Home Transmembrane Transporters Sodium Channel inhibitor Disopyramide For research use only.

Disopyramide

Disopyramide is a class IA antiarrhythmic drug which acts via blockade of sodium channels depressing phase 0 of the action potential. Disopyramide possesses significant negative inotropic, anticholinergic effects and enhances AV nodal conduction.

Disopyramide Chemical Structure

Disopyramide Chemical Structure

CAS: 3737-09-5

Purity & Quality Control

Batch: S549001 DMSO] 67 mg/mL] false] ] ] false] ] ] false Purity: 98%
98

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Signaling Pathway

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Sodium Channel Signaling Pathway

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Biological Activity

Description Disopyramide is a class IA antiarrhythmic drug which acts via blockade of sodium channels depressing phase 0 of the action potential. Disopyramide possesses significant negative inotropic, anticholinergic effects and enhances AV nodal conduction.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02917395 Unknown status
Cardiomyopathy
Rabin Medical Center
 November 2016 Not Applicable

Chemical Information & Solubility

Molecular Weight 339.47 Formula

C21H29N3O
CAS No. 3737-09-5 SDF --
Smiles CC(C)N(CCC(C1=CC=CC=C1)(C2=CC=CC=N2)C(=O)N)C(C)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 67 mg/mL ( (197.36 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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