Verapamil HCl

Catalog No.S4202

Verapamil HCl Chemical Structure

Molecular Weight(MW): 491.06

Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent.

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Cited by 3 Publications

3 Customer Reviews

  • The proportion of SP cells in HepG2 and HCCLM3 cell lines were 0.16% and 32.2%, which reduced to 0% and 0.28% in the presence of verapamil.

    Front Pharmacol, 2018, 9:1298. Verapamil HCl purchased from Selleck.

    f, Cells were pretreated with or without 5 μM verapamil and then treated with the indicated concentrations of 17-DMAG for 6 h. The proteins involved in ALK-related signaling were detected by western blot analysis.

    BMC Cancer, 2015, 15:553.. Verapamil HCl purchased from Selleck.

  • J45.01 cells were suspended in a growth medium containing 0.1 μM 5-CFDA and kept on ice for 20 min to allow its uptake. The effects of verapamil (MDR1 inhibitor) and MK571 (MRP1 inhibitor) on the efflux of 5-CF at 37°C was determined by flow cytometry (B).

    Exp Hematol, 2017, 2.436. Verapamil HCl purchased from Selleck.

Purity & Quality Control

Choose Selective Calcium Channel Inhibitors

Biological Activity

Description Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent.
Targets
Calcium channel [2]
In vitro

The enzyme hydrolase activity of recombinant CES2 is substantially inhibited by diltiazem and verapamil (Ki = 0.25 ± 0.02 and 3.84 ± 0.99μM, respectively).

