Quinidine sulfate

For research use only.

Catalog No.S3751 Synonyms: Chinidin Sodium, Pitayine Sodium, β-quinine Sodium, (+)-quinidine Sodium

Quinidine sulfate Chemical Structure

Molecular Weight(MW): 648.83

Quinidine acts as a blocker of voltage-gated sodium channels, also an antimuscarinic and antimalarial.

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Biological Activity

Description Quinidine acts as a blocker of voltage-gated sodium channels, also an antimuscarinic and antimalarial.
Sodium channel [1]
In vitro

Quinidine selectively reduces the proliferation of merlin-deficient HMM cell lines by causing a G0/G1 arrest, whereas the proliferation rates of merlinexpressing HMM cell lines remain unchanged. In addtion to its function as a channel blocker, quinidine is an inhibitor of a specific isoform of the cytochrome P450 family (CYP2D6), which is involved in the detoxification and metabolism of multiple commonly prescribed drugs as well as numerous endogenous substrates[1].

In vivo Quinidine is a potent and selective inhibitor of P450db and that quinidine can inhibit the in vivo metabolism of debrisoquine in humans. Quinidine is an inhibitor of amphetamine metabolism in vivo[2].


Cell Research:


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  • Cell lines: HMM cell lines HIB, and TRA
  • Concentrations: 2.5, 5, 10, 25 μM
  • Incubation Time: 4 days
  • Method:

    Cells were cultured on T25 cm2 flasks in the presence of different concentrations of quinidine for 4 days. Bromodeoxyuridine was added for 8.5 hours, after which cells were trypsinized and spun down for 10 minutes at 1500 revolutions per minute. Cells were washed twice in 1% BSA/phosphate-buffered saline (PBS) and fixed with 70% ethanol on ice. DNA was denatured by 2N HCl/Triton X100 at room temperature for 30 minutes and sodium tetraborate was added to neutralize the pH level. After centrifugation, cells were resuspended in 1% BSA/0.5% Tween 20/PBS and the cell concentration was adjusted to 1 x 106 cells per test.

    (Only for Reference)
Animal Research:


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  • Animal Models: Lewis rats
  • Dosages: 80 mg/kg
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (154.12 mM)
Ethanol 100 mg/mL (154.12 mM)
Water 9 mg/mL (13.87 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 648.83


CAS No. 6591-63-5
Storage powder
in solvent
Synonyms Chinidin Sodium, Pitayine Sodium, β-quinine Sodium, (+)-quinidine Sodium

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Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID