Sodium Channel

Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S1614 Riluzole <1 mg/mL 46 mg/mL 46 mg/mL
S2454 Bupivacaine HCl 23 mg/mL 65 mg/mL 65 mg/mL
S1811 Amiloride HCl 6 mg/mL 53 mg/mL 5 mg/mL
S1256 Rufinamide <1 mg/mL 18 mg/mL <1 mg/mL
S1603 Furosemide <1 mg/mL 66 mg/mL <1 mg/mL
S5814 cariporide <1 mg/mL 87 mg/mL 3 mg/mL
S5710 Ambroxol -1 mg/mL 76 mg/mL -1 mg/mL
S5490 Disopyramide -1 mg/mL 67 mg/mL -1 mg/mL
S5274 GS967 <1 mg/mL 45 mg/mL 46 mg/mL
S3907 Bulleyaconi cine A -1 mg/mL 7 mg/mL -1 mg/mL
S1445 Zonisamide <1 mg/mL 42 mg/mL 5 mg/mL
S2524 Phenytoin Sodium 3 mg/mL 32 mg/mL 11 mg/mL
S1693 Carbamazepine <1 mg/mL 47 mg/mL 18 mg/mL
S2785 A-803467 <1 mg/mL 72 mg/mL 11 mg/mL
S2560 Amiloride HCl dihydrate 17 mg/mL 0 mg/mL 0 mg/mL
S2525 Phenytoin <1 mg/mL 50 mg/mL 13 mg/mL
S2874 Camostat Mesilate 10 mg/mL 99 mg/mL <1 mg/mL
S2114 Dronedarone HCl <1 mg/mL 80 mg/mL 40 mg/mL
S3024 Lamotrigine <1 mg/mL 10 mg/mL 3 mg/mL
S4016 Ouabain <1 mg/mL 100 mg/mL 100 mg/mL
S1965 Primidone <1 mg/mL 44 mg/mL 3 mg/mL
S3064 Ambroxol HCl <1 mg/mL 4 mg/mL <1 mg/mL
S2041 Dyclonine HCl 6 mg/mL 15 mg/mL 36 mg/mL
S4229 Oxybuprocaine HCl 69 mg/mL 69 mg/mL 69 mg/mL
S3155 Mepivacaine HCl 57 mg/mL 3 mg/mL 8 mg/mL
S2500 Propafenone HCl <1 mg/mL 69 mg/mL <1 mg/mL
S4023 Procaine HCl 55 mg/mL 55 mg/mL <1 mg/mL
S1619 Prilocaine <1 mg/mL 44 mg/mL 44 mg/mL
S4038 Dibucaine HCl 76 mg/mL 76 mg/mL 76 mg/mL
S1391 Oxcarbazepine <1 mg/mL 7 mg/mL <1 mg/mL
S4058 Ropivacaine HCl 46 mg/mL 62 mg/mL <1 mg/mL
S4180 Nefopam HCl 21 mg/mL 1 mg/mL <1 mg/mL
S4061 Levobupivacaine HCl 64 mg/mL 64 mg/mL 57 mg/mL
S4080 Triamterene <1 mg/mL 20 mg/mL <1 mg/mL
S4200 Tolperisone HCl 56 mg/mL 56 mg/mL 56 mg/mL
S4210 Benzocaine <1 mg/mL 33 mg/mL 33 mg/mL
S4669 Benzocaine hydrochloride <1 mg/mL 40 mg/mL 40 mg/mL
S4668 Procaine <1 mg/mL 47 mg/mL 47 mg/mL
S4225 Mexiletine HCl 43 mg/mL 43 mg/mL 43 mg/mL
S4235 Phenazopyridine HCl <1 mg/mL 50 mg/mL <1 mg/mL
S3751 Quinidine sulfate 9 mg/mL 100 mg/mL 100 mg/mL
S4284 Chloroprocaine HCl 61 mg/mL 61 mg/mL <1 mg/mL
S2110 Vinpocetine <1 mg/mL 3 mg/mL
S4290 Digoxin <1 mg/mL 100 mg/mL <1 mg/mL
S2118 Ibutilide Fumarate 89 mg/mL 89 mg/mL 89 mg/mL
S4294 Procainamide HCl 54 mg/mL 54 mg/mL 54 mg/mL
S3911 Veratramine -1 mg/mL 63 mg/mL -1 mg/mL
S1828 Proparacaine HCl 66 mg/mL 12 mg/mL <1 mg/mL
Catalog No. Information Product Use Citations Product Validations


Riluzole is a glutamate release inhibitor with neuroprotective, anticonvulsant, anxiolytic and anesthetic qualities.


Bupivacaine HCl

Bupivacaine HCl binds to the intracellular portion of voltage-gated sodium channels and blocks sodium influx into nerve cells, used for treating cardiac arrhythmias.


Amiloride HCl

Amiloride is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA)(Ki=7 μM).



Rufinamide is a voltage-gated sodium channel blocker, used an anticonvulsant medication.



Furosemide is a potent NKCC2 (Na-K-2Cl symporter) inhibitor, used in the treatment of congestive heart failure and edema.



Cariporide is a selective and potent inhibitor of NHE1 with an IC50 of 30 nM for hNHE1 in CHO-K1 cells.



Ambroxol, a substituted benzylamine, is an active metabolite of bromhexine. It is a potent inhibitor of the neuronal Na+ channels.



Sparteine, which could be extracted from scotch broom, is a sodium channel blocker and a class 1a antiarrhythmic agent.


(-)-Sparteine Sulfate

Sparteine Sulfate, a quinolizidine alkaloid, is the sulfate form of sparteini, which is a sodium channel blocker used as an oxytocic and an anti-arrhythmia agent.



Disopyramide is a class IA antiarrhythmic drug which acts via blockade of sodium channels depressing phase 0 of the action potential. Disopyramide possesses significant negative inotropic, anticholinergic effects and enhances AV nodal conduction.



GS967 is a potent and selective inhibitor of late INa with anti-arrhythmic actions.


Bulleyaconi cine A

Bulleyaconitine A (BLA) is an active ingredient of Aconitum bulleyanum plants and classified as an "aconitine-like" alkaloid. It is a potent use-dependent blocker for both Nav1.7 and Nav1.8 Na+ currents.



Zonisamide is a voltage-dependent sodium channel and T-type calcium channel blocker, used as an antiepileptic drug.


Phenytoin Sodium

Phenytoin Sodium is an inactive voltage-gated sodium channel stabilizer.



Carbamazepine (Carbatrol) is a sodium channel blocker with IC50 of 131 μM in rat brain synaptosomes.



A-803467 is a selective NaV1.8 channel blocker with IC50 of 8 nM, blocks tetrodotoxin-resistant currents, exhibits >100-fold selectivity against human NaV1.2, NaV1.3, NaV1.5, and NaV1.7.


Amiloride HCl dihydrate

Amiloride HCl dihydrate is a potent epithelial sodium channel (ENaC) blocker, used in the management of hypertension and congestive heart failure.



Phenytoin is an inactive voltage-gated sodium channel stabilizer.


Camostat Mesilate

Camostat is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trpsin, prostasin and matriptase.


Dronedarone HCl

Dronedarone HCl is a multichannel blocker targeting potassium channel, sodium channel and calcium channel, used as an antiarrhythmic drug for treatment of atrial fibrillation (AF).



Lamotrigine is a novel anticonvulsant drug for inhibition of 5-HT with IC50 of 240 μM and 474 μM in human platelets and rat brain synaptosomes, and also is a sodium channel blocker.



Ouabain is a selective Na+/K+, -ATPase inhibitor, binds to α2 /α3 subunit with Ki of 41 nM/15 nM.



Primidone is an anticonvulsant of the pyrimidinedione class.


Ambroxol HCl

AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. Phase 3.


Dyclonine HCl

Dyclonine HCl is a hydrochloride salt form of dyclonine which is an oral anaesthetic, reversibly binds to activated sodium channels on the neuronal membrane, thereby decreasing the neuronal membrane's permeability to sodium ions, leading to an increased threshold for excitation.


Oxybuprocaine HCl

Oxybuprocaine HCl is a local anesthetic, which is used especially in ophthalmology and otolaryngology. Oxybuprocaine binds to sodium channel and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions


Mepivacaine HCl

Mepivacaine is a tertiary amine used as a local anesthetic.


Propafenone HCl

Propafenone HCl is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias.


Procaine HCl

Procaine is an inhibitor of sodium channel, NMDA receptor and nAChR with IC50 of 60 μM, 0.296 mM and 45.5 μM, which is also an inhibitor of 5-HT3 with KD of 1.7 μM.



Prilocaine is a local anesthetic of the amino amide type. It acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation.


Dibucaine HCl

Dibucaine HCl is a local anesthetics.



Oxcarbazepine inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22Na+ into rat brain synaptosomes with IC50 about 100 μM.


Ropivacaine HCl

Ropivacaine HCl is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.


Nefopam HCl

Nefopam HCl is a centrally-acting but non-opioid analgesic drug by blocking voltage-gated sodium channel and inhibition of serotonin, dopamine and noradrenaline reuptake.


Levobupivacaine HCl

Levobupivacaine HCl, the pure S(-)-enantiomer of bupivacaine, is a reversible neuronal sodium channel inhibitor, used as a long-acting local anesthetic.



Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner with IC50 of 4.5 μM.



Lappaconitine (LC) is a natural diterpenoid alkaloid (DTA), acting as a human heart sodium channel blocker and possessing a wide range of biological activities, including anti-arrhythmic, anti-inflammatory, antioxidative, anticancer, epileptiform etc.


Tolperisone HCl

Tolperisone HCl is an ion channel blocker and centrally-acting muscle relaxant.



Benzocaine is the ethyl ester of p-aminobenzoic acid (PABA), it is a local anesthetic commonly used as a topical pain reliever or in cough drops.


Benzocaine hydrochloride

Benzocaine hydrochloride is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.



Procaine is a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses.


Mexiletine HCl

Mexiletine HCl belongs to Class IB anti-arrhythmic group of medicines, inhibits sodium channels to reduce the inward sodium current.


Phenazopyridine HCl

Phenazopyridine HCl is a local analgesic that has been used in urinary tract disorders. It is an inhibitor of sodium channel protein type 1 subunit alpha.


Quinidine sulfate

Quinidine acts as a blocker of voltage-gated sodium channels, also an antimuscarinic and antimalarial.


Chloroprocaine HCl

Chloroprocaine HCl is a local anesthetic during surgical procedures.



Vinpocetine is a selective inhibitor of voltage-sensitive sodium channel for the treatment of stroke, vascular dementia and Alzheimer's disease.



Digoxin is a classical Na,K-ATPase inhibitor, with selectivity for the α2β3 isoform over the common α1β1 isoform, used in the treatment of atrial fibrillation and heart failure.


Ibutilide Fumarate

Ibutilide Fumarate is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm by induction of slow inward sodium current, which prolongs action potential and refractory period of myocardial cells.


Procainamide HCl

Procainamide HCl is a sodium channel blocker, and also a DNA methyltransferase inhibitor, used in the treatment of cardiac arrhythmias.



Veratramine, a major alkaloid from Veratrum nigrum L., has distinct anti-tumor and anti-hypertension effects. It is a good membrane permeant, undergoes rapid passive diffusion, and has a good stability in the gastrointestinal tract during its absorption.


Proparacaine HCl

Proparacaine HCl is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.