Verapamil (CP-16533-1) HCl

For research use only.

Catalog No.S4202

17 publications

Verapamil (CP-16533-1) HCl Chemical Structure

CAS No. 152-11-4

Verapamil HCl (CP-16533-1) is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits both permeability-glycoprotein (P-gp) and CYP3A4.

Selleck's Verapamil (CP-16533-1) HCl has been cited by 17 publications

3 Customer Reviews

  • The proportion of SP cells in HepG2 and HCCLM3 cell lines were 0.16% and 32.2%, which reduced to 0% and 0.28% in the presence of verapamil.

    Front Pharmacol, 2018, 9:1298. Verapamil (CP-16533-1) HCl purchased from Selleck.

  • f, Cells were pretreated with or without 5 μM verapamil and then treated with the indicated concentrations of 17-DMAG for 6 h. The proteins involved in ALK-related signaling were detected by western blot analysis.

    BMC Cancer, 2015, 15:553.. Verapamil (CP-16533-1) HCl purchased from Selleck.

  • J45.01 cells were suspended in a growth medium containing 0.1 μM 5-CFDA and kept on ice for 20 min to allow its uptake. The effects of verapamil (MDR1 inhibitor) and MK571 (MRP1 inhibitor) on the efflux of 5-CF at 37°C was determined by flow cytometry (B).

    Exp Hematol, 2017, 2.436. Verapamil (CP-16533-1) HCl purchased from Selleck.

Purity & Quality Control

Choose Selective Calcium Channel Inhibitors

Biological Activity

Description Verapamil HCl (CP-16533-1) is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits both permeability-glycoprotein (P-gp) and CYP3A4.
Targets
Calcium channel [2]
In vitro

The enzyme hydrolase activity of recombinant CES2 is substantially inhibited by diltiazem and verapamil (Ki = 0.25 ± 0.02 and 3.84 ± 0.99μM, respectively).

