Genistein

For research use only.

Catalog No.S1342

7 publications

Genistein Chemical Structure

Molecular Weight(MW): 270.24

Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM.

Size Price Stock Quantity  
10mM (1mL in DMSO) USD 90 In stock
USD 70 In stock
USD 110 In stock
USD 170 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Purity & Quality Control

Choose Selective EGFR Inhibitors

Biological Activity

Description Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM.
Targets
EGFR [1] topo II [1]
In vitro

Genistein is an ATP competitive inhibitor. Genistein inhibits tyrosine phosphorylation in isolated enzyme and receptor preparations and in whole cells including platelets, lymphocytes and a variety of cultured cells. It also inhibits EGF-stimulated phosphorylation in cultured cells as well as inhibition of Topo II (topoisomerase II). Genistein inhibits EGF-stimulated tyrosine phosphorylation in cultured A431 epidermoid carcinoma cells. Inhibition is competitive with ATP and noncompetitive with substrate. [1] Genistein blocks the mitogenic effect mediated by EGF, insulin and thrombin on NIH-3T3 cells.[2] Genistein also acts as an agonist at the GPR30 receptor and binds to PPARγ and estrogen receptors. Genistein also binds to PPARγ, acting as an agonist at this receptor with Ki of 5.7 μM. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
293T cells MYDGeY5kfGmxbjDhd5NigQ>? MWHEbZNxdGGlZX3lcpQhd2ZiW{PIYVE4[mW2YT3ld5Rz[WSrb3yg[pJwdSC{ZXPvcYJqdmGwdDDoeY1idiCHUnLleIEh\XiycnXzd4VlKGmwIEK5N3Qh[2WubIOsJGlEPTB;MD6wNFE{KM7:TR?= MVqxOlIyQTR4Mx?=
HeLa cells NXXxc2Z1TnWwY4Tpc44h[XO|YYm= MXLBZ5RqfmG2aX;uJI9nKGW|dILv[4VvKHKnc4DvcpNmKGWuZX3lcpQhcW5iSHXMZUBk\WyuczDzeIFjdHlidILhcpNn\WO2ZXSge4l1cCCqdX3hckBGe3S{b3flckBz\WOncITvdkBj\XSjLDDFR|UxRTBwMEC0NUDPxE1? NF;zdo4yOTlyNkK4NC=>
human Ishikawa cells MoLNSpVv[3Srb36gZZN{[Xl? NHT5[Ww1KGSjeYO= MmrkSZN1em:pZX7pZ{Bi[3Srdnn0fUBqdiCqdX3hckBKe2ira3H3ZUBk\WyuczDhd5Nme3OnZDDhd{BqdmS3Y4Tpc44hd2ZiYXzrZYxqdmVicHjvd5Bp[XSjc3WgZYN1cX[rdImgZYZ1\XJiNDDkZZl{KGK7IIDhdoEudmm2cn;wbIVvd2xicnXs[YF{\SCjc4PhfUwhUUN3ME2wMlUyKM7:TR?= NGPDUIUyOjVyMkOwOy=>
human MCF7 cells NGi4[o1EgXSxdH;4bYPDqGG|c3H5 NX;Hdox1PDhiaB?= NF2zcHdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUC9NUDPxE1? MkT6NlA5OTN3MkS=
NIH3T3 cells NGjudFFHfW6ldHnvckBie3OjeR?= NVfXNJplSWexbnnzeEBi[3Srdnn0fUBifCCFRmTSMYRmdHSjRkWwPEBufXSjboSg[ZhxemW|c3XkJIlvKE6LSEPUN{Bk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCob4Lzb49tcW5vc4TpcZVt[XSnZDDjeZJz\W62LDDFR|UxRTRwNDFOwG0> NFv0cWEyQDV7NU[5Oi=>
human HL60 cells M4q3PWZ2dmO2aX;uJIF{e2G7 NVj4WZoyOjRiaB?= NWq0bGZmSW62aXzleYtmdWmlIHHjeIl3cXS7IHHnZYlve3RiaIXtZY4hUEx4MDDj[YxteyCjZoTldkAzPCCqcoOgZpkh[2yxbn;n[Y5q[yCjc4PhfUwhVEN3ME22MlMh|ryP NYPhVoZWOThzNkO1PFk>
mouse L1210 cells M4DCRmZ2dmO2aX;uJIF{e2G7 M4rqOFI1KGh? M4\zTGFvfGmuZYXr[Y1q[yCjY4Tpeol1gSCjZ3HpcpN1KG2xdYPlJGwyOjFyIHPlcIx{KGGodHXyJFI1KGi{czDifUBkdG:wb3flcolkKGG|c3H5MEBNSzVyPU[uOUDPxE1? NUjIRlBoOThzNkO1PFk>
MDCK cells  M37me2Z2dmO2aX;uJIF{e2G7 MkPuTY5pcWKrdHnvckBw\iCEQ2LQJIV5eHKnc4Pl[EBqdiCPRFPLJINmdGy|IIXzbY5oKEixZXPod5QhOzN|NEKgd5RicW6rbnesJGlEPTB;Nj65JO69VQ>? MYiyNVM2PDhyMB?=
human MOLT3 cells NGnIfHZHfW6ldHnvckBie3OjeR?= M3XIWFI1KGh? M3TsPWFvfGmuZYXr[Y1q[yCjY4Tpeol1gSCjZ3HpcpN1KGi3bXHuJG1QVFR|IHPlcIx{KGGodHXyJFI1KGi{czDifUBkdG:wb3flcolkKGG|c3H5MEBNSzVyPUeuOUDPxE1? M2LheVE5OTZ|NUi5
ANN-1 cells NYr3coZ[S3m2b4TvfIlkyqCjc4PhfS=> Mnq3R5l1d3SxeHnjJIVn\mWldDDvckB3NWGkbDD0doFve2[xcn3l[EBufXKrbnWgRW5PNTFiY3XscJMtKEmFNUC9PEDPxE1? MV:4NlAyPjB|
human MCF7 cells NXf3SXN7WHKxbHnm[ZJifGmxbjDhd5NigQ>? NEf0Uo9CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIV{fHKxZ3XuJJJm[2WydH;yJIV5eHKnc4PpcochcHWvYX6gUWNHPyClZXzsd{whT0l3ME2xNEDPxE1? MVKxPVgyQDZzMh?=
human Raji cells NH:w[IhHfW6ldHnvckBie3OjeR?= M1nsS|I1KGh? NUTqPXk4SW62aXzleYtmdWmlIHHjeIl3cXS7IHHnZYlve3RiaIXtZY4hWmGsaTDj[YxteyCjZoTldkAzPCCqcoOgZpkh[2yxbn;n[Y5q[yCjc4PhfUwhVEN3ME2xN{44KM7:TR?= M2jnSVE5OTZ|NUi5
human LoVo cells M1vodGN6fG:2b4jpZ:Kh[XO|YYm= NXOwZZRiPzJiaB?= NITURpJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBNd1[xIHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NVUvQDhizszN MVyyNVEzQTl5Nx?=
K562 cells M1y5PWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mn\1OUBl[Xm| M3TJT2dzd3e2aDDpcohq[mm2aX;uJI9nKEt3NkKgZ4VtdHNiYomgXHRVKGG|c3H5JIFnfGW{IEWg[IF6eyxiSVO1NF0yPy53NjFOwG0> M3;PNFE4PDFzMEmy
RAW 264 cells MX;GeY5kfGmxbjDhd5NigQ>? NYL5eYxlOjRiaB?= NFHBXnpKdmirYnn0bY9vKG:oIEGgeYcwdWxiTGDTMZN1cW23bHH0[YQhXE6IYXzwbIEh[WOldX31cIF1cW:wIHnuJHJCXyB{NkSgZ4VtdHNiYX\0[ZIhOjRiaILzMEBKSzVyPUG4MlEh|ryP NFzWNXUyPzN{MEK0Oi=>
mouse RAW264.7 cells MVzGeY5kfGmxbjDhd5NigQ>? NWTCPWlyOjRiaB?= NIjkeIpCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIlvKG2xdYPlJHJCXzJ4ND63JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgWG5H[WyyaHGgdJJw\HWldHnvckB1emWjdHXkJFIhcHK|IHLl[o9z\SCOUGOgZ4hidGynbnflJI1m[XO3cnXkJIFnfGW{IEK0JIhzeyCkeTDFUGlUSSxiSVO1NF0yQS5zIN88US=> M1;VeFIyOjh6N{K3
HEK293 cells NV73TIIxTnWwY4Tpc44h[XO|YYm= MXfBcpRi\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJJJm[2:vYnnuZY51KEy[UnLleIEh\XiycnXzd4VlKGmwIFjFT|I6OyClZXzsd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGlEPTB;MkKg{txO MVyxPFM1OzF{Nh?=
3T3 cells NHK4S|NEgXSxdH;4bYPDqGG|c3H5 M2TmOmN6fG:2b4jpZ{Bm\m[nY4Sgc44hO1R|IHPlcIx{NCCLQ{WwQVI1KM7:TR?= NYL3O5FrQDJyMU[wNy=>
human MCF7 cells MofpSpVv[3Srb36gZZN{[Xl? MUi2JIg> MofvTY5pcWKrdHnvckBw\iCyaH;yZo9tKGW|dHXyMYlv\HWlZXSgc5JvcXSqaX7lJIRm[2G{Yn;4fYxie2ViaX6gbJVu[W5iTVPGO{Bk\WyuczDh[pRmeiB4IHjyd{whUUN3ME2yOkDPxE1? M2LVU|ExODd3N{Sy
WiDr human colon cells NWPX[GpiS3m2b4TvfIlkyqCjc4PhfS=> MVLDfZRwfG:6aXOg[YZn\WO2IH;uJHdqTHJiaIXtZY4h[2:ub36gZ4VtdHNuIFnDOVA:OjdwNzFOwG0> MkHTPFIxOTZyMx?=
NHEM cells M1zkR2Z2dmO2aX;uJIF{e2G7 MUm3NkBp MYnJcohq[mm2aX;uJI9nKG2nbHHubY4he3mwdHjld4l{KGmwIF7ISW0h[2WubIOgZZN{\XO|ZXSgZZMhYzF2Q230bIlwfXKjY3nsJIlv[2:{cH;yZZRqd25iYX\0[ZIhPzJiaILzJIJ6KGyrcYXp[EB{[2mwdHnscIF1cW:wIHPveY51cW6pLDDJR|UxRTJ7LkKg{txO MnXNNVkyOzJ7M{S=
human BxPC3 cell MkPMVJJwdGmoZYLheIlwdiCjc4PhfS=> MXLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEK6UFOzJINmdGxibHnu[UBjgSCPVGSgZZN{[XluIFnDOVA:OzBizszN MV:xOlc5QTd|Nx?=
human LNCAP cells NGHFOYREgXSxdH;4bYPDqGG|c3H5 NF:0[5Q4OiCq Mke4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUG5ESVBiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME2zNE43PSEQvF2= MV2yNVEzQTl5Nx?=
HEK293 cells MV3GeY5kfGmxbjDhd5NigQ>? MWfBcpRi\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJJJm[2:vYnnuZY51KEy[UnHsdIhiKGW6cILld5Nm\CCrbjDISWszQTNiY3XscJMh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBKSzVyPUOxJO69VQ>? NEja[GsyQDN2M{GyOi=>
human HCT116 cells NG\tOY9EgXSxdH;4bYPDqGG|c3H5 NVzyOFZuPzJiaB?= NG\TXnNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJS1RzMU[gZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0{PC57IN88US=> NXe1SJJVOjFzMkm5O|c>
human AGS cells NVzoe|d6S3m2b4TvfIlkyqCjc4PhfS=> NWfxfpltPzJiaB?= NET2[pJEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCT1NiY3XscJMh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME20NU43PyEQvF2= NIHmc5AzOTF{OUm3Oy=>
human PC3 cells MkHMVJJwdGmoZYLheIlwdiCjc4PhfS=> NVG5dVA6PDhiaB?= NHfoN4JCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIFv\HKxZ3XuJJJm[2WydH;yMYRm\mmlaXXueEBpfW2jbjDQR|Mh[2WubIOgbY5kfWKjdHXkJJdqfGhiMD62JI5OKG:oIHXzeJJi\GmxbDDhcoQhOC55IH7NJI9nKHSnc4Tvd5Rmem:wZTDh[pRmeiB2ODDodpMh[nlic4Xs[o9zcG:mYX3pcoUhSiCjc4PhfUwhT0l3ME20Nk43PThizszN MXSyNVUyOzJ5NR?=
human A549 cells M{[4PGN6fG:2b4jpZ:Kh[XO|YYm= MVK3NkBp MlfZR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bi\nSncjC3NkBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUSzMlA6KM7:TR?= MUSyNVEzQTl5Nx?=
human BT20 cell MXXQdo9tcW[ncnH0bY9vKGG|c3H5 NFe4UGNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFLUNlAh[2WubDDsbY5mKGK7IF3UWEBie3OjeTygTWM2OD12NjFOwG0> M4jkbFE3Pzh7N{O3
human DU145 cells MYrDfZRwfG:6aXRCpIF{e2G7 NIPh[lQ4OiCq NIG4WoFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBFXTF2NTDj[YxteyCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVQ4NjJ7IN88US=> NGHLUYQzOTF{OUm3Oy=>
human U937 cells NXy3[lNLWHKxbHnm[ZJifGmxbjDhd5NigQ>? NE\Cc3I4OiCq MmXoRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCXOUO3JINmdGy|IHHmeIVzKDd{IHjyd{BjgSCZU2StPEBie3OjeTygTWM2OD12ODFOwG0> NWrvSHhGOTdzNUiwOVQ>
human MOLT3 cells NHK4WnVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkX5OFghcA>? M{\tSmdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG1QVFR|IHPlcIx{KGGodHXyJFQ5KGi{cx?= M33kTlE5OTZ|NUi5
human T47D cells MX;GeY5kfGmxbjDhd5NigQ>? NGnsbFBGe3S{b3flcolkKGGldHn2bZR6KGmwIHj1cYFvKFR2N1SgZ4VtdHNiYYPz[ZN{\WRiYYOg[JJ2\yCuZY\lcEBk[XW|aX7nJJN1cW23bHH0bY9vKG:oIHPlcIwheHKxbHnm[ZJifGmxbjDldZVqfmGuZX70JJRwKDFyIIDNJIV{fHKjZHnvcEBjgSCjbHHtZZIh[my3ZTDhd5NigQ>? MX6xOVc5PzR|Nh?=
human MDA-kb2 cells M{n4VWZ2dmO2aX;uJIF{e2G7 MYDB[49vcXO2IHHjeIl3cXS7IHH0JIFv\HKxZ3XuJJJm[2WydH;yJIlvKGi3bXHuJG1FSS2tYkKgZ4VtdHNiYYPz[ZN{\WRiYYOgd5RqdXWuYYTpc44hd2ZibIXjbYZmemG|ZTDhZ5Rqfmm2eTDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[Xl? MYOxPVU6OjJ2NR?=
human MCF7 cells MnnXSpVv[3Srb36gZZN{[Xl? NETEcncxNjFvMkCg{txO NEnDWow1KGSjeYO= M{PHPXN1cW23bHH0bY9vKG:oIHfyc5d1cCCrbjDoeY1idiCPQ1[3JINmdGy|IHH0JFAvOSC2bzCyNEB2VSCjZoTldkA1KGSjeYOgZpkhVVSWIHHzd4F6 NV;KOHA5OjVyN{izNVQ>
HUVE12 cells NF\pXJNHfW6ldHnvckBie3OjeR?= NXvrWZh[WmW4ZYLzZYwhd2ZiaInkdo9o\W5icHXyc5hq\GVvaX7keYNm\CCORFigZYN1cX[rdImgbY4hcHWvYX6gTHVXTTF{IHPlcIx{ NVPT[ZJ2OThyNki5PFA>
human MCF7 cells NXjCSYZUT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYOyNE0yODBizszN NIXwN4s1KGSjeYO= Ml\1S5Jwf3SqIHnubIljcXSrb36gbY4hcHWvYX6gUWNHPyClZXzsd{BifCB{MDD0c{AyODBidV2gZYZ1\XJiNDDkZZl{KGK7IF3UWEBie3OjeR?= NXm3UnVjOjVyN{izNVQ>
A431 cells MY\GeY5kfGmxbjDhd5NigQ>? M1LvZlUxKHSxIEe1JJVO M2HzNlM3KGh? NXfBZlk{S2WubDDjfYNt\SCjcoLld5QhcW5iaIXtZY4hSTR|MTDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBi[2O3bYXsZZRqd25iYYSgS|AwTzFicHjhd4Uh[XRiNUCgeI8hPzVidV2gZYZ1\XJiM{[gbJJ{KGK7IIDyc5Bq\Gm3bTDpc4Rq\GVic4ThbY5qdmdvYnHz[YQh\myxdzDjfZRwdWW2cnnjJIFv[Wy7c3nz NGXWSIkzPDR3NkCwOC=>
human SKBR3 cells NEjvTGNHfW6ldHnvckBie3OjeR?= NELjU282OCC2bzC3OUB2VQ>? MUizOkBp NXLjVnA{S2WubDDjfYNt\SCjcoLld5QhcW5iaIXtZY4hW0uEUkOgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h[WOldX31cIF1cW:wIHH0JGcxN0dzIIDoZZNmKGG2IEWwJJRwKDd3IIXNJIFnfGW{IEO2JIhzeyCkeTDwdo9xcWSrdX2gbY9lcWSnIIP0ZYlvcW6pLXLhd4VlKG[ub4egZ5l1d22ndILpZ{BidmGueYPpdy=> M1;KZVI1PDV4MEC0

