Ropivacaine HCl

Catalog No.S4058 Synonyms: LEA-103 HCl

For research use only.

Ropivacaine HCl (LEA-103) is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.

Ropivacaine HCl Chemical Structure

CAS No. 98717-15-8

Selleck's Ropivacaine HCl has been cited by 3 Publications

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Biological Activity

Description Ropivacaine HCl (LEA-103) is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.
In vitro

Ropivacaine HCl is a local anaesthetic agent. Ropivacaine HCl elicits nerve block via reversible inhibition of sodium ion influx in nerve fibres. The pKa of ropivacaine HCl is ~8.2. Ropivacaine HCl has the potential to induce cardiovascular toxicity and CNS toxicity at high plasma concentrations. [1]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 62 mg/mL
(199.44 mM)
Water 46 mg/mL
(147.97 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 310.86
Formula

C17H26N2O.HCl

CAS No. 98717-15-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C.O.Cl

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04916418 Not yet recruiting Drug: Placebo|Drug: Ropivacaine Pain Postoperative|Anesthesia Local|Coronary Artery Disease|Heart Valve Diseases Turku University Hospital October 15 2021 Phase 4
NCT05015907 Not yet recruiting Drug: Ropivacaine|Other: Control (without intervention) Cancer Pediatric Seoul National University Hospital September 30 2021 Not Applicable
NCT04959123 Not yet recruiting Other: pharmacokinetic analysis Bowel Disease Centre Hospitalier Universitaire de Nice July 2 2021 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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