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Vernakalant (RSD1235) Hydrochloride Potassium Channel inhibitor

Name: Vernakalant (RSD1235) Hydrochloride
Brand: Selleck Chemicals
SKU: E0144
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.E0144

Vernakalant (RSD-1235, MK-6621) is a novel, frequency-dependent Na+ channel and early activating K+ channel blocker that selectively prolongs the atrial refractory period.

Chemical Structure

Molecular Weight: 385.93

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: E014401 DMSO]77 mg/mL]false]Water]77 mg/mL]false]Ethanol]77 mg/mL]false Purity: 99.84%

99.84

Related Targets	CD markers AChR Calcium Channel Sodium Channel GABA Receptor ATPase TRP Channel GluR NMDAR P2 Receptor Proton Pump P-gp CFTR SGLT Chloride Channel MCT Amino acid transporter GLUT CRM1 VDAC BCRP NKCC OCT NCX OAT VMAT Aquaporin EAAT GlyT GlyR
Related Products	Nicorandil TRAM-34 Sophocarpine ML133 HCl Hydralazine HCl Gliquidone PAP-1

Chemical Information, Storage & Stability

Molecular Weight	385.93	Formula	C₂₀H₃₁NO₄.ClH	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	748810-28-8	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	MK-6621			Smiles	Cl.COC1=C(OC)C=C(CCOC2CCCCC2N3CCC(O)C3)C=C1

Solubility

In vitro
Batch:

DMSO : 77 mg/mL ( (199.51 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 77 mg/mL

Ethanol : 77 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC₅₀/Ki	K+ channel ^[1] Na+ channel ^[1]
References	https://www.annemergmed.com/article/S0196-0644(06)01605-2/fulltext

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT00125320	Completed	Atrial Fibrillation\|Atrial Flutter	Astellas Pharma Inc\|Astellas Pharma US Inc.\|Advanz Pharma	June 2004	Phase 3
NCT00115791	Completed	Atrial Flutter\|Atrial Fibrillation	Astellas Pharma Inc\|Advanz Pharma	June 2004	Phase 3
NCT00476112	Completed	Atrial Flutter	Advanz Pharma\|Astellas Pharma US Inc.	August 2003	Phase 2\|Phase 3
NCT00468767	Completed	Atrial Fibrillation	Advanz Pharma\|Astellas Pharma US Inc.	August 2003	Phase 3

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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