Proparacaine HCl

Catalog No.S1828

Proparacaine HCl Chemical Structure

Molecular Weight(MW): 330.85

Proparacaine HCl is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.

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In DMSO USD 130 In stock
USD 97 In stock
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Biological Activity

Description Proparacaine HCl is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.
Targets
Voltage-gated sodium channel [1]
3.4 mM(ED50)
In vitro

Proparacaine is more potent and less toxic than cocaine. [1] Proparacaine significantly increases in FHV-1 (P < 0.01), C. felis, and 28S rDNA Ct values when fusidic acid is used. [2]

In vivo Proparacaine inhibits corneal epithelial migration and adhesion through alteration of the actin cytoskeleton. [3] Proparacaine acts like bupivacaine or lidocaine and produces dose-related spinal blockades of motor function, proprioception and nociception. Intrathecal proxymetacaine also produces longer sensory blockade than motor blockade. [4]

Protocol

Animal Research:[4]
+ Expand
  • Animal Models: Male Sprague–Dawley rats
  • Formulation: Saline
  • Dosages: ~10 μmol/kg
  • Administration: Intrathecally
    (Only for Reference)

Solubility (25°C)

In vitro Water 66 mg/mL (199.48 mM)
DMSO 12 mg/mL (36.27 mM)
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
Saline
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 330.85
Formula

C16H26N2O3.HCl

CAS No. 5875-06-9
Storage powder
in solvent
Synonyms N/A

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Sodium Channel Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID