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Phenytoin Sodium Channel inhibitor

Name: Phenytoin
Brand: Selleck Chemicals
SKU: S2525
Availability: InStock
Rating: 5 (4 reviews)

Cat.No.S2525

Phenytoin (Di-Hydan, Dihycon, Dilabid, Diphedan, Diphenat, Diphenylan, Diphenylhydantoin, Hydantol, Lehydan, NSC 8722) is an inactive voltage-gated sodium channel stabilizer.

Phenytoin Sodium Channel inhibitor Chemical Structure

Quality Control

Batch: Purity: 99.91%

99.91

Related Targets	CFTR CRM1 CD markers AChR Calcium Channel Potassium Channel GABA Receptor TRP Channel ATPase GluR
Other Sodium Channel Inhibitors	Camostat Mesilate A-803467 cariporide GS967 Veratramine Tolperisone HCl Bulleyaconi cine A Vinpocetine Tenapanor PF-06869206

Solubility

In vitro
Batch:

DMSO : 50 mg/mL (198.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 13 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	2.5mg/ml (9.91mM)	Taking the 1 mL working solution as an example, add 50 μL of 50 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.16mg/ml (0.63mM)	Taking the 1 mL working solution as an example, add 50 μL of 3.2 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	252.27	Formula	C₁₅H₁₂N₂O₂	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	57-41-0	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Di-Hydan, Dihycon, Dilabid, Diphedan, Diphenat, Diphenylan, Diphenylhydantoin, Hydantol, Lehydan, NSC 8722			SMILES	C1=CC=C(C=C1)C2(C(=O)NC(=O)N2)C3=CC=CC=C3

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC₅₀/Ki	Sodium channel
References	[1] https://pubmed.ncbi.nlm.nih.gov/15208697/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-04-21)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT00162474	RECRUITING	Healthy	Hadassah Medical Organization	2003-09
NCT03778996	ACTIVE_NOT_RECRUITING	Sarcoma, Ewing; Sarcoma	Sarcoma Oncology Research Center, LLC	2020-01-03	PHASE2
NCT07590375	NOT_YET_RECRUITING	Gingival Recession	Cairo University	2026-06-01	PHASE2; PHASE3
NCT07072624	RECRUITING	Seizures; Traumatic Brain Injuries; Traumatic Brain Injury (TBI) Patients	All India Institute of Medical Sciences, Jodhpur	2025-07-23	PHASE4
NCT05637086	RECRUITING	Epilepsy	Mostafa Bahaa	2022-12-20	PHASE2
NCT07783503	NOT_YET_RECRUITING	Healthy Participants	Novartis Pharmaceuticals	2026-08-27	PHASE1

Tech Support

Handling Instructions

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