For research use only.

Catalog No.S2525 Synonyms: Diphenylhydantoin

Phenytoin Chemical Structure

Molecular Weight(MW): 252.27

Phenytoin is an inactive voltage-gated sodium channel stabilizer.

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10mM (1mL in DMSO) USD 130 In stock
USD 97 In stock
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Biological Activity

Description Phenytoin is an inactive voltage-gated sodium channel stabilizer.
Sodium channel [1]


Solubility (25°C)

In vitro DMSO 50 mg/mL (198.2 mM)
Ethanol 13 mg/mL (51.53 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 252.27


CAS No. 57-41-0
Storage powder
in solvent
Synonyms Diphenylhydantoin
Smiles O=C1NC(=O)C(N1)(C2=CC=CC=C2)C3=CC=CC=C3

In vivo Formulation Calculator (Clear solution)

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Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01635829 Completed Drug: Telaprevir|Drug: Phenytoin|Drug: Carbamazepine Healthy Participants Janssen Infectious Diseases BVBA May 2012 Phase 1
NCT01478035 Unknown status Drug: Phenytoin|Drug: placebo Seizures|Pneumococcal Meningitis M. Carmen Cabellos Minguez|Hospital Universitari de Bellvitge|Hospital Vall d''Hebron|Germans Trias i Pujol Hospital|Hospital Clinic of Barcelona|Fundació Institut de Recerca de l''Hospital de la Santa Creu i Sant Pau|Hospitales Universitarios Virgen del Rocío|Hospital Universitario La Paz|Hospital Universitario Ramon y Cajal|Hospital Juan Canalejo|Hospital Mutua de Terrassa|Hospital Universitario Virgen Macarena November 2011 Phase 4
NCT01122940 Completed Drug: Epamin: Reference Drug|Drug: Phenytoin: Study Drug Healthy Pfizer July 2010 Phase 1
NCT01187719 Completed Drug: phenytoin HIV-infection|Pregnancy|Mother to Child Transmission Radboud University May 2010 Phase 2
NCT01586208 Completed Drug: valproic acid (VPA) Grand Mal Status Epilepticus|Non-convulsive Status Epilepticus Hospital Universitari de Bellvitge|Hospital Vall d''Hebron|Germans Trias i Pujol Hospital|Institut d''Investigació Biomèdica de Girona Dr. Josep Trueta|Hospital Clinic of Barcelona January 2010 Phase 3
NCT00823264 Completed Drug: Activated Charcoal Phenytoin Toxicity Emory University August 2008 Not Applicable

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Sodium Channel Signaling Pathway Map

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