GS967

Catalog No.S5274 Synonyms: GS458967

For research use only.

GS967 (GS458967) is a potent and selective inhibitor of late INa with anti-arrhythmic actions.

GS967 Chemical Structure

CAS No. 1262618-39-2

Purity & Quality Control

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Biological Activity

Description GS967 (GS458967) is a potent and selective inhibitor of late INa with anti-arrhythmic actions.
Targets
late INa [1]
0.13 μM
In vitro

GS967 (3 μM) has no significant effect on L- or T-type calcium channel currents or Na+-Ca2+ exchanger current (INCX), and 1 μM GS967 has minimal or no effect on the ATP-inhibited K+ current or on human cardiac ion channels expressed in human embryonic kidney 293 or Chinese hamster ovary cells[1]. GS967 is a novel sodium channel modulatorspecifically developed to inhibit persistent sodium current, with a 42-fold preference for persistent as opposed to peakcurrent inhibition[2].

In vivo GS967 protects against seizures and prematurelethality in vivo. Chronic GS967 does not cause overt behavioraltoxicity or sedation in wild-type mice at theeffective anticonvulsant dose[2]. GS967 suppresses arrhythmogenicity evoked by ischemia, hypokalemia, and catecholamines in canine and porcine models[3].

Protocol (from reference)

Animal Research:[1]
  • Animal Models: New Zealand White adult females rabbits
  • Dosages: 30, 60 and 120 µg/kg
  • Administration: i.v.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 347.22
Formula

C14H7F6N3O

CAS No. 1262618-39-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC(=CC=C1C2=CN3C(=NN=C3C(F)(F)F)C=C2)OC(F)(F)F

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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