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
PPARγ / C/EBPα / αP2 ; 

PubMed: 18384126     


Genistein dose-dependently inhibits adipogenic gene expression. Mouse BMSC cultures were exposed to adipogenic cocktail in the presence of increasing concentrations of genistein. Cells were harvested at day 21, and whole cell proteins were subjected to western blotting analysis. 

p-ERK; 

PubMed: 18384126     


Genistein dose-dependently inhibits the phosphorylation of ERK1/2. Cells were treated as above and harvested at day 5 after 5 min exposure to adipogenic cocktail, and whole cell protein were subjected to western blotting analysis.

Foxo3; 

PubMed: 21639915     


Genistein inhibits EGF-induced translocation of FOXO3. Immunofluorescent staining of experimental monolayers revealed that EGF-induced FOXO3 translocation from the nucleus to the cytosol was inhibited by genistein. This experiment was repeated two times in triplicate.

CIP2A / PARP / Cleaved PARP / Caspase-3 / Cleaved Caspase-3 ; 

PubMed: 27574003     


MCF-7, MCF-7-C3 and T47D cells were treated with genistein (GENI) at indicated concentrations for 48 h. Protein levels of CIP2A and PARP in all three cell lines, and caspase-3, cleaved caspase-3 (C-caspase-3) in MCF-7-C3 and T47D cells were detected with western blot analysis.

p-AKT / AKT ; 

PubMed: 27574003     


Genistein inhibits Akt phosphorylation. MCF-7-C3 and T47D cells were treated with genistein at indicated concentrations for 16 h. Phospho-Akt and Akt were detected with western blotting. *P<0.05.

DNMT-1 / DNMT-3a / DNMT-3b ; 

PubMed: 25931004     


Western blot analysis of the effect of physiological concentrations of genistein (0.5–10 µmol/L) on protein expression of the three DNMT subtypes, DNMT1, DNMT3a and DNMT3b in PCa cells.

18384126 21639915 27574003 25931004
Immunofluorescence
ER-β / pS87 ER-β ; 

PubMed: 25931004     


Cells were treated with DMSO (vehicle) or genistein 1 µmol/L and 10 µmol/L for 4hr. Then, cells were fixed, immunostained with pan ER-β and pS87 antibodies simultaneously and visualized by the confocal microscope. The red fluorescent staining in the first column is for pan ER-β, the green fluorescent staining in the second column is for pS87 and the third column is for both images merged together using image J software.

25931004
In vivo Genistein has chemopreventive effects on breast, prostate, and other endocrine-dependent tumors in adult animals. Genistein in the diet reduced the incidence of poorly differentiated prostatic adenocarcinomas in a dose-dependent manner and down-regulated androgen receptor, estrogen receptor-alpha, progesterone receptor, epidermal growth factor receptor, insulin-like growth factor-I, and extracellular signal-regulated kinase-1 but not estrogen receptor-beta and transforming growth factor-alpha mRNA expressions. Dietary genistein protects against mammary and prostate cancers by regulating specific sex steroid receptors and growth factor signaling pathways.[4] Genistein combined with prostate tumor irradiation causes greater inhibition of primary tumor growth and increases control of spontaneous metastasis to para-aortic lymph nodes, increasing mouse survival. Paradoxically, treatment with genistein alone increases metastasis to lymph nodes. [5]

Protocol

Solubility (25°C)

In vitro DMSO 54 mg/mL (199.82 mM)
Ethanol 2 mg/mL (7.4 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 270.24
Formula

C15H10O5

CAS No. 446-72-0
Storage powder
in solvent
Synonyms N/A
Smiles OC1=CC=C(C=C1)C2=COC3=C(C(=CC(=C3)O)O)C2=O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01982578 Recruiting Dietary Supplement: Genistein|Other: Placebo Alzheimer''s Disease Fundación para la Investigación del Hospital Clínico de Valencia|University of Valencia September 1 2017 Not Applicable
NCT02499861 Completed Drug: Decitabine and Genistein Cancer St. Justine''s Hospital July 2015 Phase 1|Phase 2
NCT01628471 Completed Drug: decitabine in combination with genistein Non Small Cell Lung Cancer Uman Pharma|DSM Nutritional Products Inc.|MDEIE Ministry Québec Government|INRS-Institut Armand Frappier Université du Québec November 2012 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

EGFR Signaling Pathway Map

Related EGFR Products

Tags: buy Genistein | Genistein supplier | purchase Genistein | Genistein cost | Genistein manufacturer | order Genistein | Genistein distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID