QX-314 chloride

Catalog No.S7848

For research use only.

QX-314 chloride directly activates and permeates the human isoforms of TRPV1 and TRPA1 to induce inhibition of sodium channels.

QX-314 chloride Chemical Structure

CAS No. 5369-03-9

Purity & Quality Control

Choose Selective TRP Channel Inhibitors

Biological Activity

Description QX-314 chloride directly activates and permeates the human isoforms of TRPV1 and TRPA1 to induce inhibition of sodium channels.
Targets
TRPV1 [1] TRPA1 [1] sodium channel [1]
In vitro

As a sodium channel blocker, QX-314 chloride exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels (TRPV1) in a concentration-dependent manner. QX-314 chloride (10 mM) inhibits calcium currents in hippocampal CA1 pyramidal neurons intracellular, and the low-threshold (T-type) Ca<sup>2+</sup> currents are on average <45% of control amplitude.<sup><a class="sref"href="#s_ref">[1]</a></sup> <sup><a class="sref"href="#s_ref">[2]</a></sup>

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 298.85
Formula

C16H27ClN2O

CAS No. 5369-03-9
Storage 3 years -20°C powder
2 years -80°C in solvent

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