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Levobupivacaine Sodium Channel inhibitor

Levobupivacaine (Chirocaine, (S)-(-)-Bupivacaine, L-(-)-Bupivacaine), the S (-)-enantiomer of bupivacaine, is a long-acting amide local anaesthetic used in analgesia and anaesthesia. This compound exhibits effects on motor and sensory nerves by inhibiting the opening of voltage-gated sodium channels.

Levobupivacaine Sodium Channel inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 288.43

Purity & Quality Control

Batch: S518101 DMSO]58 mg/mL]false]Ethanol]58 mg/mL]false]Water]Insoluble]false Purity: 99.49%
99.49

Related Products

Signaling Pathway

Sodium Channel Signaling Pathways

Sodium Channel Signaling Pathway

Mechanism of Action

Targets
voltage-gated sodium channels [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04221568 Unknown status
Labor Pain
Assiut University
 March 1 2020 Phase 1
NCT03258697 Unknown status
Arthropathy
Chang Gung Memorial Hospital
 October 17 2017 Not Applicable

References
  • https://pubmed.ncbi.nlm.nih.gov/32034727/

Chemical Information

Molecular Weight 288.43 Formula

C18H28N2O
CAS No. 27262-47-1 SDF --
Synonyms Chirocaine, (S)-(-)-Bupivacaine, L-(-)-Bupivacaine
Smiles CCCCN1CCCCC1C(=O)NC2=C(C)C=CC=C2C

Storage and Stability

Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 58 mg/mL ( (201.08 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 58 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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