Home Transmembrane Transporters Sodium Channel inhibitor Dibucaine HCl For research use only.

Dibucaine HCl

Synonyms: Cinchocaine HCl

Dibucaine HCl (Cinchocaine) is a local anesthetics.

Dibucaine HCl Chemical Structure

Dibucaine HCl Chemical Structure

CAS: 61-12-1

Purity & Quality Control

Batch: S403801 DMSO] 76 mg/mL] false] Water] 76 mg/mL] false] Ethanol] 76 mg/mL] false Purity: 99.46%
99.46

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Signaling Pathway

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Biological Activity

Description Dibucaine HCl (Cinchocaine) is a local anesthetics.
Targets
Sodium channel [2]
In vitro
In vitro Dibucaine (Cinchocaine) HCl is one of the most potent and toxic of the long-acting local anesthetics. [1] Dibucaine (Cinchocaine) HCl blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade. [2]

Chemical Information & Solubility

Molecular Weight 379.92 Formula

C20H29N3O2.HCl
CAS No. 61-12-1 SDF Download Dibucaine HCl SDF
Smiles CCCCOC1=NC2=CC=CC=C2C(=C1)C(=O)NCCN(CC)CC.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 76 mg/mL ( (200.04 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 76 mg/mL

Ethanol : 76 mg/mL


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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