Verapamil HCl

For research use only.

Catalog No.S4202

10 publications

Verapamil HCl Chemical Structure

Molecular Weight(MW): 491.06

Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent.

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Selleck's Verapamil HCl has been cited by 10 publications

3 Customer Reviews

  • The proportion of SP cells in HepG2 and HCCLM3 cell lines were 0.16% and 32.2%, which reduced to 0% and 0.28% in the presence of verapamil.

    Front Pharmacol, 2018, 9:1298. Verapamil HCl purchased from Selleck.

    f, Cells were pretreated with or without 5 μM verapamil and then treated with the indicated concentrations of 17-DMAG for 6 h. The proteins involved in ALK-related signaling were detected by western blot analysis.

    BMC Cancer, 2015, 15:553.. Verapamil HCl purchased from Selleck.

  • J45.01 cells were suspended in a growth medium containing 0.1 μM 5-CFDA and kept on ice for 20 min to allow its uptake. The effects of verapamil (MDR1 inhibitor) and MK571 (MRP1 inhibitor) on the efflux of 5-CF at 37°C was determined by flow cytometry (B).

    Exp Hematol, 2017, 2.436. Verapamil HCl purchased from Selleck.

Purity & Quality Control

Choose Selective Calcium Channel Inhibitors

Biological Activity

Description Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent.
Targets
Calcium channel [2]
In vitro

The enzyme hydrolase activity of recombinant CES2 is substantially inhibited by diltiazem and verapamil (Ki = 0.25 ± 0.02 and 3.84 ± 0.99μM, respectively).

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MDA435/LCC6 cells M3jPWGZ2dmO2aX;uJIF{e2G7 NIXI[5VT\X[ncoPhcEBw\iC4aX7icIF{fGmwZTDy[ZNqe3SjbnPlJIlvKG23bITp[JJ2\yC{ZYPpd5RidnRiTVTBOFM2N0yFQ{[gZ4VtdHNiYomgUXRUKGG|c3H5MEBKSzVyPUCuNFAxOjVizszN Moq0NVcyPTR3MEW=
HCT116/VM46 cell Mn\zSpVv[3Srb36gZZN{[Xl? MYCxJO69VQ>? M{XWe2Vn\mWldDDvckB3cW6kbHHzeIlv\SCLQ{WwJIFo[Wmwc4SgUWRTKGi3bXHuJINiemOrbn;tZUBJS1RzMU[vWm01PiClZXzsJIxqdmViYYSgZUBld3OnIH;mJFEhfU1iY3;uZ4VvfHKjdHnvckwhUUN3ME2wMlAxPCEQvF2= NHfu[VEyOjd{OU[2Ny=>
KB-3-1 cells M3\jUWZ2dmO2aX;uJIF{e2G7 MXi1JO69VQ>? MXy2PEBp MYTS[ZZmenOjbDDv[kBRNWeyLX3l[IlifGWmIH31cJRq\HK3ZzDy[ZNqe3SjbnPlJJRwKEO7dH;0c5hq[2m2eTDv[kBkd2ylaHnjbY5mKGGpYXnud5QhcHWvYX6gT2IuOy1zIHPlcIx{KGG2IEWgeW0h[W[2ZYKgOlghcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2wMlAxPDdizszN MUmxO|Q5QDF{OB?=
human KBV20C cells NFTPO2NEgXSxdH;4bYPDqGG|c3H5 NV\ETYhUS3m2b4TvfIlkcXS7IHHnZYlve3RibYXseIllenWpIILld4l{fGGwdDDQMYdxKGW6cILld5NqdmdiaIXtZY4hU0KYMkDDJINmdGy|IHHzd4V{e2WmIHHzJINmdGxidnnhZoltcXS7IHnuJJBz\XOnbnPlJI9nKHCjY3zpeIF5\WxiYomgUXRUKGG|c3H5MEBKSzVyPUCuNFEh|ryP M37F[FE5Ojl3NEmw
human KB/VCR cells NU[4SY13S3m2b4TvfIlkyqCjc4PhfS=> NITOdFczPSEQvF2= MWq3NkBp NXXjbGk{S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hU0JxVlPSJINmdGy|IHHzd4V{e2WmIHHzJJZqdmO{aYP0bY5mKEmFNUCgZZQhOjVidV2gZYZ1\XJiN{KgbJJ{KGK7IGPSRkBu\XSqb3SsJGlEPTB;MD6wNkDPxE1? NUnGTlFiOjV3OUewNVA>
K562 cells MnPESpVv[3Srb36gZZN{[Xl? MWCzJO69VQ>? M4jkTlczKGh? MojrUY9lfWyjdH;yfUBi[3Srdnn0fUBifCCSLXfwJIF{e2W|c3XkJIF{KGSxeH;yeYJq[2mwIFnDOVAhcW5iaIXtZY4hUzV4MjDj[YxteyCjdDCzJJVOKGGodHXyJFczKGi{czDifUBOXFRiYYPzZZkhMFK4YjDkc5hwenWkaXPpckBidG:wZTDJR|UxKD1iMD6wNlMhMy9vIECuNFA1KHWPKTygTWM2OD1yLkCyPUDPxE1? MmXjNlUzQDJ{NkO=
CCRF-CEM cells M1TPNWZ2dmO2aX;uJIF{e2G7 M1HxV|Uh|ryP MVLUbIUh\W[oZXP0bZZmKGSxc3Wge4F{KG2nYYP1doVlKGGpYXnud5QhWC2pbInjc5Bzd3SnaX6g[ZhxemW|c3nu[{BES1KILVPFUUBk\WyuczDpckB1cGVicILld4Vv[2Vib3[gOUB2VSCmYYXuc416[2mwLDDFSFUxRTBwMES1JO69VQ>? MnzqO|YzQThzNx?=
KB-C2 cells M4XsPWZ2dmO2aX;uJIF{e2G7 NIP3V2o2KM7:TR?= M3vOXFY5KGh? NFXTe4FT\X[ncoPhcEBw\iCSLXfwMY1m\GmjdHXkJI12dHSrZIL1[{Bz\XOrc4ThcoNmKHSxIFP5eI91d3irY3n0fUBw\iClb3zjbIlkcW6nIHHnZYlve3RiaIXtZY4hU0JvQ{KgZ4VtdHNiYYSgOUB2VSCjZoTldkA3QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvOSEQvF2= NVrWdWlmOTd2OEixNlg>
CHO cells M{TuRmZ2dmO2aX;uJIF{e2G7 M4L0O2lvcGmkaYTpc44hd2ZiaIXtZY4hTVKJIHX4dJJme3OnZDDpckBEUE9iY3XscJMh[nlid3jvcIUh[2WubDDwZZRkcCClbHHtdEB1\WOqbnnxeYUtKEmFNUC9NE4yPDF{NTFOwG0> NWH6R4VCOTh2NEizOFI>
MCF7 cells MkLGSpVv[3Srb36gZZN{[Xl? MoT4TY5pcWKrdHnvckBw\iCqdX3hckBGWkdiaX6gUWNHPyClZXzsd{whUUN3ME2wMlE1PDV2IN88US=> MnXmNVkyOTB|NEG=
NCI-H292 cells MWfGeY5kfGmxbjDhd5NigQ>? NHW3RpE2OCEQvF2= NH[ycXo4OiCq NXHUZpAyWG:2ZX70bYF1cW:wIH;mJIdm\mm2aX7pZk1qdmS3Y3XkJIN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5EUS2KMkmyJINmdGy|IHHzd4V{e2WmIHHzJIdm\mm2aX7pZkBKSzVyIHH0JFUxKHWPIHHmeIVzKDd{IHjyd{BjgSCVUlKgZZN{[XluIFnDOVA:OC5zODFOwG0> MXyyOVIyPTh3Nh?=
