Proparacaine HCl

For research use only.

Catalog No.S1828

Proparacaine HCl Chemical Structure

Molecular Weight(MW): 330.85

Proparacaine HCl is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.

Size Price Stock Quantity  
10mM (1mL in DMSO) USD 130 In stock
USD 97 In stock
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Biological Activity

Description Proparacaine HCl is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.
Voltage-gated sodium channel [1]
3.4 mM(ED50)
In vitro

Proparacaine is more potent and less toxic than cocaine. [1] Proparacaine significantly increases in FHV-1 (P < 0.01), C. felis, and 28S rDNA Ct values when fusidic acid is used. [2]

In vivo Proparacaine inhibits corneal epithelial migration and adhesion through alteration of the actin cytoskeleton. [3] Proparacaine acts like bupivacaine or lidocaine and produces dose-related spinal blockades of motor function, proprioception and nociception. Intrathecal proxymetacaine also produces longer sensory blockade than motor blockade. [4]


Animal Research:[4]
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  • Animal Models: Male Sprague–Dawley rats
  • Dosages: ~10 μmol/kg
  • Administration: Intrathecally
    (Only for Reference)

Solubility (25°C)

In vitro Water 66 mg/mL (199.48 mM)
DMSO 12 mg/mL (36.27 mM)
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 330.85


CAS No. 5875-06-9
Storage powder
in solvent
Synonyms N/A

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Sodium Channel Signaling Pathway Map

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