Ibutilide Fumarate

Licensed by Pfizer Catalog No.S2118 Synonyms: U-70226E

For research use only.

Ibutilide Fumarate (U-70226E) is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm by induction of slow inward sodium current, which prolongs action potential and refractory period of myocardial cells.

Ibutilide Fumarate Chemical Structure

CAS No. 122647-32-9

Selleck's Ibutilide Fumarate has been cited by 1 Publication

Purity & Quality Control

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Biological Activity

Description Ibutilide Fumarate (U-70226E) is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm by induction of slow inward sodium current, which prolongs action potential and refractory period of myocardial cells.
Targets
Sodium channel [1]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 89 mg/mL
(100.53 mM)
Water 89 mg/mL
(100.53 mM)
Ethanol ''89 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 885.23
Formula

(C20H36N2O3S)2.C4H4O4

CAS No. 122647-32-9
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCCCCCCN(CC)CCCC(C1=CC=C(C=C1)NS(=O)(=O)C)O.CCCCCCCN(CC)CCCC(C1=CC=C(C=C1)NS(=O)(=O)C)O.C(=CC(=O)O)C(=O)O

In vivo Formulation Calculator (Clear solution)

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%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03834883 Recruiting Drug: Progesterone|Drug: Ibutilide Long QT Syndrome|Abnormalities Drug-Induced Indiana University|American Heart Association|Purdue University March 26 2019 Phase 4
NCT01929083 Completed Drug: Progesterone|Drug: Placebo|Drug: Ibutilide Prolonged QT Interval in EKG and Sudden Death Indiana University|American Heart Association April 2013 Phase 2
NCT00589992 Unknown status Drug: Ibutilide fumarate Atrial Fibrillation|Pulmonary Vein Ablation Ball Memorial Hospital|Abbott Medical Devices October 2007 Not Applicable

(data from https://clinicaltrials.gov, updated on 2021-09-06)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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