human KBV20C cells Mn2zR5l1d3SxeHnjxsBie3OjeR?= NFLhbplEgXSxdH;4bYNqfHliYXfhbY5{fCCvdXz0bYRzfWdicnXzbZN1[W62IGCt[5Ah\XiycnXzd4lv\yCqdX3hckBMSlZ{MFOgZ4VtdHNiYYPz[ZN{\WRiYYOgZ4VtdCC4aXHibYxqfHliaX6gdJJme2WwY3Wgc4YhfmmwY4Lpd5RqdmViYomgUXRUKGG|c3H5MEBKSzVyPUCuNkDPxE1? NX3oXod{OTh{OUW0PVA>
human LCC6MDR cells NYLjZ3I4TnWwY4Tpc44h[XO|YYm= NXW4UplTPSCmYYnz NYrPS2hwWmW4ZYLzZYwhd2ZiUD3ndE1u\WSrYYTl[EBld3ixcoXibYNqdi2{ZYPpd5RidmOnIHnuJIh2dWGwIFzDR|ZOTFJiY3XscJMh[W[2ZYKgOUBl[Xm|IHL5JG1VWyCjc4PhfUwhTUN3ME2wMlI1PSEQvF2= Mo\rNlI{OjB2MEK=
rat A7R5 cells NYXG[XFjTnWwY4Tpc44h[XO|YYm= Mo[1NVUhdWmwcx?= NI\r[YxCdnSjZ3;ubZN1KGGldHn2bZR6KGG2IHPhcINqfW1iY3jhco5mdCCrbjDyZZQhSTeUNTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEOjY3yyM2tEdC2rbnT1Z4VlKGmwY4LlZZNmKGmwIHnueJJi[2WubIXsZZIhS2F{KzDpcoN2[mG2ZXSg[o9zKDF3IH3pcpMheHKrb4KgeI8hS2GlbEKvT2NtKGOqYXzs[Y5o\SCkeTDmcJVwemW|Y3XuZ4Uh[XO|YYmsJGlEPTB;MD6zJO69VQ>? NXK2cY5IOjV|MUG1OlQ>
MDCK cells MXvGeY5kfGmxbjDhd5NigQ>? NF;BW5E{OCCvaX7z NUT4SmxZUW6qaXLpeIlwdiCxZjDoeY1idiCPRGKxJIV5eHKnc4Pl[EBqdiCPRFPLJINmdGy|IHHzd4V{e2WmIHHzJINidGOnaX6gRW0h[WOldX31cIF1cW:wIHHmeIVzKDNyIH3pcpMh[nliZnz1c5Jme2OnbnPlJIF{e2G7LDDJR|UxRTBwNTFOwG0> MXKyNlEyOjJyOB?=
human CEM/VLB500 cells NH7mZZJHfW6ldHnvckBie3OjeR?= Mof0N{Bl[Xm| MYHS[ZZmenOjbDDv[kBRNWeyLX3l[IlifGWmIH31cJRq\HK3ZzDy[ZNqe3SjbnPlJJRwKH[rbnLsZZN1cW6nIHnuJIh2dWGwIFPFUU9XVEJ3MECgZ4VtdHNiYX\0[ZIhOyCmYYnzJIJ6KHKnc3H6eZJqdiCjc4PhfUwhTUN3ME2xMlA1OSEQvF2= MWKxO|M6QTl7MB?=
human NCI-H292 cells MkPqSpVv[3Srb36gZZN{[Xl? MlnCOVAh|ryP MlrhO|IhcA>? MWnQc5RmdnSrYYTpc44hd2ZiZYLsc5RqdmmkLXnu[JVk\WRiY4n0c5RwgGmlaYT5JIFo[Wmwc4SgbJVu[W5iTlPJMWgzQTJiY3XscJMh[XO|ZYPz[YQh[XNiZYLsc5RqdmmkIFnDOVAh[XRiNUCgeW0h[W[2ZYKgO|IhcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME2xMlIh|ryP MYSyOVIyPTh3Nh?=
human KB/VCR cells MUfGeY5kfGmxbjDhd5NigQ>? NIO2UJE4OiCq MlXZTY5pcWKrdHnvckBw\iCyLXfwJIlvKGi3bXHuJGtDN1[FUjDj[YxteyCjc4Pld5Nm\CCjczDwc5RmdnSrYYTpc44hd2ZiMUCwJI5OKGSxY3X0ZZhmdC2rbnT1Z4VlKGO7dH;0c5hq[2m2eTDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDFR|UxRTFwMkWzJO69VQ>? NGPjfJAzOzZ6M{izOC=>
human K562/DOX cells M2LISWZ2dmO2aX;uJIF{e2G7 MomzUY9lfWyjdH;yfUBi[3Srdnn0fUBifCCSLXfwJIlvKGi3bXHuJGs2PjJxRF;YJINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKG63Y3zlZZIh[2:wY3XueJJifGmxbjDv[kBxcXKjcoXibYNqdiCkeTDzdIVkfHKxZnz1c5JwdWW2cnnjJIF{e2G7LDDJR|UxRTFwNjFOwG0> NIjBcGszPTJ6MkK2Ny=>
human KBV1 cells NGLybXZEgXSxdH;4bYPDqGG|c3H5 MYS0PEBp MYrDfZRwfG:6aXPpeJkh[WejaX7zeEB3cW6kbHHzeIlv\SC{ZYPpd5RidnRiaIXtZY4hU0KYMTDj[YxteyCjZoTldkA1QCCqcoOgbY4heHKnc3XuZ4Uhd2ZiMUCwJI5OKH[rbnLsZZN1cW6nIHL5JHNTSiCvZYToc4QtKEmFNUC9NU43KM7:TR?= M2npeFExOzR4OUS4
A2780 cells NFriWJBHfW6ldHnvckBie3OjeR?= MlS2TY5pcWKrdHnvckBw\iCSLXfwJIlvKGi3bXHuJIFlemmjbYnjbY4uemW|aYP0ZY51KEF{N{iwJINmdGy|IHL5JGhw\WOqc4SgN|M{PDJiYYPzZZktKEmFNUC9OE42PzB6ODFOwG0> MU[xPFY4QDR7NR?=
