Home Transmembrane Transporters Sodium Channel inhibitor Quinidine hemisulfate hydrate

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Quinidine hemisulfate hydrate Sodium Channel inhibitor

Cat.No.S3751

Quinidine hemisulfate hydrate(Chinidin, Pitayine, β-quinine, (+)-quinidine) acts as a blocker of voltage-gated sodium channels, also an antimuscarinic and antimalarial.
Quinidine hemisulfate hydrate Sodium Channel inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 391.47

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Chemical Information, Storage & Stability

Molecular Weight 391.47 Formula

C20H24N2O2.1/2H2SO4.H2O

 Storage (From the date of receipt)
CAS No. 6591-63-5 Download SDF Storage of Stock Solutions

Synonyms Chinidin Sodium, Pitayine Sodium, β-quinine Sodium, (+)-quinidine Sodium Smiles COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.O.O.OS(=O)(=O)O

Mechanism of Action

Targets/IC50/Ki
Sodium channel
In vitro

Quinidine selectively reduces the proliferation of merlin-deficient HMM cell lines by causing a G0/G1 arrest, whereas the proliferation rates of merlinexpressing HMM cell lines remain unchanged. In addtion to its function as a channel blocker, quinidine is an inhibitor of a specific isoform of the cytochrome P450 family (CYP2D6), which is involved in the detoxification and metabolism of multiple commonly prescribed drugs as well as numerous endogenous substrates.
In vivo

Quinidine is a potent and selective inhibitor of P450db and that quinidine can inhibit the in vivo metabolism of debrisoquine in humans. Quinidine is an inhibitor of amphetamine metabolism in vivo.
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