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MDA435/LCC6 cells NVGxZ3hxTnWwY4Tpc44h[XO|YYm= M4jlR3JmfmW{c3HsJI9nKH[rbnLsZZN1cW6nIILld4l{fGGwY3WgbY4hdXWudHnkdpVoKHKnc3nzeIFvfCCPRFG0N|UwVEOFNjDj[YxteyCkeTDNWHMh[XO|YYmsJGlEPTB;MD6wNFAzPSEQvF2= Mn;PNVcyPTR3MEW=
HCT116/VM46 cell NF;yXXVHfW6ldHnvckBie3OjeR?= NH7WOJoyKM7:TR?= MUjF[oZm[3Rib36geolv[myjc4TpcoUhUUN3MDDh[4FqdnO2IF3EVkBpfW2jbjDjZZJkcW6xbXGgTGNVOTF4L2\NOFYh[2WubDDsbY5mKGG2IHGg[I9{\SCxZjCxJJVOKGOxbnPlcpRz[XSrb36sJGlEPTB;MD6wNFQh|ryP M12yZ|EzPzJ7Nk[z
KB-3-1 cells NYPOOm9OTnWwY4Tpc44h[XO|YYm= M3v3[FUh|ryP NFz5Uo43QCCq NI\yW4tT\X[ncoPhcEBw\iCSLXfwMY1m\GmjdHXkJI12dHSrZIL1[{Bz\XOrc4ThcoNmKHSxIFP5eI91d3irY3n0fUBw\iClb3zjbIlkcW6nIHHnZYlve3RiaIXtZY4hU0JvMz2xJINmdGy|IHH0JFUhfU1iYX\0[ZIhPjhiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0xNjByNEeg{txO MoPSNVc1QDhzMki=
human KBV20C cells M2DOZ2N6fG:2b4jpZ:Kh[XO|YYm= NUn0dnc5S3m2b4TvfIlkcXS7IHHnZYlve3RibYXseIllenWpIILld4l{fGGwdDDQMYdxKGW6cILld5NqdmdiaIXtZY4hU0KYMkDDJINmdGy|IHHzd4V{e2WmIHHzJINmdGxidnnhZoltcXS7IHnuJJBz\XOnbnPlJI9nKHCjY3zpeIF5\WxiYomgUXRUKGG|c3H5MEBKSzVyPUCuNFEh|ryP M4TVRlE5Ojl3NEmw
human KB/VCR cells MYHDfZRwfG:6aXRCpIF{e2G7 NX;B[o9HOjVizszN NEO5Oog4OiCq MX7DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLRk9XS1JiY3XscJMh[XO|ZYPz[YQh[XNidnnuZ5Jqe3SrbnWgTWM2OCCjdDCyOUB2VSCjZoTldkA4OiCqcoOgZpkhW1KEIH3leIhw\CxiSVO1NF0xNjB{IN88US=> NGDubZczPTV7N{CxNC=>
K562 cells MmHMSpVv[3Srb36gZZN{[Xl? MXmzJO69VQ>? Mn7sO|IhcA>? M1zlZ21w\HWuYYTvdpkh[WO2aY\peJkh[XRiUD3ndEBie3Onc4Pl[EBieyCmb4jvdpVjcWOrbjDJR|UxKGmwIHj1cYFvKEt3NkKgZ4VtdHNiYYSgN{B2VSCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6KCiUdnKg[I95d3K3YnnjbY4h[WyxbnWgTWM2OCB;IECuNFI{KCtxLTCwMlAxPCC3TTmsJGlEPTB;MD6wNlkh|ryP MVOyOVI5OjJ4Mx?=
CCRF-CEM cells MWLGeY5kfGmxbjDhd5NigQ>? MmnVOUDPxE1? M2LLd3Rp\SCnZn\lZ5RqfmViZH;z[UB4[XNibXXhd5Vz\WRiYXfhbY5{fCCSLXfsfYNweHKxdHXpckBmgHC{ZYPzbY5oKEOFUl[tR2VOKGOnbHzzJIlvKHSqZTDwdoV{\W6lZTDv[kA2KHWPIHTheY5wdXmlaX6sJGVFPTB;MD6wOFUh|ryP NVHUZ3VnPzZ{OUixOy=>
KB-C2 cells M1XUN2Z2dmO2aX;uJIF{e2G7 M3S0eVUh|ryP M{TVNlY5KGh? MV\S[ZZmenOjbDDv[kBRNWeyLX3l[IlifGWmIH31cJRq\HK3ZzDy[ZNqe3SjbnPlJJRwKEO7dH;0c5hq[2m2eTDv[kBkd2ylaHnjbY5mKGGpYXnud5QhcHWvYX6gT2IuSzJiY3XscJMh[XRiNTD1UUBi\nSncjC2PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUCuNUDPxE1? M2HzelE4PDh6MUK4
CHO cells NXHFNpdyTnWwY4Tpc44h[XO|YYm= MWfJcohq[mm2aX;uJI9nKGi3bXHuJGVTTyCneIDy[ZN{\WRiaX6gR2hQKGOnbHzzJIJ6KHeqb3zlJINmdGxicHH0Z4gh[2yjbYCgeIVkcG6rcYXlMEBKSzVyPUCuNVQyOjVizszN Moq0NVg1PDh|NEK=
MCF7 cells NGTvc21HfW6ldHnvckBie3OjeR?= MnHOTY5pcWKrdHnvckBw\iCqdX3hckBGWkdiaX6gUWNHPyClZXzsd{whUUN3ME2wMlE1PDV2IN88US=> NVfYTnhtOTlzMUCzOFE>
NCI-H292 cells MUDGeY5kfGmxbjDhd5NigQ>? NGr0U3Y2OCEQvF2= NUnF[FBrPzJiaB?= NVnWbnBWWG:2ZX70bYF1cW:wIH;mJIdm\mm2aX7pZk1qdmS3Y3XkJIN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5EUS2KMkmyJINmdGy|IHHzd4V{e2WmIHHzJIdm\mm2aX7pZkBKSzVyIHH0JFUxKHWPIHHmeIVzKDd{IHjyd{BjgSCVUlKgZZN{[XluIFnDOVA:OC5zODFOwG0> MYCyOVIyPTh3Nh?=
human KBV20C cells NGHVUFNEgXSxdH;4bYPDqGG|c3H5 MX\DfZRwfG:6aXPpeJkh[WejaX7zeEBufWy2aXTyeYchemW|aYP0ZY51KFBvZ4Cg[ZhxemW|c3nu[{BpfW2jbjDLRnYzOENiY3XscJMh[XO|ZYPz[YQh[XNiY3XscEB3cWGkaXzpeJkhcW5icILld4Vv[2Vib3[geolv[3Krc4TpcoUh[nliTWTTJIF{e2G7LDDJR|UxRTBwMjFOwG0> M2P6bVE5Ojl3NEmw
human LCC6MDR cells NXzBOGZoTnWwY4Tpc44h[XO|YYm= NH33RYI2KGSjeYO= MY\S[ZZmenOjbDDv[kBRNWeyLX3l[IlifGWmIHTvfI9zfWKrY3nuMZJme2m|dHHuZ4UhcW5iaIXtZY4hVEOFNl3EVkBk\WyuczDh[pRmeiB3IHThfZMh[nliTWTTJIF{e2G7LDDFR|UxRTBwMkS1JO69VQ>? NF7qfmUzOjN{MESwNi=>
rat A7R5 cells NXPSV3NkTnWwY4Tpc44h[XO|YYm= MnrvNVUhdWmwcx?= M4W0VmFvfGGpb37pd5Qh[WO2aY\peJkh[XRiY3HsZ4l2dSClaHHucoVtKGmwIILheEBCP1J3IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhS2GlbEKvT2NtNWmwZIXj[YQhcW6lcnXhd4UhcW5iaX70doFk\WyudXzhdkBE[TJtIHnuZ5Vj[XSnZDDmc5IhOTVibXnud{BxemmxcjD0c{BE[WOuMj;LR4wh[2ijbHzlcodmKGK7IH\seY9z\XOlZX7j[UBie3OjeTygTWM2OD1yLkOg{txO NX3DZ3RPOjV|MUG1OlQ>
MDCK cells NI\4d5lHfW6ldHnvckBie3OjeR?= MkjQN|AhdWmwcx?= NX7yZWlpUW6qaXLpeIlwdiCxZjDoeY1idiCPRGKxJIV5eHKnc4Pl[EBqdiCPRFPLJINmdGy|IHHzd4V{e2WmIHHzJINidGOnaX6gRW0h[WOldX31cIF1cW:wIHHmeIVzKDNyIH3pcpMh[nliZnz1c5Jme2OnbnPlJIF{e2G7LDDJR|UxRTBwNTFOwG0> MnzVNlIyOTJ{MEi=
human CEM/VLB500 cells MWTGeY5kfGmxbjDhd5NigQ>? NWPhXpNGOyCmYYnz NF;MfHFT\X[ncoPhcEBw\iCSLXfwMY1m\GmjdHXkJI12dHSrZIL1[{Bz\XOrc4ThcoNmKHSxII\pcoJt[XO2aX7lJIlvKGi3bXHuJGNGVS:YTFK1NFAh[2WubIOgZYZ1\XJiMzDkZZl{KGK7IILld4F7fXKrbjDhd5NigSxiRVO1NF0yNjB2MTFOwG0> MlPGNVc{QTl7OUC=
human NCI-H292 cells NFKwcIZHfW6ldHnvckBie3OjeR?= MkDuOVAh|ryP MWS3NkBp NV3WSmc5WG:2ZX70bYF1cW:wIH;mJIVzdG:2aX7pZk1qdmS3Y3XkJIN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG5EUS2KMkmyJINmdGy|IHHzd4V{e2WmIHHzJIVzdG:2aX7pZkBKSzVyIHH0JFUxKHWPIHHmeIVzKDd{IHjyd{BjgSCVUlKgZZN{[XluIFnDOVA:OS5{IN88US=> MYiyOVIyPTh3Nh?=
human KB/VCR cells NIT2N|dHfW6ldHnvckBie3OjeR?= MX[3NkBp NG\KT4JKdmirYnn0bY9vKG:oIICt[5AhcW5iaIXtZY4hU0JxVlPSJINmdGy|IHHzd4V{e2WmIHHzJJBwfGWwdHnheIlwdiCxZjCxNFAhdk1iZH;j[ZRigGWuLXnu[JVk\WRiY4n0c5RwgGmlaYT5JIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGVEPTB;MT6yOVMh|ryP NWi4bI5uOjN4OEO4N|Q>
