PF-3644022

Catalog No.S8224

For research use only.

PF-3644022 is a potent freely reversible ATP-competitive inhibitor of MAPKAPK2 (MK2) with an Ki of 3 nM. PF-3644022 also potently inhibits TNFα production with an IC50 of 160 nM.

PF-3644022 Chemical Structure

CAS No. 1276121-88-0

Purity & Quality Control

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Biological Activity

Description

PF-3644022 is a potent freely reversible ATP-competitive inhibitor of MAPKAPK2 (MK2) with an Ki of 3 nM. PF-3644022 also potently inhibits TNFα production with an IC50 of 160 nM.

Targets
MK2 [1]
()
TNFα [1]
()
3 nM(Ki) 160 nM

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 75 mg/mL
(200.28 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 374.46
Formula

C21H18N4OS

CAS No. 1276121-88-0
Storage 3 years -20°C powder
2 years -80°C in solvent

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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