CYP1 Selective Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S2526 Alizarin

Alizarin strongly inhibits P450 isoform CYP1A1, CYP1A2 and CYP1B1 with IC50 of 6.2 μM, 10.0 μM and 2.7 μM, respectively; weakly inhibits CYP2A6 and CYP2E1, and does not inhibit CYP2C19, CYP3A4 and CYP3A5.

Selective CYP1A2, IC50: 10.0 μM; CYP1B1, IC50: 2.7 μM; CYP1A1, IC50: 6.2 μM
S2394 Naringenin

Naringenin is a natural predominant flavanone derived from plant food, which is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator.

Selective
S2380 Diosmetin

Diosmetin is a bioflavonoid found in spearmint, oregano, and many other plants.

Selective
S2187 Avasimibe

Avasimibe inhibits ACAT with IC50 of 3.3 μM, also inhibits human P450 isoenzymes CYP2C9, CYP1A2 and CYP2C19 with IC50 of 2.9 μM, 13.9 μM and 26.5 μM, respectively.

Pan CYP1A2, IC50: 13.9 μM