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Phenytoin

Name: Phenytoin
Brand: Selleck Chemicals
SKU: S2525
Rating: 5 (2 reviews)

Synonyms: Di-Hydan, Dihycon, Dilabid, Diphedan, Diphenat, Diphenylan, Diphenylhydantoin, Hydantol, Lehydan, NSC 8722

Catalog No.S2525 Purity: 99.91%

Phenytoin (Di-Hydan, Dihycon, Dilabid, Diphedan, Diphenat, Diphenylan, Diphenylhydantoin, Hydantol, Lehydan, NSC 8722) is an inactive voltage-gated sodium channel stabilizer.

Phenytoin Chemical Structure

CAS: 57-41-0

Selleck's Phenytoin has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 99.91%

99.91

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Signaling Pathway

Sodium Channel Signaling Pathway

Choose Selective Sodium Channel Inhibitors

Biological Activity

Description

Phenytoin (Di-Hydan, Dihycon, Dilabid, Diphedan, Diphenat, Diphenylan, Diphenylhydantoin, Hydantol, Lehydan, NSC 8722) is an inactive voltage-gated sodium channel stabilizer.

Targets

Sodium channel ^[1]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT06067412	Completed	Status Epilepticus	Shaheed Zulfiqar Ali Bhutto Medical University	August 1 2022	Not Applicable
NCT04647877	Completed	Chronic Idiopathic Axonal Polyneuropathy	David J. Kopsky\|Princess Beatrix Muscle Foundation\|Dr. C.J. Vaillant Fonds\|UMC Utrecht	September 17 2020	Phase 2\|Phase 3
NCT04829838	Unknown status	Status Epilepticus	ayesha tariq\|King Edward Medical University	July 25 2019	Phase 4
NCT01635829	Completed	Healthy Participants	Janssen Infectious Diseases BVBA	May 2012	Phase 1
NCT01478035	Terminated	Seizures\|Pneumococcal Meningitis	M. Carmen Cabellos Minguez\|Hospital Universitari de Bellvitge\|Hospital Vall d''Hebron\|Germans Trias i Pujol Hospital\|Hospital Clinic of Barcelona\|Fundació Institut de Recerca de l''Hospital de la Santa Creu i Sant Pau\|Hospitales Universitarios Virgen del Rocío\|Hospital Universitario La Paz\|Hospital Universitario Ramon y Cajal\|Hospital Juan Canalejo\|Hospital Mutua de Terrassa\|Hospital Universitario Virgen Macarena	November 2011	Phase 4

References

[1] Rogawski MA, et al. Nat Rev Neurosci,2004,5(7):553-64.

Chemical Information & Solubility

Molecular Weight	252.27	Formula	C₁₅H₁₂N₂O₂
CAS No.	57-41-0	SDF	Download Phenytoin SDF
Smiles	C1=CC=C(C=C1)C2(C(=O)NC(=O)N2)C3=CC=CC=C3
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 50 mg/mL ( (198.2 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 13 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
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