human MCF7/ADR cells NYf5R4ZETnWwY4Tpc44h[XO|YYm= NV[xUFBlOTBizszN M1;oSlQ5KGh? M2DiWGlvcGmkaYTpc44hd2ZiUD3ndEBqdiCqdX3hckBOS0Z5L1HEVkBk\WyuczDhd5Nme3OnZDDhd{Bz\X[ncoPhcEBw\iCvdXz0bYRzfWdicnXzbZN1[W6lZTDheEAyOCC3TTDifUBu\WG|dYLpcochTUN3MDDmc5Ih[WS{aXHtfYNqdi2rbnT1Z4VlKGO7dH;0c5hq[2m2eTDh[pRmeiB2ODDodpMh[nliU2LCJINwdG:{aX3leJJq[yCjc4PhfUwhTUN3ME20Mlg6KM7:TR?= M17yOlI2QDV4NUS1
MDCK2 cells MVTGeY5kfGmxbjDhd5NigQ>? Ml\yNlAhdWmwcx?= MmX4SY5p[W6lZX3lcpQhd2ZiY3HsZ4Vqdi2DTTD1dJRic2ViaX6gUWREUzJiY3XscJMhd3[ncjDlfJBz\XO|aX7nJG1FWjFiYX\0[ZIhOjBibXnud{whTUN3ME21MlEh|ryP MXuxPFg1QTF4Nx?=
human 2008 cells M1nmcmZ2dmO2aX;uJIF{e2G7 MkHBTY5pcWKrdHnvckBw\iCqdX3hckBOWlBzIHnuJIh2dWGwIEKwNFgh[2WubIOsJGlEPTB;OT62OkDPxE1? NWi1emJrOTh5MEe4PFQ>
human H460 cells NEXxUFRHfW6ldHnvckBie3OjeR?= NXvob3d2PTBizszN M{n3OVczKGh? NHn0XHNRd3SnboTpZZRqd25ib3[g[ZJtd3SrbnniMYlv\HWlZXSgZ5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTFQ3OCClZXzsd{Bie3Onc4Pl[EBieyCncnzveIlvcWJiSVO1NEBifCB3MDD1UUBi\nSncjC3NkBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUGwMlMh|ryP MX6yOVIyPTh3Nh?=
hamster BHK21 cells NIfJNnlEgXSxdH;4bYPDqGG|c3H5 MkX6PVYhcA>? MlTOR5l1d3SxeHnjbZR6KGGpYXnud5QhcGGvc4TldkBDUEt{MTDj[YxteyCneIDy[ZN{cW6pIF3SVFEh[W[2ZYKgPVYhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2xNE43KM7:TR?= NVjYcHJ[OjB4OUG1PVk>
KB cells NUfWToFZTnWwY4Tpc44h[XO|YYm= MkfIO|IhcA>? Mn7qTY5pcWKrdH;yfUBi[3Srdnn0fUBi\2GrboP0JGtDKGOnbHygcIlv\SCjZoTldkA4OiCqIH;mJIRzfWdiZYjwc5N2emVuIFnDOVA:OTlwNjFOwG0> M2ryXVE2PDhzOUmx
Caco-2 cells NIPLdXBHfW6ldHnvckBie3OjeR?= MVzJcohq[mm2aX;uJI9nKFCpcDDt[YF{fXKnZDDhd{BqdmirYnn0bY9vKG:oIGuzTH13cW6kbHHzeIlv\SCkYYPvcIF1\XKjbDD0c{BieGmlYXygeJJidnOyb4L0JIlvKEOjY3:tNkBk\WyuczygSWM2OD1{MDFOwG0> M17sZVE4ODZ2MEe5
human KB31 cells MUfDfZRwfG:6aXRCpIF{e2G7 MkH2OFghcA>? MkjVR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT2I{OSClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKG2ndHjv[EwhUUN3ME20OU4zKM7:TR?= NGrXcWoyODN2Nkm0PC=>

... Click to View More Cell Line Experimental Data

In vivo Verapamil confers an anti-arrhythmic effect via calcium influx inhibition, inhibition of oxygen consumption and accompanied by preservation of Cx43 protein in rat heart.

Protocol

Solubility (25°C)

In vitro DMSO 98 mg/mL (199.56 mM)
Water 50 mg/mL (101.82 mM)
Ethanol 12 mg/mL (24.43 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 491.06
Formula

C27H38N2O4.HCl

CAS No. 152-11-4
Storage powder
in solvent
Synonyms N/A
Smiles Cl.COC1=CC=C(CCN(C)CCCC(C#N)(C(C)C)C2=CC=C(OC)C(=C2)OC)C=C1OC

In vivo Formulation Calculator (Clear solution)

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Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04014634 Recruiting Drug: Methylprednisolone|Other: Placebo Cluster Headache Episodic|Greater Occipital Nerve Injection Leiden University Medical Center|Hersenstichting|Innovatiefonds Zorgverzekeraars August 1 2019 Phase 4
NCT02912663 Recruiting Drug: Verapamil and Magnesium Sulfate|Other: Placebo Ischemic Stroke Justin Fraser|University of Kentucky October 11 2017 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID