlTnWwY4Tpc44h[XO|YYm= NWDreJpWOi53IIXN NYnzb3k4PDhiaILz Mk\VVoV3\XK|YXygc4YhWC2pcD3t[YRq[XSnZDDteYx1cWS{dXegdoV{cXO2YX7j[UBqdiCqdX3hckBMPTZ{L1GwNkBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2ZiYXTybYFugWOrbjDJR|UxKGG2IEKuOUB2VSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVE2Njl{zszN NH3kSIo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUS2OFg5PCd-MkW0OlQ5QDR:L3G+
K562/A02 M3mzXmZ2dmO2aX;uJIF{e2G7 NULReZNkPSC3TR?= NH:4UGgzPCCqcoO= M2\QPXJmfmW{c3HsJI9nKFBvZ4CtcYVlcWG2ZXSgcZVtfGmmcoXnJJJme2m|dHHuZ4UhcW5iaIXtZY4hUzV4Mj;BNFIh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oIHHkdolidXmlaX6gTWM2OCCjdDC1JJVOKGmwY4XiZZRm\CCob4KgNlQhcHK|IH\vcIxwf2WmIHL5JIFlemmjbYnjbY4hfHKnYYTt[Y51KHCxc4SgZ49ueG:3bnSge4F{cG:3dDDt[YF{fXKnZDDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTRyLklOwG0> Mke2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2NkS4PFQoRjJ3NE[0PFg1RC:jPh?=
KB/VCR Mny3R5l1d3SxeHnjbZR6KGG|c3H5 M2\LfVI2KHWP NWTmNGlmPzJiaILz MljlR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT2IwXkOUIHPlcIx{KGG|c3Xzd4VlKGG|II\pcoNzcXO2aX7lJGlEPTBiYYSgNlUhfU1iYX\0[ZIhPzJiaILzJIJ6KFOUQjDt[ZRpd2RuIFnDOVA:OC5yMt88US=> MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTV7N{CxNEc,OjV3OUewNVA9N2F-
K562/R7 NF[yem5EgXSxdH;4bYNqfHliYYPzZZk> MUCxJJVO NFfTZnc4OiCqcoO= NGfIdHNRd3SnboTpZZRqd25ib3[g[I95d3K3YnnjbY4ucW6mdXPl[EBkgXSxdH;4bYNqfHliYXfhbY5{fCCmb4jvdpVjcWOrbj3y[ZNqe3SjboSgbJVu[W5iS{W2Nk9TPyClZXzsd{Bie3Onc4Pl[EBieyCmb4jvdpVjcWOrbjDJR|UxKGG2IEGgeW0h[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2wMlbPxE1? NH;3co89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[zOFA1OSd-MkW2N|QxPDF:L3G+
MDA435/LCC6MDR NHrXb3FHfW6ldHnvckBie3OjeR?= MkXwNUB2VQ>? NHLG[Y82KGSjeYO= MkfiUY9lfWyjdHnvckBw\iCSLXfwJEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5iaIXtZY4hVUSDNEO1M2xESz[PRGKgZ4VtdHNiYYPz[ZN{\WRiYYOgdoV3\XK|aXLs[UBw\iCyYXPsbZRigGWuIILld4l{fGGwY3WgcYVie3W{ZXSgZZMhUUN3MDDmc5IheGGlbHn0ZZhmdCCjdDCxJJVOKGGodHXyJFUh\GG7czDifUBE\WyuVHn0[ZIhQTZiQYH1[Y92eyCjc4PhfUwhUUN3ME2wMlA{QM7:TR?= MmfEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV7OEWxPVUoRjJ3OUi1NVk2RC:jPh?=
MDA435/LCC6MDR NX\QdIw{TnWwY4Tpc44h[XO|YYm= M{XpfVUh\GG7cx?= MWDNc4R2dGG2aX;uJI9nKFBvZ4CgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCqdX3hckBOTEF2M{WvUGNEPk2GUjDj[YxteyCjc4Pld5Nm\CCjczDy[ZZmenOrbneg[I95d3K3YnnjbY4hemW|aYP0ZY5k\SCvZXHzeZJm\CCjczDj[YxtKHO3co\peoFtKGGodHXyJFUh\GG7czDifUBOXFNiYYPzZZktKEWFNUC9NE4zPDYQvF2= M{HhOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUi1NVk2Lz5{NUm4OVE6PTxxYU6=
MDA435/LCC6MDR NEHj[pFHfW6ldHnvckBie3OjeR?= MWq1JIRigXN? NVzWOGtUVW:mdXzheIlwdiCxZjDQMYdxKCi3bnvuc5dvKG:{aXfpckkhfHKjboPm[YN1\WRiaX6gbJVu[W5iTVTBOFM2N0yFQ{\NSHIh[2WubIOgZZN{\XO|ZXSgZZMhemW4ZYLzbY5oKH[rbnPybZN1cW6nIILld4l{fGGwY3WgcYVie3W{ZXSgZZMh[2WubDDzeZJ3cX[jbDDh[pRmeiB3IHThfZMh[nliTWTTJIF{e2G7LDDFR|UxRTBwM{i1{txO M1P6SlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUi1NVk2Lz5{NUm4OVE6PTxxYU6=
MDA435/LCC6MDR NYfsOmFPTnWwY4Tpc44h[XO|YYm= Mo\uOUBl[Xm| MnnLUY9lfWyjdHnvckBw\iCSLXfwJEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5iaIXtZY4hVUSDNEO1M2xESz[PRGKgZ4VtdHNiYYPz[ZN{\WRiYYOgdoV3\XK|aX7nJJBi[2yrdHH4[YwhemW|aYP0ZY5k\SCvZXHzeZJm\CCjczDj[YxtKHO3co\peoFtKGGodHXyJFUh\GG7czDifUBOXFNiYYPzZZktKEWFNUC9NE41PDcQvF2= NH3iPJQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUm4OVE6PSd-MkW5PFUyQTV:L3G+
MDA435/LCC6MDR Mn\wSpVv[3Srb36gZZN{[Xl? NIjuS4s2KGSjeYO= MV;Nc4R2dGG2aX;uJI9nKFBvZ4CgLJVvc26xd36gc5Jq\2mwKTD0doFve2[nY4Tl[EBqdiCqdX3hckBOTEF2M{WvUGNEPk2GUjDj[YxteyCjc4Pld5Nm\CCjczDy[ZZmenOrbnegeolv[myjc4TpcoUhemW|aYP0ZY5k\SCvZXHzeZJm\CCjczDj[YxtKHO3co\peoFtKGGodHXyJFUh\GG7czDifUBOXFNiYYPzZZktKEWFNUC9NE42ODQQvF2= NFHKTpo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUm4OVE6PSd-MkW5PFUyQTV:L3G+
MDA435/LCC6MDR MmHySpVv[3Srb36gZZN{[Xl? MnHHN{B2VQ>? NGLQWo8yPTBibXnudy=> MoDLUY9lfWyjdHnvckBw\iCSLXfwJEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5iaIXtZY4hVUSDNEO1M2xESz[PRGKgZ4VtdHNiYYPz[ZN{\WRiYYOgdoV{fG:{YYTpc44hd2ZiaX70doFk\WyudXzhdkBld3ixcoXibYNqdiCjY3P1cZVt[XSrb36gZZQhOyC3TTDh[pRmeiBzNUCgcYlveyCkeTDzdIVkfHKxZnz1c5JwdWW2cnnjJIFv[Wy7c3nzJJJmdGG2aY\lJJRwKHCjcnXueIFtKGOnbHzz M4PRPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUi1NVk2Lz5{NUm4OVE6PTxxYU6=
MDA435/LCC6MDR M{\nZWZ2dmO2aX;uJIF{e2G7 NEPkWm5Od2S3bHH0bY9vKG:oIGCt[5AhcW5iaIXtZY4hVUSDNEO1M2xESz[PRGKgZ4VtdHNiYYPz[ZN{\WRiYYOgdoV3\XK|YXygc4YheGGlbHn0ZZhmdCC{ZYPpd5RidmOnLDDFR|UxRTBwNES2{txO NFnIcVU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkKzN|c6QCd-Mk[yN|M4QTh:L3G+
KB/VJ300 MlfYR5l1d3SxeHnjbZR6KGG|c3H5 MmPTO|IhcHK| MV;DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLRk9XUjNyMDDj[YxteyCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6KGmwIIDy[ZNmdmOnIH;mJFAvOTJzIIXNJJZqdmO{aYP0bY5mNCCLQ{WwQVExNjQQvF2= M3rNTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4N{G3NFUxLz5{NkexO|A2ODxxYU6=
NIH/3T3 MoPhR5l1d3SxeHnjbZR6KGG|c3H5 M3KxSGlvfHKrboPpZ{BkgXSxdH;4bYNqfHliYXfhbY5{fCCvb4Xz[UBPUUhxM2SzJINmdGy|IHL5JG1VXCCjc4PhfUwhS0N3ME2yO:69VQ>? NI\tSmg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkizOlM3PCd-Mk[4N|Y{PjR:L3G+
MCF7/D70 MXvGeY5kfGmxbjDhd5NigQ>? Ml7xNVAhfU1? Ml;XO|IhcHK| NFvhTpZKdmirYnn0bY9vKG:oIGCt[5AhcW5iaIXtZY4hVUOINz;EO|Ah[2WubIOgZZN{\XO|ZXSgZZMh\GWlcnXhd4UhcW5iZH;4c5J2[mmlaX6gTWM2OCCjdDCxNEB2VSCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6KCiUdnKg[I95d3K3YnnjbY4h[WyxbnWgTWM2OCB;IECuPVA3KCtxLTCwMlAzKHWPKTygTWM2OD1yLkNOwG0> NVjTVplyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[4OFA{PjJpPkK2PFQxOzZ{PD;hQi=>
A549/CDDP NHvZdXlHfW6ldHnvckBie3OjeR?= MXixMlIhfU1? Ml7aTY5pcWKrdHnvckBw\iCSLXfwJIlvKGi3bXHuJGE2PDlxQ1TEVEBk\WyuczDhd5Nme3OnZDDhd{Bi[2O3bYXsZZRqd25ib3[gdohw\GGvaX7lJFEzOyCjdDCxMlIhfU1iYomg[oxwfyCleYTvcYV1enl? NVXydnBJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[4PVExQTlpPkK2PFkyODl7PD;hQi=>
