Phenytoin Sodium

For research use only.

Catalog No.S2524 Synonyms: Diphenylhydantoin Sodium

Phenytoin Sodium Chemical Structure

CAS No. 630-93-3

Phenytoin Sodium (Diphenylhydantoin) is an inactive voltage-gated sodium channel stabilizer.

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10mM (1mL in DMSO) USD 163 In stock
USD 122 In stock
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Biological Activity

Description Phenytoin Sodium (Diphenylhydantoin) is an inactive voltage-gated sodium channel stabilizer.
Sodium channel [1]



Solubility (25°C)

In vitro DMSO 32 mg/mL (116.68 mM)
Ethanol 11 mg/mL (40.1 mM)
Water 3 mg/mL (10.93 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 274.25


CAS No. 630-93-3
Storage powder
in solvent
Synonyms Diphenylhydantoin Sodium
Smiles C1=CC=C(C=C1)C2(C(=O)[N-]C(=O)N2)C3=CC=CC=C3.[Na+]

In vivo Formulation Calculator (Clear solution)

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04647877 Recruiting Drug: phenytoin cream|Other: Placebo cream Chronic Idiopathic Axonal Polyneuropathy David J. Kopsky|Princess Beatrix Muscle Foundation|Dr. C.J. Vaillant Fonds|UMC Utrecht September 17 2020 Phase 2|Phase 3
NCT01635829 Completed Drug: Telaprevir|Drug: Phenytoin|Drug: Carbamazepine Healthy Participants Janssen Infectious Diseases BVBA May 2012 Phase 1
NCT01478035 Unknown status Drug: Phenytoin|Drug: placebo Seizures|Pneumococcal Meningitis M. Carmen Cabellos Minguez|Hospital Universitari de Bellvitge|Hospital Vall d''Hebron|Germans Trias i Pujol Hospital|Hospital Clinic of Barcelona|Fundació Institut de Recerca de l''Hospital de la Santa Creu i Sant Pau|Hospitales Universitarios Virgen del Rocío|Hospital Universitario La Paz|Hospital Universitario Ramon y Cajal|Hospital Juan Canalejo|Hospital Mutua de Terrassa|Hospital Universitario Virgen Macarena November 2011 Phase 4
NCT01122940 Completed Drug: Epamin: Reference Drug|Drug: Phenytoin: Study Drug Healthy Pfizer July 2010 Phase 1
NCT01187719 Completed Drug: phenytoin HIV-infection|Pregnancy|Mother to Child Transmission Radboud University May 2010 Phase 2
NCT01586208 Completed Drug: valproic acid (VPA) Grand Mal Status Epilepticus|Non-convulsive Status Epilepticus Hospital Universitari de Bellvitge|Hospital Vall d''Hebron|Germans Trias i Pujol Hospital|Institut d''Investigació Biomèdica de Girona Dr. Josep Trueta|Hospital Clinic of Barcelona January 2010 Phase 3

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Sodium Channel Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID