Quinidine sulfate

Catalog No.S3751 Synonyms: Chinidin Sodium, Pitayine Sodium, β-quinine Sodium, (+)-quinidine Sodium

Quinidine sulfate Chemical Structure

Molecular Weight(MW): 648.83

Quinidine acts as a blocker of voltage-gated sodium channels, also an antimuscarinic and antimalarial.

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Biological Activity

Description Quinidine acts as a blocker of voltage-gated sodium channels, also an antimuscarinic and antimalarial.
Targets
Sodium channel [1]
()
In vitro

Quinidine selectively reduces the proliferation of merlin-deficient HMM cell lines by causing a G0/G1 arrest, whereas the proliferation rates of merlinexpressing HMM cell lines remain unchanged. In addtion to its function as a channel blocker, quinidine is an inhibitor of a specific isoform of the cytochrome P450 family (CYP2D6), which is involved in the detoxification and metabolism of multiple commonly prescribed drugs as well as numerous endogenous substrates[1].

In vivo Quinidine is a potent and selective inhibitor of P450db and that quinidine can inhibit the in vivo metabolism of debrisoquine in humans. Quinidine is an inhibitor of amphetamine metabolism in vivo[2].

Protocol

Cell Research:

[1]

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  • Cell lines: HMM cell lines HIB, and TRA
  • Concentrations: 2.5, 5, 10, 25 μM
  • Incubation Time: 4 days
  • Method:

    Cells were cultured on T25 cm2 flasks in the presence of different concentrations of quinidine for 4 days. Bromodeoxyuridine was added for 8.5 hours, after which cells were trypsinized and spun down for 10 minutes at 1500 revolutions per minute. Cells were washed twice in 1% BSA/phosphate-buffered saline (PBS) and fixed with 70% ethanol on ice. DNA was denatured by 2N HCl/Triton X100 at room temperature for 30 minutes and sodium tetraborate was added to neutralize the pH level. After centrifugation, cells were resuspended in 1% BSA/0.5% Tween 20/PBS and the cell concentration was adjusted to 1 x 106 cells per test.


    (Only for Reference)
Animal Research:

[2]

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  • Animal Models: Lewis rats
  • Formulation: 50% ethanol
  • Dosages: 80 mg/kg
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (154.12 mM)
Ethanol 100 mg/mL (154.12 mM)
Water 9 mg/mL (13.87 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 648.83
Formula

C40H48N4O4.H2SO4.2H2O

CAS No. 6591-63-5
Storage powder
in solvent
Synonyms Chinidin Sodium, Pitayine Sodium, β-quinine Sodium, (+)-quinidine Sodium

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID