For research use only.

Catalog No.S2525 Synonyms: Diphenylhydantoin

Phenytoin Chemical Structure

CAS No. 57-41-0

Phenytoin (Diphenylhydantoin) is an inactive voltage-gated sodium channel stabilizer.

Purity & Quality Control

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Biological Activity

Description Phenytoin (Diphenylhydantoin) is an inactive voltage-gated sodium channel stabilizer.
Sodium channel [1]


Solubility (25°C)

In vitro DMSO 50 mg/mL (198.2 mM)
Ethanol 13 mg/mL (51.53 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 252.27


CAS No. 57-41-0
Storage powder
in solvent
Synonyms Diphenylhydantoin
Smiles C1=CC=C(C=C1)C2(C(=O)NC(=O)N2)C3=CC=CC=C3

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

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    C4=C3/X C4: LOG(C4):
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Molecular Weight Calculator

Molecular Weight Calculator

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04647877 Recruiting Drug: phenytoin cream|Other: Placebo cream Chronic Idiopathic Axonal Polyneuropathy David J. Kopsky|Princess Beatrix Muscle Foundation|Dr. C.J. Vaillant Fonds|UMC Utrecht September 17 2020 Phase 2|Phase 3
NCT04829838 Recruiting Drug: intravenous levetireacetam Status Epilepticus ayesha tariq|King Edward Medical University July 25 2019 Phase 4
NCT01635829 Completed Drug: Telaprevir|Drug: Phenytoin|Drug: Carbamazepine Healthy Participants Janssen Infectious Diseases BVBA May 2012 Phase 1
NCT01478035 Unknown status Drug: Phenytoin|Drug: placebo Seizures|Pneumococcal Meningitis M. Carmen Cabellos Minguez|Hospital Universitari de Bellvitge|Hospital Vall d''Hebron|Germans Trias i Pujol Hospital|Hospital Clinic of Barcelona|Fundació Institut de Recerca de l''Hospital de la Santa Creu i Sant Pau|Hospitales Universitarios Virgen del Rocío|Hospital Universitario La Paz|Hospital Universitario Ramon y Cajal|Hospital Juan Canalejo|Hospital Mutua de Terrassa|Hospital Universitario Virgen Macarena November 2011 Phase 4
NCT01122940 Completed Drug: Epamin: Reference Drug|Drug: Phenytoin: Study Drug Healthy Pfizer''s Upjohn has merged with Mylan to form Viatris Inc.|Pfizer July 2010 Phase 1

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Sodium Channel Signaling Pathway Map

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