human K562/DOX cells MUHGeY5kfGmxbjDhd5NigQ>? MnrvUY9lfWyjdH;yfUBi[3Srdnn0fUBifCCSLXfwJIlvKGi3bXHuJGs2PjJxRF;YJINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKG63Y3zlZZIh[2:wY3XueJJifGmxbjDv[kBxcXKjcoXibYNqdiCkeTDzdIVkfHKxZnz1c5JwdWW2cnnjJIF{e2G7LDDJR|UxRTFwNjFOwG0> NUPhSGJLOjV{OEKyOlM>
human KBV1 cells MWHDfZRwfG:6aXRCpIF{e2G7 MV:0PEBp MknER5l1d3SxeHnjbZR6KGGpYXnud5QhfmmwYnzhd5RqdmVicnXzbZN1[W62IHj1cYFvKEuEVkGgZ4VtdHNiYX\0[ZIhPDhiaILzJIlvKHC{ZYPlcoNmKG:oIEGwNEBvVSC4aX7icIF{fGmwZTDifUBUWkJibXX0bI9lNCCLQ{WwQVEvPiEQvF2= NXTlW205OTB|NE[5OFg>
A2780 cells MmnkSpVv[3Srb36gZZN{[Xl? NHn6cm1KdmirYnn0bY9vKG:oIGCt[5AhcW5iaIXtZY4h[WS{aXHtfYNqdi2{ZYPpd5RidnRiQUK3PFAh[2WubIOgZpkhUG:nY3jzeEA{OzN2MjDhd5NigSxiSVO1NF01NjV5MEi4JO69VQ>? NHzWZ3UyQDZ5OES5OS=>
human MCF7/ADR cells MmTjSpVv[3Srb36gZZN{[Xl? MWWxNEDPxE1? MYW0PEBp NHrxS4RKdmirYnn0bY9vKG:oIGCt[5AhcW5iaIXtZY4hVUOINz;BSHIh[2WubIOgZZN{\XO|ZXSgZZMhemW4ZYLzZYwhd2ZibYXseIllenWpIILld4l{fGGwY3WgZZQhOTBidV2gZpkhdWWjc4XybY5oKEWFNUCg[o9zKGGmcnnhcZlkcW5vaX7keYNm\CCleYTveI95cWOrdImgZYZ1\XJiNEigbJJ{KGK7IGPSRkBkd2yxcnnt[ZRzcWNiYYPzZZktKEWFNUC9OE45QSEQvF2= NX;HVm1NOjV6NU[1OFU>
MDCK2 cells Mn7QSpVv[3Srb36gZZN{[Xl? MojBNlAhdWmwcx?= NX7GfndoTW6qYX7j[Y1mdnRib3[gZ4Ft[2Wrbj3BUUB2eHSja3WgbY4hVUSFS{KgZ4VtdHNib4\ldkBmgHC{ZYPzbY5oKE2GUkGgZYZ1\XJiMkCgcYlveyxiRVO1NF02NjFizszN Mn\ONVg5PDlzNke=
human 2008 cells NG\sWm5HfW6ldHnvckBie3OjeR?= MV\Jcohq[mm2aX;uJI9nKGi3bXHuJG1TWDFiaX6gbJVu[W5iMkCwPEBk\WyuczygTWM2OD17Lk[2JO69VQ>? M4HpOlE5PzB5OEi0
human H460 cells M1K3[2Z2dmO2aX;uJIF{e2G7 NXXDfm1OPTBizszN MXO3NkBp MkPzVI91\W62aXH0bY9vKG:oIHXycI91cW6rYj3pcoR2[2WmIHP5eI91d3irY3n0fUBi\2GrboP0JIh2dWGwIFi0OlAh[2WubIOgZZN{\XO|ZXSgZZMh\XKub4TpcoljKEmFNUCgZZQhPTBidV2gZYZ1\XJiN{KgbJJ{KGK7IGPSRkBie3OjeTygTWM2OD1zMD6zJO69VQ>? MlXINlUzOTV6NU[=
hamster BHK21 cells MoHqR5l1d3SxeHnjxsBie3OjeR?= MXq5OkBp NXzmfIhxS3m2b4TvfIlkcXS7IHHnZYlve3RiaHHtd5RmeiCESFuyNUBk\WyuczDlfJBz\XO|aX7nJG1TWDFiYX\0[ZIhQTZiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0yOC54IN88US=> NG\HenczODZ7MUW5PS=>
KB cells M2qzWGZ2dmO2aX;uJIF{e2G7 M3qwSVczKGh? NGntOFdKdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QhU0JiY3XscEBtcW6nIHHmeIVzKDd{IHigc4Yh\HK3ZzDlfJBwe3W{ZTygTWM2OD1zOT62JO69VQ>? M2fZVlE2PDhzOUmx
Caco-2 cells MWPGeY5kfGmxbjDhd5NigQ>? MkHoTY5pcWKrdHnvckBw\iCSZ4CgcYVie3W{ZXSgZZMhcW6qaXLpeIlwdiCxZjDbN2hefmmwYnzhd5RqdmViYnHzc4xifGW{YXygeI8h[XCrY3HsJJRz[W6|cH;yeEBqdiCFYXPvMVIh[2WubIOsJGVEPTB;MkCg{txO NE\OdW0yPzB4NEC3PS=>
human KB31 cells NH;kZlhEgXSxdH;4bYPDqGG|c3H5 MUW0PEBp Mmj5R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT2I{OSClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKG2ndHjv[EwhUUN3ME20OU4zKM7:TR?= NVLkWZA5OTB|NE[5OFg>

... Click to View More Cell Line Experimental Data

In vivo Verapamil confers an anti-arrhythmic effect via calcium influx inhibition, inhibition of oxygen consumption and accompanied by preservation of Cx43 protein in rat heart.

Protocol

Solubility (25°C)

In vitro DMSO 98 mg/mL (199.56 mM)
Water 50 mg/mL (101.82 mM)
Ethanol 12 mg/mL (24.43 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 491.06
Formula

C27H38N2O4.HCl

CAS No. 152-11-4
Storage powder
in solvent
Synonyms N/A

Bio Calculators

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03845010 Recruiting Ventricular Premature Beats Maatschap Cardiologie Zwolle February 12 2019 Not Applicable
NCT03845010 Recruiting Ventricular Premature Beats Maatschap Cardiologie Zwolle February 12 2019 Not Applicable
NCT03782662 Recruiting Respiratory Syncytial Virus Infections ReViral Ltd November 6 2018 Phase 1
NCT03782662 Recruiting Respiratory Syncytial Virus Infections ReViral Ltd November 6 2018 Phase 1
NCT03449251 Recruiting Cardiovascular Diseases|Type 2 Diabetes Mellitus Cambridge University Hospitals NHS Foundation Trust|University of Cambridge|AstraZeneca|MedImmune LLC March 28 2018 Phase 2
NCT03449251 Recruiting Cardiovascular Diseases|Type 2 Diabetes Mellitus Cambridge University Hospitals NHS Foundation Trust|University of Cambridge|AstraZeneca|MedImmune LLC March 28 2018 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Calcium Channel Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID