Dronedarone HCl

For research use only.

Catalog No.S2114 Synonyms: SR33589

2 publications

Dronedarone HCl Chemical Structure

CAS No. 141625-93-6

Dronedarone HCl (SR33589) is a multichannel blocker targeting potassium channel, sodium channel and calcium channel, used as an antiarrhythmic drug for treatment of atrial fibrillation (AF).

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10mM (1mL in DMSO) USD 130 In stock
USD 97 In stock
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Selleck's Dronedarone HCl has been cited by 2 publications

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  • Results of hit validation experiments for these four compounds for animals treated at L1 stage at four different concentrations (0.5, 5, 25, and 50 μM). The blue bars represent the values obtained from the original screen as reference points. Error bars are standard error of the mean. Statistical significance for all different doses for individual compounds was calculated with respect to the lowest concentration using two-tailed, t-test (nZ70 animals except n = 37 for Geld 25 μM). The statistical significance values are represented as P<0.05 (*) and P<0.005 (**).

    Nat Commun. 2016, 7:13023. Dronedarone HCl purchased from Selleck.

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Biological Activity

Description Dronedarone HCl (SR33589) is a multichannel blocker targeting potassium channel, sodium channel and calcium channel, used as an antiarrhythmic drug for treatment of atrial fibrillation (AF).
Potassium channel [1] Sodium channel [1] Calcium channel [1]
In vitro

Dronedarone reduces the incidence of early and delayed after depolarizations evoked by 1 mM Dofetilide and 0.2 mM Strophantidine in Purkinje fibres. Dronedarone (10 mM) markedly reduces the L-type calcium current (76.5%) and the rapid component of the delayed rectifier potassium current (97%) in ventricular myocytes. [1] Dronedarone inhibits the activity of I(K(ACh)) channels recorded from cell-attached patches by reducing the channel open probability (from 0.56 to 0.11) without modification of the single-channel conductance in single cells isolated from sinoatrial node (SAN) tissue of rabbit hearts. [2] Dronedarone exhibits a state-dependent inhibition of the fast Na(+) channel current with an IC50 of 0.7 μM in guinea pig ventricular myocytes, when the holding potential (V (hold)) is -80 mV. Dronedarone blocks Ca(2+) currents elicited by rectangular pulses at V (hold) = -40 mV with IC50 value of 0.4 μM, whereas at V (hold) = -80 mV, Dronedarone (10 μM) blocks only 20 % of the current. [3]

In vivo Dronedarone increases action potential duration in normal hearts of rats. Dronedarone reduces the late sustained K(+) current, I(K) (or Isus) by 69%. Dronedarone induces only a tonic block of I(K). Dronedarone induces a weak increase in the fast transient outward current, I(to), in rats after myocardial infarction. [4]


Solubility (25°C)

In vitro DMSO 80 mg/mL (134.85 mM)
Water Insoluble
Ethanol '40 mg/mL

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Chemical Information

Molecular Weight 593.22


CAS No. 141625-93-6
Storage powder
in solvent
Synonyms SR33589

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01430806 Unknown status Drug: Dronedarone arm|Drug: Dronedarone ICD|ICD SHOCKS|DRONEDARONE Rabin Medical Center October 2011 Not Applicable
NCT01266681 Unknown status Drug: amiodarone|Drug: Dronedarone Atrial Fibrillation Eastbourne General Hospital March 2011 Not Applicable
NCT01199081 Completed Drug: Dronedarone Atrial Fibrillation Sanofi October 2010 Phase 4
NCT01213368 Completed Drug: DRONEDARONE (SR33589)|Drug: placebo Atrial Fibrillation Sanofi September 2010 Phase 2
NCT01140581 Completed Drug: DRONEDARONE Atrial Fibrillation Sanofi September 2010 Phase 4

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Potassium Channel Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID