Verapamil HCl

For research use only.

Catalog No.S4202

11 publications

Verapamil HCl Chemical Structure

CAS No. 152-11-4

Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits both permeability-glycoprotein (P-gp) and CYP3A4.

Size Price Stock Quantity  
USD 97 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Selleck's Verapamil HCl has been cited by 11 publications

3 Customer Reviews

  • The proportion of SP cells in HepG2 and HCCLM3 cell lines were 0.16% and 32.2%, which reduced to 0% and 0.28% in the presence of verapamil.

    Front Pharmacol, 2018, 9:1298. Verapamil HCl purchased from Selleck.

    f, Cells were pretreated with or without 5 μM verapamil and then treated with the indicated concentrations of 17-DMAG for 6 h. The proteins involved in ALK-related signaling were detected by western blot analysis.

    BMC Cancer, 2015, 15:553.. Verapamil HCl purchased from Selleck.

  • J45.01 cells were suspended in a growth medium containing 0.1 μM 5-CFDA and kept on ice for 20 min to allow its uptake. The effects of verapamil (MDR1 inhibitor) and MK571 (MRP1 inhibitor) on the efflux of 5-CF at 37°C was determined by flow cytometry (B).

    Exp Hematol, 2017, 2.436. Verapamil HCl purchased from Selleck.

Purity & Quality Control

Choose Selective Calcium Channel Inhibitors

Biological Activity

Description Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits both permeability-glycoprotein (P-gp) and CYP3A4.
Targets
Calcium channel [2]
In vitro

The enzyme hydrolase activity of recombinant CES2 is substantially inhibited by diltiazem and verapamil (Ki = 0.25 ± 0.02 and 3.84 ± 0.99μM, respectively).

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MDA435/LCC6 cells NXq1SFZLTnWwY4Tpc44h[XO|YYm= MWjS[ZZmenOjbDDv[kB3cW6kbHHzeIlv\SC{ZYPpd5RidmOnIHnuJI12dHSrZIL1[{Bz\XOrc4ThcpQhVUSDNEO1M2xESzZiY3XscJMh[nliTWTTJIF{e2G7LDDJR|UxRTBwMECwNlUh|ryP M2HHbVE4OTV2NUC1
HCT116/VM46 cell Mnu2SpVv[3Srb36gZZN{[Xl? NXXDcHNXOSEQvF2= NHzJdnFG\m[nY4Sgc44hfmmwYnzhd5RqdmViSVO1NEBi\2GrboP0JG1FWiCqdX3hckBk[XKlaX7vcYEhUEOWMUG2M3ZOPDZiY3XscEBtcW6nIHH0JIEh\G:|ZTDv[kAyKHWPIHPvcoNmdnS{YYTpc44tKEmFNUC9NE4xODRizszN NETXdJMyOjd{OU[2Ny=>
KB-3-1 cells MlTESpVv[3Srb36gZZN{[Xl? M{OxfVUh|ryP NHq2UZc3QCCq MojVVoV3\XK|YXygc4YhWC2pcD3t[YRq[XSnZDDteYx1cWS{dXegdoV{cXO2YX7j[UB1dyCFeYTveI95cWOrdImgc4Yh[2:uY3jpZ4lv\SCjZ3HpcpN1KGi3bXHuJGtDNTNvMTDj[YxteyCjdDC1JJVOKGGodHXyJFY5KGi{czDifUBOXFRiYYPzZZktKEmFNUC9NE4xODR5IN88US=> NUD4WFFIOTd2OEixNlg>
human KBV20C cells MlHCR5l1d3SxeHnjxsBie3OjeR?= NYfRcHBVS3m2b4TvfIlkcXS7IHHnZYlve3RibYXseIllenWpIILld4l{fGGwdDDQMYdxKGW6cILld5NqdmdiaIXtZY4hU0KYMkDDJINmdGy|IHHzd4V{e2WmIHHzJINmdGxidnnhZoltcXS7IHnuJJBz\XOnbnPlJI9nKHCjY3zpeIF5\WxiYomgUXRUKGG|c3H5MEBKSzVyPUCuNFEh|ryP NXXVPIx6OTh{OUW0PVA>
human KB/VCR cells NFH4Z5FEgXSxdH;4bYPDqGG|c3H5 NVHVT4o{OjVizszN NHTGNWQ4OiCq NV;BU4JiS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hU0JxVlPSJINmdGy|IHHzd4V{e2WmIHHzJJZqdmO{aYP0bY5mKEmFNUCgZZQhOjVidV2gZYZ1\XJiN{KgbJJ{KGK7IGPSRkBu\XSqb3SsJGlEPTB;MD6wNkDPxE1? MWSyOVU6PzBzMB?=
K562 cells NGrlVGRHfW6ldHnvckBie3OjeR?= NFuyeZQ{KM7:TR?= M2TpT|czKGh? M1nZO21w\HWuYYTvdpkh[WO2aY\peJkh[XRiUD3ndEBie3Onc4Pl[EBieyCmb4jvdpVjcWOrbjDJR|UxKGmwIHj1cYFvKEt3NkKgZ4VtdHNiYYSgN{B2VSCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6KCiUdnKg[I95d3K3YnnjbY4h[WyxbnWgTWM2OCB;IECuNFI{KCtxLTCwMlAxPCC3TTmsJGlEPTB;MD6wNlkh|ryP NXfsbI44OjV{OEKyOlM>
CCRF-CEM cells MYTGeY5kfGmxbjDhd5NigQ>? NUfCVIMyPSEQvF2= M1L6NnRp\SCnZn\lZ5RqfmViZH;z[UB4[XNibXXhd5Vz\WRiYXfhbY5{fCCSLXfsfYNweHKxdHXpckBmgHC{ZYPzbY5oKEOFUl[tR2VOKGOnbHzzJIlvKHSqZTDwdoV{\W6lZTDv[kA2KHWPIHTheY5wdXmlaX6sJGVFPTB;MD6wOFUh|ryP MYm3OlI6QDF5
KB-C2 cells NFLNUIxHfW6ldHnvckBie3OjeR?= M1n1OFUh|ryP MUW2PEBp NXXVZ5RWWmW4ZYLzZYwhd2ZiUD3ndE1u\WSrYYTl[EBufWy2aXTyeYchemW|aYP0ZY5k\SC2bzDDfZRwfG:6aXPpeJkhd2ZiY3;sZ4hq[2mwZTDh[4FqdnO2IHj1cYFvKEuELVOyJINmdGy|IHH0JFUhfU1iYX\0[ZIhPjhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0xNjFizszN NUTEZohkOTd2OEixNlg>
CHO cells NX\zZmtMTnWwY4Tpc44h[XO|YYm= MVXJcohq[mm2aX;uJI9nKGi3bXHuJGVTTyCneIDy[ZN{\WRiaX6gR2hQKGOnbHzzJIJ6KHeqb3zlJINmdGxicHH0Z4gh[2yjbYCgeIVkcG6rcYXlMEBKSzVyPUCuNVQyOjVizszN NVe5S3FWOTh2NEizOFI>
MCF7 cells NETtRpFHfW6ldHnvckBie3OjeR?= NVuydoN5UW6qaXLpeIlwdiCxZjDoeY1idiCHUlegbY4hVUOINzDj[YxteyxiSVO1NF0xNjF2NEW0JO69VQ>? MYqxPVEyODN2MR?=
