CYP3 Selective Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S2921 PF-4981517

PF-4981517 is a potent and selective inhibitor of CYP3A4 (P450) with IC50 of 0.03 μM, exhibits >500-fold selectivity over CYP3A5 and CYP3A7.

Selective CYP3A4, IC50: 30 nM
S2900 Cobicistat (GS-9350)

Cobicistat (GS-9350) is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM.

Selective CYP3A, IC50: 30 nM-285 nM
S2555 Clarithromycin

Clarithromycin is a macrolide antibiotic and a CYP3A4 inhibitor.

Selective
S2476 Itraconazole

Itraconazole is a relatively potent inhibitor of CYP3A4, used as a triazole antifungal agent.

Selective
S2344 Piperine

Piperine (1-Piperoylpiperidine) is the alkaloid responsible for the pungency of black pepper and long pepper, which has also been used in some forms of traditional medicine and as an insecticide.

Selective
S2046 Pioglitazone HCl

Pioglitazone HCl is a hydrochloride salt form of pioglitazone which is a cytochrome P450 (CYP)2C8 and CYP3A4 enzymes inhibitor for CYP2C8, CYP3A4 and CYP2C9 with Ki of 1.7 μM, 11.8 μM and 32.1 μM, respectively.

Pan CYP3A4, Ki: 11.8 μM