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Levobupivacaine Sodium Channel inhibitor

Cat.No.S5181

Levobupivacaine (Chirocaine, (S)-(-)-Bupivacaine, L-(-)-Bupivacaine), the S (-)-enantiomer of bupivacaine, is a long-acting amide local anaesthetic used in analgesia and anaesthesia. This compound exhibits effects on motor and sensory nerves by inhibiting the opening of voltage-gated sodium channels.
Levobupivacaine Sodium Channel inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 288.43

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Quality Control

Batch: S518101 DMSO]58 mg/mL]false]Ethanol]58 mg/mL]false]Water]Insoluble]false Purity: 99.49%
99.49

Solubility

In vitro
Batch:

DMSO : 58 mg/mL (201.08 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 58 mg/mL

Water : Insoluble

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 288.43 Formula

C18H28N2O

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 27262-47-1 -- Storage of Stock Solutions

Synonyms Chirocaine, (S)-(-)-Bupivacaine, L-(-)-Bupivacaine Smiles CCCCN1CCCCC1C(=O)NC2=C(C)C=CC=C2C

Mechanism of Action

Targets/IC50/Ki
voltage-gated sodium channels
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04221568 Unknown status
Labor Pain
Assiut University
 March 1 2020 Phase 1
NCT03258697 Unknown status
Arthropathy
Chang Gung Memorial Hospital
 October 17 2017 Not Applicable

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