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HCT116/VM46 cell MmnTSpVv[3Srb36gZZN{[Xl? NX;HNXZLOSEQvF2= MkHRSYZn\WO2IH;uJJZqdmKuYYP0bY5mKEmFNUCgZYdicW6|dDDNSHIhcHWvYX6gZ4Fz[2mwb33hJGhEXDFzNj;WUVQ3KGOnbHygcIlv\SCjdDDhJIRwe2Vib3[gNUB2VSClb37j[Y51emG2aX;uMEBKSzVyPUCuNFA1KM7:TR?= M3zocVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{N{K5OlY{Lz5zMkeyPVY3OzxxYU6=
human MCF7/ADR cells NVzi[2hoTnWwY4Tpc44h[XO|YYm= NF;YRmYyOCEQvF2= M2XtWlQ5KGh? M{\ld2lvcGmkaYTpc44hd2ZiUD3ndEBqdiCqdX3hckBOS0Z5L1HEVkBk\WyuczDhd5Nme3OnZDDhd{Bz\X[ncoPhcEBw\iCvdXz0bYRzfWdicnXzbZN1[W6lZTDheEAyOCC3TTDifUBu\WG|dYLpcochTUN3MDDmc5Ih[WS{aXHtfYNqdi2rbnT1Z4VlKGO7dH;0c5hq[2m2eTDh[pRmeiB2ODDodpMh[nliU2LCJINwdG:{aX3leJJq[yCjc4PhfUwhTUN3ME20Mlg6KM7:TR?= NFnXdYc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi1OlU1PSd-MkW4OVY2PDV:L3G+
NG108-15 M2OxTmZ2dmO2aX;uJIF{e2G7 NH;nOFFVcGViY3;tdI92dmRid3HzJJRme3SnZDDmc5IhcW6qaXLpeIlwdiCxZjDjZYxkcXWvIHnu[ox2gCCrboTvJI5mfXKxbnHsJEhPTzFyOD2xOUkh[2WubIOsJGlEPTB;Nj61{txO NVXZXpp3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzN|U5PCd-MkCzN|U5PDxxYU6=
CCRF-CEM M2jQNGZ2dmO2aX;uJIF{e2G7 MVjUbIUh\W[oZXP0bZZmKGSxc3Wge4F{KG2nYYP1doVlKGGpYXnud5QhWC2pbInjc5Bzd3SnaX6g[ZhxemW|c3nu[{BES1KILVPFUUBk\WyuczDpckB1cGVicILld4Vv[2Vib3[gOUB2VSCmYYXuc416[2mwLDDFSFUxRTBwMES1{txO NVq4O|kxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxN{[yPVgyPyd-N{[yPVgyPzxxYU6=
CCRF-CEM M13UV2Z2dmO2aX;uJIF{e2G7 MnfOWIhmKGWoZnXjeIl3\SCmb4PlJJdieyCvZXHzeZJm\CCjZ3HpcpN1KFBvZ3z5Z49xem:2ZXnuJIV5eHKnc4PpcochS0OURj3DSW0h[2WubIOgbY4hfGinIIDy[ZNmdmOnIH;mJFUhfU1iZYTvdI9{cWSnLDDFSFUxRTNwNN88US=> NGrNZpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi95NkK5PFE4Lz55NkK5PFE4RC:jPh?=
MCF7/VP NXOzfZd2TnWwY4Tpc44h[XO|YYm= MoTQNlAhfU1? NYLnXnJoPDhiaILz MnHZTY5pcWKrdHnvckBw\iCPUmCg[ZhxemW|c3XkJIlvKGi3bXHuJG1ETjdxVmCgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hfmmwY4Lpd5RqdmVvaX7keYNm\CCleYTveI95cWOrdImgZZQhOjBidV2gZYZ1\XJiNEigbJJ{KGK7IGPSRkBjcW6maX7nJIF{e2G7 MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek85Pzh4M{[0K|45Pzh4M{[0QE9iRg>?
MCF/ADR NHnINo5HfW6ldHnvckBie3OjeR?= NHfRO2lT\X[ncoPhcEBw\iCSLXfwMY1m\GmjdHXkJI12dHSrZIL1[{Bz\XOrc4ThcoNmKGmwIHj1cYFvKE2FRj;BSHIh[2WubIOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5icnjv[IFucW6nIE\HJIFk[3WvdXzheIlwdg>? MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek85QTh2MUWxK|45QTh2MUWxQE9iRg>?
B16/F10 NEXnfFNHfW6ldHnvckBie3OjeR?= MlLNTY5pcWKrdHnvckBw\iCqdX3hckBOTFJzIHX4dJJme3OnZDDpckBud3W|ZTDCNVYwTjFyIHPlcIx{KGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIRwgG:{dXLpZ4lvKGGlY4XteYxifGmxbjDifUBndHWxcnnt[ZRzgSxiRVS1NF0{|ryP MljhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTR4MU[1PEc,QTR4MU[1PFww[T5?
HeLa MULGeY5kfGmxbjDhd5NigQ>? NWrvPGlGXFChVGLBUnNRV1KWRWK6JIlvcGmkaYTpc44hd2ZiVFXBJJVxfGGtZTDpckBQS1RzLXX4dJJme3OrbnegTIVN[SClZXzsd{whU2l;Mj65{txO M{TVVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzl4NUW4PFAoRjl4NUW4PFA9N2F-
K562/DOX MDR MVPDfZRwfG:6aXPpeJkh[XO|YYm= NIfIcZpC[mmuaYT5JJRwKHCxdHXueIlifGViRF;YJIN6fG:2b4jpZ4l1gSCxbjDLOVYzN0SRWDDNSHIh[2WubIOuJGNmdGxic4Xyeol3[Wxid3HzJIF{e2G7ZXSgZpkhVVSWIHPvcpZmenOrb36sJGlEPTB;M{hOwG0> MlnJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTl6NkexPEc,QTl6NkexPFww[T5?
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S1-B1-20 MkjnSpVv[3Srb36gZZN{[Xl? NYHrcmxpUW5idnn0do8h[2:wY3XueJJifGmxbjDy[ZF2cXKnZDD0c{BqdmirYnn0JJR2dW:{IHHjeIl3cXS7IH;uJJN2[mOub37lJI9nKGi3bXHuJINwdG:wIHPhdoNqdm:vYTDj[YxteyBqU{GtRlEuOjBrIILld4l{fGGwdDD0c{BjcXOjboTy[Y5mNCCLQ{WwQVE4NjJ5zszN NETzNIM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEO3O|IzOCd-MUCzO|czOjB:L3G+
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K562 NIHqPHpHfW6ldHnvckBie3OjeR?= NEDkdXAyOCC2bzCyNEB2VQ>? MXOxJIhz MXPJcohq[mm2aX;uJI9nKFBvZ3z5Z49xem:2ZXnuJIlvKGSxeH;yeYJq[2mwLYLld4l{fGGwdDDIc41wKHOjcHnlcpMhMGi3bXHuLUBMPTZ{IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJHAu\3BiYYPz[ZN{\WRiYYOgbY5kemWjc3WgbY4hcW62cnHj[YxtfWyjcjDSbFEzOyCjY3P1cZVt[XSrb36gZZQhOTBidH:gNlAhfU1iYX\0[ZIhOSCqcjDifUBndG:5IHP5eI9u\XS{aXOgZY5idHm|aYO= Ml;NQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOlk3Pi9pPlPoSW1DVDxxYU6=

... Click to View More Cell Line Experimental Data

In vivo Verapamil confers an anti-arrhythmic effect via calcium influx inhibition, inhibition of oxygen consumption and accompanied by preservation of Cx43 protein in rat heart.

Protocol

Solubility (25°C)

In vitro DMSO 98 mg/mL (199.56 mM)
Water 50 mg/mL (101.82 mM)
Ethanol ''12 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 491.06
Formula

C27H38N2O4.HCl

CAS No. 152-11-4
Storage powder
in solvent
Synonyms N/A
Smiles CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC.Cl

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04406259 Not yet recruiting Drug: Verapamil Cluster Headache Centre Hospitalier Universitaire de Nice September 1 2020 Phase 4
NCT04014634 Recruiting Drug: Methylprednisolone|Other: Placebo Cluster Headache Episodic|Greater Occipital Nerve Injection Leiden University Medical Center|Netherlands Brain Foundation|Innovatiefonds Zorgverzekeraars August 1 2019 Phase 4
NCT02912663 Completed Drug: Verapamil and Magnesium Sulfate|Other: Placebo Ischemic Stroke Justin Fraser|University of Kentucky October 11 2017 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Calcium Channel Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID