Phenytoin

Catalog No.S2525 Synonyms: Diphenylhydantoin

For research use only.

Phenytoin (Diphenylhydantoin) is an inactive voltage-gated sodium channel stabilizer.

Phenytoin Chemical Structure

CAS No. 57-41-0

Purity & Quality Control

Choose Selective Sodium Channel Inhibitors

Other Sodium Channel Products

Biological Activity

Description Phenytoin (Diphenylhydantoin) is an inactive voltage-gated sodium channel stabilizer.
Targets
Sodium channel [1]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 252.27
Formula

C15H12N2O2

CAS No. 57-41-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC=C(C=C1)C2(C(=O)NC(=O)N2)C3=CC=CC=C3

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04647877 Recruiting Drug: phenytoin cream|Other: Placebo cream Chronic Idiopathic Axonal Polyneuropathy David J. Kopsky|Princess Beatrix Muscle Foundation|Dr. C.J. Vaillant Fonds|UMC Utrecht September 17 2020 Phase 2|Phase 3
NCT04829838 Recruiting Drug: intravenous levetireacetam Status Epilepticus ayesha tariq|King Edward Medical University July 25 2019 Phase 4
NCT01635829 Completed Drug: Telaprevir|Drug: Phenytoin|Drug: Carbamazepine Healthy Participants Janssen Infectious Diseases BVBA May 2012 Phase 1
NCT01478035 Unknown status Drug: Phenytoin|Drug: placebo Seizures|Pneumococcal Meningitis M. Carmen Cabellos Minguez|Hospital Universitari de Bellvitge|Hospital Vall d''Hebron|Germans Trias i Pujol Hospital|Hospital Clinic of Barcelona|Fundació Institut de Recerca de l''Hospital de la Santa Creu i Sant Pau|Hospitales Universitarios Virgen del Rocío|Hospital Universitario La Paz|Hospital Universitario Ramon y Cajal|Hospital Juan Canalejo|Hospital Mutua de Terrassa|Hospital Universitario Virgen Macarena November 2011 Phase 4
NCT01122940 Completed Drug: Epamin: Reference Drug|Drug: Phenytoin: Study Drug Healthy Pfizer''s Upjohn has merged with Mylan to form Viatris Inc.|Pfizer July 2010 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Phenytoin | Phenytoin ic50 | Phenytoin price | Phenytoin cost | Phenytoin solubility dmso | Phenytoin purchase | Phenytoin manufacturer | Phenytoin research buy | Phenytoin order | Phenytoin mouse | Phenytoin chemical structure | Phenytoin mw | Phenytoin molecular weight | Phenytoin datasheet | Phenytoin supplier | Phenytoin in vitro | Phenytoin cell line | Phenytoin concentration | Phenytoin nmr