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Ropivacaine HCl Sodium Channel inhibitor

Name: Ropivacaine HCl
Brand: Selleck Chemicals
SKU: S4058
Availability: InStock
Rating: 5 (3 reviews)

Cat.No.S4058

Ropivacaine HCl (LEA-103) is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.

Chemical Structure

Molecular Weight: 310.86

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Quality Control

Batch: Purity: 99.97%

99.97

Related Targets	CFTR CRM1 CD markers AChR Calcium Channel Potassium Channel GABA Receptor TRP Channel ATPase GluR
Other Sodium Channel Inhibitors	Camostat Mesilate A-803467 cariporide Veratramine Tolperisone HCl Bulleyaconi cine A Vinpocetine Tenapanor PF-06869206 Sparteine

Solubility

In vitro
Batch:

DMSO : 62 mg/mL (199.44 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 62 mg/mL

Water : 46 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	310.86	Formula	C₁₇H₂₆N₂O.HCl	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	98717-15-8	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	LEA-103 HCl			Smiles	CCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C.O.Cl

Mechanism of Action

In vitro	Ropivacaine HCl is a local anaesthetic agent. It elicits nerve block via reversible inhibition of sodium ion influx in nerve fibres. The pKa of this compound is ~8.2. It has the potential to induce cardiovascular toxicity and CNS toxicity at high plasma concentrations.
References	[1] http://www.ncbi.nlm.nih.gov/pubmed/?term=16392884

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04003506	Not yet recruiting	Pain Postoperative	The University of Hong Kong	March 1 2024	Phase 4
NCT06006026	Recruiting	Colorectal Cancer	West China Hospital	August 28 2023	Not Applicable
NCT05773846	Recruiting	Bunion	PainReform LTD\|Lotus Clinical Research LLC	March 13 2023	Phase 3

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