Dazoxiben hydrochloride

For research use only.

Catalog No.S0541 Synonyms: Dazoxiben HCl

Dazoxiben hydrochloride Chemical Structure

CAS No. 74226-22-5

Dazoxiben hydrochloride (HCl) is a potent, selevtive and orally active inhibitor of thromboxane (TX) synthase. Dazoxiben inhibits TXB2 production in clotting human whole blood with IC50 of 0.3 μM and causes parallel enhancement of PGE2 production.

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Biological Activity

Description Dazoxiben hydrochloride (HCl) is a potent, selevtive and orally active inhibitor of thromboxane (TX) synthase. Dazoxiben inhibits TXB2 production in clotting human whole blood with IC50 of 0.3 μM and causes parallel enhancement of PGE2 production.
Targets
PGE2 [1]
()
TXB2 [1]
(Cell-free assay)
0.3 μM

Protocol

Solubility (25°C)

In vitro DMSO 54 mg/mL (200.96 mM)
Water 54 mg/mL (200.96 mM)
Ethanol '4 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 268.7
Formula

C12H13ClN2O3

CAS No. 74226-22-5
Storage powder
in solvent
Synonyms Dazoxiben HCl
Smiles C1=CC(=CC=C1C(=O)O)OCCN2C=CN=C2.Cl

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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P450 (e.g. CYP17) Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID