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Proparacaine HCl

Name: Proparacaine HCl
Brand: Selleck Chemicals
SKU: S1828
Rating: 5 (1 reviews)

Synonyms: Proxymetacaine Hydrochloride

Catalog No.S1828 Purity: 99.60%

Proparacaine HCl(Proxymetacaine Hydrochloride) is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.

Proparacaine HCl Chemical Structure

CAS: 5875-06-9

Purity & Quality Control

Batch: S182801 Water] 66 mg/mL] false] DMSO] 12 mg/mL] false] Ethanol] Insoluble] false Purity: 99.60%

99.60

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Signaling Pathway

Sodium Channel Signaling Pathway

Choose Selective Sodium Channel Inhibitors

Biological Activity

Description

Proparacaine HCl(Proxymetacaine Hydrochloride) is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.

Targets

Voltage-gated sodium channel ^[1]

3.4 mM(ED50)

In vitro
In vitro	Proparacaine is more potent and less toxic than cocaine. ^[1] Proparacaine significantly increases in FHV-1 (P < 0.01), C. felis, and 28S rDNA Ct values when fusidic acid is used. ^[2]

In Vivo
In vivo	Proparacaine inhibits corneal epithelial migration and adhesion through alteration of the actin cytoskeleton. ^[3] Proparacaine acts like bupivacaine or lidocaine and produces dose-related spinal blockades of motor function, proprioception and nociception. Intrathecal proxymetacaine also produces longer sensory blockade than motor blockade. ^[4]
Animal Research	Animal Models	Male Sprague–Dawley rats
	Dosages	~10 μmol/kg
	Administration	Intrathecally

References

[4] Hung CH, et al. Neurosci Lett, 2009, 454(3), 249-253.

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Chemical Information & Solubility

Molecular Weight	330.85	Formula	C₁₆H₂₆N₂O₃.HCl
CAS No.	5875-06-9	SDF	Download Proparacaine HCl SDF
Smiles	CCCOC1=C(C=C(C=C1)C(=O)OCCN(CC)CC)N.Cl
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

Water : 66 mg/mL

DMSO : 12 mg/mL ( (36.27 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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