NCI-H292 cells M2LjUGZ2dmO2aX;uJIF{e2G7 NXjPW5E1PTBizszN NGjTXoM4OiCq MkPvVI91\W62aXH0bY9vKG:oIHfl[ol1cW6rYj3pcoR2[2WmIHP5eI91d3irY3n0fUBi\2GrboP0JIh2dWGwIF7DTU1JOjl{IHPlcIx{KGG|c3Xzd4VlKGG|IHfl[ol1cW6rYjDJR|UxKGG2IEWwJJVOKGGodHXyJFczKGi{czDifUBUWkJiYYPzZZktKEmFNUC9NE4yQCEQvF2= MlTkNlUzOTV6NU[=
human KBV20C cells MmTMR5l1d3SxeHnjxsBie3OjeR?= Mkn1R5l1d3SxeHnjbZR6KGGpYXnud5QhdXWudHnkdpVoKHKnc3nzeIFvfCCSLXfwJIV5eHKnc4PpcochcHWvYX6gT2JXOjCFIHPlcIx{KGG|c3Xzd4VlKGG|IHPlcIwhfmmjYnnsbZR6KGmwIIDy[ZNmdmOnIH;mJJZqdmO{aYP0bY5mKGK7IF3UV{Bie3OjeTygTWM2OD1yLkKg{txO NHjFWZEyQDJ7NUS5NC=>
human LCC6MDR cells NFzlbWJHfW6ldHnvckBie3OjeR?= MYO1JIRigXN? M1PSWnJmfmW{c3HsJI9nKFBvZ4CtcYVlcWG2ZXSg[I95d3K3YnnjbY4uemW|aYP0ZY5k\SCrbjDoeY1idiCOQ1O2UWRTKGOnbHzzJIFnfGW{IEWg[IF6eyCkeTDNWHMh[XO|YYmsJGVEPTB;MD6yOFUh|ryP NHexbW0zOjN{MESwNi=>
rat A7R5 cells M{ewXmZ2dmO2aX;uJIF{e2G7 M37BUVE2KG2rboO= MnHGRY51[WexbnnzeEBi[3Srdnn0fUBifCClYXzjbZVuKGOqYX7u[YwhcW5icnH0JGE4WjViY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBE[WOuMj;LR4wucW6mdXPl[EBqdmO{ZXHz[UBqdiCrboTyZYNmdGy3bHHyJGNiOitiaX7jeYJifGWmIH\vdkAyPSCvaX7zJJBzcW:{IITvJGNi[2x{L1vDcEBkcGGubHXu[4Uh[nliZnz1c5Jme2OnbnPlJIF{e2G7LDDJR|UxRTBwMzFOwG0> MlzLNlU{OTF3NkS=
MDCK cells M{DPTmZ2dmO2aX;uJIF{e2G7 NFHKdIE{OCCvaX7z NFvaPVRKdmirYnn0bY9vKG:oIHj1cYFvKE2GUkGg[ZhxemW|c3XkJIlvKE2GQ1ugZ4VtdHNiYYPz[ZN{\WRiYYOgZ4Ft[2WrbjDBUUBi[2O3bYXsZZRqd25iYX\0[ZIhOzBibXnud{BjgSCobIXvdoV{[2WwY3WgZZN{[XluIFnDOVA:OC53IN88US=> NFPkW4IzOjFzMkKwPC=>
human CEM/VLB500 cells NIDIdFRHfW6ldHnvckBie3OjeR?= NX;6NYxNOyCmYYnz NXvlN2FKWmW4ZYLzZYwhd2ZiUD3ndE1u\WSrYYTl[EBufWy2aXTyeYchemW|aYP0ZY5k\SC2bzD2bY5jdGG|dHnu[UBqdiCqdX3hckBETU1xVlzCOVAxKGOnbHzzJIFnfGW{IEOg[IF6eyCkeTDy[ZNignW{aX6gZZN{[XluIFXDOVA:OS5yNEGg{txO NWq1V|RQOTd|OUm5PVA>
human NCI-H292 cells NX7BTFMxTnWwY4Tpc44h[XO|YYm= MUm1NEDPxE1? NHu0O404OiCq M1rOO3BwfGWwdHnheIlwdiCxZjDldoxwfGmwaXKtbY5lfWOnZDDjfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDOR2kuUDJ7MjDj[YxteyCjc4Pld5Nm\CCjczDldoxwfGmwaXKgTWM2OCCjdDC1NEB2VSCjZoTldkA4OiCqcoOgZpkhW1KEIHHzd4F6NCCLQ{WwQVEvOiEQvF2= M{XWNlI2OjF3OEW2
human KB/VCR cells NG\ySVJHfW6ldHnvckBie3OjeR?= Mo\LO|IhcA>? NVrXfId5UW6qaXLpeIlwdiCxZjDwMYdxKGmwIHj1cYFvKEuEL2\DVkBk\WyuczDhd5Nme3OnZDDhd{Bxd3SnboTpZZRqd25ib3[gNVAxKG6PIHTvZ4V1[XinbD3pcoR2[2WmIHP5eI91d3irY3n0fUBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBGSzVyPUGuNlU{KM7:TR?= MXuyN|Y5Ozh|NB?=
human K562/DOX cells Mn7ySpVv[3Srb36gZZN{[Xl? M3zjOm1w\HWuYYTvdpkh[WO2aY\peJkh[XRiUD3ndEBqdiCqdX3hckBMPTZ{L1TPXEBk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCwdXPs[YFzKGOxbnPlcpRz[XSrb36gc4YheGm{YYL1ZolkcW5iYomgd5Bm[3S{b3\seY9zd22ndILpZ{Bie3OjeTygTWM2OD1zLk[g{txO MWCyOVI5OjJ4Mx?=
human KBV1 cells MojDR5l1d3SxeHnjxsBie3OjeR?= MUO0PEBp M3O0Z2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KH[rbnLsZZN1cW6nIILld4l{fGGwdDDoeY1idiCNQm[xJINmdGy|IHHmeIVzKDR6IHjyd{BqdiCycnXz[Y5k\SCxZjCxNFAhdk1idnnuZoxie3SrbnWgZpkhW1KEIH3leIhw\CxiSVO1NF0yNjZizszN MVuxNFM1Pjl2OB?=
A2780 cells MUTGeY5kfGmxbjDhd5NigQ>? M3v3T2lvcGmkaYTpc44hd2ZiUD3ndEBqdiCqdX3hckBi\HKrYX35Z4lvNXKnc3nzeIFvfCCDMke4NEBk\WyuczDifUBJd2WlaIP0JFM{OzR{IHHzd4F6NCCLQ{WwQVQvPTdyOEig{txO MoXrNVg3Pzh2OUW=
human MCF7/ADR cells M2[5R2Z2dmO2aX;uJIF{e2G7 M3TsWlExKM7:TR?= MV60PEBp NInDTVFKdmirYnn0bY9vKG:oIGCt[5AhcW5iaIXtZY4hVUOINz;BSHIh[2WubIOgZZN{\XO|ZXSgZZMhemW4ZYLzZYwhd2ZibYXseIllenWpIILld4l{fGGwY3WgZZQhOTBidV2gZpkhdWWjc4XybY5oKEWFNUCg[o9zKGGmcnnhcZlkcW5vaX7keYNm\CCleYTveI95cWOrdImgZYZ1\XJiNEigbJJ{KGK7IGPSRkBkd2yxcnnt[ZRzcWNiYYPzZZktKEWFNUC9OE45QSEQvF2= NYO1SGlKOjV6NU[1OFU>
MDCK2 cells MUXGeY5kfGmxbjDhd5NigQ>? M2\mfVIxKG2rboO= M13LSWVvcGGwY3Xt[Y51KG:oIHPhcINmcW5vQV2geZB1[WunIHnuJG1FS0t{IHPlcIx{KG:4ZYKg[ZhxemW|c3nu[{BOTFJzIHHmeIVzKDJyIH3pcpMtKEWFNUC9OU4yKM7:TR?= M2X5RVE5QDR7MU[3
human 2008 cells M3jOXGZ2dmO2aX;uJIF{e2G7 NV3GNpdmUW6qaXLpeIlwdiCxZjDoeY1idiCPUmCxJIlvKGi3bXHuJFIxODhiY3XscJMtKEmFNUC9PU43PiEQvF2= NHu5WogyQDdyN{i4OC=>
human H460 cells MY\GeY5kfGmxbjDhd5NigQ>? MYS1NEDPxE1? Mnq3O|IhcA>? NUHOTZBmWG:2ZX70bYF1cW:wIH;mJIVzdG:2aX7pZk1qdmS3Y3XkJIN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGg1PjBiY3XscJMh[XO|ZYPz[YQh[XNiZYLsc5RqdmmkIFnDOVAh[XRiNUCgeW0h[W[2ZYKgO|IhcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME2xNE4{KM7:TR?= NGXn[lIzPTJzNUi1Oi=>
hamster BHK21 cells NEi5eJREgXSxdH;4bYPDqGG|c3H5 M1uwXlk3KGh? NEHoN|hEgXSxdH;4bYNqfHliYXfhbY5{fCCqYX3zeIVzKEKKS{KxJINmdGy|IHX4dJJme3OrbnegUXJROSCjZoTldkA6PiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVExNjZizszN M3jDWVIxPjlzNUm5
KB cells M{DQUWZ2dmO2aX;uJIF{e2G7 M3HOOFczKGh? M4fVbWlvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBMSiClZXzsJIxqdmViYX\0[ZIhPzJiaDDv[kBlenWpIHX4dI9{fXKnLDDJR|UxRTF7Lk[g{txO NVW5VHRtOTV2OEG5PVE>
Caco-2 cells Mm\3SpVv[3Srb36gZZN{[Xl? MoXNTY5pcWKrdHnvckBw\iCSZ4CgcYVie3W{ZXSgZZMhcW6qaXLpeIlwdiCxZjDbN2hefmmwYnzhd5RqdmViYnHzc4xifGW{YXygeI8h[XCrY3HsJJRz[W6|cH;yeEBqdiCFYXPvMVIh[2WubIOsJGVEPTB;MkCg{txO M2LBd|E4ODZ2MEe5
human KB31 cells NXTTbI13S3m2b4TvfIlkyqCjc4PhfS=> NGfBRow1QCCq MUfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLRlMyKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIhdWW2aH;kMEBKSzVyPUS1MlIh|ryP M1y0UFExOzR4OUS4

