Phenytoin

For research use only.

Catalog No.S2525 Synonyms: Diphenylhydantoin

Phenytoin Chemical Structure

CAS No. 57-41-0

Phenytoin (Diphenylhydantoin) is an inactive voltage-gated sodium channel stabilizer.

Purity & Quality Control

Choose Selective Sodium Channel Inhibitors

Biological Activity

Description Phenytoin (Diphenylhydantoin) is an inactive voltage-gated sodium channel stabilizer.
Targets
Sodium channel [1]

Protocol

Solubility (25°C)

In vitro DMSO 50 mg/mL (198.2 mM)
Ethanol 13 mg/mL (51.53 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 252.27
Formula

C15H12N2O2

CAS No. 57-41-0
Storage powder
in solvent
Synonyms Diphenylhydantoin
Smiles C1=CC=C(C=C1)C2(C(=O)NC(=O)N2)C3=CC=CC=C3

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04647877 Recruiting Drug: phenytoin cream|Other: Placebo cream Chronic Idiopathic Axonal Polyneuropathy David J. Kopsky|Princess Beatrix Muscle Foundation|Dr. C.J. Vaillant Fonds|UMC Utrecht September 17 2020 Phase 2|Phase 3
NCT04829838 Recruiting Drug: intravenous levetireacetam Status Epilepticus ayesha tariq|King Edward Medical University July 25 2019 Phase 4
NCT01635829 Completed Drug: Telaprevir|Drug: Phenytoin|Drug: Carbamazepine Healthy Participants Janssen Infectious Diseases BVBA May 2012 Phase 1
NCT01478035 Unknown status Drug: Phenytoin|Drug: placebo Seizures|Pneumococcal Meningitis M. Carmen Cabellos Minguez|Hospital Universitari de Bellvitge|Hospital Vall d''Hebron|Germans Trias i Pujol Hospital|Hospital Clinic of Barcelona|Fundació Institut de Recerca de l''Hospital de la Santa Creu i Sant Pau|Hospitales Universitarios Virgen del Rocío|Hospital Universitario La Paz|Hospital Universitario Ramon y Cajal|Hospital Juan Canalejo|Hospital Mutua de Terrassa|Hospital Universitario Virgen Macarena November 2011 Phase 4
NCT01122940 Completed Drug: Epamin: Reference Drug|Drug: Phenytoin: Study Drug Healthy Pfizer''s Upjohn has merged with Mylan to form Viatris Inc.|Pfizer July 2010 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Sodium Channel Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID