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Quercetin (Sophoretin) Flavonoid Antioxidant

Cat.No.S2391

Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Quercetin induces mitophagy, apoptosis and protective autophagy. Phase 4.

Quercetin (Sophoretin) PI3K inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 302.24

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Quality Control

Batch: Purity: 99.01%

99.01

Related Targets	Akt mTOR GSK-3 ATM/ATR DNA-PK AMPK PDPK1 PTEN PI4K PP2A
Other PI3K Inhibitors	GDC-0077 (Inavolisib) SAR405 LY294002 XL147 analogue Tersolisib (STX-478) Buparlisib (BKM120) 740 Y-P (PDGFR 740Y-P) GO-203 TFA Eganelisib (IPI-549) Paxalisib (GDC-0084)

Solubility in DMSO or Water

In vitro
Batch:

DMSO : 60 mg/mL (198.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

The solubility data above are all experimental results (not literature values).

DMSO : 61 mg/mL (201.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 20 mg/mL

Water : Insoluble

The solubility data above are all experimental results (not literature values).

DMSO : 60 mg/mL (198.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 8 mg/mL

Water : Insoluble

The solubility data above are all experimental results (not literature values).

DMSO : 60 mg/mL (198.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 4 mg/mL

Water : Insoluble

The solubility data above are all experimental results (not literature values).

DMSO : 60 mg/mL (198.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 60 mg/mL

Water : Insoluble

The solubility data above are all experimental results (not literature values).

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	3.000mg/ml (9.93mM)	Taking the 1 mL working solution as an example, add 50 μL of 60 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	7.500mg/ml (24.81mM)	Taking the 1 mL working solution as an example, add 50 μL of 150 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	3.000mg/ml (9.93mM)	Taking the 1 mL working solution as an example, add 50 μL of 60 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

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%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Read more about Quercetin (Sophoretin) solubility in DMSO or water

Search directly for a cell line, or select a cell line to find matched working concentrations

Read more about Quercetin (Sophoretin) working concentrations for cell culture treatment

Quercetin (Sophoretin) is a potent inhibitor of HIV protease (58.8 µM), Mpro of SARS-CoV-1 (19180 nM), 15-LOX enzyme (61.82±5.5 µg/mL), CaMKIV (61.3 μM), HER2 kinase (570.07 nmol/L), Adenosine Deaminase (commercial enzyme) (55.6 μM), HUVEC protein extracts (20.0 μM), Xanthine Oxidase (commercial enzyme) (3.0 μM), Purine Nucleoside Phosphorylase (commercial enzyme) (36.9 μM), CD39 (commercial enzyme) (0.57 μM), CD73 (commercial enzyme) (1.7 μM), SARS-CoV-2 Mpro (21 µM), Chemical radical scavenging system (172.13 ± 76.03 mM), recombinant human ACE2 (4.48 µM), Soybean 15-LOX enzyme (3.34mM), recombinant catalytic subunit of PI3K (human recombinant PI3K-γ (His tagged)) (14 µM), Xanthine Oxidase (6.45 ±0.26 µM), Cell-free system (0.60 ± 0.02 μM), AChE (1.22 ± 0.79 mM), BChE (2.51 ± 0.04 mM), Candida parapsilosis complex (0.5 - 16 µg/mL), Recombinant human CYP3A4.1 (17.59 ± 1.01 μM), Recombinant human CYP3A4.33 (54.51 ± 1.35 μM), Pim-1 kinase (1.31 µM), soybean 15-lipoxygenase (12.35 µg/mL), PD-1/PD-L1 interaction (29.93 mgm L−1), ACE2 (104.79 ± 8.26 μM), hPTP1B 1-400 (87.1 μM), Soybean 15-LOX (18.72 µg/mL (61.94 µM)), sBACE1 (4.89 μM), SARS-CoV 3CLpro (52.7 mM), Na+/K+-ATPase (>1000 µM), PTP1B (0.38 μg/ml), DPP4 (0.01 μM). Quercetin (Sophoretin) exhibits the greatest inhibitory potency toward DPP4 (IC50 = 10 nM).

Read more about selectivity & specificity.

Mechanism of Action

Information	Quercetin is a potent multi-target inhibitor. It affects PI3K and NF-κB pathways by scavenging ROS, inhibiting inflammation.
Read more about Quercetin (Sophoretin) IC50 for cell-based and cell-free assays
Primary Applications and Mechanism of Action

Read more about Quercetin (Sophoretin) Mechanism of Action Clinical Trials

Chemical Information, Storage & Stability

Molecular Weight	302.24	Formula	C₁₅H₁₀O₇	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	117-39-5	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Read more about storage stability stock solution CAS number

Read more comparative analysis about Quercetin (Sophoretin)

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Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

Serial Dilutions

Concentration (start):

Dilution-folds:

Computed Result

C1=C0/X	C1:		LOG(C1):
C2=C1/X	C2:		LOG(C2):
C3=C2/X	C3:		LOG(C3):
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C8=C7/X	C8:		LOG(C8):