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Sodium Channel

Other Transmembrane Transporters Related Inhibitors

CFTR CRM1 Calcium Channel Proton Pump P-gp ATPase Potassium Channel CD markers GLUT Amino acid transporter
Cat.No. Product Name Information Product Use Citations Product Validations
S1811 Amiloride HCl Amiloride HCl is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA)(Ki=7 μM).
Advanced Science, May 03, 2021, 2100962
International Journal of Polymeric Materials and Polymeric Biomaterials, March 14, 2025, nan
Proceedings of the National Academy of Sciences, August 07, 2018, E7469-E7477
S2874 Camostat Mesilate Camostat (FOY-305, FOY-S980) is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trpsin, prostasin and matriptase.
CNS Neurosci Ther, 2024, 30(6):e14822
Elife, 2022, 11e77444
Antiviral Res, 2022, 202:105325
S3024 Lamotrigine Lamotrigine (BW-430C,LTG) is a novel anticonvulsant drug for inhibition of 5-HT with IC50 of 240 μM and 474 μM in human platelets and rat brain synaptosomes, and this compound also is a sodium channel blocker.
Neuro-Oncology Advances, October 04, 2025, vdaf215
eLife, November 22, 2016, e19352
iScience, 2024, 27(10):110862
S1614 Riluzole Riluzole is a glutamate release inhibitor with neuroprotective, anticonvulsant, anxiolytic and anesthetic qualities.
Neurotherapeutics, 2023, none
J Endocr Soc, 2023, 7(10):bvad117
Front Bioeng Biotechnol, 2022, 10:855755
Verified customer review of Riluzole
S2560 Amiloride HCl dihydrate Amiloride HCl dihydrate(MK-870 hydrochloride dihydrate) is a potent epithelial sodium channel (ENaC) blocker, used in the management of hypertension and congestive heart failure.
iScience, 2025, 28(3):111931
J Immunother Cancer, 2024, 12(11)e009805
Adv Sci (Weinh), 2022, 9(29):e2202039
S1693 Carbamazepine Carbamazepine (Carbatrol, NSC 169864) is a sodium channel blocker with IC50 of 131 μM in rat brain synaptosomes.
PLoS One, February 4, 2019, e0211644
Anticancer Research, February 2021, 687-697
J Immunother Cancer, 2024, 12(11)e009805
S1445 Zonisamide Zonisamide (Zonegran,CI-912,AD 810) is a voltage-dependent sodium channel and T-type calcium channel blocker, used as an antiepileptic drug.
Communications Medicine, 2025, 420
Acta Pharmacologica Sinica, 2024 Apr, 738-750
Acta Pharmacologica Sinica, 2023, 738–750
E8150 Amiloride Amiloride (MK-870) is the first potent inhibitor of epithelial sodium channel (ENaC), inhibiting δβγ ENaC with an IC50 of 2.6 μM. It is also a typical blocker of PC2(TRPP2) channels and can be used in the research to study Autosomal dominant polycystic kidney disease (ADPKD).
Sci Rep, 2025, 15(1):18633
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2025, L428-L439
Cancer Immunology Research, 2024, 1640-1654
S2454 Bupivacaine HCl Bupivacaine HCl binds to the intracellular portion of voltage-gated sodium channels and blocks sodium influx into nerve cells, used for treating cardiac arrhythmias.
Int J Mol Sci, 2019, 20(17)
International Journal of Molecular Sciences, 2019, 4300
Journal of Steroid Biochemistry and Molecular Biology, 2017, 89-97
S2525 Phenytoin Phenytoin (Di-Hydan, Dihycon, Dilabid, Diphedan, Diphenat, Diphenylan, Diphenylhydantoin, Hydantol, Lehydan, NSC 8722) is an inactive voltage-gated sodium channel stabilizer.
World Journal of Gastroenterology, May 28, 2023, 3103-3118
Cancer Cell, 2025, 43(4):776-796.e14
Cell Mol Gastroenterol Hepatol, 2023, 16(2):223-242

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