KB/VJ300 NFnwXItIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWK3NkBpenN? MlfFS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gT2IwXkp|MECgZ4VtdHNiYX\0[ZIhPzJiaILzJIlvKHC{ZYPlcoNmKG:oII\pcoNzcXO2aX7lJIJ6KE2WVDDhd5NigSxiSVO1NF01NjcQvF2= M2D0d|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OUG4O|YyLz5{NkmxPFc3OTxxYU6=
K562/A02 M1fae2Z2dmO2aX;uJIF{e2G7 Mn;oOUB2VQ>? MYq0PEBpenN? MUHS[ZZmenOjbDDv[kBRNWeyLX3l[IlifGWmIILld4l{fGGwY3WgeI8h[WS{aXHtfYNqdiCrbjDoeY1idiCNNU[yM2ExOiClZXzsd{Bie3Onc4Pl[EBieyCjZILpZY16[2mwIFnDOVAh[XRiNTD1UUBi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5JEhTfmJiPTCzPE4xOiBtLz2gNU43PSC3TTmsJGlEPTB;OD61{txO NFXYNXQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3N|A2Oid-MkewO|MxPTJ:L3G+
K562/A02 NXTVVpY5TnWwY4Tpc44h[XO|YYm= MoXzNk42KHWP NG\1OXQ1QCCqcoO= MorVVoV3\XK|YXygc4YhWC2pcD3t[YRq[XSnZDDy[ZNqe3SjbnPlJJRwKGGmcnnhcZlkcW5iaX6gbJVu[W5iS{W2Nk9CODJiY3XscJMh[XO|ZYPz[YQh[XNiYXTybYFugWOrbjDJR|UxKGG2IEKuOUB2VSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6KCiUdnKgQUA{QC5yMjCrM{0hOS54NTD1UUktKEmFNUC9NVkvQDUQvF2= NFTkXWo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3N|A2Oid-MkewO|MxPTJ:L3G+
L5178Y M{HlXmN6fG:2b4jpZ4l1gSCjc4PhfS=> NWjlVWh7PzJiaILz NF\VbIJEgXSxdH;4bYNqfHliYXfhbY5{fCCvdXz0bU1lenWpIILld4l{fGGwdDDtc5V{\SCONUG3PHkh[2WubIOgZZN{\XO|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME20O{45Pc7:TR?= NVzIXGJ[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkexOVY4PzFpPkK3NVU3PzdzPD;hQi=>
HLF M4PlUmN6fG:2b4jpZ4l1gSCjc4PhfS=> MnjkOFghcHK| M2TLZ2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KEiORjDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKGOnbHygdJJwdGmoZYLheIlwdiCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVI4NjF6zszN MnS2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd|MkiwNlkoRjJ5M{K4NFI6RC:jPh?=
MDA435/LCC6MDR MlLYSpVv[3Srb36gZZN{[Xl? NGHOT2gyKHWP NGPtPWM2KGSjeYO= M3LFemlvcGmkaYTpc44hd2ZiUD3ndEBqdiCqdX3hckBOTEF2M{WvUGNEPk2GUjDj[YxteyCjc4Pld5Nm\CCjczDwc5RmdnSrYYTpc44hd2ZicHHjcIl1[XinbD3pcoR2[2WmIHP5eI91d3irY3n0fUBjgSCvZXHzeZJqdmdicHHjcIl1[XinbDDJR|UxKGG2IEGgeW0hdWWjc4Xy[YQh[W[2ZYKgOUBl[Xm|IHL5JGNmdGxiVHn0[ZIhQTZiQYH1[Y92eyCjc4PhfUApWn[kIE2gNVM6NjNiKz:tJFcvPSCwTTmsJGlEPTB;MD6wN|Uy|ryP NXHNNmlRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke3OVAyQTdpPkK3O|UxOTl5PD;hQi=>
MDA435/LCC6MDR MUfGeY5kfGmxbjDhd5NigQ>? NXX2VWs4PSCmYYnz NE[3fmdKdmirYnn0bY9vKG:oIGCt[5AhcW5iaIXtZY4hVUSDNEO1M2xESz[PRGKgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKGSxeH;yeYJq[2mwIHP5eI91d3irYzDJR|UxKGK7IHjhcIYh[W[2ZYKgOUBl[Xm|IHL5JGNmdGxiVHn0[ZIhQTZiQYH1[Y92eyCjc4PhfUwhTUN3ME2wMlI1Pc7:TR?= M1LGbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{WwNVk4Lz5{N{e1NFE6PzxxYU6=
MDA435/LCC6MDR M1XlfmZ2dmO2aX;uJIF{e2G7 NU\wb2JGOTVyIH3pcpM> NWHJRVZqUW6qaXLpeIlwdiCxZjDQMYdxKGmwIHj1cYFvKE2GQUSzOU9NS0N4TVTSJINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGSxeH;yeYJq[2mwIHHjZ5VufWyjdHnvckB1dyCqYXzmJI9nKHCjcnXueIFtKEyFQ{[gZ4VtdHNibXXhd5Vz\WRiYX\0[ZIhOTVyIH3pcpMh[nliZnz1c5Jme2OnbnPlJJNx\WO2cn;wbI91d22ndILpZ{Bu\XSqb3SsJGVEPTB;MD6zOe69VQ>? M37SS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{WwNVk4Lz5{N{e1NFE6PzxxYU6=
MDA435/LCC6MDR NI\ONHlHfW6ldHnvckBie3OjeR?= NUTMT4JkPSCmYYnz MkeyTY5pcWKrdHnvckBw\iCSLXfwJIlvKGi3bXHuJG1FSTR|NT;MR2M3VUSUIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDv[kB3cW6lcnnzeIlv\SCleYTveI95cWNiSVO1NEBjgSCqYXzmJI1m[XO3cnXkJIFnfGW{IEWg[IF6eyCkeTDD[YxtKFSrdHXyJFk3KEGzdXXveZMh[XO|YYmsJGVEPTB;MD6zPFXPxE1? MlzoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd5NUCxPVcoRjJ5N{WwNVk4RC:jPh?=
MDA435/LCC6MDR MlPZSpVv[3Srb36gZZN{[Xl? NHPYTFY2KGSjeYO= MXzJcohq[mm2aX;uJI9nKFBvZ4CgbY4hcHWvYX6gUWRCPDN3L1zDR|ZOTFJiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIH;mJJBi[2yrdHH4[Ywh[3m2b4TvfIlkKEmFNUCgZpkhcGGuZjDt[YF{fXKnZDDh[pRmeiB3IHThfZMh[nliQ3XscEBVcXSncjC5OkBCeXWnb4XzJIF{e2G7LDDFR|UxRTBwNES2{txO NFTpdoQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{e1NFE6Pyd-Mke3OVAyQTd:L3G+
MDA435/LCC6MDR NFP6NFRHfW6ldHnvckBie3OjeR?= NUjCboZUPSCmYYnz NEPOfG9KdmirYnn0bY9vKG:oIGCt[5AhcW5iaIXtZY4hVUSDNEO1M2xESz[PRGKgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKH[rbnLsZZN1cW6nIHP5eI91d3irYzDJR|UxKGK7IHjhcIYhdWWjc4Xy[YQh[W[2ZYKgOUBl[Xm|IHL5JGNmdGxiVHn0[ZIhQTZiQYH1[Y92eyCjc4PhfUwhTUN3ME2wMlUxO87:TR?= M3T4e|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5N{WwNVk4Lz5{N{e1NFE6PzxxYU6=
K562 Mn;tSpVv[3Srb36gZZN{[Xl? NYjEbXp4OTBidV2= M{S1[VEhcHJ? NF3yNmRKdmirYnn0bY9vKG:oIGCt[5AhcW5iZH;4c5J2[mmlaX6gdoV{cXO2YX70JIh2dWGwIFu1OlIh[2WubIOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iYXPjeY12dGG2aX;uJI9nKHKqb3ThcYlv\SBzMkOgZZQhOTBidV2gcYVie3W{ZXSgZYZ1\XJiMTDodkBjgSCobH;3JIN6fG:vZYTyfS=> MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzlyOEe1Okc,Ojd7MEi3OVY9N2F-
MES-SA/Dx5 NV:w[otQTnWwY4Tpc44h[XO|YYm= M3jCdVczKGi{cx?= NWLJWYZPUW6qaXLpeIlwdiCxZjDQMYdxKGmwIHj1cYFvKE2HUz3TRU9FgDViY3XscJMh[XO|ZYPz[YQh[XNicH;0[Y51cWG2aX;uJI9nKGSxeH;yeYJq[2mwLXnu[JVk\WRiY4n0c5RwgGmlaYT5JIJ6KG2nYYP1dolv\yClb33wc5Vv\CClb37j[Y51emG2aX;uJJJmeXWrcnXkJIZweiC{ZXT1Z5Rqd25ib3[g[I95d3K3YnnjbY4hUUN3MDDifUBp[WyoIHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFXDOVA:OC55zszN NWr2NVNXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiwOFM4PzdpPkK4NFQ{Pzd5PD;hQi=>
MES-SA/Dx5 NGHzNYhHfW6ldHnvckBie3OjeR?= MkTxO|IhcHK| MkHTTY5pcWKrdHnvckBw\iCSLXfwJIlvKGi3bXHuJG1GWy2VQT;EfFUh[2WubIOgZZN{\XO|ZXSgZZMheG:2ZX70bYF1cW:wIH;mJJBi[2yrdHH4[YwucW6mdXPl[EBkgXSxdH;4bYNqfHliYomgcYVie3W{aX7nJINwdXCxdX7kJINwdmOnboTyZZRqd25icnXxeYlz\WRiZn;yJJJm\HWldHnvckBw\iCyYXPsbZRigGWuIFnDOVAh[nliaHHs[kBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBGSzVyPUCuPO69VQ>? NEj2SVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEC0N|c4Pyd-MkiwOFM4Pzd:L3G+
MES-SA/Dx5 Mn30SpVv[3Srb36gZZN{[Xl? MVW3NkBpenN? NF6zNGRKdmirYnn0bY9vKG:oIGCt[5AhcW5iaIXtZY4hVUWVLWPBM2R5PSClZXzsd{Bie3Onc4Pl[EBieyCyb4TlcpRq[XSrb36gc4Yh[WO2aX7vcZlkcW5iRD3pcoR2[2WmIHP5eI91d3irY3n0fUBjgSCvZXHzeZJqdmdiY3;tdI92dmRiY3;uZ4VvfHKjdHnvckBz\XG3aYLl[EBnd3JicnXkeYN1cW:wIH;mJIFkfGmwb335Z4lvKERiSVO1NEBjgSCqYXzmJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGVEPTB;MD65{txO MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB2M{e3O{c,OjhyNEO3O|c9N2F-
MES-SA/Dx5 M2nme2Z2dmO2aX;uJIF{e2G7 MVm3NkBpenN? MoL3TY5pcWKrdHnvckBw\iCSLXfwJIlvKGi3bXHuJG1GWy2VQT;EfFUh[2WubIOgZZN{\XO|ZXSgZZMheG:2ZX70bYF1cW:wIH;mJJZqdmKuYYP0bY5mNWmwZIXj[YQh[3m2b4TvfIlkcXS7IHL5JI1m[XO3cnnu[{Bkd22yb4Xu[EBkd26lZX70doF1cW:wIILldZVqemWmIH\vdkBz\WS3Y4Tpc44hd2ZidnnuZoxie3SrbnWgTWM2OCCkeTDoZYxnKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEWFNUC9Ne69VQ>? MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDB2M{e3O{c,OjhyNEO3O|c9N2F-
K562/A02 NUHM[VJqTnWwY4Tpc44h[XO|YYm= NVTNV3hXOC5|MzD0c{AyOCC3TR?= NVTmfVRlOSCqch?= NHHleXJKdmirYnn0bY9vKG:oIGCt[5AhcW5iaIXtZY4hUzV4Mj;BNFIh[2WubIOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaX70doFk\WyudXzhdkBzcG:mYX3pcoUyOjNiYXPjeY12dGG2aX;uJIF1KDBwM{OgeI8hOTBidV2gcYVie3W{ZXSgZYZ1\XJiMTDodkBjgSCobH;3JIN6fG:vZYTyfS=> MmrvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhyNkiwPVUoRjJ6ME[4NFk2RC:jPh?=
LoVo/DX NVm5S4o6TnWwY4Tpc44h[XO|YYm= Mn\hNk42KHSxIEGwJJVO NGW0[ogyPSCvaX7z NV2xXZE5UW6qaXLpeIlwdiCxZjDQMYdxKGmwIHj1cYFvKEyxVn:vSHgh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIGLoc4RidWmwZUGyN{Bm\m[udYigZZQhOi53IITvJFExKHWPIIDy[Ylv[3WkYYTl[EBnd3JiMUWgcYlveyCob3zsc5dm\CCkeTDSbI9l[W2rbnWxNlMh[WSmaYTpc44hdWWjc4Xy[YQh[W[2ZYKgNUBpeiCkeTDmcI94KGO7dH;t[ZRzgQ>? MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDFyOUm1NEc,OjhzMEm5OVA9N2F-
LoVo/DX NXXST5RPTnWwY4Tpc44h[XO|YYm= NFm0PWcyOCC3TR?= NHm1XlAzKGi{cx?= NF;BS4VUfWK|dILheIUh[WO2aY\peJkh[XRiUD3ndEBqdiCqdX3hckBNd1[xL1TYJINmdGy|IHHzd4V{e2WmIHHzJGFVWCClb37zeY1xfGmxbjDheEAyOCC3TTDh[pRmeiB{IHjyd{BjgSCDVGDsbZRmKGG|c3H5 M37wdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MUC5PVUxLz5{OEGwPVk2ODxxYU6=
K562/DOX M1y0fGZ2dmO2aX;uJIF{e2G7 NVHqXHh3OzBibXnudy=> NXm1WWVnUW6qaXLpeIlwdiCxZjDQMYdxKGmwIHj1cYFvKEt3NkKvSG9ZKGOnbHzzJIF{e2W|c3XkJIF{KGS{dXegcIV3\WxiY3H1d4lv\yB3MDWgbY5kemWjc3WgbY4hdnWlbHXhdkBxcXKjcoXibYNqdiClb37j[Y51emG2aX;uJIlv[3WkYYTl[EBnd3JiM{CgcYlveyCkeTDzdIVkfHKxZnz1do9u\XS{eTygTVAvPT1zLkdOwG0> Mn3UQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhzMUOxNlgoRjJ6MUGzNVI5RC:jPh?=
MCF7/DX NVr0XXZ5TnWwY4Tpc44h[XO|YYm= MXe1JJVO NUi5U2M{PDhiaILz MlW4VoV3\XK|YXygc4YhdXWudHnkdpVoKHKnc3nzeIFv[2ViaX6gbJVu[W5iTVPGO{9FYCClZXzsd{Bie3Onc4Pl[EBieyCyb4TlcpRq[XSrb36g[I95d3K3YnnjbY4ucW6mdXPl[EBkgXSxdH;4bYNqfHliYomgcYVie3W{aX7nJIRwgG:{dXLpZ4lvKEmFNUCgcIV3\WxiYYSgOUB2VSCrbnP1ZoF1\WRiZn;yJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUC9Ok42Qc7:TR?= M1\iOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MkS1NVE{Lz5{OEK0OVEyOzxxYU6=
K562/A02 MYfDfZRwfG:6aXPpeJkh[XO|YYm= NFjwem41QCCqcoO= NEfISHVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMPTZ{L1GwNkBk\WyuczDveoVz\XiycnXzd4lv\yCSLXfwJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;M{GuNljPxE1? NXTle5VbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkizNFEyPTVpPkK4N|AyOTV3PD;hQi=>
K562 MWHDfZRwfG:6aXPpeJkh[XO|YYm= Mo[zOFghcHK| MnzDR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT|U3OiClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUO2MlfPxE1? MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDNyMUG1OUc,Ojh|MEGxOVU9N2F-
K562/A02 M3niPWZ2dmO2aX;uJIF{e2G7 MWq1JJVO NX63NYZbOi53IHjydy=> M2T3cWlvcGmkaYTpc44hd2ZiQVLDRlEhcW5iaIXtZY4hUzV4Mj;BNFIh[2WubIOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaX70doFk\WyudXzhdkBi\HKrYX35Z4lvKGGlY4XteYxifGmxbjDheEA2KHWPIHHmeIVzKDJwNTDodpMh[nlic4DlZ5Rzd2[udX;ybY1mfHKrYzDhcoFtgXOrcx?= NF3VZZo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEOwNVE2PSd-MkizNFEyPTV:L3G+
K562/A02 NIfQTlJHfW6ldHnvckBie3OjeR?= MXq1JJVO NYHSWYFUfXBidH:gPVAhdWmwcx?= MonmTY5pcWKrdHnvckBw\iCDQlPCNUBqdiCqdX3hckBMPTZ{L1GwNkBk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCrboTyZYNmdGy3bHHyJHJpOTJ|IHHjZ5VufWyjdHnvckBifCB3IIXNJJVxKHSxIEmwJI1qdnNiYomg[oxwfyCleYTvcYV1enl? MnHWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh|MEGxOVUoRjJ6M{CxNVU2RC:jPh?=
K562/A02 MUHGeY5kfGmxbjDhd5NigQ>? MYe1MlAhfU1? MYf1dEB1dyB7MDDtbY5{ NXPic|lkUW6qaXLpeIlwdiCxZjDQMYdxKG2nZHnheIVlKGWoZnz1fEBqdiCqdX3hckBMPTZ{L1GwNkBk\WyuczDhd5Nme3OnZDDhd{BqdnS{YXPlcIx2dGG{IGLoNVI{KGGlY4XteYxifGmxbjDheEA2NjBidV2gcYVie3W{ZTD1dEB1dyB7MDDtbY5{KGK7IH\sc5ch[3m2b33leJJq[yCjbnHsfZNqew>? NFS3WY49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEO1OVA3QSd-MkizOVUxPjl:L3G+
K562/A02 M2KzWmZ2dmO2aX;uJIF{e2G7 M4LlV|UhfU1? NIDqWVMzPCCqcoO= NGiyR3dKdmirYnn0bY9vKG:oIGCt[5AhcW5iaIXtZY4hUzV4Mj;BNFIh[2WubIOgZZN{\XO|ZXSgZZMheG:2ZX70bYF1cW:wIH;mJIRwgG:{dXLpZ4lvNWmwZIXj[YQh[3m2b4TvfIlkcXS7IHH0JFUhfU1icILlbY5kfWKjdHXkJIZweiB{NDDodpMh\m:ubH;3[YQh[nliZH;4c5J2[mmlaX6gZYRlcXSrb36gcYVie3W{ZXSgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeR?= MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDN3NUC2PUc,Ojh|NUWwOlk9N2F-
K562/A02 NGX3WFRHfW6ldHnvckBie3OjeR?= MWS1MlAhfU1? NFu2Ro4yPTBibXnudy=> MoDCTY5pcWKrdHnvckBw\iCSLXfwJIlvKGi3bXHuJGs2PjJxQUCyJINmdGy|IHHzd4V{e2WmIHHzJIFk[3WvdXzheIlwdiCxZjDkc5hwenWkaXPpckBifCB3LkCgeW0h[W[2ZYKgNVUxKG2rboOgZpkh\my3b4Lld4NmdmOnIIPw[YN1em:yaH;0c41mfHKrYzDhcoFtgXOrcx?= NWnHTZRbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkizOVUxPjlpPkK4N|U2ODZ7PD;hQi=>
K562/A02 MXHGeY5kfGmxbjDhd5NigQ>? NIrEbFk1QCCqcoO= M1LoPGlvcGmkaYTpc44hd2ZiQVLDRlEhcW5iaIXtZY4hUzV4Mj;BNFIh[2WubIOgZZN{\XO|ZXSgZZMheG:2ZX70bYF1cW:wIH;mJIFlemmjbYnjbY4ucW6mdXPl[EBkgXSxdH;4bYNqfHliYomgcYVie3W{aX7nJGFFWiCLQ{WwJI1m[XO3cnXkJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmgLHJ3[iB;IEWxMlM1KCtxLTC1MlEhfU1rLDDJR|UxRTFyLkez{txO NV[5bWp5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2OFU5OzFpPkK4OlQ2QDNzPD;hQi=>
K562/A02 NGDiVVNHfW6ldHnvckBie3OjeR?= MVu1JJVO Moi5OFghcHK| M1\FVGlvcGmkaYTpc44hd2ZiQVLDRlEhcW5iaIXtZY4hUzV4Mj;BNFIh[2WubIOgZZN{\XO|ZXSgZZMheG:2ZX70bYF1cW:wIH;mJIFlemmjbYnjbY4ucW6mdXPl[EBkgXSxdH;4bYNqfHliYomgcYVie3W{aX7nJGFFWiCLQ{WwJIF1KDVidV2gcYVie3W{ZXSgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTCoVpZjKD1iNEOuO|UhfG9iOU[uPVEhfU1rLDDJR|UxRTF5LkW1{txO NWqxNXE4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2OFU5OzFpPkK4OlQ2QDNzPD;hQi=>
K562/A02 Mn;nSpVv[3Srb36gZZN{[Xl? NYThZZhkPDhiaILz NWjnRpVSUW6qaXLpeIlwdiCxZjDBRmNDOSCrbjDoeY1idiCNNU[yM2ExOiClZXzsd{Bie3Onc4Pl[EBieyCyb4TlcpRq[XSrb36gc4Yh[WS{aXHtfYNqdi2rbnT1Z4VlKGO7dH;0c5hq[2m2eTDifUBu\WG|dYLpcochSUSUIFnDOVAhfHKnYYTl[EBnd3JiNEigbJJ{KG[xbHzve4VlKGK7IHPvcZBwfW6mIIfhd4hwfXRibXXhd5Vz\WRiaX3t[YRq[XSnbImgZpkhVVSWIHHzd4F6KCiUdnKgQUA2OS5|NDCrM{0hPS5zIIXNLUwhUUN3ME2zNU4zQM7:TR?= NHjWcYU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OE[0OVg{OSd-Mki2OFU5OzF:L3G+
K562/A02 NFrCSpBHfW6ldHnvckBie3OjeR?= MXywMlUhfG9iMj61JJVO NXTtNIxbPjBibXnudy=> MV7Jcohq[mm2aX;uJI9nKEGEQ1KxJIlvKGi3bXHuJGs2PjJxQUCyJINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGGmcnnhcZlkcW5iYXPjeY12dGG2aX;uJIF1KDBwNTD0c{AzNjVidV2gdJJmfHKnYYTl[EBnd3JiNkCgcYlveyCob3zsc5dm\CCkeTDBSHIh[WSmaYTpc44h[W[2ZYKgPVAhdWmwczDifUBndHWxcnXzZ4Vv[2Vic4DlZ5Rzd3Cqb4TvcYV1emmlIH3leIhw\A>? MkLKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4NEW4N|EoRjJ6NkS1PFMyRC:jPh?=
CHO MoLrSpVv[3Srb36gZZN{[Xl? MnXlTY5pcWKrdHnvckBw\iCqdX3hckBGWkdiZYjwdoV{e2WmIHnuJGNJVyClZXzsd{BifCCqb3zkbY5oKHCxdHXueIlidCCxZjCtPVAhdVZiYomgdIF1[2hiY3zhcZAhdWW2aH;kMEBKSzVyPUCuOVPPxE1? MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDd7N{e3NUc,Ojh5OUe3O|E9N2F-
SW620/AD300 M{\kVmZ2dmO2aX;uJIF{e2G7 NGLIcZQzKHWP Ml7vN|AhfG9iMUKwJI1qdnN? NIf2OllKdmirYnn0bY9vKG:oIFHCR2IyKGmwIHj1cYFvKFOZNkKwM2FFOzByIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBTcDF{MzDl[oZtfXhiYYSgNkB2VSC2cnXheIVlKG[xbHzve4VlKGK7IGLoNVI{KGGmZHn0bY9vKGmwIGLoNVI{KG[{ZXWgcYVlcXWvIH\vdkA{OCC2bzCxNlAhdWmwczDifUBndG:5IHP5eI9u\XS{eR?= MoXJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlzMk[3NlYoRjJ7MUK2O|I3RC:jPh?=
K562/Dox MULGeY5kfGmxbjDhd5NigQ>? MV;Jcohq[mm2aX;uJI9nKFBvZ4CgbY4hcHWvYX6gT|U3Oi:Gb4igZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hdnWlbHXhdkBi[2O3bYXsZZRqd25ib3[gdIlz[XK3YnnjbY4h[nlic4DlZ5Rzd2[udX;yc41mfHKrYzDhd5NigSxiSVO1NF0yNjcQvF2= NEWycpI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUG2NlMxQSd-MkmxOlI{ODl:L3G+
MCF7/ADR NWLtSmZDTnWwY4Tpc44h[XO|YYm= NI\3dmM1QCCqcoO= MYPJcohq[mm2aX;uJI9nKFBvZ4CgbY4hcHWvYX6gUWNHPy:DRGKgZ4VtdHNiYYPz[ZN{\WRiYYOgdI91\W62aXH0bY9vKG:oIHTvfI9zfWKrY3nuMYlv\HWlZXSgZ5l1d3SxeHnjbZR6KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEWFNUC9NE4zPDVzzszN NVroZZNGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0NFc6PDdpPkK5OFA4QTR5PD;hQi=>
MCF7/ADR NIq1e|FHfW6ldHnvckBie3OjeR?= Mme1NVUxKG2rboO= MWnDc41x\XSrdHn2[UBqdmirYnn0bY9vKG:oIGCt[5AhcW5iaIXtZY4hVUOINz;BSHIh[2WubIOgZYZ1\XJiMUWwJI1qdnNiaX6gdJJme2WwY3Wgc4Yh\G:6b4L1ZolkcW5iYomgUIlv\XenYY\ldk1DfXKtIIDsc5Qh[W6jbInzbZMtKEurPUKuPFjPxE1? NYDPXZVURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0NFc6PDdpPkK5OFA4QTR5PD;hQi=>
MCF7/ADR MkO1SpVv[3Srb36gZZN{[Xl? NITTdGYyPTBibXnudy=> Mn7TR49ueGW2aYTpeoUhcW6qaXLpeIlwdiCxZjDQMYdxKGmwIHj1cYFvKE2FRkevRWRTKGOnbHzzJIFnfGW{IEG1NEBucW6|IHnuJJBz\XOnbnPlJI9nKGSxeH;yeYJq[2mwIHL5JGRqgG:wIIDsc5Qh[W6jbInzbZMtKEurPUKuPVLPxE1? MnXVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2MEe5OFcoRjJ7NEC3PVQ4RC:jPh?=
MCF7/ADR NH;SfXlHfW6ldHnvckBie3OjeR?= MVixOVAhdWmwcx?= M{GxSGlvcGmkaYTpc44hd2ZiUD3ndEBqdiCqdX3hckBOS0Z5L1HEVkBk\WyuczDhd5Nme3OnZDDhd{Bkd26lZX70doF1cW:wIILldZVqemWmIITvJJJme3SxcnWg[I95d3K3YnnjbY4h[WOldX31cIF1cW:wIHnuJINmdGy|IHHmeIVzKDF3MDDtbY5{KGK7IH\seY9z\XOlZX7j[UBie3OjeTDy[YxifGm4ZTD0c{BOS0Z5IHPlcIx{NCCDY4Tpeol1gT12MN88US=> M2X6fFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEC3PVQ4Lz5{OUSwO|k1PzxxYU6=
MCF7 MV;DfZRwfG:6aXPpeJkh[XO|YYm= NYTzUJZUPDhiaILz MUnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;NEiuPVHPxE1? MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTRyN{m0O{c,Ojl2MEe5OFc9N2F-
MCF7/ADR NYfyOWcyTnWwY4Tpc44h[XO|YYm= NYnxXZNtOTBidV2= MlvYOEBpenN? NYjicFhHUW6qaXLpeIlwdiCxZjDQMYdxKG2nZHnheIVlKGWoZnz1fEBqdiCqdX3hckBOS0Z5L1HEVkBk\WyuczDheEAyOCC3TTDh[pRmeiB2IHjyd{BjgSCUaEGyN{BlgWVvYnHz[YQh\myxdzDjfZRwdWW2cnnjJI1mfGixZB?= NIT5fGM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSwO|k1Pyd-Mkm0NFc6PDd:L3G+
K562/Dox Ml\iSpVv[3Srb36gZZN{[Xl? NUXIVnRlUW6qaXLpeIlwdiCxZjDQMYdxKGmwIHj1cYFvKEt3NkKvSI95KGOnbHzzJIF{e2W|c3XkJIF{KGOxbYDveY5lKGOxbnPlcpRz[XSrb36gZ4F2e2mwZzC1NEUhcW6lcnXhd4UhcW5iboXjcIVieiCjY3P1cZVt[XSrb36gc4YheGm{YYL1ZolkcW5iYomgd5Bm[3S{b3\seY9zd22ndILpZ{Bu\XSqb3SsJGFkfGm4aYT5QVEvPs7:TR?= MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR{MUW3Nkc,Ojl2MkG1O|I9N2F-
K562/A02 MUPGeY5kfGmxbjDhd5NigQ>? M4HKWFUhfU1? MlnwNk42KGi{cx?= Mo\BTY5pcWKrdHnvckBw\iCSLXfwJIlvKGi3bXHuJGs2PjJxQUCyJINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGGmcnnhcZlkcW5iYXPjeY12dGG2aX;uJIF1KDVidV2gZYZ1\XJiMj61JIhzeyCkeTDmcI94KGO7dH;t[ZRzgSCvZYToc4Q> MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ|MUe4Okc,Ojl4M{G3PFY9N2F-
K562 NHXmZoJHfW6ldHnvckBie3OjeR?= M4\XZ|UhfU1? NHzvPWczNjViaILz NYLnb3Y{UW6qaXLpeIlwdiCxZjDQMYdxKGmwIHj1cYFvKEt3NkKgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hWmhzMkOgZYNkfW23bHH0bY9vKGG2IEWgeW0h[W[2ZYKgNk42KGi{czDifUBjgSCobH;3JIN6fG:vZYTyfUBu\XSqb3S= NIPTb|g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OU[zNVc5Pid-Mkm2N|E4QDZ:L3G+
MCF7/ADR Mly4SpVv[3Srb36gZZN{[Xl? NV\uUmFiPDhiaILz M4Dy[GlvcGmkaYTpc44hd2ZiUD3ndEBqdiCqdX3hckBOS0Z5L1HEVkBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDFR|UxRTJyLkW0{txO MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTZ3NkG5PEc,Ojl4NU[xPVg9N2F-
KB/VJ300 MX;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEL4XGQ4OiCqcoO= MUTHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDLRk9XUjNyMDDj[YxteyCjZoTldkA4OiCqcoOgbY4heHKnc3XuZ4Uhd2ZiMD6xJJVOKG:oII\pcoNzcXO2aX7lJIJ6KE2WVDDhd5NigSxiSVO1NF0xNjIQvF2= Mk\XQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl5NE[xN|QoRjJ7N{S2NVM1RC:jPh?=
MCF7/ADR M{ja[2Z2dmO2aX;uJIF{e2G7 NUjrTW9UOTBidV2= Mn;1NkBpenN? MULJcohq[mm2aX;uJI9nKFBvZ4CgbY4hcHWvYX6gUWNHPy:DRGKgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcW62cnHj[YxtfWyjcjDSbFEzOyCjY3P1cZVt[XSrb36gZZQhOTBidV2gZYZ1\XJiMjDodpMh[nliZnzve{BkgXSxbXX0dpk> NWPV[mhGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm5NFM3PjNpPkK5PVA{PjZ|PD;hQi=>
SW620/AD300 MWPGeY5kfGmxbjDhd5NigQ>? NETBeHAzKGi{cx?= M3PmW2lvcGmkaYTpc44hd2ZiQVLDRlEhcW5iaIXtZY4hW1d4MkCvRWQ{ODBiY3XscJMh[XO|ZYPz[YQh[XNiaX70doFk\WyudXzhdkBi[2O3bYXsZZRqd25ib3[gdIFkdGm2YYjlcEB2eCC2bzCyJJVOKHS{ZXH0[YQh[XRiMjDodpMheG:|dDDwZYNtcXSjeHXsJJRz\WG2bXXueEBnd3JiM{CgcYlveyCrbjDwZYNtcXSjeHXsJIZz\WVibXXkbZVuKGK7IFjQUGMh[W6jbInzbZM> NV;SOFVqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm5O|U2OjlpPkK5PVc2PTJ7PD;hQi=>
SW620/AD300 NGO3Xm1HfW6ldHnvckBie3OjeR?= NEnNb3k1KGi{cx?= MmfYTY5pcWKrdHnvckBw\iCDQlPCNUBqdiCqdX3hckBUXzZ{MD;BSFMxOCClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDybI9l[W2rbnWgNVI{KGWoZnz1fEB2eCC2bzCyJJVOKHC{ZXnuZ5Vj[XSnZDDmc5IhPCCqcoOg[o9tdG:5ZXSgZpkhOzBibXnud{BqdmO3YnH0bY9vKGmwIGLoc{0yOjNiY3;ueIFqdmmwZzDt[YRqfW1iYX7kJJN2[nOncYXlcpQhcW6ldXLheIlwdiCrbjDSbI8uOTJ|IH\y[YUhdWWmaYXtJJVxKHSxIEGyNEBucW6|IHL5JIZt M1LSNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7OUe1OVI6Lz5{OUm3OVUzQTxxYU6=
SW620/AD300 NIf2PZNHfW6ldHnvckBie3OjeR?= M3rxXlQhcHK| NVXwepp6UW6qaXLpeIlwdiCxZjDBRmNDOSCrbjDoeY1idiCVV{[yNE9CTDNyMDDj[YxteyCjc4Pld5Nm\CCjczDpcpRz[WOnbHz1cIFzKGGlY4XteYxifGmxbjDv[kBcO0ifLYDhZ4xqfGG6ZXygeZAhfG9iMjD1UUBxemWrbnP1ZoF1\WRiZn;yJFQhcHK|IH\vcIxwf2WmIHL5JHs{UF1vcHHjcIl1[XinbDDh[IRqfGmxbjDt[YF{fXKnZDDh[pRmeiB{IHjyd{BjgSCuaYH1bYQhe2OrboTpcIxifGmxbjDjc5VvfGmwZzDt[ZRpd2R? NFW4S3U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUm3OVUzQSd-Mkm5O|U2Ojl:L3G+
MCF7 MmT3R5l1d3SxeHnjbZR6KGG|c3H5 NFLyUmQyOCC3Zz;tcC=> NVzwO3hrPDhiaILz NVrEW|JYWG:2ZX70bYF1cW:wIH;mJIFlemmjbYnjbY4ucW6mdXPl[EBkgXSxdH;4bYNqfHliaX6gbJVu[W5iTVPGO{Bk\WyuczDhd5Nme3OnZDDhd{Bi\HKrYX35Z4lvKEmFNUCgZZQhOTBidXevcYwh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUApWn[kIE2gNU4{KCtxLTCwMlIhfU1rLDDJR|UxRTFwNd88US=> NF;hUWc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEGzO|k5PSd-M{CxN|c6QDV:L3G+
MCF7/ADR NVjEd3dPTnWwY4Tpc44h[XO|YYm= MW[xNEB2\y:vbB?= NVL0SFBoOjRiaILz MnjFTY5pcWKrdHnvckBw\iCSLXfwJIlvKGi3bXHuJG1ETjdxQVTSJINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGmwdILhZ4VtdHWuYYKgZYNkfW23bHH0bY9vKG:oIHHkdolidXmlaX6gZpkhdWWjc4XybY5oKGmwY4LlZZNmKGmwIH\seY9z\XOlZX7j[UBqdnSnboPpeJkh[XRiMUCgeYcwdWxiYX\0[ZIhOjRiaILzJIJ6KG[udX;y[ZNk\W6lZTDtbYNzd3Olb4DpZ{BidmGueYPpdy=> NFPQU2Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEGzO|k5PSd-M{CxN|c6QDV:L3G+
KBV NIfvZpJHfW6ldHnvckBie3OjeR?= M1vOTFExKHWP MWG3NkBpenN? NUCwPXR7WmW4ZYLzZYwhd2ZiUD3ndE1u\WSrYYTl[EBufWy2aXTyeYchemW|aYP0ZY5k\SCrbjDoeY1idiCNQm[gZ4VtdHNiYYPz[ZN{\WRiYYOgdI91\W62aXH0bY9vKG:oIIDhZ4xqfGG6ZXytbY5lfWOnZDDjfZRwfG:6aXPpeJkh[nlibXXhd5VzcW6pIIDhZ4xqfGG6ZXygTWM2OCCjdDCxNEB2VSCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6KCiUdnKgQUAyOzV|Lkm4JEswNSB|MEOuN|Mhdk1rLDDJR|UxRTBwMEK4NVbPxE1? MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODN2N{OyOkc,OzB|NEezNlY9N2F-
KBV M{jrW2Z2dmO2aX;uJIF{e2G7 MYWxNEB2VQ>? NVrjb5Q2OiCqcoO= M1e2NWlvcGmkaYTpc44hd2ZiUD3ndE1u\WSrYYTl[EBTcC1zMkOg[YZndHW6IHnuJIh2dWGwIFvCWkBk\WyuczDhd5Nme3OnZDDhd{BTcC1zMkOgZYNkfW23bHH0bY9vKGG2IEGwJJVOKHC{ZXnuZ5Vj[XSnZDDmc5IhOiCqcoOg[o9tdG:5ZXSgZpkhWmhvMUKzJIFl\Gm2aX;uJI1m[XO3cnXkJIFnfGW{IEOwJI1qdnNiYomg[oxwfyCleYTvcYV1enl? NV;1WoRzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CzOFc{OjZpPkOwN|Q4OzJ4PD;hQi=>
2008/MRP1 M33DdGZ2dmO2aX;uJIF{e2G7 M2rMUFUh\GG7cx?= M1zMPWlvcGmkaYTpc44hd2ZiTWLQNUBqdiCqdX3hckAzODB6L13SVFEh[2WubIOgZZN{\XO|ZXSgZZMheG:2ZX70bYF1cW:wIH;mJIRwgG:{dXLpZ4lvNWmwZIXj[YQh[3m2b4TvfIlkcXS7IHL5JI1m[XO3cnnu[{Bz\WS3Y4Tpc44hcW5iY3XscEB{fXK4aY\hcEBi\nSncjC1JIRigXNiYomgUXRUKGG|c3H5MEBGSzVyPUGuPVI2|ryP MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODN3MUmzOEc,OzB|NUG5N|Q9N2F-
KBV NHvZT25HfW6ldHnvckBie3OjeR?= NFrGUWwyOCC3TR?= MlXTVoV3\XK|YXygc4YhWC2pcD3t[YRq[XSnZDDkdpVoKHKnc3nzeIFv[2ViaX6gbJVu[W5iS1LWJINmdGy|IHHzd4V{e2WmIHHzJJBwfGWwdHnheIlwdiCxZjDwZYNtcXSjeHXsMYlv\HWlZXSgZ5l1d3SxeHnjbZR6KGK7IH3lZZN2emmwZzDwZYNtcXSjeHXsJGlEPTBiYYSgNVAhfU1uIFnDOVA:OC5yMES5{txO NHryfVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEO4OFA1Oid-M{CzPFQxPDJ:L3G+
KBV MYPGeY5kfGmxbjDhd5NigQ>? NH;kXZMyOCC3TR?= NXXQdZRPPzJiaILz Mn;hVoV3\XK|YXygc4YhWC2pcD3t[YRq[XSnZDDkdpVoKHKnc3nzeIFv[2ViaX6gbJVu[W5iS1LWJINmdGy|IHHzd4V{e2WmIHHzJJBwfGWwdHnheIlwdiCxZjDwZYNtcXSjeHXsMYlv\HWlZXSgZ5l1d3SxeHnjbZR6KGK7IH3lZZN2emmwZzDwZYNtcXSjeHXsJGlEPTBiYYSgNVAhfU1iYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSBqUo\iJF0hOzl6LkO0JEswNSByLkW4JJVOMSxiSVO1NF03NjF3zszN NX7q[ohtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CzPFQxPDJpPkOwN|g1ODR{PD;hQi=>
MDCK NWq2ZZVWTnWwY4Tpc44h[XO|YYm= NHv6T2g{OCCvaX7z NUnWfphMUW6qaXLpeIlwdiCxZjDNSHIyKCi3bnvuc5dvKG:{aXfpckkh\XiycnXzd4VlKGmwIF3ER2sh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPhcINmcW5vQV2g[YZndHW6IIDy[Ylv[3WkYYTl[EBnd3JiM{CgcYlveyCob3zsc5dm\CCkeTDjZYxk\WmwLVHNJIFl\Gm2aX;uJI1m[XO3cnXkJIFnfGW{IEOwJI1qdnNiYomgd5Bm[3S{b3\seY9zcW2ndILpZ{Bu\XSqb3SsJGlEPTB;MT6z{txO M2D3e|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyM{i0NFQ3Lz5|MEO4OFA1PjxxYU6=
MDCK MVnGeY5kfGmxbjDhd5NigQ>? M3v3elMxKG2rboO= M3\5XmlvcGmkaYTpc44hd2ZiTWLQNUApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCPRFPLJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClYXzj[YlvNUGPIHXm[ox2gCCycnXpcoN2[mG2ZXSg[o9zKDNyIH3pcpMh\m:ubH;3[YQh[nliY3HsZ4Vqdi2DTTDh[IRqfGmxbjDt[YF{fXKnZDDh[pRmeiB|MDDtbY5{KGK7IIPw[YN1em:obIXvdolu\XS{aXOgcYV1cG:mLDDJR|UxRTRwNd88US=> M4m1Z|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyM{i0NFQ3Lz5|MEO4OFA1PjxxYU6=
KBV NGfrSHNEgXSxdH;4bYNqfHliYYPzZZk> NVLKXJNsOTBidV2= NVLKRYdmPDhiaILz NIW0UHpRd3SnboTpZZRqd25ib3[geolv[3Krc4TpcoUucW6mdXPl[EBkgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMSlZiY3XscJMh[XO|ZYPz[YQh[XNidnnuZ5Jqe3SrbnWgTWM2OCCjdDCxNEB2VSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6KCiUdnKgQUA3PjZwMzDuUUktKEmFNUC9NE4xODF|Md88US=> NH3YO449[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MES1OVE1QCd-M{C0OVUyPDh:L3G+
A2780/TAX NGC1cXhEgXSxdH;4bYNqfHliYYPzZZk> NYfwTGdXOTBidV2= M2jFeVQ5KGi{cx?= NFHGe5VRd3SnboTpZZRqd25ib3[gdIFkdGm2YYjlcE1qdmS3Y3XkJIN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGEzPzhyL2TBXEBk\WyuczDhd5Nme3OnZDDhd{Bx[WOuaYThfIVtKEmFNUCgZZQhOTBidV2gZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTCoVpZjKD1iM{m3NEBvVSluIFnDOVA:OC5yMUi4{txO MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODR3NUG0PEc,OzB2NUWxOFg9N2F-
A2780/CDDP NWnL[olWS3m2b4TvfIlkcXS7IHHzd4F6 NWThe|ZSOTBidV2= NVTVPYNkPDhiaILz NHfDXFVRd3SnboTpZZRqd25ib3[gZ4l{eGyjdHnuMYlv\HWlZXSgZ5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVI4QDBxQ1TEVEBk\WyuczDhd5Nme3OnZDDhd{BkcXOybHH0bY4hUUN3MDDheEAyOCC3TTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7IDjSeoIhRSB2Mz6xNUBvVSluIFnDOVA:OC5yNECxNe69VQ>? M3XjPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyNEW1NVQ5Lz5|MES1OVE1QDxxYU6=
Lucena 1 NVS5d2NKTnWwY4Tpc44h[XO|YYm= MUexNk42KHWP MYixJIhz NGTXbJlKdmirYnn0bY9vKG:oIGCt[5AudWWmaXH0[YQhWmixLUGyN{Bm\m[udYigbY4hcHWvYX6gUJVk\W6jIEGgZ4VtdHNiYYSgNVIvPSC3TTDwdoVqdmO3YnH0[YQh\m:{IEGgbJIh\m:ubH;3[YQh[nliUnjvMVEzOyCjZHTpeIlwdiCvZXHzeZJm\CCjZoTldkAyKGi{IHL5JIZtd3diY4n0c41mfHK7 M3LVNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyNkGzN|I1Lz5|ME[xN|MzPDxxYU6=
Lucena 1 NEXMdmVHfW6ldHnvckBie3OjeR?= NVnaenJnOjVidV2= Mn7jNUBpeg>? NILkWm9KdmirYnn0bY9vKG:oIGCt[5AudWWmaXH0[YQhWmixLUGyN{Bm\m[udYigbY4hcHWvYX6gUJVk\W6jIEGgZ4VtdHNiYYSgNlUhfU1icILlbY5kfWKjdHXkJIZweiBzIHjyJIZwdGyxd3XkJIJ6KFKqbz2xNlMh[WSmaYTpc44hdWWjc4Xy[YQh[W[2ZYKgNUBpeiCkeTDmcI94KGO7dH;t[ZRzgQ>? Ml\uQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB4MUOzNlQoRjNyNkGzN|I1RC:jPh?=
MCF7/ADR MmS3RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NX[4T3V7PSC3TR?= MY[0PEBpenN? NH7TSFZRd3SnboTpZZRqd25ib3[gZYRzcWGveXPpck1qdmS3Y3XkJIFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{9CTFJiY3XscJMh[XO|ZYPz[YQh[XNiYXTybYFugWOrbjDJR|UxKGG2IEWgeW0hdWWjc4Xy[YQh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUApWn[kIE2gPFkvOTRiKz:tJFQvQDlidV2pMEBKSzVyPUKuNlXPxE1? M3vHTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyOEO3NFk4Lz5|MEizO|A6PzxxYU6=
MCF7/ADR NUP2OHBKTnWwY4Tpc44h[XO|YYm= MXq0PEBpenN? MmXUTY5pcWKrdHnvckBw\iCSLXfwJIlvKGSxeH;yeYJq[2mwLYLld4l{fGGwdDDoeY1idiCPQ1[3M2FFWiClZXzsd{Bie3Onc4Pl[EBieyC{ZY\ldpNidCCxZjDkc5hwenWkaXPpckBz\XOrc4ThcoNmKGK7IH3lZZN2emmwZzDkc5hwenWkaXPpckBKSzVyIHnuZ5Vj[XSnZDDmc5IhPDhiaILzJIJ6KE2WVDDhd5NigSBqUo\iJF0h\G:6b4L1ZolkcW5iYXzvcoUhRSB4ND64JEswNSB{LkGgeW0qNCCLQ{WwQVQvP87:TR?= MmTwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB6NkCzO|MoRjNyOE[wN|c{RC:jPh?=
KB/VJ300 NX35TI9ES3m2b4TvfIlkcXS7IHHzd4F6 MXm3NkBpenN? NWPVdYF4S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hU0JxVlqzNFAh[2WubIOgZYZ1\XJiN{KgbJJ{KGmwIIDy[ZNmdmOnIH;mJJZqdmO{aYP0bY5mKGK7IF3UWEBie3OjeTygTWM2OD1yLklOwG0> MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODh4OUi5NEc,OzB6Nkm4PVA9N2F-
MCF7/Dox MUjGeY5kfGmxbjDhd5NigQ>? MnvINVIvPSC3TR?= MVG0PEBpenN? M1rWbnJmfmW{c3HsJI9nKFBvZ4CtcYVlcWG2ZXSgcZVtfGmmcoXnJJJme2m|dHHuZ4UhcW5iaIXtZY4hVUOINz;Ec5gh[2WubIOgZZN{\XO|ZXSgZZMheG:2ZX70bYF1cW:wIH;mJIRwgG:{dXLpZ4lvNWmwZIXj[YQh[3m2b4TvfIlkcXS7IHL5JI1m[XO3cnnu[{Bld3ixcoXibYNqdiCLQ{WwJIF1KDF{LkWgeW0h[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUApWn[kIE2gOVEvOTliKz:tJFAvQTVibXnjdo9OMSxiSVO1NF0yOC5zzszN M1PneFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzM{K1O|g{Lz5|MUOyOVc5OzxxYU6=
KBtax Mny0SpVv[3Srb36gZZN{[Xl? M37XZVExOCC3TR?= MXuxJIhz NGHGNpRKdmirYnn0bY9vKG:oIGCt[5Ah\W[obIX4JIlvKGi3bXHuJGtDfGG6IHPlcIx{KGG2IEGwNEB2VSCjZoTldkAyKGi{IHL5JIZtd3diY4n0c41mfHK7 NF7qc3A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUSxPVc1OCd-M{G0NVk4PDB:L3G+
MDCK-MDR1 Mn3CSpVv[3Srb36gZZN{[Xl? MlywN|AhdWmwcx?= MWXJcohq[mm2aX;uJI9nKFBvZ4CgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO|ZXSgbY4hVUSFSz3NSHIyKGOnbHzzJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHPhcINmcW5vQV2gZYNkfW23bHH0bY9vKGmwY4XiZZRm\CCob4KgN|AhdWmwczDifUBk[WylZXnuMWFOKGS7ZTDiZZNm\CCobIXvdoV{[2WwY3WgZZN{[XluIFXDOVA:OC53zszN MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTR7NES2PEc,OzF2OUS0Olg9N2F-
MDCK MkK5SpVv[3Srb36gZZN{[Xl? M4LhWFMxKG2rboO= NEOxdYxKdmirYnn0bY9vKG:oIFLDVnAhMHWwa37ve44hd3KrZ3nuLUBmgHC{ZYPz[YQhcW5iTVTDT{Bk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCKb3XjbJN1KDN|M{SyJIFk[3WvdXzheIlwdiCrbnP1ZoF1\WRiZn;yJFMxKG2rboOgZpkhUG:nY3jzeEA{OzN2MjDkfYUh[mG|ZXSg[ox2d3Knc3PlcoNmKGG|c3H5MEBGSzVyPUCuPe69VQ>? MmHRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF2OUS0OlgoRjNzNEm0OFY5RC:jPh?=
K562/DOX MlzLSpVv[3Srb36gZZN{[Xl? M4rRcVMxKG2rboO= NGXpVGVKdmirYnn0bY9vKG:oIGCt[5AhcW5iaIXtZY4hUzV4Mj;EU3gh[2WubIOgZZN{\XO|ZXSgZZMh\HK3ZzDs[ZZmdCClYYXzbY5oKDVyJTDpcoNz\WG|ZTDpckBvfWOuZXHyJJBqemG{dXLpZ4lvKGOxbnPlcpRz[XSrb36gbY5kfWKjdHXkJIZweiB|MDDtbY5{KGK7IH\seY9z\XOlZX7j[UBj[XOnZDDhd5NigSxiSUCuOV0yNjcQvF2= MmewQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF2OUS0OlgoRjNzNEm0OFY5RC:jPh?=
MDCK MXLGeY5kfGmxbjDhd5NigQ>? MoLPN|AhdWmwcx?= M1fwR2lvcGmkaYTpc44hd2ZiTWLQNUApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCPRFPLJINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGOjbHPlbY4uSU1iYXPjeY12dGG2aX;uJIlv[3WkYYTl[EBnd3JiM{CgcYlveyCkeTDjZYxk\WmwLVHNJIR6\SCkYYPl[EBndHWxcnXzZ4Vv[2ViYYPzZZktKEWFNUC9Ok45|ryP MkL2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF2OUS0OlgoRjNzNEm0OFY5RC:jPh?=
KBV MoDCSpVv[3Srb36gZZN{[Xl? NV2zU4RQOTBidV2= M4WxS|czKGi{cx?= NX;s[oZKWmW4ZYLzZYwhd2ZiUD3ndE1u\WSrYYTl[EBufWy2aXTyeYchemW|aYP0ZY5k\SCrbjDoeY1idiCNQm[gZ4VtdHNiYYPz[ZN{\WRiYYOgdI91\W62aXH0bY9vKG:oIIDhZ4xqfGG6ZXytbY5lfWOnZDDjfZRwfG:6aXPpeJkh[nlibXXhd5VzcW6pIIDhZ4xqfGG6ZXygTWM2OCCjdDCxNEB2VSCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6KCiUdnKgQUA{PTJwM{GgL{8uKDFyLkmgcm0qNCCLQ{WwQVAvODF6NEROwG0> MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTVyNUS1NUc,OzF3MEW0OVE9N2F-
KBV M1LzVmZ2dmO2aX;uJIF{e2G7 M2jmWlExKHWP MXm3NkBpenN? NV;M[VZzWmW4ZYLzZYwhd2ZiUD3ndE1u\WSrYYTl[EBufWy2aXTyeYchemW|aYP0ZY5k\SCrbjDoeY1idiCNQm[gZ4VtdHNiYYPz[ZN{\WRiYYOgdI91\W62aXH0bY9vKG:oII\pcoNzcXO2aX7lMYlv\HWlZXSgZ5l1d3SxeHnjbZR6KGK7IH3lZZN2emmwZzD2bY5kemm|dHnu[UBKSzVyIHH0JFExKHWPIHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XliKGL2ZkA:KDJwOUKgL{8uKDBwM{Ggcm0qNCCLQ{WwQVAvODN3MENOwG0> NIXB[o09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUWwOVQ2OSd-M{G1NFU1PTF:L3G+
KBV M1z0PWZ2dmO2aX;uJIF{e2G7 Mmq5NVAhfU1? M4Py[VczKGi{cx?= NUHFN2hpWmW4ZYLzZYwhd2ZiUD3ndE1u\WSrYYTl[EBufWy2aXTyeYchemW|aYP0ZY5k\SCrbjDoeY1idiCNQm[gZ4VtdHNiYYPz[ZN{\WRiYYOgdI91\W62aXH0bY9vKG:oIHnybY5wfGWlYX6tbY5lfWOnZDDjfZRwfG:6aXPpeJkh[nlibXXhd5VzcW6pIHnybY5wfGWlYX6gTWM2OCCjdDCxNEB2VSCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6KCiUdnKgQUA1QS5{IDuvMUAxNjR4IH7NLUwhUUN3ME2xNE4{P87:TR?= MmTvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF3MEW0OVEoRjNzNUC1OFUyRC:jPh?=
12D7-MDR MV\GeY5kfGmxbjDhd5NigQ>? NVznOlVOUW6qaXLpeIlwdiCxZjDQMYdxKGmwIHj1cYFvKDF{REetUWRTKGOnbHzzJJV{cW6pIHPhcINmcW5vQV2gZZMhe3Wkc4TyZZRmNCCLQ{WwQVEvOs7:TR?= NVfENFVyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G1NFU6OjhpPkOxOVA2QTJ6PD;hQi=>
HepG2/DOX NWHwVplLTnWwY4Tpc44h[XO|YYm= NUCwXYppOTBidV2= MUTS[ZZmenOjbDDv[kBRNWeyIH3l[IlifGWmIH31cJRq\HK3ZzDy[ZNqe3SjbnPlJIlvKGi3bXHuJGhmeEd{L1TPXEBk\WyuczDhd5Nme3OnZDDhd{Bld3ixcoXibYNqdiCLQ{WwJIF1KDFyIIXNJI1m[XO3cnXkJJdqfGirbjC0PEBpenNiYomgUXRVKGG|c3H5JEhTfmJiPTC2PU4{KCtxLTCzMlkhfU1rLDDJR|UxRTFwM988US=> NWnUVJY{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G1PFUzPzVpPkOxOVg2Ojd3PD;hQi=>
MCF7/ADM M1;CUGZ2dmO2aX;uJIF{e2G7 NGPa[noyOCC3TR?= M2fGb3JmfmW{c3HsJI9nKFBvZ4CgcYVlcWG2ZXSgcZVtfGmmcoXnJJJme2m|dHHuZ4UhcW5iaIXtZY4hVUOINz;BSG0h[2WubIOgZZN{\XO|ZXSgZZMh\G:6b4L1ZolkcW5iSVO1NEBifCBzMDD1UUBu\WG|dYLl[EB4cXSqaX6gOFghcHK|IHL5JG1VXCCjc4PhfUApWn[kIE2gNVUyNjdiKz:tJFUhfU1rLDDJR|UxRTNwN988US=> M{Pxb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzNUi1Nlc2Lz5|MUW4OVI4PTxxYU6=
HepG2/DOX M{DLbGZ2dmO2aX;uJIF{e2G7 NYHocXJwPSC3TR?= NGDy[WRT\X[ncoPhcEBw\iCSLXfwJI1m\GmjdHXkJI12dHSrZIL1[{Bz\XOrc4ThcoNmKGmwIHj1cYFvKEincFeyM2RQYCClZXzsd{Bie3Onc4Pl[EBieyCmb4jvdpVjcWOrbjDJR|UxKGG2IEWgeW0hdWWjc4Xy[YQhf2m2aHnuJFQ5KGi{czDifUBOXFRiYYPzZZkhMFK4YjC9JFY6NjNiKz:tJFMvQSC3TTmsJGlEPTB;ND63{txO MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTV6NUK3OUc,OzF3OEWyO|U9N2F-
MCF7/ADM M2XzeGZ2dmO2aX;uJIF{e2G7 MWO1JJVO NV;2ZXZ5WmW4ZYLzZYwhd2ZiUD3ndEBu\WSrYYTl[EBufWy2aXTyeYchemW|aYP0ZY5k\SCrbjDoeY1idiCPQ1[3M2FFVSClZXzsd{Bie3Onc4Pl[EBieyCmb4jvdpVjcWOrbjDJR|UxKGG2IEWgeW0hdWWjc4Xy[YQhf2m2aHnuJFQ5KGi{czDifUBOXFRiYYPzZZkhMFK4YjC9JFE2OS55IDuvMUA2KHWPKTygTWM2OD1zNz64{txO Ml3zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF3OEWyO|UoRjNzNUi1Nlc2RC:jPh?=
HepG2/Dox NInNfXNHfW6ldHnvckBie3OjeR?= MlLhNVAhfU1? MkO5OEBpenN? NFXU[IZT\X[ncoPhcEBw\iCSLXfwJI1m\GmjdHXkJIRzfWdiZX\mcJV5KGmwIHj1cYFvKEincFeyM2RwgCClZXzsd{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDpcpRz[WOnbHz1cIFzKGSxeH;yeYJq[2mwIHHjZ5VufWyjdHnvckBifCBzMDD1UUBxemWrbnP1ZoF1\WRiZn;yJFQhcHK|IH\vcIxwf2WmIHL5JIRwgG:{dXLpZ4lvKGGmZHn0bY9vKG2nYYP1doVlKGGodHXyJFEhcHJiaX7jeYJifGmxbjDifUBndHWxcnXzZ4Vv[2VibXnjdo9{[2:yaXOgZY5idHl? NYThV5hFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G1PFUzPzVpPkOxOVg2Ojd3PD;hQi=>
HepG2/Dox M1XBc2Z2dmO2aX;uJIF{e2G7 M3PlSVExKHWP MonUOEBpenN? NF;MR2RT\X[ncoPhcEBw\iCSLXfwJI1m\GmjdHXkJIRzfWdiZX\mcJV5KGmwIHj1cYFvKEincFeyM2RwgCClZXzsd{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDpcpRz[WOnbHz1cIFzKFKqb3ThcYlv\TF{MzDhZ4N2dXWuYYTpc44h[XRiMUCgeW0heHKnaX7jeYJifGWmIH\vdkA1KGi{czDmc4xtd3enZDDifUBTcDF{MzDh[IRqfGmxbjDt[YF{fXKnZDDh[pRmeiBzIHjyJIlv[3WkYYTpc44h[nliZnz1c5Jme2OnbnPlJI1q[3Kxc3PvdIlkKGGwYXz5d4l{ M3fyc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzNUi1Nlc2Lz5|MUW4OVI4PTxxYU6=
HepG2/Dox MWPGeY5kfGmxbjDhd5NigQ>? MUm1JJRwKDFyIIXN M1LpblQhcHK| NVLTWHNjWmW4ZYLzZYwhd2ZiUD3ndEBu\WSrYYTl[EBlenWpIHXm[ox2gCCrbjDoeY1idiCKZYDHNk9Fd3hiY3XscJMh[XO|ZYPz[YQh[XNiaX7jdoVie2ViaX6gbY51emGlZXzseYxieiCmb4jvdpVjcWOrbjDhZ4N2dXWuYYTpc44h[XRiNTD0c{AyOCC3TTDwdoVqdmO3YnH0[YQh\m:{IESgbJJ{KG[xbHzve4VlKGK7IHTvfI9zfWKrY3nuJIFl\Gm2aX;uJI1m[XO3cnXkJIFnfGW{IEGgbJIhcW6ldXLheIlwdiCkeTDmcI94KGO7dH;t[ZRzgSCjbnHsfZNqew>? MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTV6NUK3OUc,OzF3OEWyO|U9N2F-
HepG2/Dox MmX2SpVv[3Srb36gZZN{[Xl? MXm1JJRwKDFyIIXN M{\hXVQhcHK| MXXS[ZZmenOjbDDv[kBRNWeyIH3l[IlifGWmIHTyeYch\W[obIX4JIlvKGi3bXHuJGhmeEd{L1TvfEBk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCrboTyZYNmdGy3bHHyJHJpd2SjbXnu[VEzOyCjY3P1cZVt[XSrb36gZZQhPSC2bzCxNEB2VSCycnXpcoN2[mG2ZXSg[o9zKDRiaILzJIZwdGyxd3XkJIJ6KFKqMUKzJIFl\Gm2aX;uJI1m[XO3cnXkJIFnfGW{IEGgbJIhcW6ldXLheIlwdiCkeTDmcI94KGO7dH;t[ZRzgSCjbnHsfZNqew>? NEPUTGY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUW4OVI4PSd-M{G1PFUzPzV:L3G+
MCF7/ADM MUXGeY5kfGmxbjDhd5NigQ>? M17mTlExKHWP MlvlOEBpenN? M3focnJmfmW{c3HsJI9nKFBvZ4CgcYVlcWG2ZXSg[JJ2\yCnZn\seZghcW5iaIXtZY4hVUOINz;BSG0h[2WubIOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iaX70doFk\WyudXzhdkBld3ixcoXibYNqdiCjY3P1cZVt[XSrb36gZZQhOTBidV2gdJJmcW6ldXLheIVlKG[xcjC0JIhzeyCob3zsc5dm\CCkeTDkc5hwenWkaXPpckBi\GSrdHnvckBu\WG|dYLl[EBi\nSncjCxJIhzKGmwY4XiZZRqd25iYomg[ox2d3Knc3PlcoNmKG2rY4Lvd4NweGmlIHHuZYx6ew>? NVqwdVJWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G1PFUzPzVpPkOxOVg2Ojd3PD;hQi=>
MCF7/ADM MmXHSpVv[3Srb36gZZN{[Xl? NF3DO3IyOCC3TR?= M3:zcFQhcHK| Mk\GVoV3\XK|YXygc4YhWC2pcDDt[YRq[XSnZDDkdpVoKGWoZnz1fEBqdiCqdX3hckBOS0Z5L1HEUUBk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCrboTyZYNmdGy3bHHyJHJpd2SjbXnu[VEzOyCjY3P1cZVt[XSrb36gZZQhOTBidV2gdJJmcW6ldXLheIVlKG[xcjC0JIhzeyCob3zsc5dm\CCkeTDSbFEzOyCjZHTpeIlwdiCvZXHzeZJm\CCjZoTldkAyKGi{IHnuZ5Vj[XSrb36gZpkh\my3b4Lld4NmdmOnIH3pZ5Jwe2OxcHnjJIFv[Wy7c3nz MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTV6NUK3OUc,OzF3OEWyO|U9N2F-
HepG2/Dox Mlq3SpVv[3Srb36gZZN{[Xl? M4GwXFUhfG9iMUCgeW0> M37kTlQhcHK| MlL2TY5pcWKrdHnvckBw\iCSLXfwJI1m\GmjdHXkJIRwgG:{dXLpZ4lvKGWoZnz1fEBqdiCqdX3hckBJ\XCJMj;Ec5gh[2WubIOgZZQhPSC2bzCxNEB2VSCycnXpcoN2[mG2ZXSg[o9zKDRiaILzJIZwdGyxd3XkJIJ6KGOxLXnuZ5Vj[XSrb36ge4l1cCCmb4jvdpVjcWOrbjDmc5IhOiCqcoOg[o9tdG:5ZXSgZpkh\G:6b4L1ZolkcW5id3HzbE1wfXRiYX7kJI1m[XO3cnXkJIFnfGW{IEGyNEBucW6|IHnuZ5Vj[XSrb36ge4l1cCCmcoXnJINwdnSjaX7pcoc> M{fTVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzNUi1Nlc2Lz5|MUW4OVI4PTxxYU6=
MCF7/ADM MX;GeY5kfGmxbjDhd5NigQ>? NYDoR3BRPSC2bzCxNEB2VQ>? MlfyOEBpenN? M2LlfGlvcGmkaYTpc44hd2ZiUD3ndEBu\WSrYYTl[EBld3ixcoXibYNqdiCnZn\seZghcW5iaIXtZY4hVUOINz;BSG0h[2WubIOgZZQhPSC2bzCxNEB2VSCycnXpcoN2[mG2ZXSg[o9zKDRiaILzJIZwdGyxd3XkJIJ6KGOxLXnuZ5Vj[XSrb36ge4l1cCCmb4jvdpVjcWOrbjDmc5IhOiCqcoOg[o9tdG:5ZXSgZpkh\G:6b4L1ZolkcW5id3HzbE1wfXRiYX7kJI1m[XO3cnXkJIFnfGW{IEGyNEBucW6|IHnuZ5Vj[XSrb36ge4l1cCCmcoXnJINwdnSjaX7pcoch[w>? M4jpOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzNUi1Nlc2Lz5|MUW4OVI4PTxxYU6=
KB/VJ300 NV\vNWU{SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M2W5[lczKGi{cx?= MlztRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiC4aX7jdol{fGmwZT3yd4l{fGGwdDDLRk9XUjNyMDDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDDndo94fGhiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0xNjUQvF2= NF[we2o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MU[0NlMyPSd-M{G2OFI{OTV:L3G+
CHO NYG3SWozS3m2b4TvfIlkcXS7IHHzd4F6 MlzuR5l1d3SxeHnjbZR6KGGpYXnud5QhS0iRIHPlcIx{KGK7IF3UWEBie3OjeTygTWM2OD1yLkW2{txO M1;UWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFY6PjZxJ{7DbGVOSkx:L3G+
CHRC5 NHyyN4xHfW6ldHnvckBie3OjeR?= M1fEdXRme3SnZDDmc5IhcW5idnn0do8heHKxbHnm[ZJifGmxbjDhcoQhfmmjYnnsbZR6KG:oIH31cJRq\HK3ZzDy[ZNqe3SjboSgR2hTSzViQ3jpcoV{\SCqYX3zeIVzKGOnbHzzJIlvKHSqZTDwdoV{\W6lZTDhcoQh[WK|ZX7j[UBw\iCmb4jvdpVjcWOrbjDpckBiKG2xZHnmbYVlKE2WVDDhd5NigSxiRVO1NF0yNjMQvF2= NHW0Vnk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw3QTZ4Lze+R4hGVUKOPD;hQi=>
HeLa MUjGeY5kfGmxbjDhd5NigQ>? Mk\GN|AhdWmwcx?= NV64Wnk5UW6qaXLpeIlwdiCxZjDQMYdtgWOxcILveIVqdiBzIHnuJIh2dWGwIFjlUIEh[2WubIOgZZN{\XO|ZXSgZZMhcW62cnHj[YxtfWyjcjDhZ4N2dXWuYYTpc44hd2ZiSH;lZ4h{fCB|M{O0NkBlgWViYX\0[ZIhOzBibXnud{BjgSCobIXvdoV{[2WwY3WgcYlkem:|Y3;wbYMh[W6jbInzbZMtKEmFNUC9NU44|ryP MonYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOlk3Pi9pPlPoSW1DVDxxYU6=
HEK293 MmC3SpVv[3Srb36gZZN{[Xl? MlTQNlQhcHK| MoiwTY5pcWKrdHnvckBw\iCPYYLieZJoKH[rcoXzJIVvfmWub4DlJIdtgWOxcILveIVqdi2vZXTpZZRm\CClZXzsJIVvfHK7IHnuJJJXW0mYLXTlcJRiTy2PYYLWMWdRKHC|ZYXveJlx\SC4aYL1d{Bqdm[nY4Tl[EBJTUt{OUOgZ4VtdHNiYX\0[ZIhOjRiaILzJJBwe3RidILhcpNn\WO2aX;uJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygTWM2OD1zM988US=> MoTWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOlk3Pi9pPlPoSW1DVDxxYU6=
K562/ADR NYjHWYR1TnWwY4Tpc44h[XO|YYm= M1[wT|ExKHSxIEKwJJVO NV2wbXRkOzBibXnudy=> MXrJcohq[mm2aX;uJI9nKFBvZ3z5Z49xem:2ZXnuJIlvKGi3bXHuJGs2PjJxQVTSJINmdGy|IHH0JFExKHSxIEKwJJVOKGGodHXyJFMxKG2rboOgZpkhemixZHHtbY5mKDF{MzDzeIFqdmmwZz3iZZNm\CCobIXvdoV{[2WwY3WgZZN{[Xl? MkWyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOlk3Pi9pPlPoSW1DVDxxYU6=
K562 NV6zcIdlTnWwY4Tpc44h[XO|YYm= NV3C[ZNbOTBidH:gNlAhfU1? M{nrPFEhcHJ? MWTJcohq[mm2aX;uJI9nKFBvZ3z5Z49xem:2ZXnuJIlvKGSxeH;yeYJq[2mwLYLld4l{fGGwdDDIc41wKHOjcHnlcpMhMGi3bXHuLUBMPTZ{IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJHAu\3BiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcW62cnHj[YxtfWyjcjDSbFEzOyCjY3P1cZVt[XSrb36gZZQhOTBidH:gNlAhfU1iYX\0[ZIhOSCqcjDifUBndG:5IHP5eI9u\XS{aXOgZY5idHm|aYO= MkTWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOlk3Pi9pPlPoSW1DVDxxYU6=

... Click to View More Cell Line Experimental Data

In vivo Verapamil confers an anti-arrhythmic effect via calcium influx inhibition, inhibition of oxygen consumption and accompanied by preservation of Cx43 protein in rat heart.

Protocol

Solubility (25°C)

In vitro DMSO 98 mg/mL (199.56 mM)
Water 50 mg/mL (101.82 mM)
Ethanol ''12 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 491.06
Formula

C27H38N2O4.HCl

CAS No. 152-11-4
Storage powder
in solvent
Synonyms N/A
Smiles CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC.Cl

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04406259 Not yet recruiting Drug: Verapamil Cluster Headache Centre Hospitalier Universitaire de Nice September 1 2020 Phase 4
NCT02912663 Completed Drug: Verapamil and Magnesium Sulfate|Other: Placebo Ischemic Stroke Justin Fraser|University of Kentucky October 11 2017 Phase 1
NCT02823106 Withdrawn Drug: Verapamil and Citicoline|Other: Placebo Ischemic Stroke Justin Fraser|University of Kentucky August 2016 Phase 1
NCT02144792 Unknown status Drug: [11C] -verapamil PET Epilepsy Seoul National University Hospital May 2013 Phase 2
NCT01645709 Terminated Drug: Verapamil|Drug: Placebo Osteoarthritis of the Knee Calosyn Pharma Inc.|Health Decisions April 2012 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Calcium Channel Signaling Pathway Map

Related Calcium Channel Products

Tags: buy Verapamil (CP-16533-1) HCl | Verapamil (CP-16533-1) HCl supplier | purchase Verapamil (CP-16533-1) HCl | Verapamil (CP-16533-1) HCl cost | Verapamil (CP-16533-1) HCl manufacturer | order Verapamil (CP-16533-1) HCl | Verapamil (CP-16533-1) HCl distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID