Propafenone HCl

Catalog No.S2500

For research use only.

Propafenone HCl is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias.

Propafenone HCl Chemical Structure

CAS No. 34183-22-7

Purity & Quality Control

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Biological Activity

Description Propafenone HCl is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias.
Targets
Sodium channel [1]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 377.9
Formula

C21H27NO3.HCl

CAS No. 34183-22-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O.Cl

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03915340 Completed Drug: Propafenone|Drug: Rytmonorm Bioequivalence Pharmtechnology LLC|Altasciences Company Inc. March 23 2019 Phase 1
NCT03029169 Recruiting Drug: Propafenone i.v.|Drug: Amiodarone i.v. Supraventricular Arrhythmia|Septic Shock Charles University Czech Republic October 23 2017 Phase 4

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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