For research use only. Not for use in humans.

Lifastuzumab vedotin

Synonyms: LIFA, DNIB0600A, RG-7599 Cat.No.D4010 Purity:99%

Lifastuzumab vedotin (LIFA, DNIB0600A, RG-7599) is an antibody-drug conjugate (ADC) composed of a humanized anti-NaPi2b monoclonal antibody and an anti-mitotic cytotoxic agent, monomethyl auristatin E (MMAE) . Lifastuzumab vedotin is used in the treatment of platinum-resistant ovarian cancer.

CAS No. 1401812-88-1

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Quality Control

Batch: D401001 Purity: 99% Protein concentration: 8.79mg/ml Endotoxin Level: ＜1EU/mg

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COA
SDS
Datasheet

Specificity

Name	Citation	Sodium Channel	Others
A-803467	2	+++
Camostat Mesilate	16	+++
Ambroxol HCl	0	++
Flecainide hydrochloride	0	++++
Suzetrigine (VX-548)	0	++++
Tenapanor	0	++++
SEA0400	0	+++	ROS,ERK,p38 MAPK
SLC13A5-IN-1	0	+++
LTGO-33	0	✔
EIPA (L593754)	8	✔
Vernakalant (RSD1235) Hydrochloride	0	✔
QX-314 chloride	0	✔
VX-150	0	✔
Rimeporide	0	✔
(-)-Sparteine Sulfate	0	✔
Benzocaine	0	✔
Tolperisone HCl	1	✔
Vinpocetine	1	✔

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Lifastuzumab vedotin (LIFA, DNIB0600A, RG-7599) is an antibody-drug conjugate (ADC) composed of a humanized anti-NaPi2b monoclonal antibody and an anti-mitotic cytotoxic agent, monomethyl auristatin E (MMAE) . Lifastuzumab vedotin is used in the treatment of platinum-resistant ovarian cancer.
References	[1] https://pubmed.ncbi.nlm.nih.gov/29401246/

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	1401812-88-1
ADC antiody	Lifastuzumab
ADC cytotoxin	MMAE
Formulation	0.1 MPro-Ac，0.02 MArg-Ac，pH5.0
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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