... Click to View More Cell Line Experimental Data

In vivo Verapamil confers an anti-arrhythmic effect via calcium influx inhibition, inhibition of oxygen consumption and accompanied by preservation of Cx43 protein in rat heart.

Protocol

Solubility (25°C)

In vitro DMSO 98 mg/mL (199.56 mM)
Water 50 mg/mL (101.82 mM)
Ethanol 12 mg/mL (24.43 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 491.06
Formula

C27H38N2O4.HCl

CAS No. 152-11-4
Storage powder
in solvent
Synonyms N/A
Smiles CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC.Cl

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04406259 Not yet recruiting Drug: Verapamil Cluster Headache Centre Hospitalier Universitaire de Nice September 1 2020 Phase 4
NCT04014634 Recruiting Drug: Methylprednisolone|Other: Placebo Cluster Headache Episodic|Greater Occipital Nerve Injection Leiden University Medical Center|Hersenstichting|Innovatiefonds Zorgverzekeraars August 1 2019 Phase 4
NCT02912663 Completed Drug: Verapamil and Magnesium Sulfate|Other: Placebo Ischemic Stroke Justin Fraser|University of Kentucky October 11 2017 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Calcium Channel Signaling Pathway Map

Related Calcium Channel Products

Tags: buy Verapamil HCl | Verapamil HCl supplier | purchase Verapamil HCl | Verapamil HCl cost | Verapamil HCl manufacturer | order Verapamil HCl | Verapamil HCl distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID