CYP3 Selective Inhibitors
|Catalog No.||Product Name||Information||Selective / Pan||IC50 / Ki|
PF-4981517 is a potent and selective inhibitor of CYP3A4 (P450) with IC50 of 0.03 μM, exhibits >500-fold selectivity over CYP3A5 and CYP3A7.
|Selective||CYP3A4, IC50: 30 nM|
Cobicistat (GS-9350) is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM.
|Selective||CYP3A, IC50: 30 nM-285 nM|
Clarithromycin is a macrolide antibiotic and a CYP3A4 inhibitor.
Itraconazole is a relatively potent inhibitor of CYP3A4, used as a triazole antifungal agent.
Piperine (1-Piperoylpiperidine) is the alkaloid responsible for the pungency of black pepper and long pepper, which has also been used in some forms of traditional medicine and as an insecticide.
Pioglitazone HCl is a hydrochloride salt form of pioglitazone which is a cytochrome P450 (CYP)2C8 and CYP3A4 enzymes inhibitor for CYP2C8, CYP3A4 and CYP2C9 with Ki of 1.7 μM, 11.8 μM and 32.1 μM, respectively.
|Pan||CYP3A4, Ki: 11.8 μM|
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