Eslicarbazepine Acetate

Catalog No.S4657 Synonyms: BIA 2093, Zebinix, Exalief, Stedesa, Aptiom

For research use only.

Eslicarbazepine Acetate (BIA 2093, Zebinix, Exalief, Stedesa, Aptiom), an antiepileptic drug, is a dual a dual Inhibitor of β-Secretase and voltage-gated sodium channel.

Eslicarbazepine Acetate Chemical Structure

CAS No. 236395-14-5

Purity & Quality Control

Choose Selective BACE Inhibitors

Biological Activity

Description Eslicarbazepine Acetate (BIA 2093, Zebinix, Exalief, Stedesa, Aptiom), an antiepileptic drug, is a dual a dual Inhibitor of β-Secretase and voltage-gated sodium channel.
In vivo Eslicarbazepine acetate(ESL) has Anticonvulsant effects on the development of latrunculin A-induced seizures and paroxysmal EEG activity. ESL may also exhibit disease-modifying effects beyond suppressing just seizure activity, possibly by altering the development of a hyperexcitable network, as evidenced by the suppressed changes in glycine, taurine, glutamate and aspartate concentrations associated with an antiepileptogenic effect[1].

Protocol (from reference)

Animal Research:[1]
  • Animal Models: Adult NMRI or Swiss male mice
  • Dosages: 100 mg/kg
  • Administration: Oral administration

Solubility (25°C)

In vitro

DMSO 59 mg/mL
(199.1 mM)
Ethanol 11 mg/mL
(37.12 mM)
Water Insoluble

Chemical Information

Molecular Weight 296.32
Formula

C17H16N2O3

CAS No. 236395-14-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(=O)OC1CC2=CC=CC=C2N(C3=CC=CC=C13)C(=O)N

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Eslicarbazepine Acetate | Eslicarbazepine Acetate ic50 | Eslicarbazepine Acetate price | Eslicarbazepine Acetate cost | Eslicarbazepine Acetate solubility dmso | Eslicarbazepine Acetate purchase | Eslicarbazepine Acetate manufacturer | Eslicarbazepine Acetate research buy | Eslicarbazepine Acetate order | Eslicarbazepine Acetate mouse | Eslicarbazepine Acetate chemical structure | Eslicarbazepine Acetate mw | Eslicarbazepine Acetate molecular weight | Eslicarbazepine Acetate datasheet | Eslicarbazepine Acetate supplier | Eslicarbazepine Acetate in vitro | Eslicarbazepine Acetate cell line | Eslicarbazepine Acetate concentration | Eslicarbazepine Acetate nmr